9,634 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control
No full textIn vitro, assembly of box C/D small nucleolar ribonucleoproteins (snoRNPs) involves the sequential recruitment of core proteins to snoRNAs. In vivo, however, assembly factors are required (NUFIP, BCD1, and the HSP90–R2TP complex), and it is unknown whether a similar sequential scheme applies. In this paper, we describe systematic quantitative stable isotope labeling by amino acids in cell culture proteomic experiments and the crystal structure of the core protein Snu13p/15.5K bound to a fragment of the assembly factor Rsa1p/NUFIP. This revealed several unexpected features: (a) the existence of a protein-only pre-snoRNP complex containing five assembly factors and two core proteins, 15.5K and Nop58; (b) the characterization of ZNHIT3, which is present in the protein-only complex but gets released upon binding to C/D snoRNAs; (c) the dynamics of the R2TP complex, which appears to load/unload RuvBL AAA+ adenosine triphosphatase from pre-snoRNPs; and (d) a potential mechanism for preventing premature activation of snoRNP catalytic activity. These data provide a framework for understanding the assembly of box C/D snoRNPs
\u3ci\u3eDemocracy and Public Administration\u3c/i\u3e
No full textEditor: Richard C. Box
Chapter 2, Democracy Public Administrators and Public Policy, authored by Dale Krane, UNO faculty member.
The true measure of the successful practice of public service is its ability to remain faithful to the tenets of democratic society. This introductory text links the practice of public administration to the core concepts of American democracy. It covers the nuts and bolts of public administration in the context of delivering democracy in public service--providing what the public really wants as opposed to what self-serving bureaucracies may call for.
Chapters in Democracy and Public Administration discuss the functional topics covered in other texts, but from the perspective of this democratic ideal. Each chapter is written by an expert in the area, and summarizes previous research in the area, presents the author\u27s research and thought, and offers ways in which practitioners can apply the concepts discussed to their daily work.https://digitalcommons.unomaha.edu/facultybooks/1197/thumbnail.jp
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Bipolar disorder, Type A behavior, and coronary disease
No full textThis paper describes a model for integrating two psychological constructs--bipolar disorder and the Type A behavior pattern--each of which has been associated with enhanced risk of coronary heart disease (CHD). It highlights similarities between manic/hypomanic behaviors associated with bipolarity and the behaviors observed in Type A individuals. The proposed model conceptualizes Type A behavior as an alternating pattern of coping with challenging and stressful events. Thus, initial coping efforts are manifested as behavioral hyper-reactivity (including mania/hypomania), but this gives way to hypo-reactivity (including helplessness and depression) after repeated failure to assert control and/or attain relevant goals. This alternation of Type A coping patterns resembles the affective and behavioral transitions often seen in bipolar patients. Future research on psychological, epidemiological, and pathophysiological issues concerning CHD should document areas of commonality and independence between bipolarity and Type A behavior. Such studies would benefit from consideration of a model that identifies psychosocial dimensions common to Type A, mania/hypomania, and depression.Peer reviewedThis is an electronic version of an article published in Glass, David C. and Richard J. Contrada. "Bipolar disorder, Type A behaviour and coronary disease." Health Psychology Review, available online 15 Feb 2011. DOI:10.1080/17437199.2010.531568. Health Psychology Review is available online at: www.tandfonline.co
Books piece on a reading by Richard Price, author of Samaritan, which will b
No full textBooks piece on a reading by Richard Price, author of Samaritan, which will be presented at Rines Auditorium, Portland Public Library, on March 5
Spiritual voyage, performed in the ship Convert, under the command of Capt. Godly-Fear, from the port of Repentance-Unto-Life, to the haven of Felicity, on the continent of Glory. An allegory. By the late Rev. Edmund Botsford, A.M. A new edition, revised, corrected and improved. To which is prefixed, a sketch of the life of the author, by the late Rev. Richard Furman, D.D
No full textW. RileyA spiritual voyage, performed in the ship Convert, under the command of Capt. Godly-Fear, from the port of Repentance-Unto-Life, to the haven of Felicity, on the continent of Glory. An allegory. By the late Rev. Edmund Botsford, A.M. A new edition, revised, corrected and improved. To which is prefixed, a sketch of the life of the author, by the late Rev. Richard Furma
Considerations upon the state of public affairs, [electronic resource] : at the beginning of the year MDCCXCVIII. Part the first. France. By the author of "considerations, &c. at the Beginning of the Year 1796.".
No full textThe author of "Considerations, &c. at the beginning of the year 1796." = Thomas Richard Bentley.Electronic reproduction.English Short Title Catalog,Reproduction of original from British Library
Sarah C. Campbell & Richard, P. Campbell: Cook Prize 2023, Silver Medal Acceptance Speech.
No full textSarah Campbell (author & photographer) and Richard Campbell (photographer) give an acceptance speech and talk about their book Infinity: Figuring Out Forever. Published by Astra Young Readers.https://educate.bankstreet.edu/cook/1005/thumbnail.jp
Human box C/D snoRNAs with miRNA like functions : expanding the range of regulatory RNAs
No full textSmall nucleolar RNAs (snoRNAs) and microRNAs are two classes of non-protein-coding RNAs with distinct functions in RNA modification or post-transcriptional gene silencing. In this study, we introduce novel insights to RNA-induced gene activity adjustments in human cells by identifying numerous snoRNA-derived molecules with miRNA-like function, including H/ACA box snoRNAs and C/D box snoRNAs. In particular, we demonstrate that several C/D box snoRNAs give rise to gene regulatory RNAs, named sno-miRNAs here. Our data are complementing the increasing number of studies in the field of small RNAs with regulatory functions. In massively deep sequencing of small RNA fractions we identified high copy numbers of sub-sequences from >30 snoRNAs with lengths of ≥18 nt. RNA secondary structure prediction indicated for a majority of candidates a location in predicted stem regions. Experimental analysis revealed efficient gene silencing for 11 box C/D sno-miRNAs, indicating cytoplasmic processing and recruitment to the RNA silencing machinery. Assays in four different human cell lines indicated variations in both the snoRNA levels and their processing to active sno-miRNAs. In addition we show that box D elements are predominantly flanking at least one of the sno-miRNA strands, while the box C element locates within the sequence of the sno-miRNA guide strand
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