3,035 research outputs found
La reconstruction physique du monde à partir de l'expérience de pensée ou l'invention de la physique cartésienne.
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Rapporteur’s report – innovative geotechnologies for energy transition
No full textThe 9th Society for Underwater Technology (SUT) International Conference on Offshore Site Investigation and Geotechnics (OSIG) closed with a Rapporteur’s report given by the author. This paper provides a record of that report, transcribed from a video recording. The presentation slides are shown as Figures.</p
DEFRApH - Sample collection and handling procedures
No full textAll chemical and biogeochemical process in the sea are affected by the acidity of the water. Acidity is therefore fundamental property of seawater. The growing concern that the acidity of the oceans might be increasing has revealed weaknesses in our knowledge of this fundamental property and its variation in space and time. In 2008 the DEFRApH project (DEFRA contract ME4133) was initiated to provide this missing information in UK related waters. It required sampling for and analysis of the total inorganic carbon and total alkalinity content of samples. This reports documents the procedures sued for sampling. A companion document Hartman Dumousseaud and Roberts (NOC Internal Document No. 01) describes in detail the analytical procedures used and the calculation of the results
Culicoides hornsbyensis Lee and Reye
No full textCulicoides hornsbyensis Lee and Reye (Figs 2, 5, 6, 8, 10, 12, 15, 17, 19, 21, 25, 26, 27, 29) Culicoides hornsbyensis Lee and Reye 1962: 361 Dyce et al. 2007: 34 (female wing illustrated) Type material ex amined: Australia, NSW Holotype, Hornsby, 25.Oct. 1956, D.J. Lee, light trap (female), Paratype, same data as holotype (1 male); Hornsby, NSW, 24.Oct. 1956, DJ Lee, light trap (1 female). Non-type material examined. Australia, NSW: Hornsby, 7.Feb. 1957. light trap, D.J. Lee (1 female), Hornsby, 8.Feb. 1957, light trap, D.J. Lee (1 male); Hornsby, 29.Jan. 1957, Light trap, D.J. Lee (1 male); Mt Dromedary, light trap, 24.Nov. 1965, I. Common & M. Upton (1 male). Qld: Dittmer Mine via Proserpine, light trap, 13.Feb. 1980, C. Brennan & W. Kinsella (1 female, 2 males); Woodliegh, via Mt Garnett, Lt Tp, 14.Jun. 1990, P. Waddell (1 female, 1 male). PNG: Wabo, Lt Tp 20.Aug. 1978 E.N. Marks (1 female). Diagnosis. Tibial comb with four to five spines, apical pale spot in cell r 5 elongate, extending almost to apex of cell. Female antennae with basal segments barrel-shaped, SCo distribution 1–13, usually with multiple SCo on flagellomeres 1–7, multiple STc on flagellomeres 1–8 and only one or two SCh on distal flagellomeres; 3 rd palpal segment swollen medially. Male antennae with SCo distribution 1 –4, 11– 13; SCh in basal whorls on flagellomeres 11 and 12, absent from 13. Gonocoxite with ventral root short, obtuse, apicolateral processes longer than width at base, aedeagus long with bifid tip. Female. Head. Eyes almost touching medially (Fig 2), palpus (Fig 10) pale brown with 3 rd segment swollen medially, bearing numerous capitate sensilla scattered on the surface of the distal 2 / 3 of the segment. Flagellomeres (Fig 12) 2–8 little longer than wide, barrel-shaped; 9–13 subcylindrical, considerably longer than basal flagellomeres. Thorax. Legs (Fig 8) brown, fore femora with weak pale basal and apical bands, mid & hind femora dark; all tibiae with weak pale basal bands and unbanded apically. Wing (Fig 5) strongly patterned, apical pale spot in cell r 5 elongate and approaching wing margin apically. Tibial comb (Fig 19) with 4–5 spines, 2 nd from spur usually longest. Haltere light brown. Male. Head. Palpus with subcylindrical 3 rd segment bearing relatively few capitate sensilla, these mostly on the inner surface. Antenna (Fig 15) with flagellomeres 11 and 12 with a basal whorl of SCh. Thorax. Wing (Fig 6) patterned similarly to female but with less contrasting pale and dark areas. Tibial comb with 4 spines, 2 nd from spur longest. Genitalia. Hypopygium (Fig 25) with lateral sides of ninth tergite concave, apicolateral processes widely separated, longer than basal width, caudal margin cleft medially. Ninth sternite with shallow caudo-medial excavation. Gonocoxite with dorsal root foot-shaped; ventral root short, triangular. Gonostylus slender, distally curving gently to a rounded apex. Aedeagus (Fig 27) with moderately deep basal arch extending to about 1 / 2 of aedeagus length; septum absent; distal process moderately long, bifid. Immatures. Unknown. Distribution. (Fig 29) Australia, NSW, Qld; PNG. Biology. Unknown. Label data suggests adults are crepuscular or nocturnal. Remarks. Features enabling differentiation of this species and C. bancrofti are described in the remarks under C. bancrofti.Published as part of Bellis, Glenn & Dyce, Alan, 2012, Redescription of the adults of Culicoides bancrofti Lee and Reye and C. hornsbyensis Lee and Reye (Diptera: Ceratopogonidae), pp. 51-60 in Zootaxa 3566 on pages 56-59, DOI: 10.5281/zenodo.21127
Author Correction:Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention (Nature Communications, (2019), 10, 1, (5280), 10.1038/s41467-019-13244-9)
No full textThe original version of this Article contained an error in the spelling of the author Wilma D.J. van de Berg, which was incorrectly given as Wilma D.J. van den Berg. This has now been corrected in both the PDF and HTML versions of the Article.</p
Opschorting overwinnen: de Academische wortels van Gassendi's probabilisme
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156840.pdf (Publisher’s version ) (Open Access
The Perception of Spatial Depth in Kepler's and Descartes' Optics: a Study of an Epistemological Reversal
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Du détail symbolique à la réalité disséquée: une nouvelle appréhension du visible au XVIIe siècle
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Sunitinib treatment exacerbates intratumoral heterogeneity in metastatic renal cancer
No full textThis work was supported by the Chief Scientist Office, Scotland (ETM37; to G.D. Stewart, A.C.P. Riddick, M. Aitchison, and D.J. Harrison), Cancer Research UK (Experimental Cancer Medicine Centre; to T. Powles, London and D.J. Harrison, Edinburgh), Medical Research Council (to A. Laird and D.J. Harrison), Royal College of Surgeons of Edinburgh (to A. Laird), Melville Trust (to A. Laird), Medical Research Council (MC_UU_12018/25; to I.M. Overton), Royal Society of Edinburgh Scottish Government Fellowship cofunded by Marie Curie Actions (to I.M. Overton), Renal Cancer Research Fund (to G.D. Stewart), Kidney Cancer Scotland (to G.D. Stewart) and an educational grant from Pfizer (to T. Powles).Purpose: The aim of this study was to investigate the effect of VEGF targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell renal cancer (mccRCC). Experimental design: Multiple tumor samples (n=187 samples) were taken from the primary renal tumors of mccRCC patients who were sunitinib treated (n=23, SuMR clinical trial) or untreated (n=23, SCOTRRCC study). ITH of pathological grade, DNA (aCGH), mRNA (Illumina Beadarray) and candidate proteins (reverse phase protein array) were evaluated using unsupervised and supervised analyses (driver mutations, hypoxia and stromal related genes). ITH was analysed using intratumoral protein variance distributions and distribution of individual patient aCGH and gene expression clustering. Results: Tumor grade heterogeneity was greater in treated compared to untreated tumors (P=0.002). In unsupervised analysis, sunitinib therapy was not associated with increased ITH in DNA or mRNA. However, there was an increase in ITH for the driver mutation gene signature (DNA and mRNA) as well as increasing variability of protein expression with treatment (p<0.05). Despite this variability, significant chromosomal and transcript changes to key targets of sunitinib, such as VHL, PBRM1 and CAIX, occurred in the treated samples. Conclusions: These findings suggest that sunitinib treatment has significant effects on the expression and ITH of key tumor and treatment specific genes/proteins in mccRCC. The results, based on primary tumor analysis, do not support the hypothesis that resistant clones are selected and predominate following targeted therapy.Peer reviewe
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