1,721,192 research outputs found
Real-time unblinding for validation of a new CADe tool for colorectal polyp detection
No full textsponsorship: RB and TE are supported by a grant of Research Foundation Flanders. PR is supported by Clinical Mandate from Belgian Foundation against Cancer (Stichting tegen Kanker). FM is supported by KU Leuven internal grant C24/18/047 and by the Flemish Government (AI Research Program). (Research Foundation Flanders, Clinical Mandate from Belgian Foundation against Cancer (Stichting tegen Kanker), KU Leuven|C24/18/047, Flemish Government (AI Research Program))status: Publishe
Artificial intelligence in GI endoscopy: stumbling blocks, gold standards and the role of endoscopy societies
No full textstatus: Publishe
Is there a role for new imaging techniques in endoscopic surveillance?
Full text linkL’incidence de la dégénérescence néoplasique dans l’oesophage
de Barrett est en nette augmentation dans les pays occidentaux.
La surveillance endoscopique visant à détecter cette pathologie à
un stade précoce joue un rôle majeur dans la survie globale après
chirurgie. Grâce aux techniques nouvelles telles que la résection
endoscopique ou l’ablation par radiofréquence, maintenant disponibles
pour traiter la maladie de manière moins invasive, la détection
précoce de la dysplasie devient un enjeu de tout premier ordre.
Récemment, plusieurs procédés nouveaux ont été mis en oeuvre,
visant à une meilleure efficacité au niveau de la détection de la
dysplasie. Ce sont la chromoendoscopie classique, la chromo
endoscopie virtuelle, l’imagerie par auto-fluorescence et l’endomicroscopie
confocale. Parmi elles, l’imagerie par autofluorescence
semble la plus prometteuse en tant qu’outil d’alerte
alors que la chromoendoscopie virtuelle aide à caractériser les
lésions. L’endomicroscopie confocale permet une étude histologique
in vivo et aide à confirmer le diagnostic de lésions néoplasiques.
En règle générale, le rôle exact de ces nouveaux procédés
d’imagerie dans un programme général de détection n’a pas été
réellement envisagé, si bien qu’actuellement, le gold standard pour
la surveillance de l’oesophage de Barrett reste toujours l’endoscopie
haute définition en lumière blanche et le protocole de Seattle.The incidence of Barrett’s associated neoplasia is rising in the
Western world. Endoscopic surveillance in order to detect this
disease in an earlier stage has implication on overall survival after
surgery. With new techniques such as endoscopic resection or
radiofrequency ablation available now to treat the disease in a less
invasive way, early detection of dysplasia becomes even more
important. Recently several new imaging modalities have become
available with a possible improvement in efficiency for detecting
dysplasia. These include classical chromo-endoscopy, virtual
chromo-endoscopy, autofluorescence imaging and confocal endomicroscopy.
Of these autofluorescence imaging seems most promising
as a red flag technique, whereas (virtual) chromoendoscopy
helps to characterize lesions. Confocal endomicroscopy enables in
vivo histology and helps to confirm neoplastic lesions. In general, the
exact role of these new imaging modalities in a general screening
program has not been addressed, so currently a thorough inspection
with white light high definition endoscopy and the Seattle
protocol are still the gold standard to survey Barrett’s patients
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
How to select patients for antireflux surgery? the ICARUS guidelines (international consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for antireflux surgery)
No full textCicala, Michele/0000-0002-5370-2642; Penagini, Roberto/0000-0001-6918-9479; Watson, David/0000-0002-7683-2693; Bor, Serhat/0000-0001-5766-9598; Bisschops, Raf/0000-0002-9994-8226; Boeckxstaens, Guy/0000-0001-8267-5797; Omari, Taher/0000-0001-5108-7378; Vanuytsel, Tim/0000-0001-8728-0903; Tack, Jan/0000-0002-3206-6704Objective Antireflux surgery can be proposed in patients with GORD, especially when proton pump inhibitor (PPI) use leads to incomplete symptom improvement. However, to date, international consensus guidelines on the clinical criteria and additional technical examinations used in patient selection for antireflux surgery are lacking. We aimed at generating key recommendations in the selection of patients for antireflux surgery. Design We included 35 international experts (gastroenterologists, surgeons and physiologists) in a Delphi process and developed 37 statements that were revised by the Consensus Group, to start the Delphi process. Three voting rounds followed where each statement was presented with the evidence summary. the panel indicated the degree of agreement for the statement. When 80% of the Consensus Group agreed (A+/A) with a statement, this was defined as consensus. All votes were mutually anonymous. Results Patients with heartburn with a satisfactory response to PPIs, patients with a hiatal hernia (HH), patients with oesophagitis Los Angeles (LA) grade B or higher and patients with Barrett's oesophagus are good candidates for antireflux surgery. An endoscopy prior to antireflux surgery is mandatory and a barium swallow should be performed in patients with suspicion of a HH or short oesophagus. Oesophageal manometry is mandatory to rule out major motility disorders. Finally, oesophageal pH (+/- impedance) monitoring of PPI is mandatory to select patients for antireflux surgery, if endoscopy is negative for unequivocal reflux oesophagitis. Conclusion With the ICAR US guidelines, we generated key recommendations for selection of patients for antireflux surgery.Methusalem Grant from Leuven University - Research Foundation Flanders (FWO); Clinical Mandate from the Belgian Foundation against Cancer (Stichting tegen Kanker)JT is supported by a Methusalem Grant from Leuven University. AP is funded by a personal grant from the Research Foundation Flanders (FWO). PhR is supported by Clinical Mandate from the Belgian Foundation against Cancer (Stichting tegen Kanker)
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Optimizing Outcomes with Radiofrequency Ablation of Barrett's Esophagus: Candidates, Efficacy and Durability.
No full textThe treatment of early Barrett's esophagus (BE) has undergone a paradigm shift from surgical subtotal esophagectomy to organ-saving endoluminal treatment. Over the past 15 years, several high-quality studies were conducted to assess safe oncological outcome of endoscopic resection of mucosal adenocarcinoma and high-grade dysplasia. It became clear that add-on ablative therapy with radiofrequency ablation (RFA) significantly reduces recurrence risk of neoplasia after resection. In this review, we highlight the most essential elements to optimize outcomes of RFA of BE, addressing the correct indication and patient selection in combination with the most efficient and safest treatment protocols to obtain long-term durability.sponsorship: Medtronicstatus: Publishe
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