1,721,161 research outputs found
Higher education and economic growth: A longitudinal study of European regions 2000–2017
No full textThis paper investigates the impact of regional higher education systems (HESs) on economic growth, based upon 284 European regions (NUTS 2) over an 18-year period (from 2000 to 2017). The empirical framework specifically models the heterogeneity of the HESs by including indicators on university concentration, on the size of the HES and on HES performance and other important factors. The analysis is based on a novel and integrated dataset, created by collecting and combining indicators from different data sources (Eurostat, OECD, WHED and InCites). The results reveal that an increase in number of universities in a region is conducive to stronger economic growth within that region. The quality of research and a specialisation in STEM subjects are the primary drivers through which universities impact positively on the regions’ economic development
Higher education systems and regional economic development in Europe: A combined approach using econometric and machine learning methods
No full textThis study deals with the analysis of regional economic development in Europe. Specifically, it examines the extent to which the performance and characteristics of higher education systems (HESs) influence regional economic development. The analysis employs data at the regional level, examining 649 NUTS-3 in 29 European countries, from 2014 to 2016. The empirical analysis, based on an original dataset that we developed, employs a novel methodological strategy that combines a traditional econometric approach with random forest. The findings detect the existence of nonlinear relationships between regional GDP per capita and HES indicators, which could have been overlooked by previous studies in the literature. Furthermore, the empirical results demonstrate the importance of comprehensively modelling the diversity of HESs, since distinct characteristics and performance can contribute differently to the economy of the regions. In particular, the most important factors for regional economic development are the size of HESs, the internationalisation of the students and research productivity. Finally, this paper provides useful insights for policymakers by suggesting new instruments for driving and fostering the economic development of their regions
[The cell-mediated antiviral immune response. The possible therapeutic implications for chronic hepatitis B viral infection]
No full text
Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection
No full textCD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign
antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of
patients with chronic and resolved hepatitis B virus (HBV) infection. We demonstrated that circulating CD4+
CD25+ T cells modulate the function and expansion of HBV-specific CD8+ cells ex vivo in all patients,
regardless of whether they have chronic or resolved HBV infection. The possible role of CD4+ CD25+ T cells
in the pathogenesis of chronic HBV infection is not supported by these data. However, these results might have
implications for optimizing future immunotherapeutic approaches to HBV treatment
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
[The immunopathogenesis of hepatitis B]
No full textKnowledge of hepatitis B immunopathogenesis has greatly improved in the last few years thanks to the development of new methods of lymphocyte culture and the introduction of molecular techniques in the study of the cell-mediated antiviral immune responses. Some of the immune mechanisms likely responsible for liver cell injury and viral clearance during hepatitis B have recently been characterized. By using synthetic peptides and high efficiency recombinant expression vectors. HLA class I restricted cytotoxic T cells specifically able to recognize the nucleocapsid antigen of the hepatitis B virus (HBV) have been isolated from the blood of patients with acute self-limited hepatitis B. The observation that this cytotoxic response is lacking or very weak in chronic patients who do not succeed in clearing the virus suggests a major role for cytotoxic T cells in terminating virus infection. Similar behaviour is shown by HLA class II restricted CD4+ T cells which express much stronger levels of response to HBV nucleocapsid antigens in acute than in chronic HBV infection. Whether these defective responses in chronic patients are due to an actual lesion of the host's immune system or to viral mutations affecting immune surveillance and thereby allowing virus escape, still remain open issues. A definitive answer to these questions will, we hope, provide the appropriate tools to devise effective immune therapies against chronic HBV infection
Cell mediated immune response to hepatitis B virus nucleocapsid antigen
No full textA coordinated and efficient development of humoral and cell-mediated immune responses is believed to be required for complete eradication of viral infections. During the course of hepatitis B virus (HBV) infection, the HLA class II and class I-restricted T cell responses to HBV nucleocapsid antigens are vigorous in patients with acute infection who succeed in clearing the virus but weak or totally absent in patients with chronic persistence of the virus. These findings suggest a role for these responses in the pathogenesis of hepatitis B and in HBV clearance. Molecular analysis of T cell recognition of the HBV nucleoprotein defines the presence of immunodominant core epitopes recognized by helper and cytotoxic T cells that may represent the starting point for the design of alternative strategies for prevention and treatment of HBV infection
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