9 research outputs found
Effects of organic matter inputs on microbiological processes controlling zinc availability in soil
No full textModelling of long-term Zn, Cu, Cd and Pb dynamics from soils fertilised with organic amendments
No full textSoil contamination by trace elements (TEs) is a major concern for sustainable land management. A potential source of excessive inputs of TEs into agricultural soils are organic amendments. Here, we used dynamic simulations carried out with the Intermediate Dynamic Model for Metals (IDMM) to describe the observed trends of topsoil Zn (zinc), Cu (copper), Pb (lead) and Cd (cadmium) concentrations in a long-term (>60-year) crop trial in Switzerland, where soil plots have been treated with different organic amendments (farmyard manure, sewage sludge and compost).
The observed ethylenediaminetetraacetic acid disodium salt (EDTA)-extractable concentrations ranged between 2.6 and 27.1 mg kg−1 for Zn, 4.9 and 29.0 mg kg−1 for Cu, 6.1–26.2 mg kg−1 for Pb, and 0.08 and 0.66 mg kg−1 for Cd. Metal input rates were initially estimated based on literature data. An additional, calibrated metal flux, tentatively attributed to mineral weathering, was necessary to fit the observed data. Dissolved organic carbon fluxes were estimated using a soil organic carbon model. The model adequately reproduced the EDTA-extractable (labile) concentrations when input rates were optimised and soil lateral mixing was invoked to account for the edge effect of mechanically ploughing the trial plots. The global average root mean square error (RMSE) was 2.7, and the average bias (overestimation) was −1.66, −2.18, −4.34 and −0.05 mg kg−1 for Zn, Cu, Pb and Cd, respectively. The calibrated model was used to project the long-term metal trends in field conditions (without soil lateral mixing), under stable climate and management practices, with soil organic carbon estimated by modelling and assumed trends in soil pH. Labile metal concentrations to 2100 were largely projected to remain near constant or to decline, except for some metals in plots receiving compost. Ecotoxicological thresholds (critical limits) were predicted to be exceeded presently under sewage sludge inputs and to remain so until 2100. Ecological risks were largely not indicated in the other plots, although some minor exceedances of critical limits were projected to occur for Zn before 2100.
This study advances our understanding of TEs' long-term dynamics in agricultural fields, paving the way to quantitative applications of modelling at field scales
Multi-objective calibration of RothC using measured carbon stocks and auxiliary data of a long-term experiment in Switzerland
No full textInteractions between model parameters and low spatiotemporal resolution of available data mean that conventional soil organic carbon (SOC) models are often affected by equifinality, with consequent uncertainty in SOC forecasts. Estimation of belowground C inputs is another major source of uncertainty in SOC modelling. Models are usually calibrated on SOC stocks and fluxes from long‐term experiments (LTEs), whereas other point data are not used for constraining the model parameters. We used data from an agricultural long‐term (> 65 years) fertilization experiment to test a multi‐objective parameter estimation approach on the RothC model, combining SOC data from different fertilization treatments with microbial biomass, basal respiration and Zimmermann’s fractions data. We also compared two methods to estimate the belowground C inputs: a conventional scaling of belowground biomass from crop harvest yield and an alternative approach based on constant belowground C for cereals measured experimentally in the field. The resulting posterior parameter distributions still suffered from some equifinality; the most stable C pool kinetic constants and composition of exogenous organic matter were the most sensitive parameters. The use of fixed belowground C inputs for cereals improved the model performance, reducing the importance of treatment‐specific parameters and processes. The introduction of microbial biomass and basal respiration data was effective for increasing determination of the calibration, but also suggested a change in the model structure: the microbial biomass pool, which is proportional to the C inputs in the traditional models, could be represented by different microbial physiology functions
Identification of Heterotrophic Zinc Mobilization Processes among Bacterial Strains Isolated from Wheat Rhizosphere (Triticum aestivum L.)
No full textSoil and plant inoculation with heterotrophic zinc-solubilizing bacteria (ZSB) is considered a promising approach for increasing zinc (Zn) phytoavailability and enhancing crop growth and nutritional quality. Nevertheless, it is necessary to understand the underlying bacterial solubilization processes to predict their repeatability in inoculation strategies. Acidification via gluconic acid production remains the most reported process. In this study, wheat rhizosphere soil serial dilutions were plated on several solid microbiological media supplemented with scarcely soluble Zn oxide (ZnO), and 115 putative Zn-solubilizing isolates were directly detected based on the formation of solubilization halos around the colonies. Eight strains were selected based on their Zn solubilization efficiency and siderophore production capacity.
These included one strain of Curtobacterium, two of Plantibacter, three strains of Pseudomonas, one of Stenotrophomonas, and one strain of Streptomyces. In ZnO liquid solubilization assays, the presence of glucose clearly stimulated organic acid production, leading to medium acidification and ZnO solubilization. While solubilization by Streptomyces and Curtobacterium was attributed to the accumulated production of six and seven different organic acids, respectively, the other strains solubilized Zn via gluconic, malonic, and oxalic acids exclusively. In contrast, in the absence of glucose, ZnO dissolution resulted from proton extrusion (e.g., via ammonia consumption by Plantibacter strains) and complexation processes (i.e., complexation with glutamic acid in cultures of Curtobacterium). Therefore, while gluconic acid production was described as a major Zn solubilization mechanism in the literature, this study goes beyond and shows that solubilization mechanisms vary among ZSB and are strongly affected by growth conditions
Green manure effect on the ability of native and inoculated soil bacteria to mobilize zinc for wheat uptake (Triticum aestivum L.)
No full textISSN:0032-079XISSN:1573-5036ISSN:1573-503
Green manure and long-term fertilization effects on soil zinc and cadmium availability and uptake by wheat (Triticum aestivum L.) at different growth stages
No full textZinc (Zn) deficiency in human populations depending on cereals as a main source of Zn is a global malnutrition problem. In this field study, we investigated the potential of green manure application to increase soil Zn availability and wheat grain Zn concentrations (biofortification) on a Luvisol with different long-term fertilizer management. We also studied cadmium (Cd), as wheat is a major contributor of this undesired non-essential element to human diets. Clover (Trifolium alexandrinum L.), mustard (Sinapis alba L.) or no green manure was grown on field plots which had been managed with farmyard manure or mineral fertilizers for 65 years in Switzerland. After green manure incorporation into the soil, spring wheat (Triticum aestivum L.) was grown on all plots. The “diffusive gradients in thin films” (DGT) method and DTPA extraction were used to compare soil Zn and Cd availability among the treatments. In contrast to mustard, clover increased soil mineral nitrogen concentrations and wheat biomass; however, neither increased grain Zn concentrations. DGT-available Zn and Cd increased temporarily after both farmyard manure and mineral nitrogen fertilizer application. Higher DTPA-extractable soil Zn and Cd, lower wheat grain yields, but higher grain Zn concentrations were obtained with farmyard manure compared to mineral fertilizers, independent of the green manure treatment. Farmyard manure added Zn, Cd and organic matter that increased the soil binding capacity for Zn and Cd. The decomposition of clover residues caused higher wheat grain yields, but only marginally lower grain Zn concentrations. The absence of a stronger dilution of grain Zn was probably due to organic acid and nitrogen release from decomposing clover, which facilitated Zn uptake by wheat. The study revealed that both long- and short-term field management with organic matter alters soil Zn and Cd concentrations but that the long-term effects dominate their uptake by wheat, in Zn sufficient soil
Long-term organic matter application reduces cadmium but not zinc concentrations in wheat
No full textWheat is a staple food crop and a major source of both the essential micronutrient zinc (Zn) and the toxic heavy metal cadmium (Cd) for humans. Since Zn and Cd are chemically similar, increasing Zn concentrations in wheat grains (biofortification), while preventing Cd accumulation, is an agronomic challenge. We used two Swiss agricultural long-term field trials, the “Dynamic-Organic-Conventional System Comparison Trial” (DOK) and the “Zurich Organic Fertilization Experiment” (ZOFE), to investigate the impact of long-term organic, mineral and combined fertilizer inputs on total and phytoavailable concentrations of soil Zn and Cd and their accumulation in winter wheat (Triticum aestivum L.). “Diffusive gradients in thin films” (DGT) and diethylene-triamine-pentaacetic acid (DTPA) extraction were used as proxies for plant available soil metals. Compared to unfertilized controls, long-term organic fertilization with composted manure or green waste compost led to higher soil organic carbon, cation exchange capacity and pH, while DGT-available Zn and Cd concentrations were reduced. The DGT method was a strong predictor of shoot and grain Cd, but not Zn concentrations. Shoot and grain Zn concentrations correlated with DTPA-extractable and total soil Zn concentrations in the ZOFE, but not the DOK trial. Long-term compost fertilization led to lower accumulation of Cd in wheat grains, but did not affect grain Zn. Therefore, Zn/Cd ratios in the grains increased. High Zn and Cd inputs with organic fertilizers and high Cd inputs with phosphate fertilizers led to positive Zn and Cd mass balances when taking into account atmospheric deposition and fertilizer inputs. On the other hand, mineral fertilization led to the depletion of soil Zn due to higher yields and thus higher Zn exports than under organic management. The study supports the use of organic fertilizers for reducing Cd concentrations of wheat grains in the long-term, given that the quality of the fertilizers is guaranteed
Impact of Bacillus Calmette-Guérin (BCG) vaccination on postoperative mortality in patients with perioperative SARS-CoV-2 infection
No full text5762sinonenoneStephen Tabiri, Sivesh K Kamarajah, Dmitri Nepogodiev, Elizabeth Li, Joana Simoes, Sanskrithi Sravanam, Sheila Agyeiwaa Owusu, Haruna Mahama, Yaa Nyarko Agyeman, Joshua Arthur, Sheba Mary Kunfah, Frank Enoch Gyamfi, Emmanuel Abem Owusu, Markus W. Loffler, Paul Wandoh, Aneel Bhangu, Kwabena Siaw-Acheampong, Leah Argus, Daoud Chaudhry, Brett E Dawson, James C Glasbey, Rohan R Gujjuri, Conor S Jones, Sivesh K Kamarajah, Chetan Khatri, James M Keatley, Samuel Lawday, Elizabeth Li, Harvinder Mann, Ella J Marson, Kenneth A Mclean, Maria Picciochi, Elliott H Taylor, Abhinav Tiwari, Joana FF Simoes, Isobel M Trout, Mary L Venn, Richard JW Wilkin, Aneel Bhangu, Dmitri Nepogodiev, Irida Dajti (Albania), Arben Gjata (Albania), Luis Boccalatte (Argentina), Maria Marta Modolo (Argentina), Daniel Cox (Australia), Peter Pockney (Australia), Philip Townend (Australia), Felix Aigner (Austria), Irmgard Kronberger (Austria), Kamral Hossain (Bangladesh), Gabrielle VanRamshorst (Belgium), Ismail Lawani (Benin), Gustavo Ataide (Brazil), Glauco Baiocchi (Brazil), Igor Buarque (Brazil), Muhammad Gohar (Bulgaria), Mihail Slavchev (Bulgaria), Arnav Agarwal (Canada), Amanpreet Brar (Canada), Janet Martin (Canada), Maria Marta Modolo (Chile), Maricarmen Olivos (Chile), Jose Calvache (Colombia), Carlos Jose Perez Rivera (Colombia), Ana Danic Hadzibegovic (Croatia), Tomislav Kopjar (Croatia), Jakov Mihanovic (Croatia), Jaroslav Klat (Czech Republic), René Novysedlak (Czech Republic), Peter Christensen (Denmark), Alaa El-Hussuna (Denmark), Sylvia Batista (Dominican Republic), Eddy Lincango (Ecuador), Sameh H Emile (Egypt), Mengistu Gebreyohanes Mengesha (Ethiopia), Dr.Samuel Hailu (Ethiopia), Hailu Tamiru (Ethiopia), Joonas Kauppila (Finland), Alexis Arnaud (France), Markus Albertsmeiers (Germany), Hans Lederhuber (Germany), Markus Loffler (Germany), Stephen Tabiri (Ghana), Symeon Metallidis (Greece), Georgios Tsoulfas (Greece), Maria Aguilera Lorena (Guatemala), Gustavo Grecinos (Guatemala), Tamas Mersich (Hungary), Daniel Wettstein (Hungary), Dhruv Ghosh (India), Gabriele Kembuan (Indonesia), Peiman Brouk (Iran), Mohammad Khosravi (Iran), Masoud Mozafari (Iran), Ahmed Adil (Iraq), Helen M Mohan (Ireland), Oded Zmora (Israel), Marco Fiore (Italy), Gaetano Gallo (Italy), Francesco Pata (Italy), Gianluca Pellino (Italy), Sohei Satoi (Japan), Faris Ayasra (Jordan), Mohammad Chaar (Jordan), Ildar R Fakhradiyev (Kazakhstan), Mohammad Jamal (Kuwait), Muhammed Elhadi (Libya), Aiste Gulla (Lithuania), April Roslani (Malaysia), Laura Martinez (Mexico), Antonio Ramos De La Medina (Mexico), Oumaima Outani (Morocco), Pascal Jonker (Netherlands), Schelto Kruijff (Netherlands), Milou Noltes (Netherlands), Pieter Steinkamp (Netherlands), Willemijn van der Plas (Netherlands), Adesoji Ademuyiwa (Nigeria), Babatunde Osinaike (Nigeria), Justina Seyi-olajide (Nigeria), Emmanuel Williams (Nigeria), Sofija Pejkova (North Macedonia), Knut Magne Augestad (Norway), Kjetil Soreide (Norway), Zainab Al Balushi (Oman), Ahmad Qureshi (Pakistan), Raza Sayyed (Pakistan), Mustafa Abu Mohsen Daraghmeh (Palestine), Sadi Abukhalaf (Palestine), Moises Cukier (Panama), Hugo Gomez (Paraguay), Sebastian Shu (Peru), Ximena Vasquez (Peru), Marie Dione Parreno-Sacdalan (Philippines), Piotr Major (Poland), José Azevedo (Portugal), Miguel Cunha (Portugal), Irene Santos (Portugal), Ahmad Zarour (Qatar), Eduard-Alexandru Bonci (Romania), Ionut Negoi (Romania), Sergey Efetov (Russia), Andrey Litvin (Russia), Faustin Ntirenganya (Rwanda), Ehab AlAmeer (Saudi Arabia), Dejan Radenkovic (Serbia), Frederick Koh Hong Xiang (Singapore), Chew Min Hoe (Singapore), James Ngu Chi Yong (Singapore), Rachel Moore (South Africa), Ncamsile Nhlabathi (South Africa), Ruth Blanco Colino (Spain), Ana Minaya Bravo (Spain), Ana Minaya-Bravo (Spain), Umesh Jayarajah (Sri Lanka), Dakshitha Wickramasinghe (Sri Lanka), Mohammed Elmujtaba (Sudan), William Jebril (Sweden), Martin Rutegård (Sweden), Malin Sund (Sweden), Arda Isik (Turkey), Sezai Leventoğlu (Turkey), Tom EF Abbott (UK), Ruth Benson (UK), Ed Caruna (UK), Sohini Chakrabortee (UK), Andreas Demetriades (UK), Anant Desai (UK), Thomas D Drake (UK), John G Edwards (UK), Jonathan P Evans (UK), Samuel Ford (UK), Christina Fotopoulou (UK), Ewen Griffiths (UK), Peter Hutchinson (UK), Michael D Jenkinson (UK), Tabassum Khan (UK), Stephen Knight (UK), Angelos Kolias (UK), Elaine Leung (UK), Siobhan McKay (UK), Lisa Norman (UK), Riinu Ots (UK), Vidya Raghavan (UK), Keith Roberts (UK), Andrew Schache (UK), Richard Shaw (UK), Katie Shaw (UK), Neil Smart (UK), Grant Stewart (UK), Sudha Sundar (UK), Dale Vimalchandran (UK), Naomi Wright (UK), Sattar Alshryda (United Arab Emirates), Osaid Alser (United States), Kerry Breen (United States), Ian Ganly (United States), Haytham Kaafarani (United States), Brittany Kendall (United States), Hassan Mashbari (United States), Hamza Al Naggar (Yemen), Dennis Mazingi (Zimbabwe), EuroSurg, European Society of Coloproctology (ESCP), GlobalSurg, GlobalPaedSurg, ItSURG, PTSurg, SpainSurg, Italian Society of Colorectal Surgery (SICCR), Association of Surgeons in Training (ASiT), Irish Surgical Research Collaborative (ISRC), Joana FF Simoes (Chair), Dajti I (University Hospital Center Nene Tereza, Albania); Valenzuela JI (Hospital Velez Sarsfield, Argentina); Boccalatte LA, Gemelli NA, Smith DE (Hospital Italiano De Buenos Aires, Argentina); Dudi-Venkata NN, Kroon HM, Sammour T (Royal Adelaide Hospital, Australia); Roberts M, Mitchell D, Lah K, Pearce A, Morton A (Royal Brisbane and Women's Hospital, Australia); Dawson AC, Drane A (Gosford Hospital, Australia); Sharpin C, Nataraja RM, Pacilli M (Monash Childrens Hospital, Australia); Cox DRA, Muralidharan V, Riddiough GE, Clarke EM, Jamel W, Qin KR (Austin Hospital, Australia); Pockney P, Cope D, Egoroff N, Lott N (John Hunter Hospital, Australia); Putnis S, De Robles S, Ang Z (Wollongong Public Hospital, Wollongong, Australia); Mitteregger M, Uranitsch S, Stiegler M, Seitinger G, Aigner F (Krankenhaus der Barmherzigen Brüder Graz, Austria); Lumenta DB, Nischwitz SP, Richtig E, Pau M, Srekl-Filzmaier P, Eibinger N, Michelitsch B, Fediuk M, Papinutti A, Seidel G, Kahn J, Cohnert TU (Medical University of Graz, Austria); Messner F, Öfner D (Medical University of Innsbruck, Austria); Presl J, Varga M, Weitzendorfer M, Emmanuel K (Paracelsus Medical University, Salzburg, Austria); Binder AD (Universitätsklinikum Tulln, Tulln, Austria); Zimmermann M, Holawe S, Nkenke E, Grimm C, Kranawetter M (Medical University of Vienna, Vienna, Austria); Rahman Mitul A, Islam N, Karim S (Dhaka Shishu (Children) Hospital, Bangladesh); Komen N, Putnis S, De Robles S, Ang E (University Hospital Antwerp (UZA), Edegem, Belgium); De Praetere H, Tollens T, Schols G, Smets C, Haenen L (Imelda Hospital, Bonheiden, Belgium); Quintens J, Van Belle K (Europe Hospitals, Belgium); Van Ramshorst GH, Pattyn P, Desender L, Martens T, Van de putte D (Ghent University Hospital, Belgium); Lerut P, Grimonprez A, Janssen M, De Smul G, Wallaert P (AZ Groeninge, Belgium); Van den Eynde J, Oosterlinck W, Van den Eynde R, Sermon A, Boeckxstaens A, Cordonnier A, De Coster J, Jaekers J, Politis C, Miserez M (UZ Leuven, Belgium); Duchateau N, De Gheldere C (Heilig Hart Ziekenhuis Lier, Belgium); Flamey N, Pattyn P (AZ Delta, Belgium); Christiano A, Guidi B, Minussi AL, Castro S, Okoba W, Maldonado FHR, Oliveira P, Baldasso T, Santos L (Fundação Centro Médico De Campinas, Brazil); Gomes GMA, Buarque IL, Pol-Fachin L, Bezerra TS, Barros AV, da Silva AMR, Leite ALS, Silvestre DWA, Ferro CC (Hospital Santa Casa De Misericórdia De Maceió, Brazil); Araujo MS, Lopes LM, Damasceno PD, Araujo DHS (Hospital Universitário Antonio Pedro, Brazil); Laporte G, Salem MC (Irmandade Da Santa Casa De Misericórdia De Porto Alegre, Brazil); Guimaraes-Filho, MAC (Pedro Ernesto University Hospital, Brazil); Nacif L (Hospital Nove De Julho, Brazil); Flumignan RLG, Nakano LCU, Kuramoto DAB, Aidar ALS, Pereda MR, Correia RM, Santos BC, Carvalho AA, Amorim JE, Guedes Neto HJ, Areias LL, Sousa AF, Flumignan CDQ, Lustre WG, Moreno DH, Barros-Jr N, Baptista-Silva JCC (Hospital São Paulo, Brazil); Matos LL, Kowaski LP, Kulcsar MAV, Nunes KS, Teixeira MF (Instituto do Câncer do Estado de São Paulo, São Paulo, Brazil); Nunes RL, Ijichi TR, Kim NJ, Marreiro A, Muller B, Barakat Awada J (Notre Dame Intermédica - Hospital Salvalus, Brazil); Baiocchi G, Kowalski LP, Vartanian JG, Makdissi FB, Aguiar Jr S, Marques N, Carvalho GB, Marques TMDM, Abdallah EA, Zurstrassen CE, Gross JL, Zequi SC, Gonçalves BT, Santos SS, Duprat JP, Coimbra FJF (A.C. Camargo Cancer Center, Brazil); Cicco R (Instituto de Câncer Dr Arnaldo Vieira de Carvalho, São Paulo, Brazil); Takeda F, Cecconello I, Ribeiro Junior U (Instituto Do Câncer De Estado De São Paulo, Brazil); Gatti A, Oliva R, Nardi C (Hospital Geral De Pirajussara, Brazil); Slavchev M, Atanasov B, Belev N (University Hospital Eurohospital, Plovdiv, Bulgaria); Dell A, Bigam D, Dajani K, Al Riyami S (University of Alberta Hospital, Canada); Martin J, Cheng D, Yang H, Fayad A (London Health Sciences Centre and St Josephs Health Care London, Canada); Carrier FM, Amzallag E, Desroches J, Ruel M (Centre hospitalier de l’Université de Montréal, Canada); Caminsky NG, Boutros M, Moon J, Wong EG, Vanounou T, Pelletier J, Wong S, Girsowicz E, Bayne J, Obrand D, Gill H, Steinmetz O, MacKenzie K, Lukaszewski M, Jamjoum G (Jewish General Hospital, Canada); Richebé P, Verdonck O, Discepola S, Godin N, Idrissi M (Hôpital Maisonneuve-Rosemont, Canada); Briatico D, Sharma S, Talwar G, Bailey K (McMaster Children’s Hospital, Hamilton, Ontario, Canada); Lecluyse V (Hôpital du Sacré-Cœur-de-Montréal, Canada); Côté G (Centre hospitalier universitaire Sainte-Justine, Canada); Demyttenaere S, Garfinkle R, Boutros M (St. Mary's Hospital, Canada); Kouyoumdjian A, Boutros M, Dumitra S, Moon J, Wong EG, Khwaja K, Luo L, Lukaszewski M, Gill H, Berry G, Liberman AS, Girsowicz E, Bayne J, Obrand D, Steinmetz O, MacKenzie K, Schmid S, Spicer J, Al Farsi M (McGill University Health Center, Canada); Abou-Khalil J (The Ottawa Hospital, Canada); Couture E, Mohammadi S, Tremblay H, Gagné N, Bergeron A (Institut universitaire de cardiologie et de pneumologie de Québec, Canada); Turgeon Af, Costerousse O, Bellemare D, Babin C, Blier C (Centre hospitalier universitaire de Québec, Canada); Wood ML, Persad A, Groot G, Pham H (Saskatoon City Hospital/Royal University Hospital/St. Paul's Hospital, Canada); D'Aragon F, Carbonneau E, Bouchard M, Masse M, Pesant F, Héroux J (Centre hospitalier universitaire de Sherbrooke, Canada); Karanicolas P, Hallet J, Nadler A, Nathens A (Sunnybrook Hospital, Canada); Ko M, Brar A (St. Joseph's Health Centre, Canada); Mayson K (Vancouver General Hospital, Canada); Kidane B, Srinathan S (Health Sciences Centre, Canada); Escudero MI, Reyes JT (Hospital Clinico Universidad De Chile/ Hospital San Jose, Chile); Modolo MM, Ramirez Nieto P, Sepulveda R, Bolbarán A, Molero A, Ruiz I (Barros Luco Trudeau, Chile); Reyes GP, Salas R, Suazo C (Hospital del Salvador, Chile); Muñoz R, Grasset E, Inzunza M, Besser N, Irarrázaval MJ, Jarry C, Bellolio F, Romero Manqui CA, Ruiz Esquide M (Hospital Clínico Universidad Católica, Chile); Fuentes T, Campos J (Hospital Sotero Del Rio, Chile); Perez Rivera CJ, Cabrera PA (Fundacion Cardioinfantil-Instituto de Cardiología, Colombia); Pinilla RE, Guevara O, Jimenez Ramirez LJ, Velasquez Cuasquen BG, Herrera Mora DR, Bonilla A, Diaz S, Manrique E, Facundo H, Velez Bernal JL, Ángel J, García M, Guzmán L, Lehmann C, Cervera S, Trujillo Sanchez LM (Instituto Nacional De Cancerologia, Colombia); Guevara R, Valbuena D, Suarez L, Jimenez G, Velandia A, Vargas J, Espinosa J, Rey S (Clínica Universitaria Colombia, Bogotá., Colombia); Mendoza Quevedo Jairo (Subred Sur Occidente de Kennedy (Hospital de Kennedy), Bogota, Colombia); Calvache JA, Orozco-Chamorro CM, Sánchez-Gómez TA, Rojas-Tejada DA (Hospital Universitario San José, Popayán, Colombia); Mihanovic J, Bakmaz B, Rakvin I, Sulen N, Andabaka T (Zadar General Hospital, Croatia); Luksic I, Mamic M (University Hospital Dubrava, Zagreb, Croatia); Martinek L, Skrovina M (Hospital & Oncological Centre Novy Jicin, Czechia); Žatecký J, Peteja M (Slezská nemocnice v Opavě, p.o., Czechia); Kristensen HØ, Mekhael M, Christensen P, Westh L (Aarhus University Hospital, Denmark); Smith H, Haugstvedt AF, Jönsson ML (Bispebjerg Hospital, Denmark); Crespo A, Batista S, Rodriguez-Abreu J, Tactuk N, Diaz-Delgado PJ, Rivas R (Cedimat - Centro De Diagnóstico, Medicina Avanzada, Laboratorio Y Telemedicina, Dominican Republic); Sarmiento-Bobadilla JA (Hospital General Norte de Guayaquil, Guayaquil, Ecuador); Ashoush F, Samir Abdelaal A, Qatora MS, Elsayed Hewalla ME, Metwalli M, Atta R, Abdelmajeed A, Abosamak NE, Sabry A, Shehata S (Alexandria Main University Hospital, Egypt); Sallam I, Amira G, Sherief M, Sherif A (Misr Cancer Center, Egypt); Salem H, Hamdy R, Aboulkassem H, Ghaly G, Sherif G, Morsi A, Abdelrahman A (National Cancer Institute, Egypt); Omnia Ahmed (Coptic Hospital, Cairo, Egypt); Tawheed A, El Kassas M, Omar W (Endemic Medicine Department, Faculty of Medicine, Helwan University, Egypt); Abdelsamed A, Seleim A, Salem H, Azzam AY (Al Azhar University Hospitals, Egypt); ElFiky M, Nabil A (Kasr Alainy Faculty of Medicine, Cairo University, Egypt); Ibraheem M, Ghaly G, ELDeeb M, Fawzy M (Baheya Center for Early detection and Treatment of Breast Cancer, Egypt); Hamed H (Elkheir Hospital, Egypt); Emile S, Elfallal A, Elfeki H, Shalaby M, Sakr A (Mansoura University Hospital, Egypt); Alrahawy M, Atif H, Sakr A, Soltan H (Menofiya University Hospital, Egypt); Sayed AK, Salah A, Atiya A (Minia University Hospital, Egypt); Wassim K (Quwaysna Central Hospital, Egypt); Abbas AM, Abd Elazeem HAS, Abd-Elkariem AY, Abd-Elkarem MM, Alaa S, Ali AK, Ashraf M, Ayman A, Azizeldine MG, Elkhayat H, Emad Mashhour A, Gaber M, Hamza HM, Hawal I, Hetta HF, Elghazaly SM, Mohammed MM, Monib FA, Nageh MA, Saad A, Saad MM, Shahine M, Yousof EA, Youssef A (Assiut University Hospital, Assiut, Egypt); Esmail E, Khalaf M (Kafr Elzyat Hospital, Egypt); Eldaly A (El-Menshawy Hospital, Egypt); Ghoneim A, Hawila A, Badr H, Elhalaby I, Abdel-bari M, Elbahnasawy M, Hamada MK, Morsy MS, Hammad M, Hammad M, Essa M, Fayed MT, Elzoghby M, Rady M, Hamad O, Salman S, Sarsik S, Abd-elsalam S, Gamal Badr S, El-Masry Y (Tanta University Hospital, Egypt); Moahmmed MMH (Zagazig University Hospitals, Zagazig, Egypt); Hailu S, Wolde A, Mengesha M, Nida S, Workneh M, Y Ahmed M, Fisseha T, Kassa D, Zeleke H, Admasu A, Laeke T, Tirsit A, Gessesse M, Addissie A (Tikur Anbessa (Black Lion) Hospital-Addis Ababa University, Ethiopia); Bekele K (Maddawalabu University Goba Referral Hospital, Ethiopia); Kauppila JH, Sarjanoja E (Länsi-Pohja Central Hospital, Finland); Testelin S, Dakpé S, Devauchelle B, Bettoni J, Lavagen N (CHU Amiens, France); Schmitt F, Lemée JM, Boucher S, Breheret R, Kün-Darbois JD, Kahn A, Gueutier A, Bigot P (CHU Angers, France); Borraccino B (Centre Hospitalier Auxerre, Auxerre, France); Lakkis Z, Doussot A, Heyd B, Manfredelli S, Mathieu P, Paquette B, Turco C, Barrabe A, Louvrier A (CHU Besançon, France); Moszkowicz D, Giovinazzo D, Bretagnol F (Hôpital Louis-Mourier - Ap-Hp, France); Police A, Charre L, Volpin E, Braham H, El Arbi N, Villefranque V, Bendjemar L (Hôpital Simone Veil, France); Girard E, Abba J, Trilling B (CHU Grenoble-Alpes, Hôpital Michallon, France); Chebaro A, Lecolle K, Truant S, El Amrani M, Zerbib P, Pruvot FR, Mathieu D, Surmei E, Mattei L, Marin H (CHU Lille, France); Christou N, Ballouhey Q, Ferrero P, Coste Mazeau P, Tricard J, Barrat B, Taibi A, Usseglio J, Laloze J, Salle H, Fourcade L (Chu Limoges, France); Duchalais E, Regenet N, Rigaud J, Waast D, Denis W, Malard O, Buffenoir K, Espitalier F, Ferron C, Varenne Y, Crenn V, De Vergie S, Cristini J, Samarut E (Nantes University Hospital, France); Tzedakis S, Bouche PA, Gaujoux S (Hôpital Cochin - Aphp, France); Kantor E (AP-HP Hopital Bichat Claude Bernard, Paris, France); Gossot D, Seguin-Givelet A, Fuks D, Grigoroiu M, Sanchez Salas R, Cathelineau X, Macek P, Barbé Y, Rozet F, Barret E, Mombet A, Cathala N, Brian E, Zadegan F, Conso C (Institut Mutualiste Montsouris, France); Blanc T, Broch A, Sarnacki S, (Necker Enfants Malades University Children Hospital - APHP, Paris; Université de Paris, Paris, France); Ali L, Bonnard A, Peycelon M (Robert-Debré Children University Hospital - APHP, Paris; Université de Paris, Paris, France); Hervieux E, Clermidi P, Maisonneuve E, Aubry E, Thomin A, Langlais T (Hôpital Trousseau - Aphp, France); Passot G, Glehen O, Cotte E, Lifante JC (Hopital Lyon Sud, Pierre Bénite, France); De Simone B, Chouillard E (Centre Hospitalier Intercommunal Poissy Saint Germain En Laye, France); Arnaud AP, Violas P (CHU Rennes - Hôpital Sud, France); Bergeat D, Merdrignac A, Arnaud AP (Chu Rennes - Hopital Pontchaillou, France); Scalabre A, Perotto LO, Le Roy B, Haddad E, Vermersch S (Chu Saint Etienne, France); Ezanno AC, Barbier O, Vigouroux F, Malgras B, Aime A (Hia Begin, France); Seeliger B, Mutter D, Philouze G, Pessaux P (IHU-Strasbourg / Strasbourg University Hospitals, France); Germain A, Chanty H, Ayav A (CHRU Nancy, France); Kassir R, Von theobald P, Sauvat F (CHU Reunion, France); O'Connor J, Mayombo Idiata M, O'Connor Z, Tchoba S (Bongolo Hospital, Gabon); Modabber A, Winnand P, Hölzle F (University Hospital Aachen, Germany); Sommer B, Shiban E, Wolf S, Anthuber M, Sommer F (University Hospital Augsburg, Germany); Kaemmerer D, Schreiber T (Zentralklinik Bad Berka, Germany); Kamphues C, Lauscher JC, Schineis C, Loch FN, Beyer K (Charité University Medicine, Campus Benjamin Franklin, Germany); Nasser S, Sehouli J (Charité Comprehensive Cancer Center, Germany); Höhn P, Braumann C, Reinkemeier F, Uhl W (St Josef-Hospital, Bochum, Germany); Weitz J, Bork U, Welsch T, Praetorius C, Korn S, Distler M (University Hospital Carl Gustav Carus, Technical University Dresden, Germany); Fluegen G, Knoefel WT, Vay C (University Hospital Duesseldorf, Germany); Golcher H, Grützmann R, Binder J (Universitätsklinikum Erlangen, Germany); Meister P, Gallinat A, Paul A (University Hospital Essen, Essen, Germany); Schnitzbauer AA, Thoenissen P, El Youzouri H, Schreckenbach T, Nguyen TA (Frankfurt University Hospital, Goethe University, Frankfurt, Germany); Eberbach H, Bayer J, Erdle B, Sandkamp R (Medical Center – Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Germany); Nitschke C, Izbicki J, Uzunoglu FG, Koenig D, Gosau M, Böttcher A, Heuer A, Klatte TO, Priemel M, Betz CS, Burg S, Möckelmann N, Busch CJ, Bewarder J, Zeller N, Smeets R, Thole S, Vollkommer T, Speth U, Stangenberg M (University Medical Center Hamburg-Eppendorf, Germany); Hakami I, Boeker C, Mall J (KRH Nordstadt-Siloah Hospitals, Hannover, Germany); Schardey HM, von Ahnen T, von Ahnen M, Brunner U (Agatharied Hospital, Hausham, Germany); Tapking C, Kneser U, Hirche C, Jung M, Kowalewski KF (BG Trauma Center Ludwigshafen, Germany); Kienle P (Theresienkrankenhaus, Mannheim, Germany); Reissfelder C, Seyfried S, Herrle F, Hardt J, Galata C, Birgin E, Rahbari N, Vassos N (Mannheim University Medical Center (Universitätsmedizin Mannheim), Germany); Stoleriu MG, Hatz R (Asklepios Pulmonary Hospital, Munich Gauting, Germany); Albertsmeier M, Börner N, Lampert C, Werner J (Department of General, Visceral and Transplantation Surgery, Ludwig-Maximilians-Universität Munich, Munich, Germany); Kuehlmann B, Prantl L (University Hospital Regensburg, Regensburg, Germany); Brunner SM, Schlitt HJ, Brennfleck F, Pfister K, Oikonomou K (University Medical Center Regensburg, Department of Surgery, Germany); Reinhard T, Nowak K (RoMed Klinikum Rosenheim, Germany); Ronellenfitsch U, Kleeff J, Delank KS, Michalski CW, Szabo G (University Hospital Halle (Saale), Germany); Widyaningsih R, Stavrou GA (Klinikum Saarbrücken, Germany); Bschorer R, Mielke J, Peschel T (Helios Kliniken Schwerin, Germany); Königsrainer A, Quante M, Löffler MW, Yurttas C (University Hospital Tübingen, Department of General, Visceral and Transplant Surgery, Germany); Doerner J, Seiberth R (Helios Universitätsklinikum Wuppertal (Universität Witten/Herdecke), Germany); Bouchagier K, Klimopoulos S, Paspaliari D, Stylianidis G (Evaggelismos General Hospital, Greece); Syllaios A, Baili E, Schizas D, Liakakos T, Charalabopoulos A, Zografos C, Spartalis E (Laiko University Hospital, Greece); Manatakis DK, Tasis N, Antonopoulou MI (Athens Naval and Veterans Hospital, Greece); Xenaki S, Xynos E, Chrysos E, Athanasakis E, Tsiaousis J (University Hospital of Heraklion Crete and Interclinic Hospital of Crete, Greece); Lostoridis E, Tourountzi P (Kavala General Hospital, Greece); Tzovaras G, Tepetes K, Zacharoulis D, Baloyiannis I, Perivoliotis K, Hajiioannou J, Korais C, Gkrinia E, Skoulakis CE, Saratziotis A, Koukoura O, Symeonidis D, Diamantis A (General University Hospital of Larissa, Greece); Tsoulfas G, Christou CD, Tooulias A, Papadopoulos V, Anthoulakis C, Grimbizis G, Zouzoulas D, Tsolakidis D (Papageorgiou General Hospital, Greece); Tatsis D, Christidis P, Loutzidou L, Ioannidis O, Astreidis I, Antoniou A, Antoniadis K, Vachtsevanos K, Paraskevopoulos K, Kalaitsidou I, Alexoudi V, Stavroglou A, Mantevas A, Michailidou D, Grivas T, Deligiannidis D, Politis S, (George Papanikolaou General Hospital of Thessaloniki, Greece); Barrios Duarte A, Portilla AL, Lowey MJ, Recinos G, Lopez Muralles I (Hospital General De Enfermedades, Guatemala); Siguantay MA (Hospital Roosevelt, Guatemala City, Guatemala); Estrada EE, Aguilera-Arévalo ML, Cojulun JM, Echeverría-Dávila G (Hospital General San Juan De Dios
Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial
No full textBackground: There is controversy regarding the optimal renal-replacement therapy (RRT) modality for critically ill patients with acute kidney injury (AKI). Methods: We conducted a secondary analysis of the STandard versus Accelerated Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial to compare outcomes among patients who initiated RRT with either continuous renal replacement therapy (CRRT) or intermittent hemodialysis (IHD). We generated a propensity score for the likelihood of receiving CRRT and used inverse probability of treatment with overlap-weighting to address baseline inter-group differences. The primary outcome was a composite of death or RRT dependence at 90-days after randomization. Results: We identified 1590 trial participants who initially received CRRT and 606 who initially received IHD. The composite outcome of death or RRT dependence at 90-days occurred in 823 (51.8%) patients who commenced CRRT and 329 (54.3%) patients who commenced IHD (unadjusted odds ratio (OR) 0.90; 95% confidence interval (CI) 0.75-1.09). After balancing baseline characteristics with overlap weighting, initial receipt of CRRT was associated with a lower risk of death or RRT dependence at 90-days compared with initial receipt of IHD (OR 0.81; 95% CI 0.66-0.99). This association was predominantly driven by a lower risk of RRT dependence at 90-days (OR 0.61; 95% CI 0.39-0.94). Conclusions: In critically ill patients with severe AKI, initiation of CRRT, as compared to IHD, was associated with a significant reduction in the composite outcome of death or RRT dependence at 90-days
