118 research outputs found
R16. Formulation and Evaluation of Doxorubicin HCl Nanoliposomes by Ethanol Injection Method
No full textCorresponding author (Pharmaceutics and Drug delivery): Arun Kumar Kotha, [email protected]://egrove.olemiss.edu/pharm_annual_posters/1015/thumbnail.jp
CLINICAL EVALUATION OF STEM BARK POWDER OF SHIGRU (MORINGA OLEIFERA LAM.) IN DYSLIPIDEMIA
No full textIn recent times drastic changes have taken place in dietary habits and mode of life style which has resulted in precipitation of various metabolic diseases. One such alarming condition, which is on a high rise in the society, is Dyslipidemia. Since the pathology has a clear link with a person’s life style, the body demands a more holistic approach in treatment, hence indigenous system of medicine especially herbal preparations can play major role in finding a safe, simple and cost effective solution for the management of Dyslipidemia. Shigru botanically identified as Moringa oleifera Lam. is one of such commonly available plant which is greatly praised for its Medoghna property in various Nighantus.A clinical study of Shigru twak (stem bark) was conducted on 30 patients at OPD level of Government Ayurveda College Hospital, Tripunithura, Kerala. Shigru stem bark powder (Choornam) was given in the form of capsule, in a dose of 3gm per day along with lukewarm water before food for a period of 45 days. Assessment based on blood lipid levels and clinical features was done before and after treatment. The results were statistically analyzed. After the intervention Total Cholesterol, Serum LDL, Serum VLDL, Serum Triglyceride and Body weight were significantly reduced. On symptomatic evaluation the drug was significantly effective in reducing heaviness of body, chest pain, excessive sleep, excessive sweating, and breathlessness on exertion, palpitation and lethargy. The study revealed that Shigru twak is safe and effective in Dyslipidemia
CORRELATIVE STUDY OF PRAKRITI WITH SANDHIVATA
No full textPrakriti is the health profile or unique psychosomatic temperament of an individual encompassing his or her physical, functional and behavioural characteristics. Prakriti is not only an instrument to examine the patient but also influences the onset, occurrence, pathogenesis, diagnosis, prognosis and management of a patient. Among the various specific characteristics of Ayurveda, the knowledge of ‘Prakriti’ is at the top. Charaka, while directing tenfold examination of a patient (Dasvidh Pariksha), has counted ‘Prakriti’ on the top. Prakriti is most important in achieving the goal of Ayurveda, i.e. the maintenance of health of a healthy individual and cure of a diseased person. Keeping the knowledge of Prakriti in mind, a physician can suggest the person to follow up the day, night and seasonal regimens for the maintenance of health. Not only this, a diseased person can be easily managed by the knowledge of the Prakriti in the diagnosis as well as treatment. The knowledge of Prakriti eases the process of management of a disease because according to Ayurvedic concept, no disease in the body is possible without involvement of Dosha and the management is the reestablishment of Doshas in their normal state.For the purpose of present study, 30 patients of Sandhivata were selected from OPD and IPD of Ayurvedic and Unani Tibbia College Hospital and from Multi-Speciality Hindustani Dawakhana, Delhi having complaints related to ‘Sandhivata as per the “criteria for the selection of the patients” given below. On the basis of clinical examination (signs & symptoms) and necessary investigation (X-ray of the involved joints), the diagnosis of Sandhivata was established, then the patients were included in the study. The Prakriti of each patient was identified with the help of standard proforma, based on various signs & symptoms presented by various Ayurvedic authors for this purpose. The study revealed that Sandhivata has predominance in Vata pradhan prakriti due to Samanaya siddhanta
Machine Learning Techniques on Gene Function Prediction
No full textThis eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contac
Effect of calcination temperatures on Green luminescence of Ce:YAG nanophosphor prepared by modified co-precipitation method
No full textSoft biometrics for surveillance: an overview
No full textBiometrics is the science of automatically recognizing people based on physical or behavioral characteristics such as face, fingerprint, iris, hand, voice, gait and signature. More recently, the use of soft biometric traits has been proposed to improve the performance of traditional biometric systems and allow identification based on human descriptions. Soft biometric traits include characteristics such as height, weight, body geometry, scars, marks and tattoos (SMT), gender, etc. These traits offer several advantages over traditional biometric techniques. Soft biometric traits can be typically described using human understandable labels and measurements, allowing for retrieval and recognition solely based on verbal descriptions. Unlike many primary biometric traits, soft biometrics can be obtained at a distance without subject cooperation and from low quality video footage, making them ideal for use in surveillance applications. This chapter will introduce the current state-of-the-art in the emerging field of soft biometric
Thomas Nashe and the Idea of the Author
No full textThomas Nashe was a writer whose authorial voice was impacted by a number of different sources. Beginning with figures writing in the classical age, this thesis discusses how Nashe directly engages with their authorial personae by representing them directly in his works, and examines how Nashe presented his views on authorship by examining the manner in which he utilised these authors and their works. The thesis is not limited by genre, but engages with authors across various styles, including satire, history and drama whilst also discussing how Nashe rationalised his admiration of authors whose religious views were antithetical to his own. The scope of the analysis ranges from considering Nashe’s responses to classical authors (like Apuleius and Lucian) to contemporary Europe (Aretino) and England (including Marlowe and Greene). This thesis offers an original contribution to knowledge by highlighting how Nashe’s self-fashioning of his own authorial persona is developed through his interrogation of the models of authorship offered by both classical and contemporary authorities and discussing how his utilisation of these figures assisted in his growth as a polyauthor. The thesis concludes that Nashe’s authorial voice and identity developed through exposure to various influences and was constantly evolving throughout his career
Necessary and sufficient type theorem for absolute Nörlund summability of conjugate series
No full textSufficient conditions for
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summability of the conjugate series of Fourier series have been obtained earlier. The author obtains here a set of necessary and sufficient conditions for the result. This improves earlier results and provides a unified version of them.</p
Porcine model of xenobiotic metabolism
No full textA xenobiotic is a foreign chemical substance found in the environment. The body removes xenobiotics by xenobiotic metabolism. Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination, and detoxification of xenobiotics introduced into the body. Orphan nuclear receptors play crucial role in regulation of the expression of DMEs. The pig has quickly grown into an important biomedical research tool over the past few decades. The pig is an appropriate animal model for the investigation of xenobiotic disposition, as the transporters and CYP enzymes are very similar to those in humans. The characterization of porcine drug metabolism genes and the genes involved in regulating drug metabolism can provide insights into human drug metabolic diseases and individual variability of responses toward a drug. The tissue- and stage-specific expression of the nuclear receptors in pigs and their comparison to humans will be of great interest. Consequently, the goal of the proposal is to validate pig as a model of xenobiotic metabolism in order to get a better understanding of the pharmacokinetic properties of the xenobiotics. Expression of orphan nuclear receptors were screened across various porcine organs (liver, kidney, lung, small intestine, spleen, pancreas, heart, brain and skeletal muscle). Analysis of the mRNA expression levels of porcine orphan nuclear receptors in total RNA from various porcine organs was also performed by real time reverse transcriptase PCR. Expression of all the porcine nuclear receptors studied except (PPARγ) was detected in the liver and kidney. Most of the nuclear receptors showed higher expression in the liver. The tissue distribution and the expression profiles of the porcine nuclear receptors were consistent with those of human. To evaluate the effect of xenobiotic exposure on the expression pattern of the nuclear receptors, expression pattern of nuclear receptors were evaluated in three different developmental stages i.e; three month old fetus, one month old piglet and one year old adult pig. The expression levels of the nuclear receptors in adult tissues were higher than that of one month old piglets which in turn were higher than those of a three month old fetal piglet. Porcine orphan nuclear receptors liver X receptor alpha (LXRα), liver X receptor beta (LXRβ) and constitutive androstane receptor (CAR) were cloned and the sequence analysis revealed eight novel transcript variants for LXRα and LXRβ each and five novel transcript variants for CAR. The expression profiles and the physiochemical properties of the novel identified transcript variants were analyzed. Further, we developed and characterized a porcine hepatocyte cell line representative of human primary hepatocytes to support drug toxicity and metabolism assessments. Three independent hepatocyte cell lines were developed from three different Oncopigs and all of them expressed hepatocyte specific and most important drug metabolism and regulation genes comparable to those porcine primary hepatocytes. We evaluated the effect of selective CYP modulators on three porcine hepatocyte cell lines. All the three independent porcine hepatocyte cell lines behaved the same way and the gene regulation pattern in hepatocyte cell lines was similar to that of primary hepatocytes and human models. These findings indicate that this porcine hepatocyte cell line represents a useful and predictive model for high throughput screening of new drugs as well as studies on metabolism and hepatotoxicity of chemicals.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-08-01The student, Arun De, accepted the attached license on 2016-07-12 at 13:18.The student, Arun De, submitted this Dissertation for approval on 2016-07-12 at 13:23.This Dissertation was approved for publication on 2016-07-12 at 15:10.DSpace SAF Submission Ingestion Package generated from Vireo submission #9889 on 2016-11-10 at 12:25:16Made available in DSpace on 2016-11-10T18:42:57Z (GMT). No. of bitstreams: 3
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Previous issue date: 2016-07-12Embargo set by: Seth Robbins for item 95479
Lift date: 2018-11-10T18:43:22Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 95479 on 2018-11-11T10:15:24Z
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