1,720,973 research outputs found
Determination of potentially characteristic pro-inflammatory and pro-angiogenic proteins as a new area of development of SPRi matrix biosensors
No full textNiniejsza dysertacja doktorska składa się z cyklu 6 artykułów naukowych: Lukasz Oldak, Anna Sankiewicz, Beata Zelazowska-Rutkowska, Bogdan Cylwik, Zenon Lukaszewski, Marcin Skoczylas, Ewa Gorodkiewicz, Two SPRi biosensors for the determination of cathepsin S in blood plasma. Talanta 225 (2021) 121900; Lukasz Oldak , Beata Zelazowska-Rutkowska, Anna Lesniewska, Piotr Mrozek, Marcin Skoczylas, Zenon Lukaszewski and Ewa Gorodkiewicz, Two Biosensors for the Determination of VEGF-R2 in Plasma by Array SPRi. Molecules 28 (2023) 155; Lukasz Oldak, Anna Lesniewska, Beata Zelazowska-Rutkowska, Eryk Latoch, Zenon Lukaszewski, Maryna Krawczuk-Rybak and Ewa Gorodkiewicz, An Array SPRi Biosensor for Simultaneous VEGF-A and FGF-2 Determination in Biological. Applied Sciences 12 (2022) 12699; Lukasz Oldak, Patrycja Milewska, Sylwia Chludzinska-Kasperuk, Kamil Grubczak, Joanna Reszec and Ewa Gorodkiewicz, Cathepsin B, D and S as Potential Biomarkers of Glioma Malignancy. Journal of Clinical Medicine 11 (2022) 6763; Lukasz Oldak, Sylwia Chludzinska-Kasperuk, Patrycja Milewska, Kamil Grubczak, Joanna Reszec and Ewa Gorodkiewicz, Laminin-5, Fibronectin, and Type IV Collagen as Potential Biomarkers of Brain Glioma Malignancy. Biomedicines 10 (2022) 2290; Lukasz Oldak , Sylwia Chludzinska-Kasperuk, Patrycja Milewska, Kamil Grubczak, Joanna Reszec and Ewa Gorodkiewicz. Biomolecules 12 (2022) 1477.Przedmiotem rozprawy doktorskiej jest konstrukcja trzech nowych bioczujników SPRi, czułych na czynniki proangiogenne i prozapalne oraz opracowanie trzech testów analitycznych opartych na bioczujnikach SPRi, służących do diagnostyki glejaka mózgu. Dla nowo opracowanych metod przeprowadzono procedurę walidacyjną i weryfikacyjną, które doprowadziły do wyznaczenia parametrów analitycznych i stwierdzenia, że nowe metody mogą być przydatne do celów diagnostycznych. Opracowane testy analityczne z przeznaczeniem do diagnostyki glejaka mózgu, ze względu na niemożność rozróżnienia grupy kontrolnej od łagodnych stopni choroby, umożliwiają diagnostykę tej choroby w bardziej zaawansowanych stopniach złośliwości. Mimo to, stanowią jednak wartościową propozycję metod wspierających ubogą jak dotąd diagnostykę laboratoryjną glejaka mózgu, co potwierdza analiza ROC.The subject of the doctoral dissertation is the construction of three new SPRi biosensors, sensitive to pro-angiogenic and pro-inflammatory factors, and the development of three analytical tests based on SPRi biosensors for the diagnosis of brain glioma. A validation and verification procedure was carried out for the newly developed methods, which led to the determination of analytical parameters and the conclusion that the new methods may be useful for diagnostic purposes. Analytical tests developed for the diagnosis of brain glioma, due to the inability to distinguish the control group from mild stages of the disease, enable the diagnosis of this disease in more advanced stages of malignancy. Despite this, they constitute a valuable proposition of methods supporting the so far poor laboratory diagnosis of brain glioma, which is confirmed by the ROC analysis.Uniwersytet w Białymstoku. Wydział Chemi
Comparison of the Diagnostic Power of Serum IL-6, IL-8 and TNF-α for the Idiopathic Anterior Uveitis in Children
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Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Diagnostic Usefulness of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor Binding Protein 3 in Children with Suspected Pituitary Dwarfism
No full textVariations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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