1,721,212 research outputs found
1-(4-SUBSTITUTED-BENZYL)-1,2,3-TRIAZOLES, INVITRO INHIBITORS OF PROSTAGLANDIN SYNTHESIS
No full textNew 4-(4-phenylsubstituted)-1,2,3-triazolacetic acid derivatives of general formula (I) were prepared by nucleophilic substitution, 1,3-dipolar cycloaddition and functional group interconversion reactions. These compounds were evaluated as in vitro prostaglandin synthesis inhibitors. Only the isomeric compounds (II c) and (III e), with a 4-aminophenyl substituent on the triazole ring, inhibit arachidonic acid-induced malondialdehyde formation in human platelets; (II c) and (III e) are as effective as aspirin
Clinical signs and serum protein level enhancements in 3 dogs with PLE solely treated with a homecooked diet.
No full textThymopentin treatment in patients undergoing surgery for lung carcinoma: Analysis of actuarial survival
No full textThymopentin is increasingly used in cancer patients because it has been observed to be useful in preventing infections in the post-operatory period and follow radio and chemotherapy. Two hundred forty seven patients undergoing macroscopically radical exeresis for non-small-cell lung cancer were randomly assigned to thymopentin treatment or control group. The patients were staged according to TNM system indications and classified as follows; I = 138pts, II = 54pts, IIIa = 55pts. Drug regimen was 1 mg/kg/die in the 3/7 days before surgery and throughout the post-operatory period, and 1 mg/kg every other day in the first year. In subseqent years the frug was administered at the same dosage for one month every three. We calculated the profile of the lymphocyte Leu 1, 4, 7, 3a, 2a subpopulation, and the helper/suppressor ratio within the controll group both prior and following one year from the treatment. We also observed a significant increase of Leu 1, 4 and 3a profile. Survival curves obtained by actuarial evaluation of the patients treated with thymopentin vs non treated patients showed that after 66 months the probability of survival in stage I patients was 78% vs 60% (p < 0.05); in stage II, 65% VS 58% (p = n.s.); in stage IIIa, 16% vs 13% (p = n.s.). In our opinion a positive interaction on survival was probably obtained by an aspecific activation of the immune system; in stage I when exeresis reduces residual disease to a minimum; in stage II and IIIa aspecific stimulation, if any, did not result in increased survival
Problemi tossicologici a livello di allevamento bovino: gestione dei rischi e sicurezza delle produzioni
No full textAn organic acid blend can modulate swine intestinal fermentation and reduce microbial proteolysis
No full textThe increased use of slow-release organic acids in swine nutrition has prompted more research to assess their possible role in modulating the intestinal microflora as an alternative to antibiotics. Three diets for growing pigs containing 0 (L-NDF), 100 (M-NDF), and 200 g kg-1 (H-NDF) dried sugar beet pulp (SBP) were pre-digested to simulate ileal digestion, and used as substrate in an in vitro cecal fermentation study. The inoculum was collected from pigs immediately after slaughter. Diets tested were L-NDF, M-NDF, and H-NDF with or without the addition of an organic acid blend providing phosphoric, citric, fumaric, and malic acid at 1.53, 0.78, 2.59, and 1.12 mmol L-1, respectively. Cecal microbial growth was monitored using the cumulative gas production technique. Fermentation fluid was analyzed for ammonia and volatile fatty acids concentrations. The maximum rate of gas production was higher when H-NDF rather than L-NDF or M-NDF (+ 18%; P < 0.05) was fed; such a high rate of growth (+ 14%; P < 0.05) was also achieved when the acid blend was added to L-NDF. After 24 h, the acid blend reduced ammonia, isoacids, and acetic acid concentrations in fermentation fluid regardless of the type of diet (P < 0.05). Organic acids stimulated bacterial fermentation when added to a low-fiber diet and were able to reduce ammonia in all diets tested
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Studio RP-HPLC dei tempi di sospensione di preparazioni contenenti Cefapirina in latte vaccino crudo
No full textTra Bologna e Uppsala, la Repubblica delle Lettere
No full textNel secolo dei Lumi gli scambi di saperi e, per gli scienziati, di oggetti di natura concessero di superare confini territoriali, linguistici, politici, religiosi; l'indagine dei fenomeni scientifici animò di sé le menti più libere e acute, permettendo avanzamenti stupefacenti in campo fisico, medico, astronomico, naturalistico. Tra quanti vollero intessere rapporti proficui molti i biologi, il cui compito era di investigare i fenomeni della natura per giungere alla corretta classificazione della straordinaria varietà di esemplari presenti nel mondo occidentale, in Oriente, in Africa, nel Nuovo Mondo, oggetto di attenzione in Bologna sino dal Cinquecento di Ulisse Aldrovandi; un botanico bolognese, Ferdinando Bassi, si distinse per la capacità intuitiva nella ricerca e la generosità nella diffusione del suo sapere. Fu dunque esponente di vaglia della Repubblica delle Lettere, comunità cosmopolita di dotti che miravano al progresso per l'umanità. Lo attestano i molti volumi del suo Commercio Letterario, raccolte di missive che recano le firme più prestigiose, da Duhamel de Monceau a D'Argenville a Rozier a Gottlieb a Pontedera, e le sue lettere a Linneo (A. Managlia), significative non solo di una stima concreta ma della vivacità e concretezza del rapporto tra i due, nonché della ricerca dell'universaltà della conoscenza.Two prominent scholars leaded botanical studies in Bologna at Linnaeus’ times. The older, Giuseppe Monti (1682 - 1760) had the chair of Botany and the direction of the botanical garden during about forty years. The plants of his huge herbarium are named after the pre-linnaean polynomial nomenclature. Monti was unanimously considered as one of the major botanists of his time. Much younger was Ferdinando Bassi (1710 – 1774), who dedicated all of his life to the study of many aspects of natural sciences, and to plant science in particular. In spite of his relevant contribution to science, Bassi never obtained academic recognition.
Both of these scholars played a role in the edification of the linnaean systema naturae. It is well known that Linnaeus travelled very little: he pursued his goal of creating an all-comprehensive classification system almost without moving away from Scandinavia. In this frame, the contribution by his correspondents all around the world was essential, and is documented by thousands of letters and herbarium specimens.
Giuseppe Monti and Ferdinando Bassi were among the correspondents. The former seems to have sent letters only, while the latter sent to Linnaeus a number of dryed specimens and seeds, and obtained plants from Scandinavia in his turn. The gratitude by Linnaeus is documented by the names of two plant genera, Montia and Bassia, dedicated to the Bononian botanists. Plants sent by Bassi have been identified in the Linnean Herbarium, while some plants sent by Linnaeus have been recently discovered in the Bassian Herbarium in Bologna. These findings open a window on the cultural exchanges through Europe during the second half of the Eighteenth Century, and on the scientific relationships of the Bononian school
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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