1,721,053 research outputs found
Comparison of the influence on some spirometric parameters produced by aerosol administration of reproterol and salbutamol to patients with chronic obstructive lung disease. Reproterol exerts a favorable action on bronchial obstruction, comparable but more prolonged than that of salbutamol [EFFETTI DELLA SOMMINISTRAZIONE DI REPROTEROLO AEROSOL DOSATO SU ALCUNI PARAMETRI SPIROMETRICI IN PAZIENTI AFFETTI DA BRONCOPNEUMOPATIA CRONICA OSTRUTTIVA. CONFRONTO CON IL SALBUTAMOLO]
No full textPotassium sparing effect of amiloride in patients receiving diuretics: a quantitative study.
No full textThis study was undertaken in order to assess the K+ sparing ability of amiloride. Thirty patients with liver cirrhosis and ascites or congestive heart failure were divided into three groups and treated with amiloride (Group A), hydrochlorothiazide (Group B) and amiloride plus hydrochlorothiazide (Group C) for 15 days. In all groups there was an increased diuresis while only in group A and C there was a statistically significant rise of K+ serum levels and a slight increment of K+ urinary loss. Total body K+ evaluated by 42K increased in group A and C while decreased in group B. Our results seem to confirm that amiloride has a mild diuretic action with a powerful K+ sparing capacity; amiloride is also able to counterbalance and reverse hydrochlorthiazide induced K+ urinary loss
Effetti dell'estere guaiacolico dell'acido acetilsalicilico su alcuni parametri spirometrici e pletismografici in soggetti affetti da broncopneumopatia cronica ostruttiva. [Effects of guaiacolic ester of acetylsalicylic acid on spirometric and plethysmographic parameters in subjects with chronic obstructive bronchopneumopathy].
No full textThe effects of oral administration of guaiacolic ester of acetyl salicilic acid in 24 patients with chronic obstructive lung disease have been evaluated. 1.5 g of this drug were given daily into 3 administrations improving both objective and subjective symptomatology in 19 of the 24 patients after 1 or 3 weeks of treatment. Moreover, a statistically significant improvement of FEV 1" (p less than 0.001), Raw (p less than 0.005) and FEV 1"/VC (p less than 0.01) was observed. The remaining 5 patients discontinued the treatment failing the improvement of the subjective symptomatology
Effect of mexiletine on reperfusion-induced ventricular arrhythmias - comparison with lidocaine
No full textThirty mongrel dogs underwent proximal occlusion of the left anterior descending
coronary artery to evaluate the comparative action of mexiletine and lidocaine on
ventricular arrhythmias during myocardial reperfusion. Heart rate, arterial blood
pressure, left ventricular end-diastolic pressure and dp/dt max were evaluated
before and at the 20th and 25th min after coronary occlusion; at the 25th min
coronary occlusion was removed. Dogs were randomly assigned to one of the
following groups of 10: 1) control group; 2) dogs given i.v. mexiletine; 3) dogs
given i.v. lidocaine. As expected, during ischemia, myocardial contractility
decreased after mexiletine or lidocaine administration more than in the control
group. Ventricular arrhythmias during myocardial reperfusion occurred in 9 dogs
of the control group (ventricular tachycardia in 2 cases and ventricular
fibrillation in 7 cases). Among dogs given mexiletine only 1 had ventricular
fibrillation (p less than 0.001 vs control). Six of the 10 dogs given lidocaine
had ventricular arrhythmias (ventricular tachycardia in 5 cases and ventricular
fibrillation in 1 case) (p = ns vs control group; p less than 0.05 vs mexiletine
group). Thus mexiletine and lidocaine had similar effects on cardiac function
during myocardial ischemia and only mexiletine showed a protective effect against
reperfusion ventricular arrhythmias
Effect of beta-blockade on thallium-201 dipyridamole myocardial scintigraphy
No full textThe effect of beta-blockade on dipyridamole thallium-201 images was assessed in 8
patients with coronary artery disease and positive dipyridamole test. Three
dipyridamole thallium-201 tests were performed, the first in basal conditions,
the second 30' after propranolol and the third with propranolol and atrial
pacing. After dipyridamole heart rate and double product increased respectively
from 75 +/- 7 to 98 +/- 15 b/min (p less than 0.01 vs starting values) and from
10 551 +/- 1255 to 11 740 +/- 4542 mmHg X b/min (p less than 0.05 vs starting
values). Propranolol reduced heart rate to 64 +/- 6 b/min (p less than 0.05 vs
basal conditions), systolic blood pressure to 136 +/- 13 and double product to
8733 +/- 1248 (p less than 0.05 vs basal conditions). Dipyridamole when infused
after propranolol, induced an increase in heart rate to 70 +/- 5 b/min (p less
than 0.05 vs starting values) while double product was 9133 +/- 1189 mmHg X b/min
(p = NS vs starting values). Atrial pacing prevented the fall in heart rate and
double product induced by propranolol so during dipyridamole infusion double
product increased to 13 271 +/- 1868 (p less than 0.05 vs propranolol treatment;
p less than 0.05 vs starting values). Segmental score calculated after
dipyridamole was 5.2 +/- 2.0 in basal conditions, 5.1 +/- 1.3 after propranolol
(p = NS) and 4.8 +/- 1.3 after propranolol plus atrial pacing (p = NS). Thus the
results of the study show that beta-blockade does not worsen dipyridamole
thallium-201 images. Furthermore the steal phenomenon seems to be the main
mechanism of the dipyridamole induced ischemia. In fact, also when the increase, oxygen consumption is blunted with beta-blockade the disparity in myocardial blood flow resulted unaffected
Effetti emodinamici del reproterolo in soggetti affetti da broncopneumopatia cronica ostruttiva. [The hemodynamic effects of reproterol in patients with chronic obstructive lung disease (author's transl)].
No full textOur study was undertaken in order to evaluate hemodynamic effects of intravenous administration of Reproterol in patients with chronic obstructive lung disease (COLD). Reproterol is a monomulecolar combination of catecholamine and theophilline. Diastolic pulmonary pressure and wedge pressure decreased 20 minutes after Reproterol while total pulmonary resistances were reduced 10 minutes after drug administration; sistolic pulmonary pressure and cardiac index increased only after 10 minutes; heart rate increased until 15th minute. Reproterol, as a catecholamine-theophylline combination, has an additional site of action over and above the pure catecholamine effect owing to inhibition of phosphodiesterase; so an increase in cAMP content is achieved either by increasing the synthesis or by blocking the breakdown. Our results assess that Reproterol has a beneficial effect on pulmonary hemodynamics in COLD
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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