40 research outputs found
The effect of a worksite based walking programme on cardiovascular risk in previously sedentary civil servants
No full textBackground: A significant proportion of Europeans do not meet the recommendations for 30 mins of physical activity 5 times per week. Whether lower frequency, moderate intensity exercise alters cardiovascular disease (CVD) risk has received little attention. This study examined the effects of 45 minutes self-paced walking, 2 d· wk-1 on aerobic fitness, blood pressure (BP), body composition, lipids and C-Reactive Protein (CRP) in previously sedentary civil servants. Methods: 37 subjects (24 women) aged 41.5 ± 9.3 years were randomly assigned to either two 45 minute walks per week (walking group) or no training (control group). Aerobic fitness, body composition, blood pressure (BP), CRP and lipoprotein variables were measured at baseline and following 8 weeks. Steps counts were measured at baseline and during weeks 4 and 8 of the intervention. Results: Compared to the control group, the walking group showed a significant reduction in systolic BP and maintained body fat levels (P < 0.05). There were no changes other risk factors. Subjects took significantly more steps on the days when prescribed walking was performed (9303 ± 2665) compared to rest days (5803 ± 2749; P < 0.001). Conclusion: These findings suggest that walking twice per week for 45 minutes at ~ 62% HRmax, improves activity levels, reduces systolic BP and prevents an increase in body fat in previously sedentary adults. This walking prescription, however, failed to induce significant improvements in other markers of cardiovascular disease risk following eight weeks of training
Carbon sinks and climate change: Forests in the fight against global warming
No full textReforestation and avoiding deforestation are methods of harnessing nature to tackle global warming - the greatest challenge facing humankind. In this book, Colin Hunt deals comprehensively with the present and future role of forests in climate change policy and practice. The author provides signposts for the way ahead in climate change policy and offers practical examples of forestry's role in climate change mitigation in both developed and tropical developing countries. Chapters on measuring carbon in plantations, their biodiversity benefits and potential for biofuel production complement the analysis. He also discusses the potential for forestry in climate change policy in the United States and other countries where policies to limit greenhouse gas emissions have been foreshadowed
Continuing Questions in Canadian Political Finance Law: Third Parties and Small Political Parties
No full textCanadian political finance law has struggled with the question of how to treat small political parties and third parties. The author contends that data gathered by Elections Canada concerning third party expenditures over the last four federal elections provides an opportunity to re-evaluate Harper v. Canada (A.G.), which was decided without a strong evidential foundation on the grounds of a reasonable apprehension of harm. The Ontario Court of Appeal’s decision in Longley v. Canada (A.G.) upholding Canada Elections Act provisions that require political parties to meet vote thresholds to qualify for annual allowances, raises constitutional questions about the role of small political parties. The author questions whether a distinction should be made in law between large and small political parties and whether the fear that third parties may become political parties is a sufficient justification to limit the rights of small political parties
Training effects of accumulated daily stair-climbing exercise in previously sedentary young women.
No full textBACKGROUND: The health and fitness benefits associated with short, intermittent bouts of exercise accumulated throughout the day have been seldom investigated. Stair climbing provides an ideal model for this purpose. METHODS: Twenty-two healthy female volunteers (18-22 years) were randomly assigned to control (N = 10) or stair-climbing (N = 12) groups. Stair climbers then underwent a 7-week stair-climbing program, progressing from one ascent per day in week 1 to six ascents per day in weeks 6 and 7, using a public access staircase (199 steps). Controls were instructed to maintain their normal lifestyle. Standardized stair-climbing tests were administered to both groups immediately before and after the program. Each paced ascent lasted 135 s, during which oxygen uptake (VO(2)) and heart rate (HR) were monitored continuously. Blood lactate concentration was also measured immediately following each test ascent. Fasting blood samples from before and after the program were analyzed for serum lipids. Data were analyzed using a two-way ANOVA with repeated measures. RESULTS: Relative to the insignificant changes in the control group, the stair-climbing group displayed a rise in HDL cholesterol concentration (P<0.05) and a reduced total:HDL ratio (P<0.01) over the course of the program. VO(2) and HR during the stair-climbing test were also reduced, as was blood lactate (all P<0.01). CONCLUSION: A short-term stair-climbing program can confer considerable cardiovascular health benefits on previously sedentary young women, lending credence to the potential public health benefits of this form of exercis
The effects of 60 minutes of brisk walking per week, accumulated in two different patterns, on cardiovascular risk
No full textMaking vision into power : Britain's acquisition of the world's first radar-based integrated air defence system 1935 - 1941
No full textThis thesis represents the first application of a current conceptual model of defence acquisition to analyse the historical process, the 1935 - 1941 British acquisition of an integrated air defence system pivoted upon the innovative technology of radar. For successful acquisition of a military capability, the model posits that balanced attention must be focused acoss eight 'lines of developmen' - not only equipment, but also doctrine and concepts, logistics, structures, personnel, organisation, training and information with an overarching requirement for interoperability. This thesis contrasts what turned out to be a successful acquisition, of radar to achive air interception capability by day in the Battle of Britain, with less successful acquisition, or radar to achieve the same capability at night, where an effective system arrived too late to ward off the Blitz. The results establish the validity of the model and its attendant lines of development concepts, and furnish new insights into acquisition processes and military history. Acquisition lessons are derived for the capability-based involvement of industry, for the experience and personality necessary for key managers at different 'life stages' of an acquisition and for the avoidance of over-rapid 'dysfunctional diffusion' of innovative technologies. Historical insights for the Battle of Britain include the sub-optimal performance, for trivial reasons, of key South Coast radars, and the critical importance of the human elements of the radar-based air defence system. For the Blitz, airborne radar hardware has previously been identified as a key problem, whereas research here exposes the greater need for accurate ground control radar, the sound selection and training of pilots and operators in new tactics, and provision of equipment maintainers and test gear. New evidence illustrates that pursuit of an alternative to radar significantly delayed the optimal solution, and throws fresh light both on personalities and on development process management
Pro12Ala Polymorphism in Preterm Birth
No full textThe links between preterm birth, low birth weight, and adult vascular/metabolic morbidity remain unclear. Genetic susceptibility of babies related to these three conditions might contribute to this long-term association. We tested whether the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma (PPARG) gene could play a role in birth weight and duration of gestation. We genotyped two independent cross-sectional studies from Northern Ireland (n = 382 and 620). In combined populations, the PPARG Ala12 allele was associated (P = 0.03) with lower birth weight, primarily caused by shorter gestational duration (P = 0.04). The frequency of Ala12 allele carriers was higher (P = 0.027) in the group of individuals born before term (35%, n = 60) than in the group of individuals born at term (22%, n = 942). The odds ratios (95% CI) of preterm birth for Ala12 allele carriers were 1.9 (1.1-3.4), P = 0.022, and 4.2 (1.9-9.7), P = 0.0006 (adjusted for sex, maternal age, and study), when considering 37 or 35 weeks of pregnancy as a threshold for preterm birth, respectively. Interestingly, the same allele was also associated with a moderate decreased risk of miscarriages in mothers. In conclusion, the PPARG Pro12Ala polymorphism might represent a genetic susceptibility factor for preterm birth and constitute a link between preterm birth and metabolic diseases later in life.The links between preterm birth, low birth weight, and adult vascular/metabolic morbidity remain unclear. Genetic susceptibility of babies related to these three conditions might contribute to this long-term association. We tested whether the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma (PPARG) gene could play a role in birth weight and duration of gestation. We genotyped two independent cross-sectional studies from Northern Ireland (n = 382 and 620). In combined populations, the PPARG Ala12 allele was associated (P = 0.03) with lower birth weight, primarily caused by shorter gestational duration (P = 0.04). The frequency of Ala12 allele carriers was higher (P = 0.027) in the group of individuals born before term (35%, n = 60) than in the group of individuals born at term (22%, n = 942). The odds ratios (95% CI) of preterm birth for Ala12 allele carriers were 1.9 (1.1-3.4), P = 0.022, and 4.2 (1.9-9.7), P = 0.0006 (adjusted for sex, maternal age, and study), when considering 37 or 35 weeks of pregnancy as a threshold for preterm birth, respectively. Interestingly, the same allele was also associated with a moderate decreased risk of miscarriages in mothers. In conclusion, the PPARG Pro12Ala polymorphism might represent a genetic susceptibility factor for preterm birth and constitute a link between preterm birth and metabolic diseases later in life
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
No full textMultiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
No full textApproaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups
Insulin sensitivity and clustering of coronary heart disease risk factors in young adults. the northern ireland young hearts study
No full textBackground.Coronary heart disease (CHD) is usually associated with "clustering" of risk factors. Insulin resistance may cause deleterious changes in several CHD risk factors and is of potential interest in the aetiology of clustered risk. We analyzed how glucose and insulin variables were associated with clustered risk. Methods.Participants were 489 young adults from Northern Ireland. Data were collected between October 1997 and October 1999. Nine risk factors were included in the clustered risk variable. Being "at risk" was defined as being in the upper quartile of risk for a particular risk factor. Subjects with clustered risk were defined as those displaying four or more risk factors. Blood glucose and insulin were measured in the fasting state and 2 h after ingestion of a 75 g glucose load. Results.Fasting insulin and the homeostasis model assessment insulin resistance score (HOMA) were strong, graded predictors of clustered risk. The odds ratio (OR) for having clustered risk was 10.8 (95% CI: 3.6-32.4) for the upper quartile of fasting insulin compared to the lowest quartile, and the corresponding OR for HOMA was 23.2 (95% CI: 5.3-101.6). Conclusion.HOMA score predicts clustering of CHD risk factors. Fasting glucose alone did not predict clustering of risk factors, which may indicate that insulin resistance was compensated for by increased insulin secretion. </p
