20 research outputs found
Re: L. D. Miles' speech to Society for Advancement of Management "enhanc[ed] the reputation of our Company.--Correspondence
No full textRe: L. D. Miles' speech to Society for Advancement of Management "enhanc[ed] the reputation of our Company." Mentions companies represented; author seems to feel it will help with GE sales
Current directions in videoconferencing tele-mental health research
No full textThe provision of mental health services via videoconferencing tele-mental health has become an increasingly routine component of mental health service delivery throughout the world. Emphasizing the research literature since 2003, we examine (a) the extent to which the field of tele-mental health has advanced the research agenda previously suggested and (b) implications for tele-mental healthcare delivery for special clinical populations. Previous findings have demonstrated that tele-mental health services are satisfactory to patients, improve outcomes, and are probably cost effective. In the very small number of randomized controlled studies that have been conducted to date, tele-mental health has demonstrated equivalent efficacy compared to face-to-face care in a variety of clinical settings and with specific patient populations. However, methodologically flawed or limited research studies are the norm, and thus the research agenda for tele-mental health has not been fully maximized. Implications for future research and practice are discussed
The Mathematical Foundation of Structural Mechanics
No full textThis book attempts to acquaint engineers who have mastered the essentials of structural mechanics with the mathematical foundation of their science, of structural mechanics of continua. The prerequisites are modest. A good working knowledge of calculus is sufficient. The intent is to develop a consistent and logical framework of theory which will provide a general understanding of how mathematics forms the basis of structural mechanics. Emphasis is placed on a systematic, unifying and rigorous treatment. Acknowledgements The author feels indebted to the engineers Prof. D. Gross, Prof. G. Mehlhorn and Prof. H. G. Schafer (TH Darmstadt) whose financial support allowed him to follow his inclinations and to study mathematics, to Prof. E. Klingbeil and Prof. W. Wendland (TH Darmstadt) for their unceasing effort to achieve the impossible, to teach an engineer mathematics, to the staff of the Department of Civil Engineering at the University of California, Irvine, for their generous hospitality in the academic year 1980-1981, to Prof. R. Szilard (Univ. of Dortmund) for the liberty he granted the author in his daily chores, to Mrs. Thompson (Univ. of Dortmund) and Prof. L. Kollar (Budapest/Univ. of Dortmund) for their help in the preparation of the final draft, to my young colleagues, Dipl.-Ing. S. Pickhardt, Dipl.-Ing. D. Ziesing and Dipl.-Ing. R. Zotemantel for many fruitful discussions, and to cando ing. P. Schopp and Frau Middeldorf for their help in the production of the manuscript. Dortmund, January 1985 Friedel Hartmann Contents Notations ........................................................... XII Introduction .......................................................
Brain activation in frontotemporal and Alzheimer’s dementia: a functional near-infrared spectroscopy study
No full textInterhemispheric effects of iTBS on the fronto-parietal network:Evidence from dual-site stimulation
No full textThis study investigated the neuromodulatory effects of Theta Burst Stimulation (TBS) on resting-state functional connectivity (FC) following psychosocial stress induced by the Trier Social Stress Test (TSST). Given its key role in cognitive control and emotion regulation - processes highly relevant for rumination - we focused on the frontoparietal network. Across two studies, intermittent (iTBS) and continuous (cTBS) protocols were applied to the left Dorsolateral Prefrontal Cortex (DLPFC; study 1) and right Ventrolateral Prefrontal Cortex (VLPFC; study 2) prior to stress induction. Functional Near-Infrared Spectroscopy (fNIRS) was used to assess neural changes. A total of 88 (study 1) and 89 (study 2) healthy participants were recruited, balanced for low and high trait rumination. Each participant received both active and sham TBS (iTBS or cTBS), in a randomized, counterbalanced design. Results indicated that iTBS elicited excitatory effects on prefrontal and fronto-parietal connectivity, whereas cTBS effects were more variable. Trait rumination emerged as a modulator of TBS effects: In study 1, significant interactions for FC between the right VLPFC and Somatosensory Association Cortex (SAC) when stimulating the left DLPFC emerged, while study 2 revealed similar interactions for FC between the left DLPFC and SAC and intra-SAC FC when stimulating the right VLPFC. Correlations between post-stress state rumination and FC changes further support these findings. These results underscore the importance of neural assessments in TBS research and highlight the complexity of individual differences in state and trait rumination. Understanding the interplay between TBS, fronto-parietal connectivity, and rumination may provide valuable insights into personalized neuromodulation strategies
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Interference of papillomavirus E6 protein with single-strand break repair by interaction with XRCC1
No full textXRCC1 protein is required for the repair of DNA single-strand breaks and genetic stability, and is essential for viability in mammals. XRCC1 functions as a scaffold protein by interacting and modulating polypeptide components of the single-strand break repair machinery, including AP endonuclease-1, DNA ligase III, poly (ADP-ribose) polymerase, DNA polymerase and human polynucleotide kinase. We show here that the E6 protein of human papillomavirus type 1, 8 and 16 directly binds XRCC1. When tested in CHO derived XRCC1 'knock out' EM9 cells, co-expression of human papillomavirus 16 E6 with human XRCC1 reduced the ability of the latter protein to correct the methyl methane sulfate sensitivity of XRCC1 mutant CHO cell line EM9. These data identify a novel link between small DNA tumour viruses and DNA repair pathways, and suggest a novel explanation for the development of genomic instability in tissue cells persistently infected with papillomaviruses
Additional file 2: of Brain activation in frontotemporal and Alzheimer’s dementia: a functional near-infrared spectroscopy study
No full textStatistical source data for Fig. 3. Contrast of two groups each concerning the contrast of phonematic condition, semantic condition, and the control condition; grey background signifies significant contrasts. AD Alzheimer’s dementia, bvFTD behavioral variant of frontotemporal dementia, CAT category (semantic) condition, HC healthy controls, LET letter (phonematic) condition, WD weekday (control) condition. (XLSX 13 kb
Additional file 1: of Brain activation in frontotemporal and Alzheimer’s dementia: a functional near-infrared spectroscopy study
No full textStatistical source data for Fig. 2. Contrast of phonematic condition, semantic condition, and the control condition in the three groups; grey background signifies significant contrasts. AD Alzheimer’s dementia, bvFTD behavioral variant of frontotemporal dementia, CAT category (semantic) condition, HC healthy controls, LET letter (phonematic) condition, WD weekday (control) condition. (XLSX 13 kb
Repeated theta burst stimulation of the right ventrolateral prefrontal cortex reveals strong habituation in the context of stress and rumination
No full textAbstract Prefrontal hypoactivation under stress has been consistently observed in individuals with high trait rumination and in patients with depression. However, no study has yet investigated the mechanisms of modulating activity of the Ventrolateral Prefrontal Cortex (VLPFC) by using excitatory and inhibitory Theta Burst Stimulation (TBS) in this context. To address this, we recruited 89 healthy participants (44 low trait ruminators and 45 high trait ruminators) who attended two lab sessions, each including stress induction via the Trier Social Stress Test (TSST). Participants received either excitatory intermittent TBS (iTBS) or inhibitory continuous TBS (cTBS). One session involved active TBS, while the other used sham TBS (sTBS), with the order randomized and balanced across stimulation conditions and groups. In high ruminators, we observed a significant impact of iTBS in the hypothesized direction when considering cortical oxygenation in the right VLPFC. We found higher subjective stress following iTBS and cTBS compared to sTBS during recovery of the TSST but only at the first appointment. No stimulation-dependent effects were found for other measures (state rumination, positive and negative affect, and heart rates). In our discussion, we draw conclusions concerning repeated-measures designs in TBS-studies
Carbon control and competitiveness post 2020: the cement report
No full textCement industry top management now has little confidence in the EU ETS; structural reform is needed to help investment in energy efficiency and innovation, and reduce energy costs and carbon emissions in Europe” said Karsten Neuhoff, from the German Institute for Economic Research (DIW Berlin), launching a key new economic report today. Neuhoff is lead author of the report, on the European cement industry by the international research network Climate Strategies. The study looks at the experience of the European cement sector with the EU ETS and other energy and climate policy instruments
