17 research outputs found
Introduction : industrialization and agencification
No full textChapter IThe chapter looks at patterns in economic development and the rise of independent regulators and the regulatory state model. The author argues that development is shaped primarily by transnational factors and not by domestic factors, tracing the “regulatory logic of the periphery” in terms of geography as well as public and private regulation. The regulatory state is both the product of, and remains dependent on the experience of industrialization. Regulatory agencies administer the objective law and need to be perceived as administering that law in a neutral manner. The world’s first independent regulatory agency was the Interstate Commerce Commission (ICC) in 1887
Nontyphoidal Salmonella septic arthritis in an immunocompetent child – An atypical presentation highlighting the importance of definitive diagnosis
No full textJournal of Mormon History, Vol 39, no. 2 (Spring 2013)
No full textPRESIDENTIAL ADDRESS
--Mr. Samuelsen Goes to Copenhagen: The First Mormon Member of a National Parliament, Richard L. Jensen, 1
TANNER LECTURE
--The Latter-day Saints, the Doughnut, and Post-Christian Canada, David B. Marshall, 35
ARTICLES
--Minding the House of Church History: Reflections of a Church Historian at the End of His Time, Marlin K. Jensen, 78
--Writing an Honorable Remembrance: Nineteenth-Century LDS Women’s Autobiography, Katherine Sarah Massoth, 91
--Community of Christ’s Evolving Approach to Mission, Steven L. Shields, 139
--“A Negro Preacher”: The Worlds of Elijah Ables, Russell W. Stevenson, 165
REVIEWS
--Karen Lynn Davidson, David J. Whittaker, Mark Ashurst-McGee, and Richard L. Jensen, eds. Histories, Volume 1: Joseph Smith Histories, 1832–1844, Brett D. Dowdle and Samuel Morris Brown, 255
--Brant A. Gardner. The Gift and the Power: Translating the Book of Mormon, Grant Hardy, 258
--J. Spencer Fluhman. A Peculiar People : Anti-Mormonism and the Making of Religion in Nineteenth-Century America, Benjamin E. Park, 264
--Reid L. Neilson. Early Mormon Missionaries in Japan, 1901–1924, Ronald E. Bartholomew, 267
BOOK NOTICES
--Douglas J. Bell. Defender\u27s of the Faith: The Book of Mormon from a Soldier’s Perspective, 274
--Gary D. Toyn, comp. Life Lessons from Mothers of Faith: Inspiring True Stories about Latter Day Moms, 275
--Mike Mcpheters. Agent Bishop: True Stories of an FBI Agent Moonlighting as a Mormon Bishop, 277
--David Beagley. One Lost Boy: His Escape from Polygamy, 27
Low rates of repeat HIV testing despite increased availability of antiretroviral therapy in rural Tanzania: findings from 2003-2010.
No full textBACKGROUND: HIV counselling and testing (HCT) services can play an important role in HIV prevention by encouraging safe sexual behaviours and linking HIV-infected clients to antiretroviral therapy (ART). However, regular repeat testing by high-risk HIV-negative individuals is important for timely initiation of ART as part of the 'treatment as prevention' approach. AIM: To investigate HCT use during a round of HIV serological surveillance in northwest Tanzania in 2010, and to explore rates of repeat testing between 2003 and 2010. METHODS: HCT services were provided during the fourth, fifth and sixth rounds of serological surveillance in 2003-2004 (Sero-4), 2006-2007 (Sero-5) and 2010 (Sero-6). HCT services have also been available at a government-run health centre and at other clinics in the study area since 2005. Questionnaires administered during sero-surveys collected information on socio-demographic characteristics, sexual behaviour and reported previous use of HCT services. RESULTS: The proportion of participants using HCT increased from 9.4% at Sero-4 to 16.6% at Sero-5 and 25.5% at Sero-6. Among participants attending all three sero-survey rounds (n = 2,010), the proportions using HCT twice or more were low, with 11.1% using the HCT service offered at sero-surveys twice or more, and 25.3% having tested twice or more if reported use of HCT outside of sero-surveys was taken into account. In multivariable analyses, individuals testing HIV-positive were less likely to repeat test than individuals testing HIV-negative (aOR 0.17, 95% CI 0.006-0.52). DISCUSSION/CONCLUSIONS: Although HCT service use increased over time, it was disappointing that the proportions ever testing and ever repeat-testing were not even larger, considering the increasing availability of HCT and ART in the study area. There was some evidence that HIV-negative people with higher risk sexual behaviours were most likely to repeat test, which was encouraging in terms of the potential to pick-up those at greatest risk of HIV-infection
Inactivated vaccines. 2. Laboratory indices of protectionPresented by the senior author before the symposium on Influenza Vaccines, London, 27 April 1972.
No full textAuthor Correction: Gray and white matter integrity influence TMS signal propagation: a multimodal evaluation in cocaine-dependent individuals
No full textA correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.</jats:p
Inactivated vaccines. 1. Volunteer studies with very high doses of influenza vaccine purified by zonal ultracentrifugationPresented by the senior author before the symposium on Influenza Vaccines, London, 27 April 1972.
No full textCell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3
No full textDespite their high clinical relevance, obtaining structural and biophysical data on transmembrane proteins has been hindered by challenges involved in their expression and extraction in a homogeneous, functionally-active form. The inherent enzymatic activity of receptor tyrosine kinases (RTKs) presents additional challenges. Oncogenic fusions of RTKs with heterologous partners represent a particularly difficult-to-express protein subtype due to their high flexibility, aggregation propensity and the lack of a known method for extraction within the native lipid environment. One such protein is the fibroblast growth factor receptor 3 fused with transforming acidic coiled-coil-containing protein 3 (FGFR3-TACC3), which has failed to express to sufficient quality or functionality in traditional expression systems. Cell-free protein expression (CFPE) is a burgeoning arm of synthetic biology, enabling the rapid and efficient generation of recombinant proteins. This platform is characterised by utilising an optimised solution of cellular machinery to facilitate protein synthesis in vitro. In doing so, CFPE can act as a surrogate system for a range of proteins that are otherwise difficult to express through traditional host cell-based approaches. Here, functional FGFR3-TACC3 was expressed through a novel cell-free expression system in under 48 h. The resultant protein was reconstituted using SMA copolymers with a specific yield of 300 µg/mL of lysate. Functionally, the protein demonstrated significant kinase domain phosphorylation (t < 0.0001). Currently, there is no published, high-resolution structure of any full-length RTK. These findings form a promising foundation for future research on oncogenic RTKs and the application of cell-free systems for synthesising functional membrane proteins
Molecular characterisation of erythropoietic protoporphyria in South Africa
No full textIncludes bibliographical references
