922 research outputs found
D.H. Lawrence, La Volpe, traduzione e cura di Stefania Michelucci, edizione bilingue
No full textIt is the bilingual and critical edition of D.H. Lawrence's The Fox in the series, Elsinore, Collana di Classici Inglesi, edited and translated by Stefania Michelucci
The volume consists of a long introduction to the text, pp 11-37, of a biographical article on the author and his work (l'autore e l'opera), pp. 39-45), of a note to the text (pp. 47-48) (English and Italian, page to page, pp. 49-227) of explicatory notes (pp. 229-243) and of a biographical section (pp. 245-252)
Genetic abnormalities in pancreatic cancer
No full textAbstract The incidence and mortality of pancreatic adenocarcinoma are nearly coincident having a five-year survival of less than 5%. Enormous advances have been made in our knowledge of the molecular alterations commonly present in ductal cancer and other pancreatic malignancies. One significant outcome of these studies is the recognition that common ductal cancers have a distinct molecular fingerprint compared to other nonductal or endocrine tumors. Ductal carcinomas typically show alteration of K-ras, p53, p16INK4, DPC4 and FHIT, while other pancreatic tumor types show different aberrations. Among those tumors arising from the exocrine pancreas, only ampullary cancers have a molecular fingerprint that may involve some of the same genes most frequently altered in common ductal cancers. Significant molecular heterogeneity also exists among pancreatic endocrine tumors. Nonfunctioning pancreatic endocrine tumors have frequent mutations in MEN-1 and may be further subdivided into two clinically relevant subgroups based on the amount of chromosomal alterations. The present review will provide a brief overview of the genetic alterations that have been identified in the various subgroups of pancreatic tumors. These results have important implications for the development of genetic screening tests, early diagnosis, and prognostic genetic markers.</p
Ricordo di Stefania Rossi Minutelli
No full textThe author commemorates Stefania Rossi Minutelli – librarian at the Marciana National Library from 1971 to 2005, who died on october 10th, 2008 – remembering her professional career and her role within the Italian Library Association.L'autore ricorda con affetto e stima professionale Stefania Rossi Minutelli – bibliotecaria marciana dal 1971 al 2005, scomparsa nell'ottobre 2008 – ripercorrendo il tratto di strada fatto insieme all'interno dell'Associazione Italiana Biblioteche e del mondo bibliotecario italiano
Hypoallergenic properties of donkey’s milk: a preliminary study
No full textCow’s milk protein allergy (CMPA) is an abnormal immunological response to cow milk
proteins, which results in IgE-mediated reactions. The therapeutic strategy to respond to
CMPA envisages the total elimination of milk or the administration of cow’s milk substitutes.
For this reason the use of milk from other mammalian species was tested. Among them,
donkey’s milk proved to be the best alternative in feeding infants affected by CMPA, since
its chemical composition is comparable to human milk. In this work an in vitro study was
performed in order to analyze the IgE reactivity to milk protein allergens from cow, donkey
and goat. In particular, immunoblotting experiments using sera from milk-allergic and
non-allergic adult volunteers were conducted with the aim of verifying the hypoallergenic
property of donkey’s milk. This study provided a preliminary evidence of the hypoallergenicity
of donkey’s milk when compared to bovine and goat milk. Considering the obtained results,
it would be possible to develop a sensitive diagnostic method for CMPA detection, based on
chromatographic and immunoblotting analysis
The Global Art Gallery Report with Richard Taittinger, Magnus Resch, Stefania Bortolami, and James Fuentes
No full textModerator: Magnus Resch Book Author and Art Entrepreneur
Panelists:
Stefania Bortolami, Gallery Owner
James Fuentes, Gallery Owner
Richard Taittinger, Gallery Owner
The Global Art Gallery Report is the first and the most wide-ranging report on today\u27s commercial art galleries. Published by Phaidon, it is the first insight of its kind, presenting a detailed and comprehensive portrait of today\u27s gallery scene. In a panel discussion, Magnus Resch will discuss his findings with gallerists Jeffrey Deitch, Stefania Bortolami and James Fuentes. Panelists will shine a light on the future of the art gallery.
Founded in 1969, the Sotheby’s Institute of Art is the first and foremost graduate school for the study of art and its markets. With more than 6,000 alumni working internationally in art fairs, galleries, museums, auction houses, and nonprofits, the Institute’s alumni are shaping the future of the art industry. Past guest speakers at the Institute have included artists, such as: Ulay and Jaša, Dan Graham, Alexandre Singh, Glenn Ligon, Sanford Biggers, Carolee Schneemann, Dara Birnbaum, Alfredo Jaar, Ahmed Alsoudani; and art industry experts from Sotheby’s, Art Basel, Paddle8, Auctionata, Armory Show, Artsy, Whitney Museum, Swiss Institute, MoMA, and others.https://digitalcommons.sia.edu/speaker/1007/thumbnail.jp
A Human Rights Approach to Environmental Health
No full textThis chapter explores the interface between health and the environment through the human rights prism, focusing on the environmental dimension of the right to health and on the now widely recognized right to a healthy, safe and clean environment. To this end, the chapter intends to offers a comprehensive analysis of the relevant provisions contained in human rights treaties and the obligations stemming therefrom. The review of these legal sources is completed by a critical assessment of the case law produced by regional human rights bodies and their evolutive interpretation of individual rights and corresponding State obligations in this field, with a special focus on the case law of the European Court of Human Rights. The aim of this legal analysis is to evaluate the added value of a human rights approach to environmental health litigation, with a view to best achieving the overarching goal of public health protection from environmental harm. The author highlights that human rights can be used in court as effective tools to protect public health against the adverse effects of environmental degradation and severe pollution. She also stresses that the potential of human rights bodies in the field of environmental health is yet fully unexpressed, but further positive developments towards the protection of collective and intergenerational rights related to the environment and human health can be achieved thanks to the dynamic and evolutive approach adopted by these bodies and through the virtuous circle created by judicial cross-fertilization
Pancreatic endocrine tumours: evidence for a tumour suppressor pathogenesis and for a tumour suppressor gene on chromosome 17p
No full textTwo molecular pathways leading to cancer are known. Common-type cancers arise from the 'tumour suppressor' pathway, characterized by gross chromosomal changes and allelic losses (LOH) in an average of 25 per cent or more of randomly chosen chromosomal loci. The 'mutator pathway' has been recognized in a subset of cancers, characterized by widespread microsatellite DNA instability and rarity of chromosomal losses. The present study has investigated 20 pancreatic endocrine tumours (PETs) for loss of heterozygosity (LOH) at seven chromosomal loci (3p14, 7q31-32, 11q13, 13q14, 18q21, 17p13, and 17q21); microsatellite instability; and Ki-ras, N-ras, and p53 gene mutations. LOH was found in an average of 24 per cent of the chromosomal loci analysed. No tumour showed microsatellite instability. Ki-ras and p53 mutations were each found in one case. The frequency of losses was higher in malignant (40 per cent) than in benign (17 per cent) tumours (p = 0.009), and the specific chromosome 17p13 LOH was associated with extrapancreatic extension of disease (p = 0.007), high proliferative activity (p = 0.001), and absence of progesterone receptors (p = 0.01). A common deleted region on chromosome 17p13 and the rarity of p53 gene mutations suggest the existence of a novel tumour suppressor gene involved in the pathogenesis of PETs in this chromosomal area
A Multitude of Women: The Challenges of the Contemporary Italian Novel
No full textA Multitude of Women looks at the ways in which both Italian literary tradition and external influences have assisted Italian women writers in rethinking the theoretical and aesthetic ties between author, text, and readership in the construction of the novel. Stefania Lucamante discusses the valuable contributions that Italian women writers have made to the contemporary novel and illustrates the relevance of the novelistic examples set by their predecessors. She addresses various discursive communities, reading works by Di Lascia, Ferrante, Vinci, and others with reference to intertextuality and the theories of Elsa Morante and Simone de Beauvoir.
This study identifies a positive deviation from literary and ideological orthodoxy, a deviation that helps give meaning to the Italian novel and to transform the traditional notion of the canon in Italian literature. Lucamante argues that this is partly due to the merits of women writers and their ability to eschew obsolete patterns in narrative while favoring forms that are more attuned to the ever-changing needs of society. She shows that contemporary novels by women authors mirror a shift from previous trends in which the need for female emancipation interfered with the actual literary and aesthetic significance of the novel. A Multitude of Women offers a new epistemology of the novel and will appeal to those interested in women's writing, readership, Italian studies, and literary studies in general
Expression pattern of claudins 3 and 5 distinguishes intestinal from pancreaticobiliary ampulla of vater carcinoma
No full textReview of the clinical, histological, and molecular aspects of pancreatic endocrine neoplasms
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