1,721,095 research outputs found
Beware of the dangers along the path towards the diagnosis of HPV-driven oropharyngeal squamous cell carcinoma
Full text linkBeware of the dangers along the path towards the diagnosis of HPV-driven oropharyngeal squamous cell carcinoma
p53 Mutation in histologically normal mucosa of the aero-digestive tract is not a marker of increased risk for second primary carcinoma in head and neck cancer patients.
Full text linkComprehensive Chemosensory Psychophysical Evaluation of Self-reported Gustatory Dysfunction in Patients with Long-term COVID-19: A Cross-sectional Study
No full textThis cross-sectional study evaluates self-reported gustatory dysfunction in patients with long-term COVID-19
CARCINOMA METASTATIC TO CERVICAL LYMPH NODES FROM AN OCCULT PRIMARY TUMOR: THE OUTCOME AFTER COMBINED-MODALITY THERAPY
No full textBACKGROUND: The aim of this retrospective analysis was to analyze the results of treatment of patients with cervical node metastases from carcinoma of occult primary with a policy including neck dissection and postoperative comprehensive radiotherapy.
METHODS: Ninety patients were treated with curative intent from 1990 to 2002.
RESULTS: The actuarial rate of neck disease control was 68.8% at 5 years (95% confidence interval [CI], 58.9%-78.7%). On multivariate analysis, the rate of neck disease control was significantly related to lymph nodal metastatic level (P = .006). The actuarial rate of developing head and neck primary tumors at 5 years was 8.9% (95% CI, 2.6%-15.2%). The 5-year actuarial rate of distant metastases was 19.1% (95% CI, 9.4%-28.9%). In multivariate analysis, a statistically significant difference in the rate of distant metastasis was obtained when patients were stratified according to the level of nodal involvement (P = .01) and the presence of extracapsular extension (P = .013). At the time of analysis, 50 of the 90 patients were alive. A total of 32 (35.6%) had died from causes related to their primary disease. Actuarial disease-specific survival at 2 and 5 years was 73.6% (95% CI, 64.3%-82.9%) and 62.8% (95% CI, 51.9%-73.7%), respectively. In multivariate analysis, a statistically significant difference in disease-specific survival was obtained when patients were stratified according to the level of nodal involvement and the presence of extracapsular extension.
CONCLUSIONS: Our study seems to support the use of combined-modality therapy in patients with neck metastases from carcinoma of occult primary. However, in the absence of randomized trials, comprehensive irradiation cannot be routinely advised
Otolaryngologic manifestations of the ongoing outbreak of human monkeypox: ENT specialists should be on the alert
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Transglottic Acinic Cell Carcinoma. Review
No full textAcinic cell carcinoma (ACC) is a rare tumor generally involving the parotid gland and infrequently the minor salivary glands with the potential for both local recurrence and metastatic spread when tracked for decades. The biological behavior of ACC cannot be predicted on the basis of histological features, and surgical stage is still the best predictor of clinical outcome. Only 5 cases of ACC of the larynx have been reported in the English literature. The authors present a case of a rare transglottic ACC in a 74-year-old woman. At admission, a submucosal mass involving the left arytenoid and adjacent aryepiglottic fold was noted. A CT scan of the head and neck region showed a mass of the left hemilarynx involving the paraglottic space and extending from the aryepiglottic fold to the sinus piriformis. Definitive histopathological examination showed an ACC with a large amount of clear cells. The patient was treated by radiotherapy alone (66 Gy in 7 weeks) with complete remission
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