19,869 research outputs found
Bora Gazi Giray Han: Hayatı ve eserleri
No full textÇalışmamızda, çeşitli kütüphanelerdeki on altı adet yazmadan topladığımız metinler temelinde, Gazi Giray Han'ın hayatının araştırılmasına ve eserlerinin dil bilgisi ve üslûp açılarından incelenmesine çalışılmıştır. Giriş kısmında çalışmamızın daha iyi anlaşılmasına katkıda bulunmak amacıyla Gazi Giray Han'ın külliyatı için başvurduğumuz yazma eserler, katalog bilgileriyle birlikte sıralanmıştır. Çalışmamız toplam yedi bölümden oluşmaktadır. 1. Bölüm'de genel olarak Gazi Giray Han dönemi Kırım'ın tarihsel, kültürel durumu, Gazi Giray'ın hayatı ve sanatkârlığı açıklanmıştır. 2. Bölüm'de Gazi Giray'ın eserlerinin ayrıntılı tasnifi yapılmıştır. 3. Bölüm Gazi Giray Han eserlerinin dil bilgisi açısından incelenmesine ayrılmıştır. 4. Bölüm'de Gazi Giray Han eserleri üslûp açısından incelenmiştir. 5. Bölüm'de çalışmamızın asıl malzemesi olarak kullanılan metinler yer almaktadır. 6. Bölüm'de mensur eserlerin çevirileri verilmiştir. 7. Bölüm'de ise metnin gramatikal dizini bulunmaktadır. Sonda Kaynaklar, eserlerin tıpkıbasımı yer almaktadır.AbstractIn our works, we have tried to research Gazi Giray Han?s life and examine his works in terms of grammar and literary style by collecting the texts from 16 scripts in different libraries. The written works which we consulted for Gazi Giray Han?s complete works have been arranged with catalogue information for making contribution to be understood well at prologue part. Our work consists of seven parts. The first part has been generally separated for Crimean?s historical and cultural situations at Gazi Giray Han period and also for explaining his literary activities and life, The detailed classification of Gazi Giray?s works have been done in the 2nd part. The 3rd part has been separated for examining Gazi Giray Han`s works in terms of grammar. In the 4th part, Gazi Giray Han`s works have been examined in terms of literary style. In the 5th part, there have been the texts which are used as basis materials. In the 6th part, translations of the prose works have been given. In the 7th part, there has been a grammatical index of the text. At the last part, there have been references and original text
Dataset to support the article "High-resolution 𝜙-OFDR using phase unwrap and nonlinearity suppression"
No full textThis dataset is used for realizing high resolution of phase-sensitive Optical Frequency Domain Reflectometer. It is associated with the research paper:
Guo Z, Yan J, Han G, Yu Y, Greenwood D and Marco J (2023) "High-Resolution φ-OFDR Using Phase Unwrap and Nonlinearity Suppression". Journal of Lightwave Technology, 41 (9), 2885-2891. (https://doi.org/10.1109/JLT.2023.3236775).
The data is presented as an excel file:
High_resolution_OFDR_using_phase_unwrap_and_nonlinearity_suppression.xlsx
This work was funded by High Value Manufacturing Catapult and the Engineer and Physical Sciences Research Council - EPSRC EP/V000624/1. The author Gaoce Han would like to acknowledge the China Scholarship Council for sponsoring.</span
Han Suyin (Chinese author) speaking at Dallas Brookes Hall.
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/276390Han Suyin (Chinese author) speaking at Dallas Brookes Hall.200056
Item: [1999.0081.00439] "Han Suyin (Chinese author) speaking at Dallas Brookes Hall.
Unveiling the Role of BORA in Ovarian Cancer Dissemination: a new potential targeted therapeutic strategy
No full textEl càncer d'ovari (CO) és la neoplàsia ginecològica més letal en països desenvolupats, amb una supervivència als 5 anys menor al 30%. Aquest mal pronòstic s'explica, principalment, perquè la majoria de les pacients són diagnosticades en estadis avançats, quan el càncer ja ha disseminat per la cavitat peritoneal i on les opcions terapèutiques són limitades.
BORA és el principal cofactor de PLK1, una quinasa amb múltiples rols en mitosis, entre els quals destaca el seu paper en la transició G2/M. A més, PLK1 també té diferents funcions fora del cicle cel·lular, entre les quals hi ha promoure la transició epiteli-mesènquima (EMT). La EMT és un procés clau en la disseminació del càncer degut a que confereix a les cèl·lules més motilitat, propietats de cèl·lules mare, resistència a la mort per anoikis, i major resistència a la quimioteràpia. Tant BORA com PLK1 s'han trobat sobreexpressades en diferents neoplàsies, incloent el CO, on se'ls hi han atribuït propietats oncogèniques. Considerant això, en aquesta tesis hem avaluat el paper de BORA en la disseminació del CO, en concret, la seva capacitat de promoure la EMT de forma PLK1-dependent.
En aquest projecte hem demostrat que la sobreexpressió ectòpica de BORA promou la EMT, augmentant el potencial de migrar i envair de les cèl·lules tumorals in vitro, i incrementant la formació de metàstasis in vivo. A més, hem demostrat que les cèl·lules amb nivells endògens de BORA alts migren més que la població parental, el que ens fa postular que alta expressió endògena de BORA confereix a les cèl·lules canceroses més flexibilitat per iniciar la EMT, un estat cel·lular conegut com a "metastable". D'altra banda, els nostres resultats també indiquen que nivells ectòpics elevats de BORA afavoreixen la angiogènesis, un procés necessari pel creixement tant del tumor primari com del secundari. Finalment, també hem testat la inhibició de BORA utilitzant siRNAs contra BORA conjugats amb un tipus de nanopartícules anomenades Quatsomes. Amb aquesta estratègia, hem demostrat que silenciar BORA redueix la viabilitat de les cèl·lules de CO, disminueix la seva capacitat de migrar i que, quan es combina amb els fàrmacs que s'utilitzen actualment contra el CO en la clínica, augmenta el seu benefici terapèutic.
En resum, els nostres resultats suggereixen que BORA contribueix a la disseminació del CO a través de promoure la EMT. Per tant, la inhibició de BORA podria bloquejar aquest procés i així reduir la capacitat del CO de disseminar, així com també disminuiria la viabilitat de les cèl·lules. Per tant, els nostres resultats descriuen una nova potencial estratègia terapèutica per tractar les pacients amb CO avançat.El cáncer de ovario (CO) es la neoplasia ginecológica más letal en los países desarrollados, con una supervivencia a los 5 años menor al 30%. Este mal pronóstico se explica, principalmente, debido a que la mayoría de las pacientes son diagnosticadas en estadios avanzados de la enfermedad, cuando el cáncer ya ha diseminado por la cavidad peritoneal y donde las opciones terapéuticas son limitadas.
BORA es el principal cofactor de PLK1, una quinasa con múltiples funciones en la mitosis, destacando su papel en la transición G2/M. Además, PLK1 también tiene funciones fuera del ciclo celular, entre las cuales está promover la transición epitelio-mesénquima (EMT). La EMT se considera un proceso clave en la diseminación del cáncer debido a que confiere a las células mayor motilidad, propiedades de células madre, resistencia a la muerte por anoikis, y mayor resistencia a los fármacos quimioterapéuticos. Tanto BORA como PLK1 se han visto sobreexpresadas en diferentes neoplasias, incluyendo el CO, donde se les han atribuido propiedades oncogénicas. Considerando esto, en esta tesis hemos evaluado el papel de BORA en la diseminación del CO, en concreto, su capacidad de promover la EMT de forma PLK1-dependiente.
Hemos demostrado que la sobreexpresión ectópica de BORA promueve la EMT, aumentando el potencial de migrar e invadir de las células tumorales in vitro, e incrementando la formación de metástasis in vivo. Además, hemos demostrado que aquellas células con niveles endógenos altos de BORA migran más que la población parental, lo que nos hace postular que una alta expresión endógena de BORA confiere a las células cancerosas más flexibilidad para iniciar la EMT, un estado celular conocido como "metastable". Por otro lado, nuestros resultados indican que niveles ectópicos elevados de BORA favorecen la angiogénesis, un proceso necesario para el crecimiento tanto del tumor primario como del secundario. Finalmente, hemos testado la inhibición de BORA mediante siRNAs contra BORA conjugados con un tipo de nanopartículas llamadas Quatsomes. Con esta aproximación hemos demostrado que silenciar BORA reduce la viabilidad de las células de CO, disminuye su capacidad de migrar y que, al combinarse con los fármacos utilizados actualmente contra el CO en la clínica, aumenta su beneficio terapéutico.
En resumen, nuestros resultados sugieren que BORA contribuye a la diseminación del CO a través de promover la EMT. Por lo tanto, la inhibición de BORA podría bloquear este proceso y así reducir la capacidad del CO de diseminar, así como también disminuiría la viabilidad de las células. Por lo tanto, nuestros resultados describen una nueva potencial estrategia terapéutica para tratar a las pacientes con CO avanzado.Ovarian cancer (OC) accounts for the most lethal gynecologic malignancy in developed countries, with a five-year survival of less than 30%. This poor outcome is mainly explained because the majority of OC cases are diagnosed at advanced stages, when the disease has already spread into the peritoneal cavity and the therapeutic options available are limited.
BORA is the main cofactor of PLK1, a kinase with key roles in multiple steps of mitosis, highlighting its implication in G2/M transition. Furthermore, PLK1 has also several functions beyond cell cycle, among which there is the triggering of the epithelial-mesenchymal transition (EMT). EMT is a key event for cancer dissemination, which gives to cancer cells increased motility, stem cell properties, resistance to anoikis, and increased chemoresistance. Both PLK1 and BORA have been found overexpressed in several malignancies, including OC, where have been associated with oncogenic functions. Considering this, in this thesis we have evaluated the role of BORA in OC dissemination, particularly its capacity to promote EMT in a PLK1-dependent manner.
We have demonstrated that ectopic BORA overexpression induces EMT, which gives OC cells increased migration and invasion capabilities in vitro, resulting in increased metastasis formation in vivo. Furthermore, we have proven that cells with high endogenous BORA expression migrate more than the average, hence we postulate that high endogenous BORA levels might confer to cancer cells increased flexibility to undergo EMT, a cell state referred to as "metastable". Additionally, we have shown that high ectopic BORA expression promotes angiogenesis, a process required for the outgrowth of both the primary and the secondary tumors. Finally, we have tested BORA inhibition using siRNAs against BORA delivered via a type of nanoparticles named Quatsomes. We have demonstrated that BORA silencing decreases OC cells viability, reduces their migration potential, and enhances the therapeutic benefit when combined with the standard of care.
In summary, our findings indicate that BORA contributes to OC dissemination by triggering EMT. Therefore, BORA inhibition might block this process and thus it might reduce the disseminative potential of OC, while also decreasing OC cells viability. Altogether, our results point out a new potential therapeutic strategy to treat advanced OC patients.Universitat Autònoma de Barcelona. Programa de Doctorat en Bioquímica, Biologia Molecular i Biomedicin
Unveiling the Role of BORA in Ovarian Cancer Dissemination : a new potential targeted therapeutic strategy
No full textEl càncer d'ovari (CO) és la neoplàsia ginecològica més letal en països desenvolupats, amb una supervivència als 5 anys menor al 30%. Aquest mal pronòstic s'explica, principalment, perquè la majoria de les pacients són diagnosticades en estadis avançats, quan el càncer ja ha disseminat per la cavitat peritoneal i on les opcions terapèutiques són limitades. BORA és el principal cofactor de PLK1, una quinasa amb múltiples rols en mitosis, entre els quals destaca el seu paper en la transició G2/M. A més, PLK1 també té diferents funcions fora del cicle cel·lular, entre les quals hi ha promoure la transició epiteli-mesènquima (EMT). La EMT és un procés clau en la disseminació del càncer degut a que confereix a les cèl·lules més motilitat, propietats de cèl·lules mare, resistència a la mort per anoikis, i major resistència a la quimioteràpia. Tant BORA com PLK1 s'han trobat sobreexpressades en diferents neoplàsies, incloent el CO, on se'ls hi han atribuït propietats oncogèniques. Considerant això, en aquesta tesis hem avaluat el paper de BORA en la disseminació del CO, en concret, la seva capacitat de promoure la EMT de forma PLK1-dependent. En aquest projecte hem demostrat que la sobreexpressió ectòpica de BORA promou la EMT, augmentant el potencial de migrar i envair de les cèl·lules tumorals in vitro, i incrementant la formació de metàstasis in vivo. A més, hem demostrat que les cèl·lules amb nivells endògens de BORA alts migren més que la població parental, el que ens fa postular que alta expressió endògena de BORA confereix a les cèl·lules canceroses més flexibilitat per iniciar la EMT, un estat cel·lular conegut com a "metastable". D'altra banda, els nostres resultats també indiquen que nivells ectòpics elevats de BORA afavoreixen la angiogènesis, un procés necessari pel creixement tant del tumor primari com del secundari. Finalment, també hem testat la inhibició de BORA utilitzant siRNAs contra BORA conjugats amb un tipus de nanopartícules anomenades Quatsomes. Amb aquesta estratègia, hem demostrat que silenciar BORA redueix la viabilitat de les cèl·lules de CO, disminueix la seva capacitat de migrar i que, quan es combina amb els fàrmacs que s'utilitzen actualment contra el CO en la clínica, augmenta el seu benefici terapèutic. En resum, els nostres resultats suggereixen que BORA contribueix a la disseminació del CO a través de promoure la EMT. Per tant, la inhibició de BORA podria bloquejar aquest procés i així reduir la capacitat del CO de disseminar, així com també disminuiria la viabilitat de les cèl·lules. Per tant, els nostres resultats descriuen una nova potencial estratègia terapèutica per tractar les pacients amb CO avançat.El cáncer de ovario (CO) es la neoplasia ginecológica más letal en los países desarrollados, con una supervivencia a los 5 años menor al 30%. Este mal pronóstico se explica, principalmente, debido a que la mayoría de las pacientes son diagnosticadas en estadios avanzados de la enfermedad, cuando el cáncer ya ha diseminado por la cavidad peritoneal y donde las opciones terapéuticas son limitadas. BORA es el principal cofactor de PLK1, una quinasa con múltiples funciones en la mitosis, destacando su papel en la transición G2/M. Además, PLK1 también tiene funciones fuera del ciclo celular, entre las cuales está promover la transición epitelio-mesénquima (EMT). La EMT se considera un proceso clave en la diseminación del cáncer debido a que confiere a las células mayor motilidad, propiedades de células madre, resistencia a la muerte por anoikis, y mayor resistencia a los fármacos quimioterapéuticos. Tanto BORA como PLK1 se han visto sobreexpresadas en diferentes neoplasias, incluyendo el CO, donde se les han atribuido propiedades oncogénicas. Considerando esto, en esta tesis hemos evaluado el papel de BORA en la diseminación del CO, en concreto, su capacidad de promover la EMT de forma PLK1-dependiente. Hemos demostrado que la sobreexpresión ectópica de BORA promueve la EMT, aumentando el potencial de migrar e invadir de las células tumorales in vitro, e incrementando la formación de metástasis in vivo. Además, hemos demostrado que aquellas células con niveles endógenos altos de BORA migran más que la población parental, lo que nos hace postular que una alta expresión endógena de BORA confiere a las células cancerosas más flexibilidad para iniciar la EMT, un estado celular conocido como "metastable". Por otro lado, nuestros resultados indican que niveles ectópicos elevados de BORA favorecen la angiogénesis, un proceso necesario para el crecimiento tanto del tumor primario como del secundario. Finalmente, hemos testado la inhibición de BORA mediante siRNAs contra BORA conjugados con un tipo de nanopartículas llamadas Quatsomes. Con esta aproximación hemos demostrado que silenciar BORA reduce la viabilidad de las células de CO, disminuye su capacidad de migrar y que, al combinarse con los fármacos utilizados actualmente contra el CO en la clínica, aumenta su beneficio terapéutico. En resumen, nuestros resultados sugieren que BORA contribuye a la diseminación del CO a través de promover la EMT. Por lo tanto, la inhibición de BORA podría bloquear este proceso y así reducir la capacidad del CO de diseminar, así como también disminuiría la viabilidad de las células. Por lo tanto, nuestros resultados describen una nueva potencial estrategia terapéutica para tratar a las pacientes con CO avanzado.Ovarian cancer (OC) accounts for the most lethal gynecologic malignancy in developed countries, with a five-year survival of less than 30%. This poor outcome is mainly explained because the majority of OC cases are diagnosed at advanced stages, when the disease has already spread into the peritoneal cavity and the therapeutic options available are limited. BORA is the main cofactor of PLK1, a kinase with key roles in multiple steps of mitosis, highlighting its implication in G2/M transition. Furthermore, PLK1 has also several functions beyond cell cycle, among which there is the triggering of the epithelial-mesenchymal transition (EMT). EMT is a key event for cancer dissemination, which gives to cancer cells increased motility, stem cell properties, resistance to anoikis, and increased chemoresistance. Both PLK1 and BORA have been found overexpressed in several malignancies, including OC, where have been associated with oncogenic functions. Considering this, in this thesis we have evaluated the role of BORA in OC dissemination, particularly its capacity to promote EMT in a PLK1-dependent manner. We have demonstrated that ectopic BORA overexpression induces EMT, which gives OC cells increased migration and invasion capabilities in vitro, resulting in increased metastasis formation in vivo. Furthermore, we have proven that cells with high endogenous BORA expression migrate more than the average, hence we postulate that high endogenous BORA levels might confer to cancer cells increased flexibility to undergo EMT, a cell state referred to as "metastable". Additionally, we have shown that high ectopic BORA expression promotes angiogenesis, a process required for the outgrowth of both the primary and the secondary tumors. Finally, we have tested BORA inhibition using siRNAs against BORA delivered via a type of nanoparticles named Quatsomes. We have demonstrated that BORA silencing decreases OC cells viability, reduces their migration potential, and enhances the therapeutic benefit when combined with the standard of care. In summary, our findings indicate that BORA contributes to OC dissemination by triggering EMT. Therefore, BORA inhibition might block this process and thus it might reduce the disseminative potential of OC, while also decreasing OC cells viability. Altogether, our results point out a new potential therapeutic strategy to treat advanced OC patients
A Study on the mathematics textbooks in the era of the Great Han Empire
No full text이 글은 갑오경장(1894)과 경술 국치(1910) 사이에 간행된 산학(수학) 교재류의 목록을 확인하고, 각 텍스트의 출판과 관련된 사항, 소장처, 이본 등의 서지적 정보와 함께 이 시기 산학 교재류의 국어사 자료로서의 의의를 언어 사용 상의 측면에 초점을 두어 정리하는 것을 목적으로 한다. 이는 현대 한국어 태동기의 분과 학문의 도입 양상에 대한 연구의 일환인 한편, 학술 용어의 번역과 정착을 중심으로 이 시기의 한국어의 어휘 확장 양상을 확인하는 데에 필요한 기초 자료를 정리하는 작업의 한 부분이다. 본 연구에 앞선 산학(수학) 교재류에 대한 연구로는 산학 교재류의 서지 사항에 대해 기술한 강윤호(1973:187-199), 김봉희(1992:247-253), 한길준(2009), 오채환 외(2010) 등이 있고, 한국 수학사를 기술하면서 교재류를 함께 다룬 것으로 김용운·김용국(1982)와 이상구(2013)이 있다.This paper aims to make a whole list of the mathematics textbooks in the era of the Great Han Empire and summerize bibliographical data and linguistic characteristics in view of Korean history. In chapter 1, the author reviewed former studies which deals with the mathematics textbooks in the era of the Great Han Empire. In chapter 2, the author summerized bibliographical data of 45 volumes of 32 kinds textbooks. In chapter 3, the author described linguistic characteristics of the textbooks, especially focusing on writing systems, the use of Arabic numerals, horizontal writing, and presence of index or glossary
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
Dataset to support the article "High Sensing Accuracy Realisation with Millimetre/sub-Millimetre Resolution in Optical Frequency Domain Reflectometer"
No full textThis dataset is used for realizing high sensing accuracy and sub-millimetre resolution of Optical Frequency Domain Reflectometer. It is associated with the research paper "High Sensing Accuracy Realisation with Millimetre sub-Millimetre Resolution in Optical Frequency Domain Reflectometer" in Journal: Journal of Lightwave Technology.
This work was funded by High Value Manufacturing Catapult, grant reference, 160080 CORE (WMG), titled ‘Smart Sensing for Future Batteries’ and the EPSRC (Engineering and Physical Sciences Research Council), grant reference EP/R004927/1, titled ‘Prosperity Partnership’. The author Gaoce Han would like to acknowledge the China Scholarship Council for sponsoring.</span
Photoresponsiveness of Anthracene-Based Supramolecular Polymers Regulated via a σ‑Platinated 4,4-Difluoro-4-bora-3a,4a-diaza‑<i>s</i>‑indacene Photosensitizer
No full textAnthracene and its derivatives have
attracted tremendous interest in recent years because of their intriguing
photoresponsive behaviors. Our research group has previously constructed
anthracene-based supramolecular polymers, which display multicycle
anthracene–endoperoxide photoswitching in a macroscopic manner.
However, high-energy light excitation (λ = 365–460 nm)
is required for anthracene-to-endoperoxide photooxygenation, giving
rise to severe photodegradation problems. In this work, we have developed
an effective approach to addressing this issue, by encapsulating a
σ-platinated
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)
photosensitizer into anthracene-based supramolecular polymeric systems.
The platination effect enhances π-electron delocalization, while
promoting intersystem crossing from singlet to triplet excited states.
Accordingly, the σ-platinated BODIPY photosensitizer displays
excellent 1O2 production capability, facilitating
anthracene-to-endoperoxide transformation under low-energy irradiation
conditions (λ = 520–590 nm). This leads to the breakup
of supramolecular polymers and gels, which can be restored at room
and elevated temperatures because of the reversible endoperoxide-to-anthracene
deoxygenation process. Overall, the rational design of a σ-metalated
photosensitizer opens up a new avenue to regulating the photoresponsiveness
of supramolecular polymers under mild and nondestructive conditions
Corvèe under Han
No full textThe author distinguishes between the corvee systems of Ch'in and Han. In spite of the fact that the corvee system underwent a marked change in 167 B. C. in the reign of Emperor Wen of Former Han, the fact has been hitherto almost entirely overlooked. The author tries to reconstruct the Ch'in corvee system from various sources. In the sense that these two ancient empires were despotic in their constitution there was no essential difference between their system of government, but Han succeeded in melting feudalistic residues of the Chan-kuo period into her own system, while Ch'in failed in doing so due to the short period of her rule. Moreover, Ch'in failed in taking local differences into consideration in establishing her institutions. In the author's view the reign of Emperor Wen is significant in the sense that it represents renovation of the feudalistic taxation system and of the uniform and artificial system of local administration
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