1,721,017 research outputs found
Urinary infection management in frail or comorbid older individuals
No full textUrinary tract infection (UTI) is common among older individuals, especially those with frailty and comorbidity. Asymptomatic bacteriuria is also common in this group and does not require treatment. UTI diagnosis is complicated by atypical signs and symptoms such as confusion or functional decline. This necessitates a more holistic assessment according to a diagnostic algorithm that includes nonspecific symptoms to avoid overdiagnosis or underdiagnosis. Treatment strategies for UTI in older people generally align with those for younger people, with some exceptions. Prophylaxis is similar to that for postmenopausal women. However, it is crucial to carefully consider comorbidities, polypharmacy, and the risk of potential adverse events
Transperineal Is the Way To Go.
No full textThe evidence available shows that transperineal prostate biopsy is significantly superior to transrectal biopsy in terms of infectious complications and is therefore recommended as the first choice in the European Association of Urology guidelines
About the influence of septic plasma and different drugs used in the intensiv care unit on the cytokin- and procalcitonin release from in vitro stimulated pbmc from septic patients and immuncompetent volunteers
No full textIn der vorliegenden Arbeit wurde der Einfluss von verschiedenen in der Intensivtherapie der Sepsis etablierten Medikamenten auf die peripheren mononukleären Zellen gesunder Probanden und septischer Patienten untersucht. Als ein weiteres Ziel untersuchten wir, ob Plasma, das von septischen Patienten gewonnen wurde, ebenfalls eine die Mediatorproduktion der Zellen modifizierende Wirkung besitzt. Als Parameter dieser Studie dienten auf der einen Seite die proinflammatorischen Zytokine TNF-alpha, Interleukin-6 und Interferon-gamma, auf der anderen Seite Interleukin-10, dem antiinflammatorische Eigenschaften zugesprochen werden, und Procalcitonin.The present study was conducted to clarify the influence of various drugs, established in the intensiv therapie of sepsis, and septic plasma on the mediatorproduction of LPS-stimulated peripheral blood mononuclear cells isolated from healthy volunteers and septic patients. The mediators measured include TNF-alpha, IL-6, Interferon-gamma (proinflammatory cytokines), interleukin 10 (an anti-inflammatory cytokine) and procalcitonin
The efficacy and tollerability of pollen extract in combination with hyaluronic acid and vitamins in the management of patients affected by chronic prostatitis/chronic pelvic pain syndrome: a 26 weeks, randomized, controlled, single-blinded, phase III study
No full textChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) remains a challenging clinical condition to manage. Here, we evaluate the efficacy and tolerability of a new treatment option (suppositories) containing pollen extract in combination with hyaluronic acid and vitamins in the management of patients with CP/CPPS
Is Preoperative Assessment and Treatment of Asymptomatic Bacteriuria Necessary for Reducing the Risk of Postoperative Symptomatic Urinary Tract Infections After Urologic Surgical Procedures?
No full textGuidelines in urology: Lights and shadows
No full textClinical practice guidelines have become increasingly important in the decision-making process in many clinical conditions and have been recognized as key instruments to improve the quality of care. On the one hand, guidelines represent a good tool for improving patient's outcome, and on the other hand, the adherence to guidelines and good practice recommendations is mandatory to reduce the risk of legal disputes. A recent revision by the Italian Parliament of the legal system that rules the responsibilities of health professionals and health care safety stimulated all clinicians to improve their adhesion to clinical guidelines. It is justified by the high-quality level obtained in the recent years by the international guidelines. In the recent years, a revision of the clinical guideline development has been done. In particular, the European Association of Urology Guideline Office changed the "Guidelines for Guidelines," and a rigorous development process has been established. A clinical recommendation is produced after a rigorous methodological process using an analysis of all published clinical trials, and the expert opinion is not yet considered. For oncological guidelines, the adherence to the producing process is easily feasible due to the high number of clinical trials; for non-oncological guidelines, instead, the small number of clinical trials could represent a problem for obtaining recommendation based on rigorous methodology. Here, on the basis of these considerations, we aim to discuss the lights and the shadows of the clinical applicability of guidelines in urology
Perioperative antimicrobial prophylaxis for preventing infectious complications after transurethral resection of the bladder: to use or not to use?
No full textPurpose Transurethral Resection of the Bladder (TURB) is a very common endoscopic procedure. Perioperative antimicrobial prophylaxis (AMP) is used to reduce the risk of infectious complications. However, there is a lack of knowledge about both incidence of infectious complications after TURB and advantage of AMP in general. The objective of this study is to determinate the prevalence of post-operative infectious complications after routine TURB without AMP. Methods We retrospectively reviewed clinical data of all patients who underwent TURB in the same Academic Urological Department between January 2011 and December 2013. We consider as relevant for analysis, patients that underwent TURB without receiving any AMP. Infection was defined as a body temperature >37.5 °C sustained for at least 24h. Sepsis was defined according to the third international consensus definition for sepsis and septic shock. Results In the period of the study, 223 TURBs were performed without use of AMP. Mean age was 70,3 years (Standard deviation [SD] 11,3). Mean operative time was: 25.14 minutes (SD 16). Median length of hospital stay was 3 days (IQR: 2-4). 6 (2,7%) patients developed postoperative infective complications. No case of sepsis was reported. 2 (0,9%) patients received an antimicrobial therapy with fluoroquinolones despite absence of any signs of infection. 215 (96,4%) patients-TURBs did not receive any antimicrobial drugs and did not developed any infectious complications. Conclusion In our series, infectious complications after TURB occurred in less than 3% of cases. In conclusion AMP should not be routinely used prior TURB
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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