471 research outputs found
James's Turn of the Screw
No full text[sound recording] / John Smith. Hardy's Tess of the d'Urbervilles by J.J. Coyle.; 1 sound cassette (60 minutes); Broadcast on CFCY Radio, Charlottetown, December 16 & 20, 1971.; Hardy's Tess of the d'Urberville
Book review: how to speak money by John Lanchester
No full textJohn Lanchester, the bestselling author of Capital and Whoops!, aims to decode the global language of money for all of us, in an amusing and jargon-free read. Diane Coyle finds this is a very entertaining read and a clear guide to the kind of economics spoken in the financial markets and the media. Those who already speak the language would do well to read the initial essay and reflect on it, and in particular on what normal people hear when they are using the jargon
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Remains
No full text'Remains' is a text composed by Annabel Frearson using the last words from the remaining books of a recently deceased artist. It was performed by the author at the launch event for the publication of Issue 2 of '...Or maybe it's the same for everyone' with contributing artists: Martin Westwood, Annabel Frearson, Patrick Coyle and Lizzy Kane.
A launch event was held with performances by the authors at Cafe Oto, London 6 May 2014
Blackhearts #2: Blacksouls
No full textFinally reaching Nassau, Anne and her friends, Cara and Coyle Flynn, seek out their uncle, Alastair Flynn, for work and safety. Meanwhile, Teach’s ship, the Deliverance, is attacked by pirates. The captain refuses to fight and is killed, causing Teach to take command. Teach and the crew are arrested for mutiny in Nassau by Governor Webb. Webb releases Teach but holds the crew hostage to force Teach into capturing the pirate, George Easton. Anne and Beth discover Mrs. Webb\u27s secret, but she kills Beth and tortures Anne to hide her crimes. Teach rescues Anne and locates Easton, but realizes Webb is the real criminal. Joining forces with Easton, Teach returns to Nassau to find his crew and Coyle dead and Alastair kidnapped. Webb is killed during the confrontation, but a new threat, Lord Pelham, takes his place. Escaping with Cara, Teach and Easton join with Anne on planning how to overthrow Lord Pelham
Domestic Relations Lawyers celebrating at Helen Coe’s Christmas Party [date unknown]
No full textDomestic Relations Lawyers celebrating at Helen Coe’s Christmas Party. Top row from left: Catherine H. Noble, Donna Engwert-Loyd, Colleen M. Dooley, Jill Hayes, Lami H. Coyle. Second Row from left: Doris K. Wohl, Patricia Hayden Kurt. Elizabeth “Betsy” Hazard, Mary Beth Moran. Third Row from left: Martha L. Riewaldt, Carla B. Davis, Helen Coe. Bottom: Judge David E. Lewandowski (Santa)
Osteopontin as a regulator of leukemia inhibitory factor mRNA levels in the AtT-20 mouse pituitary cell line
No full textThe highly phosphorylated glycoprotein Osteopontin (OPN) is a multifaceted protein with a diversity of roles in many immunological processes, and has recently been found to have a significant role in the Hypothalamus-Pituitary-Adrenal (HPA) axis. Its role was discovered when unstressed OPN-knockout mice were found to have abnormally high basal corticosterone levels, which is the hormone typically elevated following stress induction of the HPA axis. Another protein rigorously studied and repeatedly identified in the successful functioning of the HPA axis is Leukemia Inhibitory Factor (LIF). I propose that OPN may possess a regulatory role in the expression of LIF, with the absence of OPN leading to a greater abundance of LIF mRNA, and consequently, over-production of corticosterone in non-stressful situations. Using the mouse anterior pituitary cell-line AtT-20, a common and highly useful model in HPA axis research, I have found evidence that treatment of these cells with OPN partially inhibits the expression of LIF mRNA. The dose-dependency of this inhibition appears to behave as either positive or negative depending on the cellular density of the culture treated with OPN. Should OPN turn out to be a regulator of LIF mRNA expression, then absence of OPN may lead to an over-abundance of LIF, therefore affecting the expression of several proteins downstream of LIF that potently stimulate corticosterone production, such as the cholesterol transport protein StAR. It may turn out that OPN has an especially significant and indispensable role in the HPA axis via regulation of LIF mRNA levels.M.S.Includes bibliographical referencesby Luke Coyl
Developing compact and innovative dual-band thermal imagers using multi-layer diffractive optical elements
No full textInfrared (IR) remote sensing offers a huge range of applications, mostly addressing make-or-break issues of our century (wildfires, irrigation monitoring, etc.). Multispectral spaceborne instruments require bulky optical systems designed for a specific scientific goal and have very low revisit time. Thereby, constellations of small satellites embarking compact dual-band IR imagers are very promising solutions. We study a dual-band IR diffractive element called multilayer diffractive optical elements (MLDOE). It replaces classical diffractive lenses (DOEs) that cannot operate simultaneously in two distinct wavebands. An MLDOE design is studied using the rigorous finite difference time domain (FDTD) method. Its performance at the ”best” focal plane is deduced using free-space Fourier optics wave propagation. The presented MLDOE design has over 80% Strehl ratio in both bands, outperforming classical DOEs. Its chromatic focal shift has a negative variation, in opposition to refractive lenses, allowing efficient and compact dual-band hybrid lenses.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Spaceborne Instrumentatio
Bioelectronic Modulation of Glioblastoma via Wireless Carbon Nanotube Porin Interfaces
No full textData set associated with the manuscript
Establishing an In Vitro 3D Spheroid Model to Study Medulloblastoma Drug Response and Tumor Dissemination
No full textMedulloblastoma is the most common malignant pediatric brain tumor. Current treatment involves surgery, chemotherapy, and craniospinal radiotherapy, and these are associated with a significant reduction in quality of life. Metastatic dissemination at diagnosis is found in up to 30% of medulloblastoma cases and, alongside therapy resistance, is a significant feature in determining poor outcome. Development of new therapeutic approaches requires models where drug resistance and migration can be readily quantified and that are representative of patient disease. 3D medulloblastoma (3D-MB) spheroids are a simple yet effective means of bridging the gap between 2D culture and in vivo methods, providing users with highly reproducible in vitro models that more accurately recapitulate tumor morphology, drug response, and migration from a tumor mass. Unlike other cancer types, medulloblastoma spheroids fail to grow in their different standard cell culture media; instead, each cell line requires the same stem cell–enriching conditions. This requirement, however, has the advantage that it allows direct comparison of growth and response between cell lines in the absence of any potential media bias. In addition, spheroids can be used to model the initial stages of metastatic dissemination, something that cannot be achieved in 2D culture, providing insight into key changes occurring in migratory cells. Here, we provide protocols that detail the initial generation and maintenance of 3D-MB spheroids from sonic-hedgehog, Group 3, and Group 4 medulloblastoma subgroups, as well as describing functional assays to study drug response and cell migration across hyaluronan matrices, which represent the extracellular matrix backbone of the brain parenchyma. Through application of these simple yet highly representative models, it will be possible to test novel therapeutics targeting metastasis and drug resistance, as well as to develop insights into the mechanistic processes driving relapse in this malignant pediatric brain tumor. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC
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