7,308 research outputs found
Interview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American City
No full textInterview with Nicholas Christopher, author of Somewhere in the Night: Film Noir and the American Cit
Resurrecting the Author
No full textPresentation of Nicholas Wolterstorff\u27s Paper Resurrecting the Author with time after for questions beginning at 18:00
Effects of combustion derived air pollution on vascular and fibrinolytic function in man
No full textProject (03/017/15071)Observational studies have consistently demonstrated associations between exposure to air pollution and increased cardiovascular morbidity and mortality. These associations are strongest for fine particulate matter (PM), of which particulates from the combustion of fossil fuels are an important component. In Europe, the contribution to urban PM from diesel emissions is increasing with the popularity of diesel engines for road transport. Despite the strength of the epidemiological evidence and the emergence of promising hypotheses, the important constituents and biological mechanisms responsible for the cardiovascular effects of air pollution are largely unknown.
It is possible that nanoparticulates or soluble components of PM may translocate into the bloodstream, resulting in direct effects on the vascular endothelium and thrombotic pathways. I investigated the potential for inhaled radiolabelled nanoparticulates to translocate into the circulation in man. Using two unique human exposure facilities I assessed the effects of exposure to combustion-derived particulates in dilute diesel exhaust and concentrated ambient fine and ultrafine particles on vascular endothelial, endogenous fibrinolytic and myocardial function in healthy volunteers and patients with stable coronary artery disease.
In total, forty-two healthy men and thirty-two patients with stable coronary artery disease were exposed to particulates or filtered air for 1-2 hours in a series of double blind randomised crossover studies. At levels encountered in an urban environment, inhalation of dilute diesel exhaust impaired two important and complementary aspects of vascular function in man: the regulation of vascular tone and endogenous fibrinolysis. Vascular dysfunction persisted for up to 24-hours following exposure and was associated with an increase in systemic inflammatory cytokines. In patients with coronary heart disease exposure to diesel exhaust did not aggravate pre-existing vasomotor dysfunction, but did exacerbate exercise-induced myocardial ischemia and reduce acute endothelial tissue plasminogen activator release.
In contrast, exposure to concentrated ambient particulates, low in combustion component, did not affect vascular function in either healthy volunteers or patients. I found little evidence that inhaled radiolabelled nanoparticles translocate into the circulation and suggest the adverse vascular effects of combustion derived air pollution are mediated primarily by their soluble components rather than by a direct interaction between nanoparticles and the vasculature.
My findings have identified ischemic, vascular and thrombotic mechanisms that may explain in part the observations that exposure to combustion-derived air pollution is associated with adverse cardiovascular events including acute myocardial infarction. Ongoing research in this area will provide further insight into the adverse effects of PM, with the possibility of targeted interventions, such as the use of retrofit particle traps on diesel powered vehicles, to reduce the impact of environmental air pollution on cardiovascular disease a realistic goal
Heritability and Linkage Analysis of Appendicitis Utilizing Age at Onset
No full textAppendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3. Author(s): Christopher Oldmeadow 1 * | Kerrie Mengersen 2 | Nicholas Martin 3 | David L. Duffy
Nicholas de Monchaux: Local Code / Real Estates
No full textNicholas de Monchaux is an architect and urbanist whose work explores the intersections between nature, technology, and the city. He is the author of Spacesuit: Fashioning Apollo (MIT Press, 2011), an architectural history of the Apollo 11 spacesuit. He is Assistant Professor of Architecture and Urban Design at UC Berkeley. The work of his design studio has been exhibited widely and is currently being featured in the US Pavillion of the 13th Venice Biennale
Nicholas Meyer: 10-31-1979
No full textNicholas Meyer is a screenwriter, producer, director, and author, and a graduate of the University of Iowa. He is the author of the screenplay the Seven Per Cent Solution and co-author of The Black Orchid. He begins the interview by discussing his professional career as both a film writer/director and a novelist. He then talks about how he began writing novels, and discusses the research that goes into his novels. Meyer continues by discussing his movie Time After Time and concludes the interview by listing prominent teachers and writing influences.Archived web contentSUNY BrockportWriters Forum Video
Nicholas Meyer: 10-31-1979
No full textNicholas Meyer is a screenwriter, producer, director, and author, and a graduate of the University of Iowa. He is the author of the screenplay the Seven Per Cent Solution and co-author of The Black Orchid. He begins the interview by discussing his professional career as both a film writer/director and a novelist. He then talks about how he began writing novels, and discusses the research that goes into his novels. Meyer continues by discussing his movie Time After Time and concludes the interview by listing prominent teachers and writing influences.https://digitalcommons.brockport.edu/writers_videos/1022/thumbnail.jp
Interview with Nicholas Wade by Marni Siegel, November 8, 2007
No full textThe interview was a project of the Center for Public Genomics (http://www.genome.duke.edu/centers/cpg/).Nicholas Wade is a science writer for the New York Times and author of several books, including LifeScripts, about genetics and genomics. He also covered the Asilomar Conference for Science magazine.Funded by a grant from the National Human Genome Research Institute and the US Department of Energy (P50 HG003391)
LSE festival Beveridge 2.0 preview: the five giants by Nicholas Timmins
No full textOn Monday 19 February, LSE Festival opened with ‘The Five Giants and the Ministers Who Made a Difference’. Chaired by LSE Director Minouche Shafik, Nicholas Timmins, author of The Five Giants: A Biography of the Welfare State, and Professor Sir Julian Le Grand debated the key UK politicians who really made a difference when it came to Beveridge’s ‘Five Giants’: listen to the podcast here. Ahead of the event, Nicholas Timmins gives insight into the reception and impact of Beveridge’s 1942 report, as well as its enduring significance in today’s global, 21st-century context
01-06-2020 Author Nicholas Sparks Speaking at SWOSU on February 5
No full textAuthor Nicholas Sparks speaks at Southwestern Oklahoma State University in Weatherford on Wednesday, February 5, and the public is invited
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