1,721,211 research outputs found
Familial macular disease. Clinical and genetic studies on age-related macular degeneration and inherited macular dystrophies
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148916.pdf (Publisher’s version ) (Open Access)Radboud Universiteit Nijmegen, 18 december 2015Promotores : Hoyng, C.B., Hollander, A.I. den Co-promotor : Boon, C.J.F
Chronic central serous chorioretinopathy: studies on the clinical and genetic characteristics
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162522.pdf (Publisher’s version ) (Open Access)Radboud University, 27 januari 2017Promotores : Hoyng, C.B., Keunen, J.E.E. Co-promotores : Boon, C.J.F., Hollander, A.I. de
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
SD-OCT and Fundus Autofluorescence Imaging for Differential Diagnosis of Macular and Retinal Dystrophies
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Hereditary Retinal Disease, clinical and molecular genetic studies on the role of the BEST1 gene, peripherin/RDS gene and the CFH gene.
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74414.pdf (Publisher’s version ) (Open Access)Mutations in the peripherin/RDS gene, the BEST1 gene, and the CFH gene appear to be relatively frequent causes of hereditary retinal diseases that principally affect the macula. Intriguingly, a single mutation may be associated with a broad range of retinal phenotypes. Even in a single family, one mutation may show a striking phenotypic variability. Best vitelliform macular dystrophy, caused by mutations in the BEST1 gene, and retinal dystrophies caused by peripherin/RDS gene mutations, are good examples of such variability. This phenotypic variation can only be explained by additional genetic and environmental modifying factors. Conversely, a particular phenotype, such as multifocal vitelliform dystrophy or basal laminar drusen, can be genetically heterogeneous. Despite this variability, distinct genotype-phenotype correlations may be observed in association with specific peripherin/RDS, BEST1, and CFH gene variants. Some phenotypes can be remarkably similar. Multifocal pattern dystrophy simulating Stargardt disease/fundus flavimaculatus, caused by autosomal dominant peripherin/RDS gene mutations, may be confused with autosomal recessive Stargardt disease, which is caused by mutations in the ABCA4 gene. Central areolar choroidal dystrophy, caused by autosomal dominant peripherin/RDS mutations with decreased penetrance, may closely resemble atrophic age-related macular degeneration (AMD). Basal laminar drusen is another phenotype that may be particularly difficult to discern from AMD. This is not surprising, as both conditions are associated with specific variants in the CFH gene. The differential diagnosis of hereditary retinal diseases becomes more difficult in cases of overlapping age at onset and non-penetrance. A combination of well-established but also relatively new imaging techniques such as fundus autofluorescence is useful in the differentiation of these entities. Molecular genetic analysis is able to establish the definitive diagnosis.RU Radboud Universiteit Nijmegen, 10 juli 2009Promotores : Keunen, J.E.E., Cremers, F.P.M. Co-promotores : Hoyng, C.B., Klevering, B.J.437 p
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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