130,895 research outputs found
Entrevista al Dr. Armando García de León Loza
No full textFil: Baxendale, Claudia Alicia. Universidad Nacional de Luján. Instituto de Investigaciones Geográficas (INIGEO); Argentina.Fil: Baxendale, Claudia Alicia. Universidad de Buenos (UBA). Facultad de Arquitectura, Diseño y Urbanismo (FADU). Grupo de Ecología del Paisaje y Medio Ambiente (GEPAMA); Argentina.La entrevista fue planteada por la Lic. Esp. Claudia A. Baxendale el domingo 30 de Octubre 2022
en el Bar La Opera de la Ciudad Autónoma de Buenos Aires al despedir, junto a Gustavo D. Buzai,
al Dr. Armando García de León Loza en el marco de su participación en el VI Congreso
Internacional de Ordenamiento Territorial y Tecnologías de la Información Geográfica
(CIOTTIG) organizado por el Instituto de Investigaciones Geográficas (INIGEO) de la
Universidad Nacional de Luján del 26 al 29 de Octubre. Cabe recordar que el Doctor Armando
García de León Loza fue distinguido en dicho evento con el Reconocimiento “Elena M. Chiozza”
otorgado por dicha unidad académica
The discursive production of homosexual regulation
No full textThis thesis explores the pivotal place of the 1885 Labouchère Amendment and the 1967 Sexual Offences Act in the discourse of homosexual regulation presented by 20th century homophile histories. These twin events of ‘criminalisation’ and ‘decriminalisation’ are revisited to explore how and why they occurred and how they came to assume such a central position in both academic and popular understanding. The thesis draws on two streams of evidence. The literature on homosexual regulation is examined to establish the claims that are made about Labouchère Amendment and the Sexual Offences Act and the place that they are accorded, and the relationship that is established between them, within widely accepted homophile histories of the UK. Alongside this, primary sources – in the form of parliamentary debates, government papers, newspaper archives, and biographies – are interrogated to unpick the motivations and intentions of those involved in these pieces of legislation and to position them within a wider historical context.The thesis argues that this literature on homosexual regulation contributed to and institutionalised a homophile discourse geared especially towards establishing a history of what specific events might mean for political imperatives of the time and future prospects of homosexual communities. I will suggest that this led to uncritical acceptance of particular interpretations of the Labouchère Amendment and the Sexual Offences Act, which were reproduced over time and thus established as ‘truths’ within academia, the gay community and the wider public. Whilst some authors have recently subsequently questioned the importance of the Labouchère Amendment in the process of criminalisation (e.g. Cocks, 2003:17) these accounts have by-passed this event altogether, rather than offering an alternative account for its passage. Consequently, they have not supplanted earlier public, academic and political understandings of Labouchère. Specifically they have not explored how earlier understandings informed the debate about decriminalisation which, as this thesis will show, was premised on these historical interpretations. More broadly, the thesis argues that the over-concentration and mistaken interpretation of the Labouchère Amendment, which has misinformed understandings of the SOA (1967), has prevented the development of a more thorough, genealogical analysis of simultaneous sexual regulation more generally. In turn, developing a combined analysis of heterosexual as well as homosexual regulation contributes to the critique of existing interpretations which uncritically present certain events as homophobic rather than part of a more encompassing punitive heteronormativity.Part One critiques homosexual regulation’s historiography, before exploring theoretical and methodological issues raised in my thesis. Part Two then questions the Labouchère Amendment’s status as a fundamental adjustment in homosexual regulation making private homosexual acts short of sodomy illegal for the first time (Weeks, 1977). I provide an alternative history showing all homosexual acts were previously punishable and show that Labouchère’s Amendment was not homophobic but a measure for the protection of male youths from sexual exploitation and as such part in keeping with the wider punitive heteronormativity. I achieve this through analysing the primary sources on Labouchère’s Amendment from that period alongside the genealogical contextualization provided by contemporaneous heterosexual regulation. This establishes the foundations for Part 3 to repeat this methodology in analysing the decriminalisation process, this questions the centrality ascribed to the 1957 Wolfenden Report. I establish that this concentration ignores that decriminalisation was a highly politicised and negotiated process reliant upon the same social and political transformations that also re-ordered heterosexual regulation. This radically changes the interpretation of the how and why decriminalisation occurred and what had been possible
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Simple access to L-glycero-D-manno heptose at scale - a milestone towards more convenient syntheses of bacterial LPS-substructures
No full textThe seven-carbon sugar L-glycero-D-manno-heptose (LD-heptose, 1) is a major constituent of the inner core region of the lipopolysaccharide (LPS) of many Gram-negative bacteria. All established syntheses to this rare sugar require multiple steps and purifications, a drawback regularly addressed by installing the desired protecting group pattern alongside the chain elongation. We are convinced that a simpler (commercial) access to LD-heptose will greatly encourage more variable strategies towards the building blocks required for the assembly of oligoheptoside target structures. Such strategies greatly facilitate the late-stage optimization of the glycosyl donor and acceptor compared to an early introduction of the protecting group pattern.
In this light, we have recently accomplished a short and scalable process towards LD-heptose 1 and its crystalline, bench-stable α-pyranose peracetate 2. With an indium mediated acyloxyallylation of unprotected L-lyxose as the key transformation and only two recrystallizations pure 2 was obtained at >100mmol scale in single batch operations.[1] Next, we set out to establish a reliable methodology for the fast and variable preparation of heptose building blocks starting from 2. The presented approach is based on the exocyclic TIPDS-protection and its partial deprotection[2] (as in 4 to 5) and further utilizes a fine-tuned orthoester-methodology for the differentiation of the manno-configured endocyclic triol (3 to 4). It was applied to O- and S-glycosides of LD-manno and DD-manno configuration (as in the biochemical precursor of 1) and allows a variety of glycosylation building blocks to be prepared within a few days' work.
[1] Stanetty, C.; Baxendale, I. R.; Eur. J. Org. Chem. 2015, 2015, 2718-2726.
[2] Stanetty, C.; Walter, M.; Kosma, P.; J. Org. Chem. 2014, 79, 582-59
Immunogenetic analysis of the immune response to pneumococcal polysaccharide
No full textPneumococcal serotype-specific anti-capsular polysaccharide antibodies protect against invasive pneumococcal disease. Within an individual the diversity of these antibodies is limited. To evaluate the repertoire of antibodies to pneumococcus and determine whether oligoclonality is seen both between serotypes and between individuals, we sampled the B cell repertoire induced by polysaccharide and conjugate vaccine in adult volunteers. Fifteen hybridomas secreting pneumococcus-specific monoclonal antibodies were generated from five volunteers. Ten were isotype switched, six were IgG2 and four were IgA. These included two isotype switch variants of the same clone. V(H)3 and V(kappa)2 were used by 10/15 and 7/13 of the sequenced clones, respectively, with identical genes, V(H)3-48 and V(kappa)2-A17 used by a number of volunteers to a variety of serotypes. VDJ junctional characteristics and complementarity-determining region (CDR) 3 length were variable. High levels of somatic mutation in CDR1 and 2, inconsistent with a primary response, were found in 10/11 of the isotype-switched antibodies, including those induced by plain polysaccharide antigens. These data suggest that wild-type infection or nasopharyngeal carriage of Streptococcus pneumoniae in adults may induce memory and the response to subsequent immunization with plain polysaccharide or conjugate pneumococcal vaccines may have the characteristics of a secondary response
Scholarly Communication and Publishing Lunch and Learn Talk #11: The ULS Open Access Author Fee Fund
No full textAt the May 2014 talk, you will learn about the ULS Open Access Author Fee Fund--what it is, why we do it, how it works, and how the program is going so far
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