170,096 research outputs found
D-XYLANASE PRODUCED BY SCHIZOPHYLLUM-RADIATUM
No full textd-Xylanase (1,4-β-xylan xylanohydrolase, EC 3.2.1.8) was obtained from mycelial submerged culture of the mushroom Schizophyllum radiatum, grown on wheat straw pretreated with "steam explosion" as the substrate. The enzyme was purified 192-fold (specific activity 455 IU mg-1 protein), with 37% yield with respect to total d-xylanase activity. Polyacrylamide electrophoresis of the d-xylanase peak showed a single band of protein whose molecular weight, calculated by electrophoretic mobility, was 25 700. The enzyme exhibited maximum activity at pH 4.9 and 55°C. d-Xylanase was stable from pH 5.0 to 7.5; its half-life was 12 h at 45°C. The Michaelis constant was 9.5 mg ml-1 and Vmax 0.37 μ mole min-1. End-product analysis of the d-xylan hydrolysate showed the presence of d-xylobiose, d-xylotriose, d-xylotetraose, and d-xylopentose showing the mode of action of an endo-type enzyme
Nose-to-brain delivery
No full textNose-to-brain delivery represents a big challenge. In fact there is a large number of neurological diseases that require therapies in which the drug must reach the brain, avoiding the difficulties due to the blood–brain barrier (BBB) and the problems connected with systemic administration, such as drug bioavailability and side-effects. For these reasons the development of nasal formulations able to deliver the drug directly into the brain is of increasing importance. This Editorial regards the contributions present in the Special Issue “Nose-to-Brain Delivery”
Composizioni farmaceutiche a base di zeoliti contenenti zinco ed eritromicina da impiegare nella terapia anti-acne
No full textPharmaceutical zeolite-based compositions containing zinc and erythromycin, to be used in the treatment of acne
No full textZeolites in biomedical applications: Zn-exchanged clinoptilolite-rich rock as active carrier for antibiotics in anti-acne topical therapy
No full textZeolites in biomedical application: Zn-exchanged clinoptilolite-rich rock as active carrier for antibiotics in anti-acne topical therapy
No full textUse of a Zn-exchanged clinoptilolite-bearing material as an active carrier for erythromycin to be used in anti-acne therapy
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