1,721,163 research outputs found

    La fotografia del bullismo: i dati della ricerca in Friuli Venezia Giulia

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    Nel contributo vengono presentati in maniera analitica i risultati dell'indagine su un campione di circa 3000 studenti dalla scuola primaria alla secondaria di secondo grado

    Ezio Raimondi, Camminare nel tempo.Una conversazione con Alberto Bertoni e Giorgio Zanetti

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    Raimondi, Ezio (2015). Camminare nel tempo.Una conversazione con Alberto Bertoni e Giorgio Zanetti. (Juan Carlos de Miguel y Canuto).Raimondi, Ezio (2015). Camminare nel tempo.Una conversazione con Alberto Bertoni e Giorgio Zanetti. (Juan Carlos de Miguel y Canuto).Raimondi, Ezio (2015). Camminare nel tempo.Una conversazione con Alberto Bertoni e Giorgio Zanetti. (Juan Carlos de Miguel y Canuto)

    A preliminary docking study of a potent and selective xanthinic antagonist to the adenosine A2B receptor

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    Adenosine receptors are divided into 4 subtypes, A1, A2A, A2B and A3, on the basis of their distinct molecular structures, tissue distribution and pharmacological profile. In particular, adenosine A2B receptors are implicated in mast cell activation and asthma, and therefore in inflammatory processes, vasodilatation, regulation of cell growth, intestinal function, and modulation of neurosecretion, and have been classified as low affinity receptors, in consequence of the high adenosine concentrations requested for their activation. The molecular structures of adenosine receptors remain to be determined, but they seem to be characterized by 7 trans-membrane domains (7TM), most probably having a simple a-helix structure, connected by 3 extracellular and 3 intracellular loops. The present paper describes the results of a preliminary docking study of the potent and selective xanthinic antagonist [N-benzo[1,3]dioxol-5-yl-2-[5-(2,6-dioxo-1,3- dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)-1-methyl- 1H-pyrazol-3-yloxy]-acetamide to the A2B adenosinic receptor, making use of a calculated model of the 7-chains bundle available from the literature and where the binding pocket inside the transmembrane domains has been localized on the basis of the published site-mutagenesis studies. From the docking simulation the following conclusions can be drawn: the antagonist molecule occupies a receptor region not involved in the binding of the agonists, and it can form a large number of interactions with the macromolecule which easily can account for its great affinity, when compared with the very low affinities of adenosine and other adenosinic agonists towards A2B receptors

    Il bullismo: dalla teoria alla ricerca

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    Il volume presenta il risultati di un'ampia indagine sui fenomeni del bullismo in un campione di circa 3000 studenti dalla terza primaria alla quinta superiore. Le riflessioni teoriche e metodologiche di alcuni esperti e alcune buone prassi condotte nelle scuole completano l'analisi e la discussione dei dati

    Raimondi, Ezio. Camminare nel tempo. Una conversazione con Alberto Bertoni e Giorgio Zanetti. Bologna: Il Mulino, 2015, 205 p

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    Obra ressenyada: Ezio RAIMONDI, Camminare nel tempo. Una conversazione con Alberto Bertoni e Giorgio Zanetti. Bologna: Il Mulino, 2015

    Raimondi, Ezio. Camminare nel tempo. Una conversazione con Alberto Bertoni e Giorgio Zanetti. Bologna: Il Mulino, 2015, 205 p

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    Obra ressenyada: Ezio RAIMONDI, Camminare nel tempo. Una conversazione con Alberto Bertoni e Giorgio Zanetti. Bologna: Il Mulino, 2015

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Il contributo economico-aziendale delle coperture finanziarie e le regole di hedge accounting dello IAS 39

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    Questo contributo argomenta l'opinione che le regole di hedge accounting proposte nello IAS 39 riflettono ragionevoli esigenze contabili ma non assicurano un utilizzo economico delle coperture finanziarie nelle imprese. I paragrafi 2 e 3 descrivono il contributo economico-aziendale delle coperture finanziarie. I paragrafi 4, 5 e 6 ripercorrono i contenuti dello IAS 39 evidenziando la distanza tra regole di hedge accounting ed utilizzo economico aziendale delle copertur
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