279 research outputs found
JCS „Avstonis“ possibilities for profit maximization.
No full textThis master’s thesis discusses theoretical aspects and models of profit, profitability analysis and maximization in detail. It is noticed, that seeking to maximize their value, activities, opportunities and profits, organizations rarely use systems and methods carefully prepared in advance; rarely use thorough, complex and systematic analysis of profit and profitability ratios, as well as their evaluation and practical application needed for profit maximization. The profitability analysis of JCS “Avstonis” allows determining the most important reasons of change in income and expenses, illustrate factors forming profit quality, evaluate the relation between sales income, activity expenses and profit. The results helped to formulate possible activity directions of JCS “Avstonis” as well as set the opportunities for profit maximization. The scientific working hypothesis, formed by the author of this master’s thesis, is proven – sales volume and price model based on profit margin analysis is assessed as one of the most suitable methods for profit maximization
First person - Tiina Viita
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Tiina Viita is first author on 'Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing', published in JCS. Tiina is a PhD Student in the lab of Maria Vartiainen at the Institute of Biotechnology, University of Helsinki, Finland, investigating the nucleus, proteomics, chromatin remodeling, actin and post-transitional modifications of histones.Non peer reviewe
First person - Seda Yasa
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Seda Yasa is first author on 'CLN3 regulates endosomal function by modulating Rab7A-effector interactions', published in JCS. Seda is a PhD student in the lab of Stephane Lefrancois at the INRS, Quebec, Canada, investigating the role of CLN proteins in intracellular trafficking pathways to develop novel therapeutic strategies for lysosomal storage disorders.</p
First person – Alba Delrio-Lorenzo
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Alba Delrio-Lorenzo is first author on ‘Sarcoplasmic reticulum Ca2+ decreases with age and correlates with the decline in muscle function in Drosophila’, published in JCS. Alba is a PhD student in the lab of Javier García-Sancho and María Teresa Alonso at the Instituto de Biología y Genética Molecular (IBGM), University of Valladolid, Spain, investigating the molecular mechanisms implicated in aging, particularly muscle aging.Peer reviewe
Correction: Abnormal Burnout of Nurses in Crisis; Double Pressure of Low Support and Competence
No full textIn the article titled "Abnormal Burnout of Nurses in Crisis; Double Pressure of Low Support and Competence," published in Journal of Caring Sciences (2023, Volume 12, issue 4; doi: 10.34172/jcs.2023.33177), an error was identified in the affiliation of the first author. The correct affiliation is as follows: 1. Department of Medical Surgical Nursing, Maragheh University of Medical Sciences, Maragheh, Iran. The original version of the article has been amended in both the PDF and HTML formats to reflect this correction
First person - Srija Bhagavatula.
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Srija Bhagavatula is first author on `A putative stem-loop structure in Drosophila crumbs is required for mRNA localisation in epithelia and germline cells', published in JCS. Srija is a post-doc in the lab of Dr Elisabeth Knust at Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, investigating the significance of mRNA localization in epithelia
First person – Jamie Whitelaw
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping researchers promote themselves alongside their papers. Jamie Whitelaw is first author on ‘ CYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge’, published in JCS. Jamie conducted the research described in this article while a post-doctoral researcher in Prof. Laura Machesky's lab at CRUK Scotland Institute, Glasgow, UK. He is now a Lecturer at University of the West of Scotland, Blantyre, investigating host–pathogen interactions with a focus on the role of the host cytoskeleton
The Chlamydomonas flagellar membrane glycoprotein FMG-1B is necessary for expression of force at the flagellar surface
No full textAuthor Posting. © Company of Biologists, 2019. This article is posted here by permission of Company of Biologists for personal use, not for redistribution. The definitive version was published in Journal of Cell Science 132 (2019): jcs.233429, doi:10.1242/jcs.233429.In addition to bend propagation for swimming, Chlamydomonas cells use their flagella to glide along a surface. When polystyrene microspheres are added to cells, they attach to and move along the flagellar surface, thus serving as a proxy for gliding that can be used to assay for the flagellar components required for gliding motility. Gliding and microsphere movement are dependent on intraflagellar transport (IFT). Circumstantial evidence suggests that mechanical coupling of the IFT force-transducing machinery to a substrate is mediated by the flagellar transmembrane glycoprotein FMG-1B. Here, we show that cells carrying an insertion in the 5′-UTR of the FMG-1B gene lack FMG-1B protein, yet assemble normal-length flagella despite the loss of the major protein component of the flagellar membrane. Transmission electron microscopy shows a complete loss of the glycocalyx normally observed on the flagellar surface, suggesting it is composed of the ectodomains of FMG-1B molecules. Microsphere movements and gliding motility are also greatly reduced in the 5′-UTR mutant. Together, these data provide the first rigorous demonstration that FMG-1B is necessary for the normal expression of force at the flagellar surface in Chlamydomonas.
This article has an associated First Person interview with authors from the paper.This work was made possible by a Dartmouth FRPDF (faculty research and professional development fund) generously provided by the Dean of the Faculty and by the Ira Allen Eastman (Class of 1829) Professorship, which was established in 1910 by a gift to the College from his widow, Jane Eastman.2020-08-0
First person - Aude Pascal
No full textInternational audienceFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Aude Pascal is first author on `Annexin A2 and Ahnak control cortical NuMA-dynein localization and mitotic spindle orientation', published in JCS. Aude is a research assistant in the lab of Re ' gis Giet at University of Rennes, France, who is particularly interested in developmental biology. She has always been struck by the fact that a whole organism displaying multiple functions arises from a single cell. For this reason, she has oriented her research on mitosis and meiosis to study the different steps, components and structures involved in these processes
First person - Anna Dowbaj.
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Anna Dowbaj is co-first author on 'An optogenetic method for interrogating YAP1 and TAZ nuclear-cytoplasmic shuttling', published in JCS. Anna conducted the work described in this article while a PhD student in the lab of Erik Sahai at the Francis Crick Institute, London, UK. She is now a postdoc in the lab of Meritxell Huch at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany, investigating the role of the stem cell niche in liver regeneration
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