1,721,058 research outputs found
The value of peritoneal washing cytology during intra-abdominal surgery for female genital tract neoplasms
Full text linkABSTRACT
BACKGROUND: Peritoneal washing cytology is a technique performed during surgery
for genital neoplasms to detect subclinical intraperitoneal metastases from these
tumors. The aim of this study was to evaluate PWC utility in presumed benign and
malignant female genital tract neoplasms by comparing the results of peritoneal
cytology and corresponding histopathological specimens.
PATIENTS AND METHODS: The 305 cases of female genital lesions with available
staging (International Federation of Gynecology and Obstetrics) were considered.
In cases with positive cytology, without neoplastic involvement of the ovarian
and uterine surfaces, the salpinx was accurately examined to reveal primary
malignant fallopian tubal neoplasms. For malignant ovarian neoplasms, the
correlation rate between cytological and histopathological findings was
statistically evaluated using the Fisher exact test. Statistical significance was
defined as P < .05.
RESULTS: Histopathological diagnosis revealed that of 32 cases with positive
cytology, 21 examples corresponded to primary ovarian serous carcinomas
(65.625%). Moreover, the serous carcinoma was the subtype that most frequently
revealed neoplastic elements on PWC (21 examples in 22 cases, 95.4%). Only 1 of
these malignancies with positive cytology and pT1a stage presented simultaneous
invasive and in situ serous carcinoma of contralateral tubal fimbria. Only 1 of
serous endometrial carcinomas that involved an endometrial polyp was associated
with positive cytology and with simultaneous carcinoma of tubal fimbria.
CONCLUSION: In conclusion, PWC remains a useful procedure for staging malignant
genital tract neoplasms and can be necessary to detect occult fallopian tube
malignancies
A new case of primary signet-ring cell carcinoma of the cervix with prominent endometrial and myometrial involvement: Immunohistochemical and molecular studies and review of the literature
Full text linkAbstract Background As a rule, endocervical tumours with signet-ring cell are classed as metastatic extra-genital neoplasms. In a patient aged 45 years, we describe primary cervical signet-ring cell carcinoma (PCSRCC) characterized by prominent endometrial and myometrial involvement, simulating primary endometrial adenocarcinoma with cervical extension. In addition, a review was made of the literature to identify the clinical and pathological features of this rare malignancy. Case presentation A 45-year-old woman was referred to our Gynaecology Department due to persistent abnormal vaginal bleeding. Transvaginal ultrasonography showed slight endometrial irregularities in the whole uterine cavity suggestive of endometrial neoplasms. Pelvic magnetic resonance imaging revealed diffuse enlargement of the cervix, which had been replaced by a mass. Induration extended to the parametria and sigmoid colon fat. Histological examination of endometrial curettage and a cervical biopsy revealed a neoplasm characterized by neoplastic signet-ring cells and trabecular structures. Immunohistochemical analysis and molecular studies showed certain findings consistent with a cervical neoplasm, such as positivity to CEA, keratin 7, Ca-125 and p16 and the presence of HPV (Human Papilloma Virus) DNA 18. On examination of the hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy, the lesion replacing the cervix, endometrium and myometrium, revealed the same immunohistochemical findings observed on endometrial curettage and cervical biopsy specimens. Metastases were found in an ovarian cystic lesion and the lymph nodes. Conclusion With this report the authors have demonstrated that the spread of cervical adenocarcinoma to the uterine corpus, although rare, may be observed, and that in this instance immunohistochemical and molecular studies can provide sufficient information for accurate diagnosis even on small biopsy specimens.</p
Primary pure spindle cell carcinoma (sarcomatoid carcinoma) of the ovary: A case report with immunohistochemical study
Full text linkBACKGROUND: In the ovary, sarcomatoid carcinoma has been reported only as mural
nodules in epithelial malignant or borderline serous or mucinous cystic
neoplasms, and in teratomas. In this paper we report a rare case of a solid
sarcomatoid carcinoma of the ovary, without accompanying component of giant
cells, pleomorphic cells, or glandular and other epithelial structures.
CASE PRESENTATION: This case report refers to a sarcomatoid carcinoma of the
ovary in in a 57 year-old woman with abdominal pain. Macroscopically, the
neoplasm was a 15x10x5 cm ovarian mass that featured gray white solid fleshy
areas, interspersed with areas of necrosis, hemorrhage and cystic spaces filled
with thick fluid. The epithelial differentiation of the tumor was demonstrated by
strong and diffuse reactivity to CAM5.2 and focal immunoreactivity to EMA. A
diagnosis of malignant mesenchymal tumor was excluded due to negativity for
desmin, smooth muscle actin, caldesmon, CD34, CD10, and myoglobin. Neural,
neuroendocrine neoplasm, melanoma and Perivascular Epithelioid Cell Tumor
(PEComa) were excluded because of negativity for S100, chromogranin,
synaptophysin and HMB45.
CONCLUSION: Primary ovarian spindle cell carcinoma is a rare neoplasm, which must
be considered in the differential diagnosis of solid ovarian mass with spindle
cell appearance. This case adds to our knowledge of the biological behavior of
these rare neoplasms. The distinction from true sarcomas and carcinosarcomas is
important because of the more favorable prognosis of the spindle cell carcinomas.
However their diagnosis necessitates a careful tissue sampling and
immunohistochemical staining
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Tubal ectopic pregnancy: our experience from 2000 to 2013
No full textIn this paper we summarize our experience in diagnosis and treatment of 402 retrospectively collected tubal EP and review the most recent topics from the literature. Systemic Methotrexate (MTX) was effective in 56 out of 65 patients (failure rate 13.8%), in whom hCG level was significantly lower when compared to the failure group (p<0,05); we performed 299 salpingectomies, 297 of whom through laparoscopic approach. MTX single-dose is safe and effective in eligible patients; surgery represents the treatment of most of the EPs, mainly through laparoscopic approach
Conservative treatment for interstitial monochorionic twin pregnancy: Case report and review of the published work
No full textInterstitial pregnancy is considered one of the most hazardous types of ectopic pregnancies, with a mortality rate of 22.5%. We describe a case of a viable monochorionic twin pregnancy in a 35-year-old woman successfully treated with systemic methotrexate associated with bilateral uterine arteries' embolization. Î2-hCG was undetectable 67 days after the first administration of methotrexate and the ultrasonography performed on day 67 showed the remnant of the gestational sac in the right uterine horn, a thin endometrium and a normal myometrial vascularization. Conservative treatment allowed us to avoid surgical treatment and to preserve the patient's fertility. © 2013 Japan Society of Obstetrics and Gynecology
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