17 research outputs found
Improving impact poly (propylene) morphology and production: selective poisoning of catalyst surface sites and the use of antistatic agents
No full textFormulation and Optimization of Diclofenac Sodium Loaded Ethylcellulose Nanoparticles
No full textDesign of experiment (DoE) is a useful time and cost-effective tool for analyzing the effect of independent variables on the formulation characteristics. The aim of this study is to evaluate the effect of the process variables on the characteristics involved in the preparation of Diclofenac Sodium (DC) loaded ethylcellulose (EC) nanoparticles (NP) using Central Composite Design (CCD). NP were prepared by W/O/W emulsion solvent evaporation method. Three factors were investigated (DC/EC mass ratio, PVA concentration, homogenization speed) in order to optimize the entrapment efficiency (EE) and the particle size of NP. The optimal formulation was characterized by Fourier Transform Infrared (FTIR), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), and in vitro release. Optimized formulation showed an EE of 49.09 % and an average particle size of 226.83 nm with a polydispersity index of 0.271. No drug-polymer interaction was observed in FTIR and DSC analysis. SEM images showed that the particles are spherical and uniform. The in vitro release study showed a sustained release nature, 53.98 % of the encapsulated drug has been released over 24hours period. This study demonstrated that statistical experimental design methodology can optimize the formulation and the process variables to achieve favorable responses
Influence of the rubber content and particle morphology on the mechanical properties of the (hiPP)
No full textInfluence of the rubber content and particle morphology on the mechanical properties of the (hiPP)
No full textInternational audienc
Formulation and Characterization of Poly (Acrylic Acid)- Co-Chitosan Nanoparticles as pH-Thermo-Responsive System to Control Delivery
No full textInternational audienceThe present study aims to develop a pH thermosensitive nanocarriers as a drug delivery system to better controll drug release. Nanoparticles was developed by the combination of smart polymers, chitosan and poly(acrylic acid) were chosen as biodegradable vectors to encapsulate and transport the drug. The used method was based on the polymerization of acrylic acid using reticulated chitosan as a template. Analysis of particle size, Zeta potential, and size distribution revealed that most of the resulting nanoparticles had an average diameter less than 100nm, with a high Zeta potentiel about -29.7 mV and a narrow size distribution. In addition, the developed system showed an encapsulation efficiency around 97%. In vitro release test was achieved using different buffer solutions with pH equal to 1.2, 3.6, 4.2, 4.8, 6.8 and 7.4. The release profiles showed that nanoparticles provide drug protection at different pH values. They responded at pH = 3.6 and provided sustained controlled release of up to 62.62% over 8 hours. The results reveal that the prepared nanoparticles can be used as drug delivery carriers. They can improve therapeutic efficiency of the drugs used in the treatment of inflamed tissues where the pH is around 3.6 as in the Crohn disease
Influence of the rubber content and particle morphology on the mechanical properties of the (hiPP)
No full textFormulation and Characterization of Poly (Acrylic Acid)- Co-Chitosan Nanoparticles as pH-Thermo-Responsive System to Control Delivery
No full textThe present study aims to develop a pH thermosensitive nanocarriers as a drug delivery system to better controll drug release. Nanoparticles was developed by the combination of smart polymers, chitosan and poly(acrylic acid) were chosen as biodegradable vectors to encapsulate and transport the drug. The used method was based on the polymerization of acrylic acid using reticulated chitosan as a template. Analysis of particle size, Zeta potential, and size distribution revealed that most of the resulting nanoparticles had an average diameter less than 100nm, with a high Zeta potentiel about -29.7 mV and a narrow size distribution. In addition, the developed system showed an encapsulation efficiency around 97%. In vitro release test was achieved using different buffer solutions with pH equal to 1.2, 3.6, 4.2, 4.8, 6.8 and 7.4. The release profiles showed that nanoparticles provide drug protection at different pH values. They responded at pH = 3.6 and provided sustained controlled release of up to 62.62% over 8 hours. The results reveal that the prepared nanoparticles can be used as drug delivery carriers. They can improve therapeutic efficiency of the drugs used in the treatment of inflamed tissues where the pH is around 3.6 as in the Crohn disease
Mechanical, Rheological, and Tribological Behavior of an In Situ Silica‐Reinforced Experimental Dental Composite: A Comparative Study
No full textInternational audienceIn restorative dentistry, dental composites are extensively employed owing to their advantageous mechanical and aesthetic features. However, achieving an optimal balance between handling properties and long‐term durability remains a challenge. This study compares the rheological and tribological properties of an experimental dental composite reinforced with in situ silica and a commercial composite prepared by conventional methods. Rheological tests were conducted to evaluate pre‐polymerization handling behavior, while tribological tests assessed post‐polymerization durability. Results revealed that the experimental composite exhibited enhanced thixotropic behavior, facilitating improved clinical handling. Elastic recovery tests showed that it restored its internal structure 38% faster after deformation compared to the commercial composite. Tribological analysis revealed a lower COF (0.015 vs. 0.016) and a 10% reduction in wear rate under a 20 N load, demonstrating superior resistance to mechanical wear. These findings suggest that the in situ silica‐reinforced composite provides improved handling and durability, making it a promising candidate for restorative dental applications
Enhancing photopolymerization and modeling kinetic degradation in dental composites
No full textInternational audienc
