101,006 research outputs found
cAMP: a multifaceted modulator of immune synapse assembly and T cell activation
No full textT Lymphocyte activation involves a substantial reorganization of the membranous and intracellular compartments. Signaling complexes assemble and dismantle in a highly ordered fashion in both compartments and orchestrate the activation of T cells with high sensitivity and specificity. TCR ligation leads to a short burst of cAMP production, which is centrally required for T cell activation; however, sustained elevations in intracellular cAMP concentrations are immunosuppressive. Emerging evidence of the existence of local cAMP pools gleaned from studies on other cell types suggests that cAMP compartmentalization may account, in part, for these opposing effects. Whereas cAMP compartmentalization has been identified as a central factor in the control of the cAMP-dependent processes in other cell types, this has, as yet, not been addressed in T lymphocytes. In this review, we discuss the role of cAMP in T cell activation and differentiation, with an emphasis on the effects mediated by the cAMP effectors, protein kinase A (PKA) and exchange protein activated by cAMP (EPAC)1, and on the regulatory proteins that may control the generation of local cAMP pools in T cells. We also present an overview of the available tools to image cAMP production at the subcellular level and discuss how bacterial adenylate cyclase (AC) toxins that are known to generate local cAMP pools can be exploited to address the role of cAMP compartmentalization in T cell activation
A PROJECT REPORT ON EMPLOYEE JOB SATISFACTION WITH SPECIAL REFERENCES TO BHARATHI CEMENT PVT, AT (NALLALINGAYAPALLI)
Full text linkThere are the reasons for the Employee job satisfaction at Bharathi Cement Corporation Private Ltd. The study of job satisfaction has a big impact on productivity, retention, and overall organizational effectiveness. The goal of this study is to investigate the complex relationship between job satisfaction such as motivation, work environment, leadership, organizational culture & pay. The study determines the main element that influence job satisfaction and examines the interact with by using a percentage analysis. So that employees for their participation and emphasize the importance of their feedback in making improvements within the company. So, employees are satisfied with their job satisfaction level in Bharathi Cement Pvt Ltd
Evaluation of the Indian Migration Study Physical Activity Questionnaire (IMS-PAQ): a cross-sectional study.
Full text linkABSTRACT:
Socio-cultural differences for country-specific activities are rarely addressed in physical activity questionnaires. We examined the reliability and validity of the Indian Migration Study Physical Activity Questionnaire (IMS-PAQ) in urban and rural groups in India.
A sub-sample of IMS participants (n = 479) was used to examine short term (≤1 month [n = 158]) and long term (> 1 month [n = 321]) IMS-PAQ reliability for levels of total, sedentary, light and moderate/vigorous activity (MVPA) intensity using intraclass correlation (ICC) and kappa coefficients (k). Criterion validity (n = 157) was examined by comparing the IMS-PAQ to a uniaxial accelerometer (ACC) worn ≥4 days, via Spearman's rank correlations (ρ) and k, using Bland-Altman plots to check for systematic bias. Construct validity (n = 7,000) was established using linear regression, comparing IMS-PAQ against theoretical constructs associated with physical activity (PA): BMI [kg/m2], percent body fat and pulse rate.
IMS-PAQ reliability ranged from ICC 0.42-0.88 and k = 0.37-0.61 (≤1 month) and ICC 0.26 to 0.62; kappa 0.17 to 0.45 (> 1 month). Criterion validity was ρ = 0.18-0.48; k = 0.08-0.34. Light activity was underestimated and MVPA consistently and substantially overestimated for the IMS-PAQ vs. the accelerometer. Criterion validity was moderate for total activity and MVPA. Reliability and validity were comparable for urban and rural participants but lower in women than men. Increasing time spent in total activity or MVPA, and decreasing time in sedentary activity were associated with decreasing BMI, percent body fat and pulse rate, thereby demonstrating construct validity.
IMS-PAQ reliability and validity is similar to comparable self-reported instruments. It is an appropriate tool for ranking PA of individuals in India. Some refinements may be required for sedentary populations and women in India
FIGURE 5 in Morphological and molecular approaches revealed a new species of snapping shrimp genus Alpheus Fabricius, 1798 (Decapoda: Caridea: Alpheidae) from Lakshadweep Islands, India
No full textFIGURE 5. Phylogenetic tree of Alpheus sulcipalma sp. nov. and all available sequences of congener species using partial sequences of COI gene.Published as part of Purushothaman, P., Bharathi, S., Damodhar, A. T., Ajith Kumar, T. T. & Lal, K. K., 2023, Morphological and molecular approaches revealed a new species of snapping shrimp genus Alpheus Fabricius, 1798 (Decapoda: Caridea: Alpheidae) from Lakshadweep Islands, India, pp. 426-442 in Zootaxa 5227 (4) on page 437, DOI: 10.11646/zootaxa.5227.4.2, http://zenodo.org/record/751886
Decapoda Latreille 1802
No full textOrder: Decapoda Latreille, 1802 Infraorder: Caridea Dana, 1852Published as part of Purushothaman, P., Bharathi, S., Damodhar, A. T., Ajith Kumar, T. T. & Lal, K. K., 2023, Morphological and molecular approaches revealed a new species of snapping shrimp genus Alpheus Fabricius, 1798 (Decapoda: Caridea: Alpheidae) from Lakshadweep Islands, India, pp. 426-442 in Zootaxa 5227 (4) on page 428, DOI: 10.11646/zootaxa.5227.4.2, http://zenodo.org/record/751886
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Properties of nanocomposite film combining hard TiN matrix with embedded fullerene-like WS2 nanoclusters
No full textWe have developed hard self-lubricant coatings combining a hard matrix (TiN) and a self-lubricant phase in the form of inorganic-like WS2 fullerene. The nanoparticles were injected from the preparation chamber directly to the sample surface during reactive sputtering from a Ti target in Ar/N2 atmosphere. The injection of the particles led to the local oxidation of the matrix due to the flow of residual oxygen from the preparation chamber; therefore, the final composite was TiN/Ti–O–WS2. The observation of the composite film by scanning and transmission electron microscopies showed the incorporation of the WS2 nanoparticles; however, their bonding with the matrix was weak. The analysis of the wear tracks did not show any presence of WS2 in the contact
The male characters of Devi Bharathi short stories are a feminist vision
Full text linkThe country that enhances the pride of the woman has risen in this earth. In today's age of information technology, women are progressing in various fields on par with men and more than men. They are confident that they can achieve anything in life. But a woman cannot live alone in society. They live on orders in one way or another. In the end, the woman's condition is reduced to a very bad state, no matter what mistakes the woman makes in her life. Women bear more responsibilities. Whether a man makes mistakes or a man makes mistakes, the woman ultimately accepts the consequences. In this way, the problems caused by men to women in devibharathi short story are manifestations of male and female relationship. The article is titled Male Characters A Feminist Vision in Devi Bharathi Short Story, focusing on psychological complexity and the effects of caste discrimination
Urbanization and Green Spaces—A Study on Jnana Bharathi Campus, Bangalore University
Full text linkGlobal warming is amongst the most alarming problems of the new era. Carbon emission is evidently the strongest fundamental factor for global warming. So increasing carbon emission is one of today’s major concerns, which is well addressed in the Kyoto Protocol. Trees are amongst the most significant elements of any landscape, because of both biomass and diversity, and their key role in ecosystem dynamics is well known. Trees absorb the atmospheric carbon dioxide and act as a carbon sink, since 50 % of biomass is carbon itself and the importance of carbon sequestration in forest areas is already accepted, and well documented. With this background, a carbon sequestration potential study was carried out in Jnana Bharathi campus, Bangalore University using the Quadrat method. The total geographical area is about 449.74 ha with a rich vegetation sector and the total amount of both above ground carbon (AGC) and below ground carbon (BGC) was estimated as an average of 54.8 t/ha. The total amount of carbon dioxide assimilated into the vegetation in terms of both above ground and below ground biomass was estimated as an average of 200.9 t/ha. Urbanization and habitat fragmentation seem to be increasing worldwide, substantiated by a case study in Bangalore City. The analysis revealed that increase in built-up area at the city level was by about 164.62 km2, while the vegetation and water bodies decreased by about 285.72 and 7.2 km2 respectively. However, Bangalore University, Jnana Bharathi campus attains a good vegetation cover and is seen as one of the ‘green lungs’ of Bangalore city
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
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