724 research outputs found

    René Géronimo Favaloro : pioneer of Cardiac Surgery

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    Dr. René G. Favaloro moved to the Cleveland Clinic in 1962 and proceeded to reshape the face of cardiac surgery as we knew it. Together with his colleagues at the Cleveland Clinic, Drs. Effler, Sones, Proudfit, Groves, Sheldon and countless others, he contributed to the double internal mammary arterymyocardial implantation by the Vineberg method, and by May 1967, he reconstructed the right coronary artery by the saphenous vein graft interposition. These landmark procedures paved the way for the aorto-coronary saphenous vein bypass graft in October 1967. Many similar breakthroughs ensued, with the application of the bypass technique to the left coronary artery, the combination of coronary artery bypass graft with left ventricular reconstruction and valve repair/replacement and finally, by December, a double bypass to the right coronary artery and anterior descending branch of the left coronary artery. In June, 1971, Dr. Favaloro decided to leave the Cleveland Clinic and return to Argentina where he created a medical centre, a teaching unit, a research department and finally an Institute of Cardiology and Cardiovascular Surgery. This was his greatest personal ambition. Over and above his brilliant mind and craft, Dr. Favaloro was a man of integrity, courage, honesty and humility, whose name will never cease to reverberate throughout the history of medicine.peer-reviewe

    ECOPICS Mx Floristic list for the research plots

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       ECOPICS Project : Floristic list Author: René A. Palestina Last actualization: october 2022. To derive the floristic list and define target species, sampling was carried out on a gradient of 1100 m, which ranges from 3,400 to 4,500 m altitude. Using the relevé method, 10x10 m plots were established at each site to identify the tree species and within these, three 2x2 m plots for shrubs and herbaceous species. This information allowed the selection of a structuring adult individual.</p

    Musikstädte as real and imaginary soundscapes: urban musical images as literary motifs in twentieth-century German modernism

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    PhDThis study examines German literary images of musical life as part of the wider sound identity of the modern German city at the turn of the twentieth century. Focussing on a forty-year period from 1890 to 1930, synonymous with the emergence of the modern German metropolis as an aesthetic object, the project assesses, compares and contrasts how musical life in the Musikstädte was perceived and portrayed by writers in an increasingly noisy urban environment. How does urban musical life influence and condition city writings? What are the differences and similarities between the writings on various musical cities? Can an urban textual sound identity be derived from these differences and similarities? The approach employed to answer these questions is a new, cross-disciplinary one to urban sound in literature, moving beyond reading the key sounds of the urban soundscape using urban musicology, sensorial anthropology and cultural poetics towards a literary contextualisation of the urban aural experience. The literary motifs of the symphony, the gramophone and urban noise are put under the spotlight through the analysis of a wide range of modernist works by authors who have a special relationship with music. At the centre of this analysis are the Kaffeehausliteratur authors Hermann Bahr, Alfred Polgar and Peter Altenberg, the then Munich-based author Thomas Mann and the lesser known René Schickele. The analysis of these particular works is framed in the music-geographical context of the Musikstadt and literary underpinnings of this topos, ranging from Ingeborg Bachmann to Hans Mayer and, once again, Thomas Mann. In analysing these texts, the methodological approach devised by Strohm, who identifies the blending of a range of urban sounds as a definition of urban space and identity, is applied. His ideas combine historical literary analysis, musical history and urban sociology. They are rarely used in the analysis of the auditory environment.Arts and Humanities Research Council Westfield TrustWestfield Trust Studentship Arts and Humanities Reseach Council (AHRC

    Optimized Methods for the Surface Immobilization of Collagens and Collagen Binding Assays

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    Fibrosis occurs in various tissues as a reparative response to injury or damage. If excessive, however, fibrosis can lead to tissue scarring and organ failure, which is associated with high morbidity and mortality. Collagen is a key driver of fibrosis, with type I and type III collagen being the primary types involved in many fibrotic diseases. Unlike conventional protocols used to immobilize other proteins (e.g., elastin, albumin, fibronectin, etc.), comprehensive protocols to reproducibly immobilize different types of collagens in order to produce stable coatings are not readily available. Immobilizing collagen is surprisingly challenging because multiple experimental conditions may affect the efficiency of immobilization, including the type of collagen, the pH, the temperature, and the type of microplate used. Here, a detailed protocol to reproducibly immobilize and quantify type I and III collagens resulting in stable and reproducible gels/films is provided. Furthermore, this work demonstrates how to perform, analyze, and interpret in vitro time-resolved fluorescence binding studies to investigate the interactions between collagens and candidate collagen-binding compounds (e.g., a peptide conjugated to a metal chelate carrying, for example, europium [Eu(III)]). Such an approach can be universally applied to various biomedical applications, including the field of molecular imaging to develop targeted imaging probes, drug development, cell toxicity studies, cell proliferation studies, and immunoassays

    The French Journalist René Marchand: Some Facts about “Soviet Russia’s Friend”

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    This article is devoted to the life, political views and activities of Le Figaro correspondent René Marchand (1888-1962). Marchand became widely known in Soviet Russia thanks to his open letter to French President Raymond Poincaré in 1918, which criticized the republic’s policy vis-à-vis Moscow as well as acts of sabotage by the Allies. The missive became an important episode in the confrontation between the Entente’s special services and the young Bolshevik regime. French and Russian historians tend to argue that the French journalist’s sympathies turned to socialism and Bolshevism in 1918. However, they generally pay little attention the French Left in Soviet Russia. Based on research in French diplomatic and military archives at Courneuve and Vincennes, respectively, the author concludes that René Marchand was a multi-faceted individual and the nature of his sympathies to the Bolsheviks remains questionabl

    Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging:From Basic Concepts to Emerging Methods

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    BACKGROUND:  Late gadolinium enhancement (LGE) is a widely used cardiac magnetic resonance imaging (MRI) technique to diagnose a broad range of ischemic and non-ischemic cardiomyopathies. Since its development and validation against histology already more than two decades ago, the clinical utility of LGE and its span of applications have increased considerably.METHODS:  In this review we will present the basic concepts of LGE imaging and its diagnostic and prognostic value, elaborate on recent developments and emerging methods, and finally discuss future prospects.RESULTS:  Continuous developments in 3 D imaging methods, motion correction techniques, water/fat-separated imaging, dark-blood methods, and scar quantification improved the performance and further expanded the clinical utility of LGE imaging.CONCLUSION:  LGE imaging is the current noninvasive reference standard for the assessment of myocardial viability. Improvements in spatial resolution, scar-to-blood contrast, and water/fat-separated imaging further strengthened its position.KEY POINTS:   · LGE MRI is the reference standard for the noninvasive assessment of myocardial viability. · LGE MRI is used to diagnose a broad range of non-ischemic cardiomyopathies in everyday clinical practice.. · Improvements in spatial resolution and scar-to-blood contrast further strengthened its position. · Continuous developments improve its performance and further expand its clinical utility.CITATION FORMAT: · Holtackers RJ, Emrich T, Botnar RM et al. Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging: From Basic Concepts to Emerging Methods. Fortschr Röntgenstr 2022; DOI: 10.1055/a-1718-4355.</p

    Cypridina infraoolithica Terquem 1885

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    Cypridina infraoolithica Terquem 1885 (nomen dubium) Fig. 4 H Cypridina infraoolithica Terquem 1885: 40, pl. 6: fig. 7 a,b.— Dacqué 1934: 397 (list).— Coryell 1963: 583. Holotype None selected, possibly unique specimen. Type locality Middle Jurassic (De Fontoy, France). Material Specimen not examined herein. Distribution Middle Jurassic, France. Comparisons More elongate than M. hollandica. Remarks This specimen has an unusual rostrum for a myodocopid. It is also quite small. The senior author sent for the specimen, but The Paris Museum of Natural History could not find the specimen of C. infraoolithica in their collections (Danielle Defaye, email, 8 / 22 / 05).Published as part of Kornicker, Louis S., Van, Barry W. M., Bakel, Fraaije, René H. B. & Jagt, John W. M., 2006, Revision of Mesozoic Myodocopina (Ostracoda) and a new genus and species, Mesoleberis hollandica, from the Upper Cretaceous of Belgium and The Netherlands, pp. 15-54 in Zootaxa 1246 on pages 44-45, DOI: 10.5281/zenodo.17293
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