1,368 research outputs found
Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats
No full textUromodulin (UMOD) is the most abundant renal protein secreted into urine by the thick ascending limb (TAL) epithelial cells of the loop of Henle. Genetic studies have demonstrated an association between UMOD risk variants and hypertension. We aimed to dissect the role of dietary salt in renal UMOD excretion in normotension and chronic hypertension. Normotensive Wistar–Kyoto rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) (n=8/sex/strain) were maintained on 1% NaCl for 3 weeks. A subset of salt-loaded SHRSP was treated with nifedipine. Salt-loading in SHRSP increased blood pressure (ΔSBP 35 ± 5 mmHg, P<0.0001) and kidney injury markers such as kidney injury marker-1 (KIM-1; fold change, FC 3.4; P=0.003), neutrophil gelatinase-associated lipocalin (NGAL; FC, 2.0; P=0.012) and proteinuria. After salt-loading there was a reduction in urinary UMOD excretion in WKY and SHRSP by 26 and 55% respectively, compared with baseline. Nifedipine treatment reduced blood pressure (BP) in SHRSP, however, did not prevent salt-induced reduction in urinary UMOD excretion. In all experiments, changes in urinary UMOD excretion were dissociated from kidney UMOD protein and mRNA levels. Colocalization and ex-vivo studies showed that salt-loading increased intracellular UMOD retention in both WKY and SHRSP. Our study provides novel insights into the interplay among salt, UMOD, and BP. The role of UMOD as a cardiovascular risk marker deserves mechanistic reappraisal and further investigations based on our findings
Philipp Melanchthon
No full textPhilipp Melanchthon (1497–1560) was, with Martin Luther, the most influential reformer of the church during the 16th century. He was also a reformer of university education, especially theological studies, as well as the school system in Germany. He was responsible for a theological curriculum that included Greek, Hebrew, and philosophy. He, as a professor of Greek at the University of Wittenberg since 1518, was the author of the first generally accepted Protestant confession, known as the Confessio Augustana (1530). He also wrote the first Protestant commentaries on Paul’s letter to the Romans (1519), as well as the first Protestant handbook in systematic theology (1521). He was the main negotiator of the Protestant movement during the diets and religious discussions with the Roman Catholic Church. He is known as the ‘teacher of Germany and Europe’ and is respected as the father of the ecumenical movement. Yet, Melanchthon is not known to South Africans and especially Afrikaans-speaking people who, traditionally, have close links with the reformational tradition. There is not yet one single publication on Melanchthon in Afrikaans or by a South African scholar, making this book, therefore, the first by an Afrikaans-speaking scholar on Melanchthon
#Bitcoin : an analysis of the field of a decentralized virtual currency using twitter data
No full textAuthor Philipp AllerstorferAbstract in englischer SpracheMasterarbeit Universität Linz 201
On Philipp Lersch’s Psychology, Reflection No. 2
No full textАвтор статті зазначає, що у 1930–1970 рр. Ф. Лерш був головним представником гуманітарної течії в німецькомовній психології. Наукову класифікацію людських прагнень і стремлінь було
викладено у головній праці Ф. Лерша «Структура особи» (11-те видання 1970 року). Ф. Лерш зумів
об’єднати у своїм творі інформацію із низки наук (біології, психопатології, із різних психологічних
теорій та концепцій).The author of the article notes that in 1930-1970, Philipp Lersch was the main representative of the
humanitarian direction in German psychology. A scientific classification of human aspirations and ambitions
was described in the main work by Philipp Lersch “Building the Person” (11th ed. of 1970). In his work,
Philipp Lersch managed to combine information from a number of sciences (biology, psychopathology, various
psychological theories and concepts)
Deformation Behavior and Damage Modeling of Polypropylene and Polycarbonate
No full textAuthor Philipp Siegfried StelzerKurzfassungen in deutscher und englischer SpracheMasterarbeit Universität Linz 201
Philipp Timischl x Numeró Art
No full textThis article discusses the intersections of gender and class drag in the work of Austrian artist Philipp Timischl. The essay takes the form of a letter of refusal, discussing why the author is simply too busy, then goes on to discuss other performances of industriousness, from Kevin Floyd's proposal that modern masculinity is a labour based performance through to the artist's own gender enhancing or swapping works
Skin-specific mechanisms of body fluid regulation in hypertension
No full textIncreasing evidence suggests excess skin Na+ accumulation in hypertension; however, the role of skin-specific mechanisms of local Na+/water regulation remains unclear. We investigated the association between measures of sweat and trans-epidermal water loss (TEWL) with Na+ content in the skin ([Na+]skin) and clinical characteristics in consecutive hypertensive patients. We obtained an iontophoretic pilocarpine-induced sweat sample, a skin punch biopsy for chemical analysis, and measures of TEWL from the upper limbs. Serum Vascular Endothelial Growth Factor-c (VEGF-c) and a reflectance measure of haemoglobin skin content served as surrogates of skin microvasculature. In our cohort (n=90; age 21-86 years; females=49%) sweat composition was independent of sex and BMI. Sweat Na+ concentration ([Na+]sweat) inversely correlated with [K+]sweat and was higher in patients on ACEIs/ARBs (p<0.05). A positive association was found between [Na+]sweat and [Na+]skin, independent of sex, BMI, estimated Na+ intake and use of ACEi/ARBs (padjusted=0.025); both closely correlated with age (p<0.01). Office DBP, but not SBP, inversely correlated with [Na+]sweat independent of other confounders (padjusted=0.03). Total sweat volume and Na+ loss were lower in patients with uncontrolled office BP (padjusted<0.005 for both); sweat volume also positively correlated with serum VEGF-c and TEWL. Lower TEWL was paralleled by lower skin haemoglobin content, which increased less after vasodilatory pilocarpine stimulation when BMI was higher (p=0.010). In conclusion, measures of Na+ and water handling/regulation in the skin were associated with relevant clinical characteristics, systemic Na+ status and blood pressure values, suggesting a potential role of the skin in body-fluid homeostasis and therapeutic targeting of hypertension
Author Correction: Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH
No full textIn this Article, the surname of Tobias Boettler was incorrectly shown as ‘Böttler’, and the surname of author Jan-Philipp Mallm was incorrectly shown as ‘Malm’. The original Article has been corrected online
Philipp Melanchthon: A short introduction
No full textPhilipp Melanchthon was one of the most influential theologians of the Reformation of the 16th century. He was responsible for transforming the secondary and tertiary educational systems in Germany. He was responsible for a new theological curriculum. He wrote the first Protestant ‘systematic theology’ and was the author of the Confessio Augustana. He is called the ‘teacher of Germany and Europe’. In spite of all the praises, most South Africans know very little about this important theologian. In this year of jubilee, it is imperative that a short introduction to his life and work be published – in the hope that he would receive more attention in future from South African scholars
Philipp Melanchthon: A short introduction
No full textPhilipp Melanchthon was one of the most influential theologians of the Reformation of the 16th century. He was responsible for transforming the secondary and tertiary educational systems in Germany. He was responsible for a new theological curriculum. He wrote the first Protestant ‘systematic theology’ and was the author of the Confessio Augustana. He is called the ‘teacher of Germany and Europe’. In spite of all the praises, most South Africans know very little about this important theologian. In this year of jubilee, it is imperative that a short introduction to his life and work be published – in the hope that he would receive more attention in future from South African scholars.</jats:p
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