1,721,289 research outputs found
Beasley, R L, NX26582
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/370852Surname: BEASLEY
Given Name(s) or Initials: R L
Military Service Number or Last Known Location: NX26582
Missing, Wounded and Prisoner of War Enquiry Card Index Number: 33479181207
Item: [2016.0049.03179] "Beasley, R L, NX26582
SMART for the treatment of asthma: A network meta-analysis of real-world evidence
No full textA large proportion of asthmatic patients are treated with protocols resulting from data obtained by randomized controlled trials (RCTs) for which they would not have been eligible. Therefore, the aim of this study was to undertake a quantitative synthesis on real-world evidence comparing single inhaled corticosteroid (ICS)/formoterol maintenance and reliever therapy (SMART) and maintenance ICS/long-acting β2-adrenoceptor agonist (LABA) + as-needed short-acting β2-adrenoceptor agonist (SABA). A network meta-analysis of real-world studies was performed to compare SMART with ICS/LABA + as-needed SABA therapies in asthmatic patients. The surface under the cumulative ranking curve analysis was used to rank efficacy. The posterior probability distribution was reported as 95% credible interval (95%CrI). Data of 11,360 asthmatic patients were extracted from 6 studies. SMART including an ICS at medium-dose (MD) was more effective than MD ICS/LABA FDC + as-needed SABA (RR 0.54 95%CrI 0.42–0.69; P < 0.001) and low-dose (LD) SMART (RR 0.82 95%CrI 0.70–0.95; P < 0.05) against severe asthma exacerbation. MD SMART improved the Asthma Control Questionnaire score more than MD ICS/LABA FDC + as-needed SABA (delta effect −0.33 95%CrI −0.62 to −0.01; P < 0.05). The efficacy rank was: MD SMART > LD SMART > ICS + LABA free combination + as-needed SABA > ICS/LABA FDC + as-needed SABA > MD ICS/LABA FDC + as-needed SABA. The findings of this network meta-analysis of real-world evidence, and concordance with the effect estimates resulting from previous meta-analyses of RCTs, suggest that SMART may represent the preferred therapeutic option to reduce the risk of severe exacerbation in adults with moderate to severe asthma
Strength of association between comorbidities and asthma: a meta-analysis
Full text linkBackground The strength of association between comorbidities and asthma has never been ranked in
relation to the prevalence of the comorbidity in the nonasthma population. We investigated the strength of
association between comorbidities and asthma.
Methods A comprehensive literature search was performed for observational studies reporting data on
comorbidities in asthma and nonasthma populations. A pairwise meta-analysis was performed and the
strength of association calculated by anchoring odds ratios and 95% confidence intervals with the rate of
comorbidities in nonasthma populations via Cohen’s d method. Cohen’s d=0.2, 0.5 and 0.8 were cut-off
values for small, medium and large effect sizes, respectively; very large effect size resulted for Cohen’s
d >0.8. The review was registered in the PROSPERO database; identifier number CRD42022295657.
Results Data from 5 493 776 subjects were analysed. Allergic rhinitis (OR 4.24, 95% CI 3.82–4.71),
allergic conjunctivitis (OR 2.63, 95% CI 2.22–3.11), bronchiectasis (OR 4.89, 95% CI 4.48–5.34),
hypertensive cardiomyopathy (OR 4.24, 95% CI 2.06–8.90) and nasal congestion (OR 3.30, 95% CI
2.96–3.67) were strongly associated with asthma (Cohen’s d >0.5 and ⩽0.8); COPD (OR 6.23, 95% CI 4.43–
8.77) and other chronic respiratory diseases (OR 12.85, 95% CI 10.14–16.29) were very strongly
associated with asthma (Cohen’s d >0.8). Stronger associations were detected between comorbidities and
severe asthma. No bias resulted according to funnel plots and Egger’s test.
Conclusion This meta-analysis supports the relevance of individualised strategies for disease management
that look beyond asthma. A multidimensional approach should be used to assess whether poor symptom
control is related to uncontrolled asthma or to uncontrolled underlying comorbidities
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Clinical Outcome of Hepatocellular Carcinoma Patients in Taiwan:Correlation with Steroid Hormone Receptors
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