1,358,111 research outputs found
Bob Boonstra Letter
Full text linkA letter from a former student of Theora England, Bob Boonstra, given to her on her retirement.https://nwcommons.nwciowa.edu/theorareflections/1003/thumbnail.jp
Diagnostic strategy and long-term treatment outcomes in Idiopathic Pulmonary Arterial Hypertension
Full text linkVonk Noordegraaf, A. [Promotor]Boonstra, A. [Copromotor
The Load of Pulmonary Hypertension
Full text linkVonk Noordegraaf, A. [Promotor]Boonstra, A. [Copromotor
Monitoring the right ventricle in pulmonary arterial hypertension: A non-invasive approach
Full text linkVonk Noordegraaf, A. [Promotor]Boonstra, A. [Copromotor]Marcus, J.T. [Copromotor
Boonstra, Marie, [No Service Number]
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/372611Surname: BOONSTRA
Given Name(s) or Initials: MARIE
Military Service Number or Last Known Location: No Service Number
Missing, Wounded and Prisoner of War Enquiry Card Index Number: 49899183529
Item: [2016.0049.04936] "Boonstra, Marie, [No Service Number]
De waardij van eene vroege opleiding : een onderzoek naar de implicaties van het alfabetisme op het leven van inwoners van Eindhoven en omliggende gemeenten, 1800 - 1920
No full textIn this study, research has been done into the way literates and illiterates were able to cope with the modernisation process that took place in the Netherlands during the second half of the nineteenth century. Assuming that people who had learned to read and write were better equipped to face modernisation and more eager to go along with it, the question was raised whether literates would show more signs of modern behaviour than illiterates. Research was concentrated in a region around Eindhoven, situated in the southeastern part of the Netherlands. This region was selected because, at that time, Eindhoven started to change from a small a small market town into a industrial city, while the number of illiterates still was considerably large. The analyses showed that although literates and illiterates experienced a same amount of social mobility , illiterates were forced much more to look for another profession, whereas literates moved more freely. It also became apparent that literates were more willing to migrate long distance in order to find a new job. Finally, literates showed more signs of modern demographic behaviour than illiterates. Therefore, it could be concluded that literacy really was a vehicle towards modern behaviour in a modernising society.</p
Pulmonary arterial hypertension in systemic sclerosis
Full text linkSmit, E.F. [Promotor]Dijkmans, B.A.C. [Promotor]Grünberg, K. [Copromotor]Boonstra, A. [Copromotor]Voskuijl, A.E. [Copromotor
Some Comments on the Development and Application of Linear Learning Models
No full textThis paper evaluates some learning models and explores the possibility of extending the linear learning models by adding explanatory variables, using Lilien's model as a point of departure. Two parameter estimation schemes are proposed and applied: one at the micro-level using consumer panel data (micro-data) and the other at the macro-level using aggregate time-series data (macro-data). The use of micro-data restrains the estimation of effects to a limited number of decision variables in Lilien's model, because of a lack of degrees of freedom. It is shown that by modifying the equations of Lilien's model and by considering more than two brands the number of degrees of freedom can be increased considerably. This opens the possibility of estimating the response parameters of many more explanatory variables, in theory. However, practically speaking, estimation remains difficult because the parameters in the modified model are heavily restricted by standard probabilistic and other constraints. The endeavor to estimate the parameters of the modified linear learning model using macro-data is not feasible. This leads to the conclusion that the application of learning models in the area of decision-making in marketing is rather difficult and limited.marketing: buyer behavior, marketing: measurement, marketing: pricing
L. Boonstra\u27s Buttermilk Wagon
No full textA black and white photograph postcard of L. Boonstra\u27s Buttermilk Wagon. Possibly in Totowa, New Jersey?https://digitalcommons.calvin.edu/hh_bult_postcards/1894/thumbnail.jp
Bosch-Boonstra-Schaaf Syndrome
No full textSvrha ovog diplomskog rada je prikazat rijetku genetičku bolest Bosch-Boonstra-Schaaf sindrom optičke atrofije. Bosch-Boonstra-Schaaf sindrom optičke atrofije je monogenski autosomno dominantni poremećaj NR2F1 gena, karakteriziran zaostajanjem u razvoju, intelektualnim zaostajanjem i optičkom atrofijom. NR2F1 gen se nalazi na dugom kraku 5. kromosoma, na poziciji 5q15. Protein kojeg NR2F1 gen kodira vrši funkciju nuklearnog hormonskog receptora te regulatora transkripcije. Patogene varijante gena i delecije koje zahvaćaju kromosom 5 dovode do pojave kliničke slike Bosch-Boonstra-Schaaf sindroma. Od oftalmoloških kliničkih značajki opisane su abnormalnosti optičkog živca, blijedoća diska i ekskavacija diska, strabizam i latentni nistagmus, a od ostalih značajki opisane su zaostajanje u razvoju i učenju govora, hipotonija, opsesivno kompluzivni poremećaj, oromotorna disfunkcija, repetativni pokreti, značajke iz spektra autizma i poremećaja ponašanja te stanjivanje corpusa callosuma. Najtežu kliničku sliku uzrokuju patogene varijante u DNA vezujućoj domeni proteina, zatim patogene varijante koje uzrokuju prijevremeni stop kodon te frameshift, a nešto blaže kliničke slike uzrokuju potpune delecije gena i patogene varijante u ligand vezujućoj domeni proteina. U većini opisanih slučajeva bolest je nastala de novo, međutim opisana su i dva slučaja gonadnog mozaicizma. Glavni simptomi i znakovi bolesti su hipoplazija optičkog živca ili optička atrofija u kombinaciji sa zaostajanjem u razvoju ili intelektualnom zaostajanju, a konačna dijagnoza postavlja se genetičkim testiranjima. Zbrinjavanje pacijenata usmjereno je na simptome, odnosno na poboljšanje kvalitete života.The purpose of this master's thesis is to present a rare genetic disorder called Bosch-Boonstra-Schaaf optic atrophy syndrome. Bosch-Boonstra-Schaaf optic atrophy syndrome is a monogenic autosomal dominant disorder of the NR2F1 gene, characterized by developmental delay, intellectual disability, and optic atrophy. The NR2F1 gene is located on the long arm of chromosome 5, at position 5q15. The protein encoded by the NR2F1 gene functions as a nuclear hormone receptor and transcription regulator. Pathogenic gene variants and deletions affecting chromosome 5 lead to the manifestation of the clinical features of Bosch-Boonstra-Schaaf syndrome. Ophthalmological clinical features include abnormalities of the optic nerve, optic disc pallor and excavation, strabismus and latent nystagmus. Other features include developmental and speech delay, hypotonia, obsessive-compulsive disorder, oromotor dysfunction, repetitive movements, features from the autism spectrum and behavioral disorders, as well as thinning of the corpus callosum. The most severe clinical presentation is caused by pathogenic variants in the DNA-binding domain of the protein, followed by pathogenic variants that result in premature stop codons and frameshift mutations, while complete gene deletions and pathogenic variants in the ligand-binding domain of the protein lead to milder clinical phenotypes. In most described cases, the disease arises de novo, although two cases of gonadal mosaicism have been reported. The main symptoms and signs of the disease are hypoplasia of the optic nerve or optic atrophy combined with developmental delay or intellectual disability, and the final diagnosis is established through genetic testing. Patient management is focused on addressing the symptoms and improving the quality of life
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