2,209 research outputs found
Teacher formative assessment: the missing link in response to intervention
No full textResponse to Intervention (RtI) focuses on the assessment, intervention, and progress monitoring of student academic performance and social behavior. Despite requiring highly-qualified personnel for successful implementation, the implementation of Rtl has not focused on applying its foundational principles towards promoting teacher effectiveness through assessment, intervention, and progress monitoring of teacher classroom practice. Compounding this problem is the lack of availability of reliable and valid teacher assessments to apply in an Rtl model for teacher professional development. This chapter provides a rationale for applying RtI principles to teacher professional development and how teacher formative assessment can improve educator effectiveness, student learning, and social behaviors. The Classroom Strategies Scale (CSS, Reddy & Dudek, 2014), a new multidimensional assessment of instructional and behavioral management practices is discussed as an example of one promising tool for promoting teachers professional development within an Rtl model. We offer a synthesis of the theory, research, and evidence of reliability and validity of the CSS. The application of teacher formative assessment in job-embedded professional development/coaching models for schools is discussed. Finally, implications for practice and research are outlined.Peer reviewe
Bulky N-substituted 1,3-benzazaphospholes: Access via Pd-catalyzed C-N and C-P cross coupling, lithiation, and conversion to novel P=C-PtBu2 hybrid ligands
No full textThe syntheses of novel bulky N-substituted 1,3-benzazaphospholes are presented, together with their reactions with tert-butyllithium and coupling with tBu(2)PCI to novel PP-hybrid ligands that combine the highly basic and bulky di-tert-butylphosphanyl group with g-acidic low-coordinated phosphorus. The syntheses start with the preparation of new N-seconclary 2-bromoanilines 1 by reduction of N-acyl 2-bromoanilides or more generally by Pd-catalyzed selective monoamination of o-dibromobenzene, followed by Pd-catalyzed C-P coupling with P(OEt)(3) to the respective 2-anilino-phosphonates 2. The next steps are reduction to 2-phosphanylanilines 3 and condensation with Me2NCH(OMe)(2), which leads via phosphaalkenes 4 to the corresponding N-substituted benzazaphospholes 5. The reaction with tBuLi depends on the steric demand of the N substituent. Methyl, neopentyl-, and mesityl-derivatives were converted to P=C Li species 6 and coupled with tBu(2)PCI to novel P=C-PtBU2 ligands 7, whereas N-adamany and N-2,6-diisopropylphenyl-derivatives prefer addition of tBuLi at the P=C bond to form dihydroderivatives. The chemical shifts of the low-coordinated phosphorus of 5 and 7 were found to reflect electronic and steric effects of the N substituents. The comparison of the crystal structures of N-neopentyl-1,3-benzazaphospholes 5 and 7 gives evidence of steric repulsion between the adjacent di-tert-butyl and neopentyl groups by the preferred anti orientation of the P-tert-butyl groups and moderate deviations of C2 and P3 of 7b from the ring plane
pi-Excess sigma P-2,O Hybrid Ligands: Synthesis of the First 4-Methoxy-1H-1,3-benzazaphospholes
No full textThe synthesis of the first 4-methoxy-substituted 1,3-benzazaphosphole was accomplished by using a C, O-dilithium intermediate generated from N-(3-methoxyphenyl)-2,2-dimethylpropanamide and butyllithium. This intermediate was subjected either to direct phosphonylation or to a bromination and phosphonylation sequence; subsequent reductive cyclization with excess lithium aluminum hydride led to the desired product. In addition, N-(2,2-dimethylpropyl)-3-methoxy-2-phosphinoaniline, formed in a side reaction, was cyclized with (dimethoxymethyl) dimethylamine to give 1-(2,2-dimethylpropyl)-4-methoxy-1H-1,3-benzazaphosphole. The behavior of these +M-substituted pi-excess aromatic sigma P-2-heterocycles towards moisture is reported, together with their H-1, C-13, and P-31 solution NMR spectra and a crystal-structure analysis. The new compounds represent potential sigma P-2, O hybrid or chelate ligands with a high pi-density at the phosphorus atom.Deutsche Forschungsgemeinschaft [HE 1997/12
Drinking water quality assessment of Bhaskar Rao kunta watershed, Dhamarcherla Mandal, Nalgonda District,
No full textNot AvailableSemi-arid region of Bhaskar Rao Kunta watershed groundwater quality was evaluated for suitability
irrigation; in this situation twenty groundwater samples were collected at identical locations from
deeper bore wells. The American Public Health Association (APHA) standard methods were followed
and the concentrations of physicochemical parameters of pH, electrical conductivity (EC), total
hardness (TH), Ca2+, Mg2+, Na+, K+, HCO3
-, SO4
2-, Cl- and NO3
- analyzed. The results of the concentrations
were interpreted and measured with different irrigation indexes like EC, sodium percent (SP), sodium
adsorption ratio (SAR), residual sodium carbonate (RSC), permeability index (PI) and Kelly’s ratio (KR).
The interpreted results were indicated that the groundwater quality stands on EC values; 20 and 80% of
the samples fall under medium to high salinity category in pre and post-monsoon seasons and stands
on sodium percent (SP) values, 25 and 75% of the samples fall under excellent to good category in both
seasons. The remaining indexes SAR, RSC and KR values stands on 100% of the samples and fall
under the excellent and excellent to good category in both seasons. Hence, the indexes results were
concluded that the quality of groundwater in general was suitable for irrigation.Not Availabl
Homology modeling, molecular dynamics, and virtual screening of NorA efflux pump inhibitors of Staphylococcus aureus
No full textBaki Vijaya Bhaskar,1 Tirumalasetty Muni Chandra Babu,1 Netala Vasudeva Reddy,2 Wudayagiri Rajendra1 1Division of Molecular Biology, Department of Zoology, 2Department of Biotechnology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India Abstract: Emerging drug resistance in clinical isolates of Staphylococcus aureus might be implicated to the overexpression of NorA efflux pump which is capable of extruding numerous structurally diverse compounds. However, NorA efflux pump is considered as a potential drug target for the development of efflux pump inhibitors. In the present study, NorA model was constructed based on the crystal structure of glycerol-3-phosphate transporter (PDBID: 1PW4). Molecular dynamics (MD) simulation was performed using NAMD2.7 for NorA which is embedded in the hydrated lipid bilayer. Structural design of NorA unveils amino (N)- and carboxyl (C)-terminal domains which are connected by long cytoplasmic loop. N and C domains are composed of six transmembrane α-helices (TM) which exhibits pseudo-twofold symmetry and possess voluminous substrate binding cavity between TM helices. Molecular docking of reserpine, totarol, ferruginol, salvin, thioxanthene, phenothiazine, omeprazole, verapamil, nalidixic acid, ciprofloxacin, levofloxacin, and acridine to NorA found that all the molecules were bound at the large hydrophobic cleft and indicated significant interactions with the key residues. In addition, structure-based virtual screening was employed which indicates that 14 potent novel lead molecules such as CID58685302, CID58685367, CID5799283, CID5578487, CID60028372, ZINC12196383, ZINC72140751, ZINC72137843, ZINC39227983, ZINC43742707, ZINC12196375, ZINC66166948, ZINC39228014, and ZINC14616160 have highest binding affinity for NorA. These lead molecules displayed considerable pharmacological properties as evidenced by Lipinski rule of five and prophecy of toxicity risk assessment. Thus, the present study will be helpful in designing and synthesis of a novel class of NorA efflux pump inhibitors that restore the susceptibilities of drug compounds. Keywords: Staphylococcus aureus, NorA efflux pump, molecular dynamics, virtual screening, docking 
An introduction to continuum mechanics / J.N. Reddy.
No full textengineering bookfair2015Includes bibliographical references and index.xxvi, 450 pages :"This best-selling textbook presents the concepts of continuum mechanics in a simple yet rigorous manner. The book introduces the invariant form as well as the component form of the basic equations and their applications to problems in elasticity, fluid mechanics, and heat transfer, and offers a brief introduction to linear viscoelasticity. The book is ideal for advanced undergraduates and beginning graduate students looking to gain a strong background in the basic principles common to all major engineering fields, and for those who will pursue further work in fluid dynamics, elasticity, plates and shells, viscoelasticity, plasticity, and interdisciplinary areas such as geomechanics, biomechanics, mechanobiology, and nanoscience. The book features derivations of the basic equations of mechanics in invariant (vector and tensor) form and specification of the governing equations to various coordinate systems, and numerous illustrative examples, chapter summaries, and exercise problems. This second edition includes additional explanations, examples, and problems"-
An ecotoxicological study on tin- and bismuth-catalysed PDMS based coatings containing a surface-active polymer
No full textNovel films were prepared by condensation curing reaction of a poly(dimethyl siloxane) (PDMS) matrix with bismuth neodecanoate and dibutyltin diacetate catalysts. An ecotoxicological study was performed on the leachates of the coatings using the bacterium Vibrio fischeri, the unicellular alga Dunaliella tertiolecta, the crustacean Artemia salina and the fish Sparus aurata (larvae) as testing organisms. A copper-based self-polishing commercial paint was also tested as reference. The results showed that the tin-catalysed coatings and the copper paint were highly toxic against at least two of the four test organisms, whereas bismuth-catalysed coatings did not show any toxic effect. Moreover, the same biological assessment was also carried out on PDMS coatings containing a surface-active fluorinated polymer. The toxicity of the entire polymeric system resulted only from the tin catalyst used for the condensation curing reaction, as the bismuth catalysed coatings incorporating the surface-active polymer remained atoxic toward all the tested organisms
Advancing instructional coaching with teacher formative assessment and input
No full textWith increased attention to teacher quality and accountability, instructional coaching has emerged as a popular form of teacher support and professional development in literacy and other areas of instruction. Despite significant interest from school personnel, researchers, and federal funders, there remains a lack of consensus around the key components and activities of instructional coaching. To that end, studies that use quantitative and qualitative methods can offer valuable information on the development and validation of coaching practices. This chapter briefly describes the Classroom Strategies Assessment System Coaching Model that draws on the adult learning and formative assessment literature. We offer key observations of educators' knowledge of and experience in instructional coaching from focus groups conducted with teachers in high-poverty, urban elementary schools. Directions for practice and research are discussed.Peer reviewe
Biodegradation of nickel and chromium from space maintainers: An <i>in vitro</i> study
No full textBand materials are often used in the practice of pediatric dentistry. Nickel and Chromium are the main ingredients of these materials. The potential health hazards of nickel and chromium and their compounds have been the focus of attention for more than 100 years. It has established that these metals could cause hypersensitivity. The study was undertaken to analyze in vitro biodegradation of space maintainers made out of stainless steel band materials from manufacturers Dentaurum and Unitek. The leaching effect simulating the use of one, two, three, and four space maintainers in clinical practice was studied by keeping the respective number of space maintainers in the artificial saliva incubating at 37°C and analyzing for nickel and chromium release after 1,7,14,21 and 28 days using atomic absorption spectrophotometer. Results showed that there was measurable release of both nickel and chromium which reached maximum level at the end of 7 days which was statistically significant (P < 0.05) and was very much below the dietary average intake even for four bands used and was not capable of causing any toxicity
Service-oriented models for audiovisual content storage
No full textWhat are the important topics to understand if involved with storage services to hold digital audiovisual content? This report takes a look at how content is created and moves into and out of storage; the storage service value networks and architectures found now and expected in the future; what sort of data transfer is expected to and from an audiovisual archive; what transfer protocols to use; and a summary of security and interface issues
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