271 research outputs found
Dynamic Regulation of Mitochondrial Import by the Ubiquitin System. Phu and Rose et al., Molecular Cell, 2020
No full textRaw files for Phu and Rose et al., Molecular Cell, 202
Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS. Dominguez et al., Cell Death and Differentiation, 2020
No full textUncropped immunoblotting data and raw data file
Redesign Terminal Terpadu Pinang Baris
No full textThe project chosen by the author is a terminal facility which is located at Pinang
Baris Terminal. The Pinang Baris Terminal serves public transport vehicles with a
route west to the Nanggroe Aceh Darussalam (NAD) Region. The problems found
were unified vehicle circulation, less strategic departure and arrival areas, and a lack
of a number of standard facilities not found at the Pinang Baris Bus Terminal, such
as the absence of a health post, bus maintenance and washing areas and the absence
of barriers between vehicle traffic and passengers. Other facilities required by the
regulations are available, although not all of them function properly, many of the
facilities are damaged or unused, such as waiting rooms which are rarely used by
passengers while waiting for the bus. On this project which is the scope of the design
consists of designing the terminal in accordance with the regulations, laws and
provisions of the Government, redesigning the Pinang Baris Terminal according to
the predetermined land area, and expanding the terminal. In designing this project,
the authors apply and follow the laws and regulations regarding terminals in design,
so that the Pinang Baris Integrated Terminal can become a terminal that complies
with terminal standards. With this application to the project, it is hoped that the author
will be able to produce design solutions that can provide comfort for users and make
the Pinang Baris Integrated Terminal a standard-compliant terminal108 HalamanSkripsi Sarjan
Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines
No full textThe molecular mechanisms regulating the ubiquitin proteasome system (UPS) at synapses are poorly understood. We report that CaMKIIα—an abundant postsynaptic protein kinase—mediates the activity-dependent recruitment of proteasomes to dendritic spines in hippocampal neurons. CaMKIIα is biochemically associated with proteasomes in the brain. CaMKIIα translocation to synapses is required for activity-induced proteasome accumulation in spines, and is sufficient to redistribute proteasomes to postsynaptic sites. CaMKIIα autophosphorylation enhances its binding to proteasomes and promotes proteasome recruitment to spines. In addition to this structural role, CaMKIIα stimulates proteasome activity by phosphorylating proteasome subunit Rpt6 on Serine 120. However, CaMKIIα translocation, but not its kinase activity, is required for activity-dependent degradation of polyubiquitinated proteins in spines. Our findings reveal a scaffolding role of postsynaptic CaMKIIα in activity-dependent proteasome redistribution, which is commensurate with the great abundance of CaMKIIα in synapses.Howard Hughes Medical Institute (Investigator
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First record of the genus Baris Germar, 1817 (Coleoptera: Curculionidae), in Dominican amber
No full textA new weevil species – Baris grossacavis Poinar
and Legalov, sp. nov. (Coleoptera: Curculionidae) – is described
from Dominican amber. The new species is close to
Baris rubripes Casey, 1892, but differs by possessing large
punctures over much of its body, including the pronotum;
elytral intervals with rows of narrow scales, and narrow elytral
intervals.
The fossil is the first record of the subfamily Baridinae
from any amber source and the first record from the Miocene.This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by Copernicus Publications on behalf of the Museum für Naturkunde Berlin. The published article can be found at: www.fossil-record.net/home.html
Evaluasi Karakteristik Parkir Bus Tipe A Di Terminal Pinang Baris sebagai Terminal Bus Tipe A
No full textThis study was conducted to determine how the condition Pinang Baris Terminal currently associated with the characteristics of parking. This study uses a field survey by direct observation in Terminal Pinang Baris by spreading surveyor at certain points in order to facilitate the recording of data in order to obtain a valid observation. Direct observation is done by manually recording the arrival time data and exit the bus, license plate number, and the name of the bus company. Research analysis using Microsoft Exel. Results of identification and field research has been on the analysis shows a maximum level of parking characteristics in Pinang Baris Terminal and it is known that there are three issues that must be resolved. First, the buildup of bus parking AKDP manifold small and MPU bus that we can see on the pictures and the documentation of the calculation in the Parking Index. Secondly, the vehicle bus parking AKDP which do not in place and this can be seen in the image documentation. Third, when the AKAP bus will maneuver to get into the parking lot AKAP bus, it takes quite a long time and could hinder other transport to pass. In this thesis, the author has provided solutions to three problems are found, because it must be found a solution that does not affect the operational performance in the future Pinang Baris Terminal
Ubiquitin-Proteasome System at the Synapse
No full textEach neuron in the mammalian central nervous system makes up to ten thousand synaptic connections with other neurons yet is able to regulate the strength of individual connections locally. Synaptic enhancement or depression induced at one location on the dendritic arbor does not spread through out the entire neuron. This means neurons must be able to regulate the complement and concentration of the synaptic proteins locally, near synapses. The local concentration of synaptic proteins is influenced by many processes, including protein trafficking, buffering and sequestration, and most directly by protein synthesis and degradation. In recent years, it has been shown that neurons can synthesize proteins locally in their dendrites. These studies have suggested that any cellular process that regulates protein availability could be of importance in regulating synaptic function and plasticity. Indeed, the evidence for the contribution of local protein degradation to the regulation of synaptic function and plasticity has started to emerge in recent years.
Here, we show that synapses have the machinery required to degrade proteins and local protein degradation occurs in the dendrites. Furthermore, we demonstrate the requirement for protein degradation for one of the main cellular correlates of synaptic plasticity, namely the trafficking of glutamate receptors. In turn, we demonstrate how neuronal activity regulates protein degradation at synapses, specifically by mobilizing the enzymatic machinery for protein degradation. These data show that the interplay between protein degradation and synaptic activity functions to sculpt the protein composition of the synapses.</p
Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease
No full textThe brain changes in response to experience and altered environment. This neural plasticity is largely mediated by morphological and functional modification of synapses, a process that depends on both synthesis and degradation of proteins. It is now clear that regulated proteolysis plays a critical role in the remodeling of synapses, learning and memory, and neurodevelopment. Here, we highlight the mechanisms and functions of proteolysis in synaptic plasticity and discuss its alteration in disease states
Effects of modified atmosphere packaging (MAP) on the microbiological quality and shelf life of ostrich meat
No full textEffects of various concentrations of O-2/CO2 in modified atmosphere packaging on the microbiological quality and shelf-life of ostrich meat was investigated. Nine-12 months old ostriches were used. The iliofibularis muscle was cut into small cubes that were divided into five groups and then separately packaged under various gas mixes: air and O-2:CO2:N-2 ratios of 80:20:0, 60:20:20, 60:40:0, and 40:40:20, using 2 different headspace ratios (1:1 and 3:1). The packaged meats were kept at 4 degrees C for 10 days and were analysed microbiologically, physico-chemically and sensorially. As a result, the meat quality and shelf-life of ostrich meat under various gas compositions were improved: microbial growth was delayed due to high CO2 usage and shelf-life was increased by 5-7 days. However, an undesired loss of red colour of the ostrich meat may affect consumer acceptance. (C) 2011 Elsevier Ltd. All rights reserved
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