2,505 research outputs found
Samuel Beckett and the Writers of Port-Royal
No full textIt has been observed that ‘the literary influences on Beckett have been far more important than has been acknowledged, and more important indeed, than the philosophical influences’ (Smith 2002: 3). The truth of this statement is evidenced by the description that scholars have given of Samuel Beckett’s relationship to seventeenth century French classicism. To date, critical interest has been limited for the most part to the figure of the philosopher René Descartes on the (fragile) grounds that Beckett was exclusively concerned with the Cartesian imperative of clarity and order, the fundamental dualism between body and mind, and Nominalism.
Together with the assumption that Beckett’s vision was essentially Cartesian, his literary filiation with Pascal was suggested by critics, but only in terms of Beckett’s formal approach to the theatre. In his short article on En attendant Godot in 1953, the playwright Jean Anouilh was among the first reviewers to suggest that Beckett’s drama synthesizes the encounter between ‘classicism’ and a ‘modern’ form of art. It is well known that Beckett retained a lifelong admiration for Pascal – indeed, Pascal was one of his ‘old chestnuts’ (Knowlson 1997: 653). Little attention has been paid, however, to the originality of Pascal’s thought, the specific nature of his prose, and the impact these might have had upon Beckett’s mature work, especially the trilogy and the subsequent short prose. Yet, in the literary and philosophical context of post-war France, Beckett’s filiation with Pascal, their corresponding preoccupations, were evident to his contemporaries, who identified Pascal as an underlying presence in his works
MSJ768433_supplementary_material – Supplemental material for Comparative analysis of natalizumab versus fingolimod as second-line treatment in relapsing–remitting multiple sclerosis
No full textSupplemental material, MSJ768433_supplementary_material for Comparative analysis of natalizumab versus fingolimod as second-line treatment in relapsing–remitting multiple sclerosis by Johannes Lorscheider, Pascal Benkert, Carmen Lienert, Peter Hänni, Tobias Derfuss, Jens Kuhle, Ludwig Kappos and Özgür Yaldizli in Multiple Sclerosis Journal</p
Sabil and Wikala of Dhul Fiqar Oda Bashi
No full textinterior, courtyard, "Vue de l'Okel Zoulfiqar," color plate XLIV of Pascal Coste's "Architecture arabe; ou, Monuments du Kaire, mesurés et dessinés, de 1818 à 1826", 1818-182
First person - Aude Pascal
No full textInternational audienceFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Aude Pascal is first author on `Annexin A2 and Ahnak control cortical NuMA-dynein localization and mitotic spindle orientation', published in JCS. Aude is a research assistant in the lab of Re ' gis Giet at University of Rennes, France, who is particularly interested in developmental biology. She has always been struck by the fact that a whole organism displaying multiple functions arises from a single cell. For this reason, she has oriented her research on mitosis and meiosis to study the different steps, components and structures involved in these processes
QMEANclust : estimation of protein model quality by combining a composite scoring function with structural density information
No full textABSTRACT: BACKGROUND: The selection of the most accurate protein model from a set of alternatives is a crucial step in protein structure prediction both in template-based and ab initio approaches. Scoring functions have been developed which can either return a quality estimate for a single model or derive a score from the information contained in the ensemble of models for a given sequence. Local structural features occurring more frequently in the ensemble have a greater probability of being correct. Within the context of the CASP experiment, these so called consensus methods have been shown to perform considerably better in selecting good candidate models, but tend to fail if the best models are far from the dominant structural cluster. In this paper we show that model selection can be improved if both approaches are combined by pre-filtering the models used during the calculation of the structural consensus. RESULTS: Our recently published QMEAN composite scoring function has been improved by including an all-atom interaction potential term. The preliminary model ranking based on the new QMEAN score is used to select a subset of reliable models against which the structural consensus score is calculated. This scoring function called QMEANclust achieves a correlation coefficient of predicted quality score and GDT_TS of 0.9 averaged over the 98 CASP7 targets and perform significantly better in selecting good models from the ensemble of server models than any other groups participating in the quality estimation category of CASP7. Both scoring functions are also benchmarked on the MOULDER test set consisting of 20 target proteins each with 300 alternatives models generated by MODELLER. QMEAN outperforms all other tested scoring functions operating on individual models, while the consensus method QMEANclust only works properly on decoy sets containing a certain fraction of near-native conformations. We also present a local version of QMEAN for the per-residue estimation of model quality (QMEANlocal) and compare it to a new local consensus-based approach. CONCLUSION: Improved model selection is obtained by using a composite scoring function operating on single models in order to enrich higher quality models which are subsequently used to calculate the structural consensus. The performance of consensus-based methods such as QMEANclust highly depends on the composition and quality of the model ensemble to be analysed. Therefore, performance estimates for consensus methods based on large meta-datasets (e.g. CASP) might overrate their applicability in more realistic modelling situations with smaller sets of models based on individual methods
sj-tiff-1-msj-10.1177_13524585211047977 – Supplemental material for Measurement of neurofilaments improves stratification of future disease activity in early multiple sclerosis
No full textSupplemental material, sj-tiff-1-msj-10.1177_13524585211047977 for Measurement of neurofilaments improves stratification of future disease activity in early multiple sclerosis by Tomas Uher, Eva Kubala Havrdova, Pascal Benkert, Niels Bergsland, Jan Krasensky, Barbora Srpova, Michael Dwyer, Michaela Tyblova, Stephanie Meier, Manuela Vaneckova, Dana Horakova, Robert Zivadinov, David Leppert, Tomas Kalincik and Jens Kuhle in Multiple Sclerosis Journal</p
Pascal Tutorial, 1987
No full textThere exists a limited number of tutorials for the Pascal programming language using the Apple Computer. The demand for these tutorials exceeds the supply. In this thesis an attempt was made to rectify this shortage by designing a Pascal tutorial for the Apple computer. This Pascal tutorial is designed to assist with instructing an introductory computer programming course in Pascal, incorporating Apple Superpilot as the authoring language. Emphasis is placed on making the program "user friendly." A person with no previous programming experience should be able to easily execute this tutorial. The information presented as the subject matter of the tutorial will follow the guidelines recommended by the Association for Computing Machinery
Architecture arabe; ou, Monuments du Kaire, mesurés et dessinés, de 1818 à 1826
No full textgeneral view, "Vue des Tombeaux au Nord-Est de la Ville," color plate LXIII of Pascal Coste's "Architecture arabe; ou, Monuments du Kaire, mesurés et dessinés, de 1818 à 1826", 1818-182
Gamia el-Muaiyad
No full textinterior, qibla wall, "Vue de la Niche du Sanctuaire et de la Chaire de la Mosquee el Moyed"," color plate XXVIII of Pascal Coste's "Architecture arabe; ou, Monuments du Kaire, mesurés et dessinés, de 1818 à 1826", 1818-182
Architecture arabe; ou, Monuments du Kaire, mesurés et dessinés, de 1818 à 1826
No full textsection, section of the prayer hall, and details of inscription and chandelier, Plate XXIII of Pascal Coste's "Architecture arabe; ou, Monuments du Kaire, mesurés et dessinés, de 1818 à 1826
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