92 research outputs found
Methods for in vivo CRISPR/cas editing of the adult murine retina
No full textClustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein (Cas) is used by some bacteria and most archaea to protect against viral phage intrusion and has recently been adapted to allow for efficient editing of the mammalian genome. Whilst CRISPR/Cas-based technology has been used to modify genes in mammalian cells in vitro, delivery of CRISPR/Cas system into mammalian tissue and/or organs is more difficult and often requires additional vectors. With the use of adeno-associated virus (AAV) gene delivery system, active CRISPR/Cas enzyme can be maintained for an extended period of time and enable efficient editing of genome in the retina in vivo. Herein we outline the method to edit the genome in mouse retina using a dual AAV vector -mediated CRISPR/Cas9 system
Measuring central retinal sensitivity using microperimetry
No full textMicroperimetry is an increasingly often used method of assessing the sensitivity of the central macula, analyzing fixation capabilities and loci, and accurately combining structural and functional information, even in the absence of stable fixation. Ongoing gene therapy trials have targeted the central retina, and utilized microperimetry as a main outcome measure for changes in retinal function. In retinal treatment planning, microperimetry has been used to assess the potential therapeutic window of opportunity. In the following pages, we briefly review the necessary steps to perform the Macular Integrity Assessment (MAIA) microperimetry
Initial Impact of the Gabíkovo Hydroelectric Scheme on the Species Richness and Composition of 0+ Fish Assemblages in the Slovak Flood Plain, River Danube
No full textRelatively little information exists on the effects of hydroelectric schemes on 0+ fish composition in large European rivers because few or no pre-impact data exist. We compared 0+ fish species richness and composition, relative density, fish size as well as available and used habitat using data from 12 floodplain sites sampled just prior to (1992) and four years after (1996) the start of operations of the Gabíkovo hydropower station on the River Danube (Slovakia). We also used modelling techniques to assess the change in species richness and habitat use and to predict 1996 occurrences from the 1992 data set. The floodplain was greatly modified by the hydroscheme. Only 12 of 27 sites sampled in August 1992 were extant in August 1996. Therefore, all four channel types identified (flowing, abandoned, weir, wing-dam) were more lentic in 1996 than in 1992, with increased width, smaller-sized sediment (silt, clay) and greater amounts of macrophytes. After the operations of the hydroscheme, the overall relative density of fishes (individuals per surface area) of all ages decreased, with the exception of 0+ fishes, despite a slight reduction in 0+ fish density in all channel types except weirs. Species number increased from 25 to 28, although in all channel types there was a change in the composition of the 0+ fish assemblages, with rheophiles generally replaced by limnophiles and migrants from the lower Danube. The two most important microhabitat variables were the proportion of macrophytes and gravel, the latter being the factor distinguishing 0+ fish microhabitat use in 1992 (preferences) and 1996 (indifference or avoidance). Species richness and 0+ fish density in 1996 could be predicted from the 1992 data using simple log-linear models (density, richness, sample number). Species-specific occurrence in 1996 could not be predicted using environmental/fish data from 1992 with multiple regression or generalized additive models (GAM). However, the overall GAM from 1992 could predict overall fish occurrence in 1996
Test–retest variability of mesopic microperimetry-associated parameters in patients with retinitis pigmentosa: REPEAT Study Report No. 2
No full textPURPOSE: Understanding test-retest variability (TRV) of mesopic microperimetry is critical for defining meaningful treatment effects in retinitis pigmentosa (RP) trials. This study uniquely evaluates intra- and intervisit TRV and coefficients of repeatability (CoRs) for microperimetry parameters in RP patients with varying best-corrected visual acuity (BCVA) levels. METHODS: In this single-centre prospective cohort study, RP patients were assessed on two visits, 14.0 days apart. Patients were grouped by BCVA: low (≤20/50 Snellen; ≥0.4 logMAR) or moderate (>20/50 Snellen; <0.4 logMAR). Using Bland-Altman analyses, the CoRs for intra- and intervisit variability were determined for pointwise (dB), mean (dB), and volume sensitivity (dB*deg2) on mesopic microperimetry. RESULTS: Intravisit CoRs for mean, volume, and pointwise sensitivity were 1.7 dB, 353.2 dB*deg2, and 8.6 dB, respectively, in the low-BCVA group (n = 32), and 0.9 dB, 254.5 dB*deg2, and 7.3 dB in the moderate-BCVA group (n = 15). Intervisit CoRs for mean, volume, and pointwise sensitivity were 2.4 dB, 355.2 dB*deg2, and 10.2 dB in the low-BCVA group (n = 31). The moderate-BCVA group (n = 16) showed smaller CoRs of 1.6 dB, 386.8 dB*deg2, and 7.7 dB for mean, volume, and pointwise sensitivity. BCVA and mean sensitivity, but not fixation stability, are predictors of TRV for volume sensitivity. CONCLUSIONS: Due to significant TRV, pointwise sensitivity is an unreliable endpoint for RP patients, irrespective of BCVA. Mean sensitivity is suitable as an endpoint when BCVA is relatively preserved. Volume sensitivity provides additional spatial information, and shows promise as a clinical endpoint for assessing macular sensitivity changes on mesopic microperimetry in patients with RP
THE PROXIMATE COMPOSITION, AMINO ACID PROFILE AND CHEMICAL INDICES IN FIVE FRESHWATER FISHES FROM TIGA DAM RESERVOIR, NIGERIA
No full textCroatian Journal of Fisheries, 2019, 77, 87-92A. M. Elaigwu (2019): Composition, AA profile and indices in five freshwater fishes© 2019 Author(s). This is an open access article licensed under the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/3.0/)92SAŽETAKKEMIJSKI SASTAV I AMINOKISELINSKI PROFIL PET VRSTA SLATKOVODNIH RIBA IZ AKUMU-LACIJE TIGA, NIGERIJAIstraživanje procjenjuje kemijski sastav, profil i sadržaj aminokiselina te kemijske pokazatelje Schilbe mystus, Bagrus bayad, Oreochromis niloticus, Clarias anguillarisi Petrocephalus bane bane iz akumulacije Tiga, Nigerija osušenih na suncu. Neposredni sastav značajno varira kod svih pet vrsta riba kako slijedi: vlaga (4,79 - 9,52 g / 100 g), sirovi protein (42,20 - 57,71 g / 100 g), sadržaj pepela (0,90 - 12,51 g / 100 g), ekstrakt etera (3,41 - 9,93 g/100 g), sirova vlakna (0,62 - 5,08 g/100 g), ekstrakt bez dušika (12,28 - 42,70 g/100 g) i suha tvar (90,48 - 95,21 g/100 g). Sadržaj aminokiselina se također značajno razlikovao. Devet esencijalnih aminokiselina pronađenih u pet vrsta riba bile su: lizin (4,21 - 6,34 g/100 g), histidin (1,96 - 4,30 g/100 g), arginin (5,80 - 8,21 g/100 g), treonin (1.93 - 5,05 g/100 g), valin (2,91 - 5,53 g/100 g), metionin (1,74 - 3,80 g/100 g), izoleucin (2,04 - 3,37 g/100 g), leucin (3,64 - 7,18 g/100 g). i fenilalanin (1,90 - 4,23 g/100 g). Osam ne-esencijalnih aminokiselina uključivalo je: serin (2,12 - 5,22 g/100 g), glutaminsku kiselinu (13,24 - 16,30 g/100 g), prolin (3,12 - 6,29 g / 100 g), glicin (4,20 - 9,08). g/100 g), alanin (5,00 - 6,36 g/100 g), cistein (0,94 - 1,24 g/100 g), tirozin (2,33 - 3,33 g/100 g) i asparaginska kiselina (6,34 - 11,01 g / 100 g). P. bane bane je sadržavala najviše sirovog proteina; S. mystus je imala najveći sadržaj lipida i esencijalnih aminokiselina. C. anguillaris je zabilježila najvišu kaloričnu vrijednost i najbolji sadržaj aminokiselina. P. bane bane može poslužiti kao izvor životinjskih proteina u ljudskoj prehrani. S. mystus i C. anguillaris mogu se upotrijebiti kao hranjiva baza za proizvodnju hrane i ulja visoke energije u prehrambenoj industriji.The study assesses the proximate composition, amino acid profile and its content and chemical indices of the sun-dried Schilbe mystus, Bagrus bayad, Oreochromis niloticus, Clarias anguillaris and Petrocephalus banebane from Tiga Dam Reservoir, Nigeria. The proximate composition varied significantly (
The effect of solvent viscosity on the population relaxation times of the S1 state of azulene and related compounds
No full textThe S1 population decay times of azulene and 4,6,8-trimethylazulene have been measured in solvents with a wide range of viscosities using a two-photon, two-color, pump-probe method. The S, lifetimes vary as expected on the basis of the energy gap law. No effect of solvent viscosity is observed, contrary to a previous suggestion. Data for 2-chloroazulene in non-viscous solvents are also reported.PT: J; CR: AMIRAV A, 1984, J CHEM PHYS, V81, P4200 BOTTCHER CJF, 1973, THEORY ELECTRIC POLA, V1 BRAFMAN O, 1984, J CHEM PHYS, V80, P5406 ELSAESSER T, 1991, ANNU REV PHYS CHEM, V42, P83 ENGLMAN R, 1970, MOL PHYS, V18, P145 HOCHSTRASSER RM, 1972, J MOL SPECTROSC, V41, P297 IPPEN EP, 1977, CHEM PHYS LETT, V46, P20 KULKARNI SK, 1988, J CHEM PHYS, V89, P4441 MATSUMOTO T, 1992, CHEM PHYS LETT, V191, P627 MUROV SL, 1973, HDB PHOTOCHEMISTRY NIBBERING ETJ, 1990, J CHEM PHYS, V93, P5477 NIBBERING ETJ, 1990, SPRINGER SERIES CHEM, V53, P471 NIBBERING ETJ, 1992, J PHOTOCH PHOTOBIO A, V62, P347 RENTZEPIS PM, 1968, CHEM PHYS LETT, V2, P117 SCHWARZER D, 1991, BER BUNSEN PHYS CHEM, V95, P933 SHANK CV, 1978, CHEM PHYS LETT, V57, P433 SIEBRAND W, 1967, J CHEM PHYS, V46, P440 SIEBRAND W, 1968, J CHEM PHYS, V49, P1860 SUKOWSKI U, 1990, J CHEM PHYS, V93, P4094 SUZUKI T, 1987, J PHYS CHEM-US, V91, P3537 WAGNER BD, 1992, J PHYS CHEM-US, V96, P7904 WAGNER BD, 1993, J CHEM PHYS, V98, P301; NR: 22; TC: 10; J9: CHEM PHYS LETT; PG: 5; GA: LL554Source type: Electronic(1
Tentyria platyceps Steven. He 1828
No full text<i>Tentyria platyceps</i> Steven, 1828 (Figs. 14, 49, 83, 119, 167, 200, 231, 232, 233, 234) <p> <i>Tentyria platyceps</i> Steven, 1828: 92; Schaum 1862: 70, Kraatz 1865: 116, 136, 139, Reitter 1900: 175, Fuente 1934: 31, Koch 1944a: 233, Español 1960: 410, López-Sánchez <i>et al.</i> 1985 (larval stades), Viñolas 1986: 105, Viñolas & Cartagena 2005: 84 (fig.358d), L̂bl & Smetana 2008: 208, Bujalance <i>et al.</i>, 2016: 348, Martínez 2018: 58, Iwan & L̂bl 2020: 251.</p> <p> <i>Tentyria goudoti</i> Solier, 1835: 360; Kraatz 1865: 116, 136, 139 syn., Reitter 1900: 175, Koch 1944a: 233, Español 1960: 410, Viñolas 1986: 105, Viñolas & Cartagena 2005: 277, L̂bl & Smetana 2008: 208, Bujalance <i>et al.</i> 2016: 348, Martínez 2018: 58, Iwan & L̂bl 2020: 251.</p> <p> <i>Tentyria modesta</i> Rosenhauer, 1865: 188; Schaum 1862: 70 syn., Reitter 1900: 175, Koch 1944a: 233–234, Español 1960: 410, Viñolas 1986: 105, Viñolas & Cartagena 2005: 277, L̂bl & Smetana 2008: 208, Martínez 2018: 58, Iwan & L̂bl 2020: 251.</p> <p> <i>Tentyria platyceps</i> var. <i>modesta</i> Kraatz 1865: 117, 136, Fuente 1934: 31.</p> <p> <i>Tentyria calcarata</i> Reitter, 1900: 170; Español 1960: 410–411 syn.? Viñolas 1986: 105, Viñolas & Cartagena 2005: 277, L̂bl & Smetana 2008: 208, Kaszab “ Holotype <i>in litt</i>. (MNHN)”, Bujalance <i>et al.</i> 2016: 348, Martínez 2018: 58, Iwan & L̂bl 2020: 251.</p> <p> <b>Types examined</b>: Four of the five specimens of <i>T. platyceps</i> Steven, labelled and recorded (MNHUB) as syntypes of <i>Pimelia curculionoides</i> Herbst, carrying two labels: red label indicating “ SYNTYPUS <i>Pimelia curculionoides</i> Herbst 1799 labelled by NMHUB 2006” / white label “Hist.-Col. (Coleoptera), Nr. 45574, <i>Tentyria curculionoides</i> Herbst, Lusitan, Zool. Mus. Berlin ”. In addition, one of the specimens carries two old labels: small and rectangular label: “45574” / large square label, “ <i>Orbiculata Akis</i> F., <i>curculioides</i> Ht. *, <i>Ten. Nomas</i> Pall., Lusit”. These specimens are syntypes of <i>Tentyria platyceps</i> Steven instead of <i>Tentyria curculionoides</i> Herbst.</p> <p> Syntype of <i>Tentyria goudoti</i> Solier, labelled: goudot, Tanger / Muséum Paris, Tanger, Goudot / <i>Tentyria goudoti</i> Sol. / Type. (MNHN).</p> <p> Two syntypes? of <i>Tentyria modesta</i> Rosenhauer, label: <i>T. platyceps</i> v. <i>modesta</i> Rosh., Hispania / <i>T. platyceps</i> v. <i>modesta</i> Rosh. / Hispania Rosh. (NMHUB); Hispania Rosh. (NMHUB).</p> <p> Syntype of <i>Tentyria calcarata</i> Reitter, labelled: Malaga / Holotypus 1900, <i>Tentyria calcarata</i> Reitter det. Dr. Kaszab / <i>T. calcarata</i> m. Málaga / Muséum Paris / (The specimen carried a green label) (MNHN).</p> <p> <b>Additional material</b>: Portugal, Albufeira, 2.VI.1981, B. Lassalle leg. (2 exx, CJF) / 1.VI.1977 (1 ex, CJF); idem, Praia de Galé, 13.VII.2007, (1 ex, CJLB); Mértola, 2.VI.1981, B. Lassalle leg. (2 exx, CJF); Coruche, Alto Alentejo, A. Zuzarte leg. (2 exx, CJF); Beira, 7.V.1973, A. Zuzarte leg. (CJF); Beira, 7.V.2003. J. Israel leg. (CJF); Coruche, Ribatejo, 1.V.1978 A. Zuzarte leg. (1 ex, CJF); Bordeira, 10.IV.2003, J. Israel leg. (12 exx, CJF); Monforte, Herd. de Esquilas, 23.VI.1988, A. Zuzarte leg. (CJF); Monforte, St Alexo, 24: VII.1987, A. Zuzarte leg. (CJF); Odemira, Bajo Alentejo, 23 and 27.X.1982 / 25. V.1982, A. Zuzarte leg. (4 exx, CJF). Spain: Salamanca, Los Santos, 1000 m, VII.1976, B. Lassalle leg. (1 ex, CJF), Pico Cabeza Gorda, (NRMS); Madrid, Casa de Campo, XII.1971, J. Ferrer leg. (1 ex, CJF); idem Guadarrama, Canal Isabel II, (CJF); Toledo, V.1997, Z. Korsós leg, (HMNH); idem, Aranjuez, 1.V.1995, J. Iñiguez leg. (1 ex, CJLB); Cáceres, La Montaña, VIII.2000, A. Castro Luque (3 exx, CACL); Badajoz, Alto de la Bofrera 11.XII.2005, J. Saez leg. (1 ex, CACL); idem, Sª Tentudia, Galera de León, 17.II.2007, A. Linares leg. (4 exx, CACT); Ciudad Real, Torrecilla, 3.IV.1966 (4 exx, CJF); Alicante, Benidorm (1 ex, CJF); Granada 15 km W de Baza, 16.VI.1935, O. Lundblad leg., <i>T. incerta pseudolaevis</i> Koch (1 ex, NRMS); idem, Sierrra Nevada, 1700 m, 16. V.1935, idem (1 ex, NRMS); idem, Guadix, 19.IV.1989?, R. Pellersson? (1 ex, CJF); idem, Baza, Los Balcones, Baúl, 26.XII.2003, J.L. Sánchez leg. (3 exx, CJF); Almería, Puerto de la Ragua, Laroles-Bayacal, 19.IX.2008, A Castro Tovar leg. (CACT); Córdoba, arroyo Pinadillos, VII.1998, A. Castro Luque leg. (1 ex, CACL); idem, Jardines de Ronda del Marrubial, 26.IV.1996, M. Baena leg. (CJF); idem, Baena, Torre del Montecillo, Bujalance leg. (CJLB) 27.XII.1996 and 4.V.2011 Bujalance leg. (4 exx, CJLB); Jaén, Collado de los Jadines, Despeñaperros, 30.XII.2006, A. Castro Tovar leg. (2 exx, CACT); idem, Cerro Molina, Puente Tablas, 1.IX.2003, idem (2 exx, CACT); idem, Finca el Ardal, Linares, 7.II.2004, M. López leg. (CACT); Sevilla, Guadiamar River, Cárdenas <i>et al.</i> (2011) (many exx, CJLB and CUCO); Huelva, El Rocío, 9.IV.1989? R. Pellersson? (CJF); idem, Parque Nacional de Doñana, Bujalance <i>et al.</i> (2016) (11 exx, CJLB).</p> <p> <b>Diagnosis</b>: Unmistakable species among the Iberian <i>Tentyria</i> by having the following features: black body, sub-cylindrical (Fig. 200), about 13.2 mm in average length, not very bright and very finely punctured; large and broad head (Fig. 14), sub-triangular epistome, with a well-developed tooth in the middle; barely convex eyes; wide, deep, and very well defined gular groove (Fig. 49). Pronotum (Fig. 83) provided with a very fine puncture; usually slightly transverse, and sub-cordiform, sometimes subcircular or sub-elliptical and more transverse, with the base straight or sub-straight, not sinuous before the posterior angles and generally something narrower than the apex. Elongated and medially depressed prosternal apophysis (Fig. 119), surpassing the level of the procoxae. Elytra oval elongated, variable in length, subcylindrical, sometimes slightly striated and somewhat broader than the pronotum. Small aedeagus, fusiform parameres and barely longer than phallobase (Fig. 167).</p> <p> <b>Comments</b>: Species described from “Lusitania”, not from Andalusia as Viñolas & Catagena (2005) mentioned. Steven (1828) described <i>Tentyria platyceps</i> with at least one specimen from “Lusitania” (MNHUB). Data on the Steven’s description agrees with the label that carries one of the syntypes listed as <i>T. curculionoides</i> Herbst in the Berlin Museum, before to be rectified and attributed to “ <i>T. curculioides</i> Ht. *” (Fig. 231). This confusion is the reason of that the type of <i>T. platyceps</i> Steven has remained hidden to date, not appearing in the recording book of the Museum.</p> <p> Accordingly, <i>T. platyceps</i> Steven was an unknown species to Solier (1835) and Rosenhauer (1856). Hence these authors described <i>T. goudoti</i> Solier (Fig. 232) and <i>T. modesta</i> Rosenhauer (Fig. 233), with identical characters those of <i>T. platyceps</i> Steven, as indicated Kraatz (1865) and Schaum (1862) respectively. This verifies that these last authors knew the true identity of <i>T. platyceps</i> Steven, by intuiting the confusion between <i>T. curta</i> Steven and <i>T. curculionoides</i> Herbst (Kraatz 1865). From Kraatz (1865), <i>T. platyceps</i> Steven has been a species correctly interpreted by almost all authors.</p> <p> Reitter (1900), described <i>T. calcarata</i> from Malaga, which was, dubiously, considered synonymy of <i>T. platyceps</i> Steven by Español (1960), since it was the unique species of <i>Tentyria</i> present in the mentioned locality whose description fits to that Reitter gave, even when this author does not include it in the group 3, close to <i>T. platyceps</i> Steven.</p> <p> Later, Kaszab designated in litt. “ Holotypus ” of <i>T. calcarata</i> Reitter a specimen from the MNHN labelled from Malaga (Fig. 234), and which corresponds to a variant specimen of the <i>T. platyceps</i> Steven (with the pronotum very transverse, and sub-elliptical), like the syntypes of <i>Tentyria platyceps</i> v. <i>modesta</i> Rosenhauer.</p> <p> <b> Designation of the Lectotype <i>Tentyria platyceps</i> Steven, 1828, present designation</b> :</p> <p> The specimen of the typical series that bears the following labels (two of them old): small rectangular label, “45574” / big square label, “ <i>Orbiculata Akis</i> F., <i>curculioides</i> Ht. *, <i>Ten. Nomas</i> Pall., Lusit” / red label, “ SYNTYPUS <i>Pimelia curculionoides</i> Herbst, 1799 labelled by NMHUB 2006” / white, “Hist.-Col. (Coleoptera), Nr. 45574, <i>Tentyria curculionoides</i> Herbst, Lusitan., Zool. Mus. Berlin ”, is designated Lectotype (Fig. 231). The remaining syntypes are designated “ Paralectotypes ”.</p> <p> <b> Designation of the Lectotype of <i>Tentyria goudoti</i> Solier, 1835, present designation:</b> </p> <p> The unique syntype of <i>Tentyria goudoti</i> Solier, bearing the lables: “goudot, Tanger / Muséum Paris, Tanger, Goudot / <i>Tentyria goudoti</i> Sol. / Type”, is designated Lectotype (Fig. 232).</p> <p> <b> Designation of Lectotype and Paralectotype of <i>Tentyria modesta</i> Rosenhauer, 1856, present designation:</b> </p> <p> To provide taxonomic stability, we consider necessary to designate Lectotype and Paralectotype of <i>Tentyria modesta</i> Rosenhauer to each of the two specimens examined in the MNHN, bearing the Rosenhauer’s labels and fitting to the description of this author, although they do not appear as syntypes. The specimen that bears the following labels: “ <i>T. platyceps</i> v. <i>modesta</i> Rosh. Hispania / <i>T. platyceps</i> v. <i>modesta</i> Rosh. / Hispania Rosh.”, is designated Lectotype (Fig. 233); the other that carrying the label: “Hispania Rosh.”, is designated Paralectotype.</p> <p> <b>Geographical distribution:</b> Widely distributed in central and southern Iberian Peninsula, especially in the inner areas. <i>T. platyceps</i> Steven, has been also cited in the north of Morocco (Tánger) as <i>T. goudoti</i> Solier (1835), Escalera (1914) and Kocher (1958). The record of Algeria (Reitter 1900) needs to be verified due to the historical confusion of this taxon discussed above.</p> <p> <b> Group of <i>T. bassii</i></b> </p>Published as part of <i>Bujalance, José L., Ferrer, Julio & Cárdenas, Ana M., 2023, A taxonomic revision of the genus Tentyria Latreille, 1802 in the Iberian Peninsula and Balearic Islands (Coleoptera: Tenebrionidae), pp. 1-88 in Zootaxa 5320 (1)</i> on pages 29-31, DOI: 10.11646/zootaxa.5320.1.1, <a href="http://zenodo.org/record/8203747">http://zenodo.org/record/8203747</a>
Biological characteristics of European perch (Perca fluviatilis L., 1758) inhabiting Lake Ladik (Samsun, Turkey) [Biološka Obiljezja Grgeca (Perca fluviatilis L, 1758) Koji nastanjujeje zero Ladik (Samsun, Turska)]
No full textThe aim of this study was to determine the growth features of European perch (Perca fluviatilis L., 1758) inhabiting Lake Ladik. A total of 858 individuals were caught. The total length and weight ranged from 8.2 to 27.5 cm and from 7.16 to 365.20 g, respectively. The age of the females ranged between 1 and 7 years and the age of the males ranged from 1 to 5 years. The female to male ratio was 1:0.19. The von Bertalanffy growth equation parameters were determined as L?=41.27 cm, W?=1251.40 g, K=0.10 (year1), t0 (year)=-1.98 for all samples. Length-weight relationship was calculated as W=0.0047TL3.358 for all specimens. Length-length relationships (total length-standard length, total length-fork length, standard length- fork length) were highly significant (r2>0.98). The mean condition factor value was obtained as 1.28 for all fish. Condition factor showed statistically significant increase according to length classes. © The Author(s) 2016. Published by University of Zagreb, Faculty of Agriculture. All rights reserved.Ondokuz Mayis Üniversitesi: PYO.1901.09.005 --This study was financially supported by Ondokuz Mayis University (Project No: PYO.1901.09.005). -
Ultraweitwinkel-Indocyaningrün-angiographische Veränderungen nach photodynamischer Therapie bei Chorioretinopathia centralis serosa. CERTAIN-Studienbericht 3
No full textUltrawidefield indocyanine green angiographic changes after photodynamic therapy in central serous chorioretinopathy: certain study report 3.
No full textVenous overload choroidopathy, showing pachyvessels, choroidal intervortex venous anastomoses, asymmetric venous drainage, choroidal vascular hyperpermeability (CVH), and increased choroidal thickness, is observed in most patients with central serous chorioretinopathy based on ultrawidefield indocyanine green angiography. This report investigates how photodynamic therapy alters signs of venous overload choroidopathy.
The CERTAIN study is a monocentric, retrospective study on consecutive central serous chorioretinopathy patients who underwent ultrawidefield indocyanine green angiography. For this report, patients who underwent ultrawidefield indocyanine green angiography twice were included. Two independent graders assessed changes in pachyvessels, choroidal intervortex venous anastomoses, AVD, choroidal thickness, and CVH when comparing pre-photodynamic and post-photodynamic therapy images of treated and untreated eyes.
In total, 38 eyes (19 patients) were included. Of those, 19 eyes had undergone photodynamic therapy, and 19 had not. Photodynamic therapy had no significant effect on pachyvessels, choroidal intervortex venous anastomoses, and asymmetric venous drainage (all P > 0.05). Only choroidal thickness (-51 ± 48 vs. 1 ± 43 µ m, P = 0.006) and CVH within the photodynamic therapy treatment area (79% vs. 0% reduced CVH, P < 0.0001) were significantly decreased in treated versus untreated eyes.
Photodynamic therapy reduced choroidal thickness and CVH within the treatment area while not significantly altering the overall choroidal vascular architecture associated with venous overload choroidopathy
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