1,721,141 research outputs found
Atrophoderma vermiculatum: Histological findings of the early and late lesions. Study of a case
No full textAtrophoderma Vermiculatum (AV) is a rare disease characterized by the occurrence on the face and the cheeks in particular, of fine, atrophic pits, with a bilateral distribution, producing a honeycomb, reticulate appearance. All the cases reported in the literature focus on the atrophic changes of the disease while no attention has been paid to the condition which causes atrophy. The early stages are not usually reported. MC is a girl aged 13. She had multiple, fine, pale-brown papules (1-2 mm in diameter) on her right cheek. The histopathological findings of these lesions predominantly showed lymphocytic perifolliculitis with perifollicular fibrosis. The epidermis was normal. No specific diagnosis other than perifolliculitis was possible. Eight months later the patient showed tiny, atrophic depressions and follicular plugs with reticulate teleangectases in the same area of the right cheek (with disappearance of the tiny papules). A clinical diagnosis of AV was done. The histological findings of a further biopsy showed atrophy of the epidermis, less severe perifollicular inflammation and decrease in number of the follicles. The hair follicles were widely dilated and were either empty or contained keratinous materials. Dermal atrophy and disappearance of elastic fibers was noticeable. In conclusion the late clinical features of the lesions, through unusual (asymmetry of the lesion, small and superficial atrophic scars), make the diagnosis of the early clinical and histological features of papules and perifolliculitis possible and suggest a specific name: Early stages of AV
Why a monograph on cutaneous drug-induced reactions seen in histopathological perspective
No full textVasculitides with cutaneous expression in children: clinico-pathological correlations
No full textThe most recent pediatric vasculitis classifications (EULAR/PRINTO/PRES) have proposed the use of an integration of clinical signs and symptoms, laboratory data, imaging and pathologic data. Pediatric vasculitis represent a peculiar clinical-diagnostic model, compared to the corresponding adult pathology chapter, and in particular, dermatopathologic aspects of these diseases identify more specific issues, made contingent by crucial variables such as duration of vasculitis lesion, site of the biopsy, proper biopsy depth, and possibility to correlate histopathological findings with immunopathological results. Possible additional diagnostic difficulties may arise from the fact that, in children, the same systemic disease, such as lupus erythematosus, may present with different clinical manifestations, with histopathological features of a precise type of vasculitis specific for that type of clinical manifestation. Examples are provided by hypocomplementemic urticarial vasculitis, cryoglobulinemic purpura, lymphocytic vasculitis of livedoid lesions. This paper describes the cutaneous histopathological findings of some vasculitis related pediatric diseases, be they pertaining to a systemic vasculitis with corresponding cutaneous vasculitis, to a systemic vasculitis with sporadic cutaneous vasculitic involvement, and to a systemic vasculitis without cutaneous vasculitic involvement. Type and level of histopathological vasculitic involvement, caliber of the vessel, type of vasculitis associated infiltrate, are likewise reliable integration in the complex diagnostic path of vasculitis in childhood. On the basis of these criteria dermatopathologists should be confident in identifying the type of the vasculitis and relate them to a specific pediatric disease
Ricerche comparative sull'assorbimento del paracetamolo e dell'aminofenazone nell'uomo dopo somministrazione per via orale o rettale
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Cutaneous blisters as the presenting signs of recurrent thyroglossal duct cyst in a child
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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