1,721,004 research outputs found
AI3SD Video: New Trends in Drug Discovery – Robotics & AI
No full textThe drug discovery ecosystem is undergoing transformational change. New technologies have an increasing impact on how drugs are being discovered and developed, including in particular Artificial Intelligence and robotics. A critical precondition for successful development of AI applications is having access to large amounts of structured, annotated, machine-learnable data. The talk will cover how recent advances in laboratory automation and robotics enable the generation of biomedical data at scale, providing the most critical input for AI systems. The talk will present real-world case studies, showing how leading AI drug discovery firms benefit from full automation of their discovery processes, delegating experiment execution to advanced robotics, and allowing for projects to move to the next stage faster and more efficiently
AI3SD Video: Data Generation, Data Standards and Metadata Capture in Drug Discovery
No full textBiomedical research and drug discovery are based on a continuous cycle of scientific findings being made, refined, and translated into new treatments. However, over recent years it has become clear that only a fraction of all published research findings are actually reproducible, causing waste and delays in our efforts to bring new drugs to patients. The answer is changing the way we generate and capture data, including experimental metadata. Especially in light of the increasing role of Artificial Intelligence in drug discovery, it is critical to rethink the way we approach data generation as the most important input for AI-driven drug discovery. The talk will address these recent advances in data and metadata capture based on fully automated experimentation and novel data standards
Humans of AI3SD: Dr Martin Immanuel-Bittner
No full textMartin-Immanuel Bittner MD DPhil FRSA is the chief executive officer of Arctoris, the world’s first fully automated drug discovery platform that he co-founded in Oxford in 2016. He graduated as a medical doctor from the University of Freiburg in Germany, followed by his DPhil in Oncology as a Rhodes scholar at the University of Oxford. Martin has extensive research experience covering both clinical trials and preclinical drug discovery and is an active member of several leading cancer research organisations. In this Humans of AI3SD interview he discusses how automation can provide fully reproducible, robust and reliable research data, the rise of FAIR data and why experienced postdocs should not be spending eight hours a day pipetting small amounts of liquids
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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