302 research outputs found
AI could help address challenges in marine fisheries, says NITI Aayog Vice Chairman Bhaskar Live dated 5th January 2023
Get PDFEmphasising the role of technology as a vital growth driver, NITI Aayog Vice Chairman Suman Bery said the application of frontier technologies like artificial intelligence could help address the challenges in the marine fisheries sector. He was speaking after inaugurating a high-level national workshop jointly organised by NITI Aayog, ICAR-Central Marine Fisheries Research Institute (CMFRI) and Kerala Fisheries Department at CMFRI
The Valuable Plurality of the Citizen Sciences
No full textWe are grateful to Caren Cooper, Sachit Mahajan, Hussein Zeidan, Maxson Anyolitho, and Mercy Gloria Ashepet for their comments on earlier versions of this paper. Author Anna Berti Suman’s research was supported by the Marie Skłodowska-Curie grant n. 891513, awarded under the European Union’s Horizon 2020 Funding Program. Views and opinions expressed in this article by author Anna Berti Suman are those of the author only and do not necessarily reflect those of the European Commission. The ATRAP project is financed by the Development Cooperation program of the Royal Museum for Central Africa with support of the Belgian Directorate-General Development Cooperation and Humanitarian Aid.Peer-reviewe
A microvillus based approach to model cell rolling
Get PDFThesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student submitted PDF version of thesis.Includes bibliographical references (p. 45-50).Cell rolling is a physiological phenomenon, which allows leukocytes to attach to activated vascular endothelium and reach sites of inflammation. A novel approach to model cell rolling is presented in this thesis. The model incorporates all the aspects known to be important to rolling in a semi-analytical framework making it computationally efficient. Bond kinetics have been used to define microvillus attachment probability which is in turn used to find out the net force on the cell. Deformability is also taken into account by an empirical relation which allows shear modulation of cell-surface contact area. The model showed excellent agreement with experimental results over a wide range of shear stresses. Using the model, the effects of cell deformability and microvillus structure have been studied and its implications discussed. The model was also used to predict rolling of microspheres, which showed reasonable agreement with experiments. Finally, the contribution of different features towards stabilization of rolling was elucidated by simulating different hypothetical cases with contributions from different cellular features.by Suman Bose.S.M
New Insights into the Bacterial Fitness-Associated Mechanisms Revealed by the Characterization of Large Plasmids of an Avian Pathogenic E. coli
Get PDFThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Extra-intestinal pathogenic E. coli (ExPEC), including avian pathogenic E. coli (APEC), pose a considerable threat to both human and animal health, with illness causing substantial economic loss. APEC strain chi7122 (O78ratioK80ratioH9), containing three large plasmids [pChi7122-1 (IncFIB/FIIA-FIC), pChi7122-2 (IncFII), and pChi7122-3 (IncI(2))]; and a small plasmid pChi7122-4 (ColE2-like), has been used for many years as a model strain to study the molecular mechanisms of ExPEC pathogenicity and zoonotic potential. We previously sequenced and characterized the plasmid pChi7122-1 and determined its importance in systemic APEC infection; however the roles of the other pChi7122 plasmids were still ambiguous. Herein we present the sequence of the remaining pChi7122 plasmids, confirming that pChi7122-2 and pChi7122-3 encode an ABC iron transport system (eitABCD) and a putative type IV fimbriae respectively, whereas pChi7122-4 is a cryptic plasmid. New features were also identified, including a gene cluster on pChi7122-2 that is not present in other E. coli strains but is found in Salmonella serovars and is predicted to encode the sugars catabolic pathways. In vitro evaluation of the APEC chi7122 derivative strains with the three large plasmids, either individually or in combinations, provided new insights into the role of plasmids in biofilm formation, bile and acid tolerance, and the interaction of E. coli strains with 3-D cultures of intestinal epithelial cells. In this study, we show that the nature and combinations of plasmids, as well as the background of the host strains, have an effect on these phenomena. Our data reveal new insights into the role of extra-chromosomal sequences in fitness and diversity of ExPEC in their phenotypes
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