1,721,008 research outputs found
Editorial: Nutritional modulation of central nervous system development, maintenance, plasticity, and recovery
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Sustainability achievements in building regulations. The example of Bologna
No full textThe urban development in the last decades has meant for most cities a significant increasing of land consumption and waste of natural resources. Despite the process of urban sprawl is now being reduced, there is an urgent need for corrective measures to qualify the existing town, according to more sustainable principles.The city of Bologna has recently developed new tools, in order to promote a social and economic growth without affecting the urban and environmental quality. This article aims to describe the achievements of the innovative requirements in the new Town Planning Building Regulations, to analyse their effect, in relation to the reduction of use of natural resources and the improvement of environmental quality of the interventions
Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions
No full textSex hormone-driven differences in gene expression have been identified in experimental animals, highlighting brain neuronal populations implicated in dimorphism of metabolic and behavioral functions. Neuropeptide Y-Y1 receptor (NPY-Y1R) system is sexually dimorphic and sensitive to gonadal steroids. In the present study we compared the phenotype of male and female conditional knockout mice (Npy1rrfb mice), carrying the inactivation of Npy1r gene in excitatory neurons of the brain limbic system. Compared to their male control (Npy1r2lox) littermates, male Npy1rrfb mice exhibited hyperactivation of the hypothalamic–pituitary–adrenal (HPA) axis that is associated with anxiety and executive dysfunction, reduced body weight growth, after-fasting refeeding, white adipose tissue (WAT) mass and plasma leptin levels. Conversely, female Npy1rrfb mice displayed an anxious-like behavior but no differences in HPA axis activity, executive function and body weight, compared to control females. Moreover, conditional inactivation of Npy1r gene induced an increase of subcutaneous and gonadal WAT weight and plasma leptin levels and a compensatory decrease of Agouti-related protein immunoreactivity in the hypothalamic arcuate (ARC) nucleus in females, compared to their respective control littermates. Interestingly, Npy1r mRNA expression was reduced in the ARC and in the paraventricular hypothalamic nuclei of female, but not male mice. These results demonstrated that female mice are resilient to hormonal and metabolic effects of limbic Npy1r gene inactivation, suggesting the existence of an estrogen-dependent relay necessary to ensure the maintenance of the homeostasis, that can be mediated by hypothalamic Y1R
Sex differences in behavioral and metabolic effects of gene inactivation: The neuropeptide Y and Y receptors in the brain
No full textBrain and gonadal hormones interplay controls metabolic and behavioral functions in a sex-related manner. However, most translational neuroscience research related to animal models of endocrine and psychiatric disorders are often carried out in male animals only. The Neuropeptide Y (NPY) system shows sex-dependent differences and is sensitive to gonadal steroids. Based on published data from our and other laboratories, in this review we will discuss the sex related differences of NPY action on energy balance, bone homeostasis and behavior in rodents with the genetic manipulation of genes encoding NPY and its Y1, Y2 and Y5 cognate receptors. Comparative analyses of the phenotype of transgenic and knockout NPY and Y receptor rodents unravels sex dependent differences in the functions of this neurotransmission system, potentially helping to develop therapeutics for a variety of sex-related disorders including metabolic syndrome, osteoporosis and ethanol addiction
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The multifunctional role of urban gardens through the XX century. The Bologna case study.
No full textThe multifunctional role of urban gardens in the Twentieth century. The bologna case study
No full text“Urban Agriculture (UA) is an activity that produces, processes, and markets food and other products, on land and water in urban and peri-urban areas, applying intensive production methods, and (re)using natural resources and urban wastes, to yield a diversity of crops and livestock” (UNDP, 1996). UA began to develop with the urbanization process, that is, moving of people from villages and farms to cities. Initially the activity was generally practiced for income-earning or food producing but gradually the concept of urban agriculture expanded to ecological, social, educational and even “therapeutic” aspects. The multifunctional role of agriculture and in particular of vegetable and fruits production (horticulture) in most of European urbanized areas is officially recognized at the beginning of the 1980s. Since then an increasing number of associations and hobbyists are working in this field, creating a new style of consumption based on self-production of food. In the specific case of Bologna, this has resulted in 3,000 spot gardens (land plot of approximately 30-40 m2 each for growing vegetables, fruits, flowers, ornamental shrubs or trees) grouped in 20 main community allotments, controlled by municipal administrations and assigned mainly to elderly people. However more and more often their management involves young people (usually unemployed), immigrants, women and several social associations. The community gardens have therefore became an example of places where people meet, discover old and new production techniques and exchange traditions and cultures
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