3,724 research outputs found
Author, Philosopher Alexandra Stoddard to Speak March 2 at Williams Library
No full textOXFORD, Miss. – Contemporary philosopher, author, interior designer and speaker Alexandra Stoddard gives an inspirational lecture and reading March 2 at the University of Mississippi
Stages for the More Sustainable Farm
No full textCurrently, agricultural farm units are faced with a double and most times contradictory challenge, in order to be successful: on the one hand the invested capital has to be profitable and the economic performance has to be maximised. On the other hand, given the socio-environmental situation, it is necessary to preserve and to protect the environment and natural resources. Given the potential conflict of the two aims, since the satisfaction of one implies the underperformance of the other (and vice versa), the question then is: which is the solution to choose? We intend, in this work, to formulate a farm plan with the purpose of reconciling the criteria of environmental sustainability with that of economic competitiveness. For this achievement we proceed to the comparative study of sustainability of different groups of farms identified in the study area (first evaluation cycle) through MESMIS (“Marco para la Evaluación de Sistemas de Manejo de Recursos Naturales Mediante Indicadores de Sustentabilidad” - Framework for Evaluation of Natural-Resource Systems Handling through Sustainability Indicators) methodology, that allowed to select the more sustainable group of farms. Based on the found potentialities and weakness on these production systems, we stepped to the planning of a production unit of bovine meat, which obeys simultaneously to economic and environmental objectives, using Multicriteria Decision. We finished the work with the sustainability evaluation between groups of farms identified previously and the planned farms (second evaluation cycle), based, again, in the MESMIS methodology, to confirm (or not) the greatest sustainability of the last ones. Analyses of the results allow us to confirm the greatest relative sustainability of the planned farm, for the diverse traced scenarios.Decision taking, planning, sustainability, Environmental Economics and Policy, Farm Management,
Exhibiting Fashion Symposium: Dr. Alexandra Palmer “Fashion Exhibitions: The Good, the Bad, and the Pointless”
No full textThe Museum at FIT presented Exhibiting Fashion, its twenty-first academic symposium on Friday, March 8, 2019. This symposium explored the history of fashion curating, the different ways fashion is displayed in museum settings, and how national and regional identities influence fashion exhibitions. The symposium was organized in conjunction with Exhibitionism: 50 Years of The Museum at FIT, which commemorated the rich history of the museum, the site of more than 200 exhibitions since the 1970s.Dr. Alexandra Palmer is the Nora E. Vaughan Senior Curator at the Royal Ontario Museum. She has curated numerous exhibitions including Christian Dior, and she is the author of the book Christian Dior: History and Modernity, 1947–1957
Reescrita de si pelo outro: identidade portuguesa e paródia em Deus-dará, de Alexandra Lucas Coelho / Rewriting oneself through the other: Portuguese identity and parody in Deus-dará, by Alexandra Lucas Coelho
No full textResumo: O artigo aponta o modo como o romance Deus-dará de Alexandra Lucas Coelho, escritora portuguesa contemporânea, pode ser compreendido como um exercício de renegociação da identidade portuguesa em relação a questões referentes à colonização no Brasil. Mais do que isso, problematiza-se como, por meio da estratégia da paródia no texto ficcional, a autora consegue expressar uma necessidade e possibilidade de se redefinir pelo outro em um movimento contrário ao do discurso colonial – o que também ocorre em suas entrevistas e em suas narrativas de viagens, tais como em Vai, Brasil e Cinco Voltas na Bahia e um beijo para Caetano Veloso. Palavras-chave: identidade portuguesa; paródia; pós-modernismo; escrita portuguesa contemporânea; Alexandra Lucas Coelho. Abstract: The article observes how the novel Deus-dará, by Alexandra Lucas Coelho, a Portuguese contemporary writer consists in an exercise of renegotiation for the Portuguese identity in relation to issues that refer to the colonization process in Brazil. Moreover, this text seeks to show how parody as a fictional literary strategy helps the author in expressing a necessity and a possibility of redefining oneself through the other, in a direction that goes in the opposite way of the colonial speech. This necessity and this possibility also appear in the author’s interviews and travel books, such as Vai, Brasil and Cinco Voltas na Bahia e um beijo para Caetano Veloso, which will also be mentioned in this article.Keywords: Portuguese identity; parody; post-modernism; Portuguese contemporary writing; Alexandra Lucas Coelho
Author Rights Workshop
No full textLearning material associated with Alexandra Kohn's presentation as a part of the ABC Copyright 2020 Fall Speaker Series, hosted by the University of Alberta Copyright Office
Development of a high-throughput screening assay based on pluripotent stem cells to identify modulators of dopaminergic neurogenesis in humans. Purine-dependent pathways and Lesch-Nyhan disease as proof of principle
No full textLes neurones dopaminergiques du système nerveux central sont principalement localisés dans une région du cerveau appelée le mésencéphale ventral. Ils sont divisés en plusieurs sous-groupes projetant sur différentes structures du cerveau formant ainsi les voies dopaminergiques. Ces voies sont impliquées dans la réalisation de fonctions physiologiques essentielles telles que le contrôle moteur, la mémoire, la cognition, le système de récompense ou encore les émotions. Les altérations du développement de ces neurones peuvent conduire à l'apparition de pathologies potentiellement sévères comme des troubles moteurs, des pathologies neurodégénératives ou neuropsychiatriques. C'est le cas de la maladie de Lesch-Nyhan, une pathologie neurodéveloppementale rare causée par la mutation du gène HPRT1 conduisant à un déficit total ou partiel d'une enzyme clé dans la voie de recyclage des purines : l'HGPRT.Afin de pouvoir explorer les mécanismes à l'origine du développement des neurones dopaminergiques et des pathologies les impliquant, les cellules souches pluripotentes humaines se sont avérées être un modèle in vitro intéressant. Ces dernières années, plusieurs protocoles ont été développés afin de modéliser le développement des neurones dopaminergiques et de leurs progéniteurs à partir de ces cellules, en particulier dans le cadre de la recherche sur la maladie de Parkinson. Au cours de ma thèse, j'ai adapté ces protocoles afin de réaliser la différenciation des progéniteurs du mésencéphale dans un format miniaturisé adapté au criblage à haut débit de petites molécules de façon systématique.J'ai ensuite criblé une banque de molécules afin de chercher à identifier des composés potentiels permettant d'augmenter la neurogénèse des progéniteurs dopaminergiques du mésencéphale ventral comme preuve de principe de ce test. Etant donnée l'implication des neurones dopaminergiques dans la maladie de Lesch-Nyhan et du rôle potentiel des purines dans le développement du cerveau, une banque contenant des ligands purinergiques et des voies dépendantes de l'adénosine a été choisie. Ce criblage m'a permis d'identifier un agoniste du récepteur A3 à l'adénosine comme candidat potentiel. Ce composé s'est avéré efficace pour augmenter le taux de progéniteurs compétents pour la différenciation en neurones dopaminergiques à partir de CSP saines. Il a aussi permis de corriger le défaut de genèse des neurones dopaminergiques lié à la perte de fonction de l'HGPRT dans une lignée de CSP modèle de la maladie de Lesch-Nyhan.Le développement d'un tel test ouvre la voie pour le criblage de plus larges banques de molécules pour l'optimisation du protocole et la recherche de traitement pour des pathologies neurodéveloppementales comme la LND ou, à plus grande échelle, impliquant les nDA. Les résultats obtenus à l'issu de ces travaux nous permettraient également d'explorer le rôle du récepteur à l'adénosine ciblé par le composé dans la mise en place des nDA et son implication potentielle dans la maladie de Lesch-Nyhan.Dopamine neurons of the central nervous system are mainly located in the ventral midbrain. They are divided into several subgroups projecting to different brain structures, forming the dopaminergic pathways. These pathways are involved in essential physiological functions such as motor control, memory, cognition, reward system and emotion. Developmental alterations of these neurons can lead to potentially severe pathologies such as motor disorders, neurodegenerative or neuropsychiatric diseases. Among them, Lesch-Nyhan disease represent a rare neurodevelopmental disorder caused by mutation of the HPRT1 gene leading to total or partial loss of a key enzyme in the purine salvage pathway: HGPRT.To explore the mechanisms underlying the development of dopaminergic neurons and the pathologies involving them, human pluripotent stem cells have proven to be an interesting in vitro model. To elucidate the pathway involved in the genesis of DA neurons, the implementation of a high-throughput screening test based on human pluripotent stem cells to identify modulators of dopaminergic neurogenesis was envisaged. In the past few years, several protocols have been developed to model the development of dopaminergic neurons starting from these cells, especially in the context of research on Parkinson's disease.During my PhD thesis, I modified these protocols to allow the differentiation of dopaminergic progenitors in a miniaturized format adapted to high-throughput screening of small molecules in a systematic way.I then screened a library of molecules to identify potential compounds to increase the neurogenesis of ventral midbrain dopaminergic progenitors as a proof of principle for this test. Given the involvement of dopaminergic neurons in Lesch-Nyhan disease and the potential role of purines in brain development, a library containing purinergic ligands and adenosine-dependent pathways was chosen. This screening allowed me to identify an adenosine A3 receptor agonist as a potential candidate. This compound showed efficiency at increasing the production of progenitors competent to the differentiation in dopaminergic neurons from healthy PSC. It also corrected the default of genesis of dopaminergic neurons induced by HGPRT loss of function in a PSC line model of Lesch-Nyhan disease.The development of such an assay paves the way for the screening of larger molecules libraries for protocol optimization or therapeutic research for neurodevelopmental pathologies such as LND or, on a larger scale, involving nDA. The results obtained from this work would also allow us to explore the role of the adenosine receptor targeted by the compound in the nDA establishment and its potential involvement in Lesch-Nyhan disease
Athaliah and Alexandra: Gender and Queenship in Josephus [Author Accepted Manuscript]
No full textAthaliah and Alexandra were the only two women to rule as queens of Judah/Judaea in their own right and both women’s reigns are reported in Josephus’ writings. Despite their uniqueness, however, Athaliah and Alexandra are rarely compared in scholarship; the former is usually dismissed, and focus centred on the latter. This article contends that there are historical similarities between the two, but literary differences. Josephus could have referred to Athaliah or used elements of her portrayal in his presentation of Alexandra but does not, creating the impression that Alexandra was completely different to her predecessor. It may be instructive, therefore, to consider why Josephus literarily isolates the queens and what this means for his interpretation of Alexandra
Ferromagnetism and magnetic anisotropy in exfoliated flakes of CrTe2
No full textAuthor Alexandra Wagner, BScMasterarbeit Johannes Kepler Universität Linz 202
Alexandra Walsham, Catholic Reformation in Protestant Britain
No full textSince the publication of her Church Papists: Catholicism, Conformity and Confessional Polemic in Early Modern England (1993), the prolific Alexandra Walsham has never stopped adding nuances to our understanding of early modern English Catholicism. She is also the author of Providence in Early Modern England (Oxford UP, 1999), Charitable Hatred: Tolerance and Intolerance in England 1500-1700 (Manchester UP, 2006) and The Reformation of the Landscape: Religion, Identity and Memory in Early Mode..
TRAGIC NOISE AND RHETORICAL FRIGIDITY IN LYCOPHRON'S ALEXANDRA
No full textAbstract This paper seeks to shed fresh light on the aesthetic and stylistic affiliations of Lycophron's Alexandra , approaching the poem from two distinct but complementary angles. First, it explores what can be gained by reading Lycophron's poem against the backdrop of Callimachus’ poetry. It contends that the Alexandra presents a radical and polemical departure from the Alexandrian's poetic programme, pointedly appropriating key Callimachean images while also countering Callimachus’ apparent dismissal of the ‘noisy’ tragic genre. Previous scholarship has noted links between the openings of the Aetia and of the Alexandra , but this article demonstrates that this relationship is only one part of a larger aesthetic divide between the two poets: by embracing the raucous acoustics of tragedy, Lycophron's poem offers a self-conscious and agonistic departure from Callimachus’ aesthetic preferences. Second, this article considers another way of conceiving the aesthetics of the poem beyond a Callimachean frame, highlighting how Lycophron pointedly engages with and evokes earlier Aristotelian literary criticism concerning the ‘frigid’ style: the Alexandra constructs its own independent literary history centred around the alleged name of its author, ‘Lycophron’. The article proposes that this traditional attribution is best understood as a pen name that signposts the poem's stylistic affiliations, aligning it not so much with the Ptolemaic playwright Lycophron of Chalcis but rather with Lycophron the sophist and a larger rhetorical tradition of stylistic frigidity. Ultimately, through these two approaches, the article highlights further aspects of the Alexandra 's aesthetic diversity
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