5,058 research outputs found
Professor Norton B. Smith\u27s practical treatise on the breaking and taming of wild and vicious horses
No full textCytosolic arylamine N-acetyltransferase (NAT) deficiency in the dog and other canids due to an absence of NAT genes
No full textThe purpose of this study was to determine the molecular basis in the dog for an unusual and absolute deficiency in the activity of cytosolic N-acetyltransferase (NAT), an enzyme important for the metabolism of arylamine and hydrazine compounds. NAT activity towards two NAT substrates, p-aminobenzoic acid and sulfamethazine, was undetectable in dog liver cytosol, despite substrate concentrations ranging from 10 microM to 4 mM and a wide range of incubation times. Similarly, no protein immunoreactive to NAT antibody was evident on western blot analysis of canine liver cytosol. Southern blot analysis of genomic DNA from a total of twenty-five purebred and mixed bred dogs, and eight wild canids, probed with a full-length human NAT2 cDNA, suggested an absence of NAT sequences in all canids. Polymerase chain reaction amplification of genomic DNA using degenerate primers designed to mammalian NAT1 and NAT2 consensus sequences generated products of the expected size in human, mouse, rabbit, and cat DNA, but no NAT products in any dog or wild canids. These results support the conclusion that cytosolic NAT deficiency in the domestic dog is due to a complete absence of NAT genes, and that this defect is shared by other canids.LR: 20061115; PUBM: Print; JID: 0101032; 150-13-0 (4-Aminobenzoic Acid); 57-68-1 (Sulfamethazine); 9007-49-2 (DNA); EC 2.3.1.5 (Arylamine N-Acetyltransferase); ppublishSource type: Electronic(1
Greek Author
No full textGreek Author. Naples Nat\u27l. Arch. Mus. XII.13.6https://digitalcommons.acu.edu/ferguson_photos/1276/thumbnail.jp
On the Author Correction: Magnetic field screening in hydrogen-rich high-temperature superconductors , Nat Commun 14, 5322 (2023)
No full textI analyze the implications of the recently published Author Correction (Nat Commun 14, 5322 (2023)) to a paper by Eremets and coauthors reporting magnetization measurements on hydrides under high pressure (Nat Commun 13, 3194 (2022)) to the understanding of the validity and reproducibility of the published data. This paper is a compilation of several different papers already published or to be published in the scientific literature.The underlying measured data referred to in this article as unavailable have recently been made available at https://osf.io/7wqxb/ August 9, 202
Rivierbocht model, doseerinstallatie nat zand
No full textBegonnen is voor het rivierbochtmodel een doseerinstallatie te ont-vrikkelen, die net zo nauwkeurig als het doseerapparaat voor droog zand, nat zand doseert. De grote voordelen hierbij zijn: - de mogelijkheid continu dag en nacht te doseren, - minder arbeidsintensief (niet drogen en vullen). Hiervoor is met de heer Van der Brugge en de heer Groeneveld een bezoek gebracht aan het W.L. in de Voorst, om daar te kijken hoe op de rechte goot het doseerprobleem is opgelost. Aan de hand van dit bezoek is verder gedacht over wat in ons geval een goed systeem zou zijn.oHydraulic EngineeringCivil Engineering and Geoscience
The 'Nat Turner' Controversy
No full textIn the late sixties, William Styron, who had acquired considerable reputation with his first three novels, published "The Confessions of Nat Turner", a fictionalized account of a slave rebellion in Virginia
in 1831. The author himself, as well as influential white critics, thought that the book was highly sympathetic to Nat Turner, the black rebel leader, and expected a positive response from the black
community. However, a number of black Writers attacked Styron for what they saw as profoundly racíst attitudes. This paper examines the problematic aspects of the novel and the main issues of this
controversy as generally illustrative of the difficulties involved in bridging cultural and historical misunderstandings and, in its particularities, as characteristic of America in the 196os
NAT traversal techniques for MediaSense open source platform
No full textThis thesis project concerns NAT traversal techniques and their application to P2P networking with regard to MediaSense platform. Since MediaSense open source platform, developed by Mid Sweden University, utilizes the benefits of P2P networking, it also suffers from the drawbacks provided by NAT. The issue of NAT traversal is not trivial due to the fact that the behavior of NAT devices is not standardized and vendors are free to provide their own implementations. The common knowledge is, that at least four main types of NATs exist, differing in the filtering and mapping algorithms employed. NAT traversal techniques vary accordingly. No single technique can handle all the cases. Most of the techniques can handle up to three main types of NAT. The last type is usually used in large corporate networks and is called the Symmetric NAT. The most viable, and basically the only available technique for its traversal, is data relaying. This thesis builds a NAT traversal module for the MediaSense platform. The main purpose of this module is to provide seamless NAT traversal capabilities to the platform. The module does this in several steps: UPnP enabled device discovery, NAT type determination and data relaying via the proxy. Firstly the module attempts to discover the presence of a UPnP enabled Internet Gateway Device on the network. If such a device is present on the network, a port mapping can be created, making the node located behind NAT accessible from the public Internet. If a UPnP enabled device was not found, the module will try to determine the type of NAT used. Based on the type of NAT used, the module can transit to either the proxy mode or request assistance of the STUN server to keep the created mapping alive. The resulting chapters provide the reader with the output produced by each step, conclusions the author has made while working on this project and some general ideas on future work within the subject
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
No full textGenetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10<sup>−11</sup>; odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28–1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes
Current experiments in elementary particle physics, 1976-87
No full textContains more than 1,800 experiments in elementary particle physics from the Experience database. Search and browse by author; title; experiment number or prefix; institution; date approved, started or completed; accelerator or detector; polarization, reaction, final state or particle; or by papers produced. Maintained at SLAC for the Particle Data Group. Supplies the information for Current Experiments in Particle Physics (LBL-91). Print version updated every second year
North Atlantic (NAT) Aided Inertial Navigation System Simulation: Volume I. Technical Results
No full textCurrent air traffic operations over the North ATlantic (NAT) and the application of hybrid navigation systems to obtain more accurate performance on these NAT routes are reviewed. A digital computer simulation program (NATNAV - North ATlantic NAVigation) is developed to evaluate the performance of navigation systems for future commercial NAT aircraft operations. Error models are developed for aided-inertial navigation systems with external measurements from Doppler radar, Omega, satellite-ranging or air data. (Modified author abstract
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