144,121 research outputs found
Un Analisis Politico Comparativo de los Factores de la Estabilidad Politica durante la Transicion Democratica de Rusia y Espana a finales del Siglo XX y principios del Siglo XXI
No full textBoyko S. Un Analisis Politico Comparativo de los Factores de la Estabilidad Politica durante la Transicion Democratica de Rusia y Espana a finales del Siglo XX y principios del Siglo XXI [Электронный ресурс] / Sergey Boyko// Revista Internacional de Humanidades. - Madrid, 2012. - Volumen 1, Numero 1. - P. 1-7
Un Analisis Politico Comparativo de los Factores de la Estabilidad Politica durante la Transicion Democratica de Rusia y Espana a finales del Siglo XX y principios del Siglo XXI
No full textBoyko S. Un Analisis Politico Comparativo de los Factores de la Estabilidad Politica durante la Transicion Democratica de Rusia y Espana a finales del Siglo XX y principios del Siglo XXI [Электронный ресурс] / Sergey Boyko// Revista Internacional de Humanidades. - Madrid, 2012. - Volumen 1, Numero 1. - P. 1-7
"MAGNIFICENT EDIFICE OF THE HISTORY OF SLAVIC LITERATURES": Y. BOYKO-BLOKHIN'S "PROJECT"
No full textThe article deals with Y. Boyko-Blokhin's approach to the problem of comparative analysis of Slavic literatures in the context of contemporary comparative study (U. Weisstein, R. Wellek, D. Ďurišin, A. Dima, D. Nalivayko, D. Chizhevsky). The careful attention of the scholar to "peculiarities" of national development of literatures as a subject of the research is emphasized. Specifically, the interpretation by Y. Boyko-Blokhin of such concepts as "interaction" (not only as a rapprochement, but also as a mutual repulsion) and "influence" (primarily as a creative transformation of foreign artistic and aesthetic experience, and hence, as an impetus, impulse for own original creation) is thought through.
The opinion of the scholar as to characteristic aspects of the comparative study of East Slavic literatures is analyzed and the emphasis is given to the researcher's close attention to the question of national features of each of these literatures. The efficiency and potential of Y. Boyko-Blokhin's concept of comparative study of East Slavic literatures, aimed at understanding of their place in Common Slavic and West European literary space are substantiated. The importance of the scholar's thoughts about the need for "reformatting" ("reorienting") of the Slavic paradigm for the further development of this science (in view of unjustified "domination" of Russian literature over Ukrainian and Byelorussian literatures) is underlined.
The consideration is given to Y. Boyko-Blokhin's approach ("project") to compilation of the history of Slavic literatures (vector of which is oriented from the study of peculiarities of literary works towards comprehension of the style as a unifying principle), with an emphasis on comparison of national development trends. The recognition in this context of the progress of other art forms is regarded as fully compliant with the special attention paid by contemporary comparative studies to the problem of literature in the art system (U. Weisstein, D. Chizhevsky, D. Nalivayko)
The great importance for the continuous progress of Ukrainian comparative literature of the views of Y. Boyko-Blokhin, who developed traditions of national comparative studies and at the same time used the latest West European methodology, given the impossibility of its full-fledged advance during the Soviet period, is accentuated. The relevance of the scholar's thoughts and ideas for comparative world literature even nowadays is demonstrated
"MAGNIFICENT EDIFICE OF THE HISTORY OF SLAVIC LITERATURES": Y. BOYKO-BLOKHIN'S "PROJECT"
No full textThe article deals with Y. Boyko-Blokhin's approach to the problem of comparative analysis of Slavic literatures in the context of contemporary comparative study (U. Weisstein, R. Wellek, D. Ďurišin, A. Dima, D. Nalivayko, D. Chizhevsky). The careful attention of the scholar to "peculiarities" of national development of literatures as a subject of the research is emphasized. Specifically, the interpretation by Y. Boyko-Blokhin of such concepts as "interaction" (not only as a rapprochement, but also as a mutual repulsion) and "influence" (primarily as a creative transformation of foreign artistic and aesthetic experience, and hence, as an impetus, impulse for own original creation) is thought through.
The opinion of the scholar as to characteristic aspects of the comparative study of East Slavic literatures is analyzed and the emphasis is given to the researcher's close attention to the question of national features of each of these literatures. The efficiency and potential of Y. Boyko-Blokhin's concept of comparative study of East Slavic literatures, aimed at understanding of their place in Common Slavic and West European literary space are substantiated. The importance of the scholar's thoughts about the need for "reformatting" ("reorienting") of the Slavic paradigm for the further development of this science (in view of unjustified "domination" of Russian literature over Ukrainian and Byelorussian literatures) is underlined.
The consideration is given to Y. Boyko-Blokhin's approach ("project") to compilation of the history of Slavic literatures (vector of which is oriented from the study of peculiarities of literary works towards comprehension of the style as a unifying principle), with an emphasis on comparison of national development trends. The recognition in this context of the progress of other art forms is regarded as fully compliant with the special attention paid by contemporary comparative studies to the problem of literature in the art system (U. Weisstein, D. Chizhevsky, D. Nalivayko)
The great importance for the continuous progress of Ukrainian comparative literature of the views of Y. Boyko-Blokhin, who developed traditions of national comparative studies and at the same time used the latest West European methodology, given the impossibility of its full-fledged advance during the Soviet period, is accentuated. The relevance of the scholar's thoughts and ideas for comparative world literature even nowadays is demonstrated
Application of the new structural solution in the seeders for precision sowing as a resource saving direction
No full textBoyko A. Application of the new structural solution in the seeders for precision sowing as a resource saving direction / A. Boyko, N. Gerasimchuk, P. Popik, Y. Gerasimchuk, O. Bunnyi // Eastern-european journal of enterprise technologies - 2018/ - №5/1. - c. 46-5
Application of the new structural solution in the seeders for precision sowing as a resource saving direction
No full textBoyko A. Application of the new structural solution in the seeders for precision sowing as a resource saving direction / A. Boyko, N. Gerasimchuk, P. Popik, Y. Gerasimchuk, O. Bunnyi // Eastern-european journal of enterprise technologies - 2018/ - №5/1. - c. 46-5
Cuarteto de Cuerdas Tel-aviv, cuarteto de cuerdas (Israel)
No full textConcierto celebrado por el cuarto de cuerdas Tel-aviv. El grupo está integrado por Chaim Taub, Yefim Boyko, Daniel Benyamini y Uzi Wiezel. En esta ocasión interpretaron obras de Bartok, Mozart, Beethove
Total Synthesis of Isomalabaricane Triterpenoids
No full textThe first total syntheses of (±)-rhabdastrellic acid A and (±)-stelletin E, highly cytotoxic isomalabaricane triterpenoids, have been accomplished in a linear sequence of 14 steps from commercial geranylacetone. The exceptionally strained trans-syn-trans-perhydrobenz[e]indene core characteristic of the isomalabaricanes is efficiently accessed in a selective manner through a rapid, complexity-generating sequence. This process features a reductive radical polyene cyclization, an unprecedented oxidative Rautenstrauch cycloisomerization, and umpolung α-substitution of a p-toluenesulfonylhydrazone with in situ reductive transposition. A late-stage cross-coupling in concert with a modular approach to polyunsaturated side chains renders this a general strategy for the synthesis of numerous family members of these synthetically challenging and hitherto inaccessible marine triterpenoids
Total Synthesis of Stelletins through an Unconventional Annulation Strategy
No full textConspectusMarine ecosystems present the largest source of biodiversity on the planet and an immense reservoir of novel chemical entities. Sessile marine organisms such as sponges produce a wide range of complex secondary metabolites, many of these with potent biological activity engineered for chemical defense. That such compounds exert dynamic effects outside of their native context is perhaps not surprising, and the realm of marine natural products has attracted considerable attention as a largely untapped repository of potential candidates for drug development. Only a handful of the more than 15 000 marine natural products that have been isolated to date have advanced to the clinic, and more are to be expected. The rich chemical information encoded in the intricate three-dimensional structures of many marine natural products facilitates highly discriminating interactions with cell signaling pathways, and especially within cancer cells such nuanced effects offer an exciting opportunity for the development of targeted therapies that lack the side effects and general toxicity of conventional chemotherapeutics. The isomalabaricanes are a rare class of marine triterpenoids that have been hailed as promising cytotoxic lead compounds for the treatment of cancer, and they have attracted a flurry of excitement from researchers because of their potent cytotoxicity in certain human cancer cell lines along with a range of other antineoplastic effects. Most notably, their inhibitory activity is highly cell-selective, characterized by large deviations from their mean GI50 concentrations across 3 orders of magnitude in the NCI-60 Human Tumor Cell Lines screen, suggesting mechanistic specificity rather than general and unbridled toxicity. Despite these auspicious preliminary reports, the isomalabaricane scaffold remains largely unexplored as a potential anticancer lead because of lack of material. This Account describes our recent efforts to develop a general, modular synthesis of the isomalabaricanes, as exemplified by the successful total syntheses of rhabdastrellic acid A, stelletin E, and stelletin A. The unorthodox trans-syn-trans configuration of their perhydrobenz[e]indene core severely circumscribes the synthetic methods available for its construction and required several generations of strategy to assemble. Ultimately, a series of unconventional transformations were identified that were capable of building this highly strained motif, and the syntheses of rhabdastrellic acid A and stelletin E were completed in racemic fashion. Subsequently, a second-generation approach to these natural products was developed, rendering the synthesis enantioselective as well as providing access to stelletin A. These synthetic efforts were greatly assisted by computational techniques such as 13C NMR prediction, which enabled structural assignments of hydrocarbon diastereomers, as well as relaxed surface scan conformational analysis, which informed a campaign for directed hydrogenation of an alkene. High-throughput experimentation methods were brought to bear during optimization of a late-stage Suzuki coupling on stelletin A. Finally, preliminary structure-activity relationship studies in glioblastoma and nonsmall cell lung cancer cell lines were conducted on stelletin A, revealing that the singular trans-syn-trans perhydrobenz[e]indene core is essential for the cytotoxic activity of the isomalabaricane triterpenoids
THE MYSTICAL ASPECT OF THE DRAMATIC WORKS OF LESIA UKRAINKA IN THE INTERPRETATION OF Y. BOYKO-BLOKHIN
No full textУ статті проаналізовано своєрідність художнього осмислення
елементів містичного у драматичних творах Лесі Українки
діаспорним літературознацем Ю. Бойко-Блохиним. Увага
дослідника зосереджена на тих творах поетеси, поштовхом до
написання яких стали підсвідомо-ірраціональні індивідуальні
рушії творчості. Простежено, що Ю. Бойко-Блохин писав не про
зображення вигаданого авторською уявою містичного світу, а
саме про його реальну присутність у житті; вважав, що
інтуїтивне бачення незримого, зв’язок з містичним та
потойбічним поставали з душі Лесі Українки. The article analyzes the originality of artistic
understanding of the elements of the mystical in the dramatic works
of Lesja Ukrainka by diaspora literary critic Y. Boyko-Blokhin. The
attention of the researcher is focused on those works of the poetess,
the impetus to the writing of which became unconsciously irrational
individual engines of creativity. It is traced that Y. Boyko-Blokhin did
not write about the image of the mystical world by the author’s
imagination of the author’s imagination, but about his real presence
in life; believed that the intuitive vision of the invisible, the
connection with the mystical and otherworldly arose from the soul of
Lesia Ukrainka
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