1,721,151 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Gapart (J.). Documents pour servir à l'étude de l'art égyptien. Tome II, (avec la collaboration de Baud (M.), Jéquier (G.) et Werbrouck (M.)
No full textVan De Walle B. Gapart (J.). Documents pour servir à l'étude de l'art égyptien. Tome II, (avec la collaboration de Baud (M.), Jéquier (G.) et Werbrouck (M.). In: Revue belge de philologie et d'histoire, tome 13, fasc. 3-4, 1934. pp. 857-858
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Gapart (J.). Documents pour servir à l'étude de l'art égyptien. Tome II, (avec la collaboration de Baud (M.), Jéquier (G.) et Werbrouck (M.)
No full textVan De Walle B. Gapart (J.). Documents pour servir à l'étude de l'art égyptien. Tome II, (avec la collaboration de Baud (M.), Jéquier (G.) et Werbrouck (M.). In: Revue belge de philologie et d'histoire, tome 13, fasc. 3-4, 1934. pp. 857-858
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Characterizing the beta-catenin interactome using inhibitor screens and novel interaction proteomics techniques
No full textBackgroundWnt signalling is a critical developmental pathway and associated aberrant signaling drives oncogenesis including colorectal and bone cancer. β-catenin, a central protein forms a range of protein-protein interactions(PPIs), fundamental to driving the transcription of oncogenes inducing proliferation and tumour formation. To further elucidate these interactions, we have sought to i) identify inhibitors of β-catenin PPIs and ii) employ a proximity dependent labelling technique (MiniTurbo) to characterize novel PPIs.MethodsMiniTurbo-Mutant Biotin ligase BirA is genetically fused to β-catenin and upon addition of Biotin, tagging is induced of proteins within 20nm in as quick as 10 minutes enabling streptavidin pull down and tagging to Mass spectrometry. CTNNB1 gene was successfully inserted into the Miniturbo plasmid construct using SLICE cloning. DH5alpha bacteria were transformed with plasmid and single colony selected with Ampicillin. Following plasmid purification, it was added with Retroviral components for viral transfection and production in HEK293 cells. U2OS adenocarcinoma cells transduced and selected using puromycin. Validated with western blot and immunofluorescence. 24-hour application of MSAB derivatives following induction of Miniturbo with Doxycycline. Streptavidin pulldown was carried out and samples were subjected to Mass Spectrometry following on-bead trypsin digestion. Proteomic analysis was carried out to elucidate novel PPI.Results-MSAB derivatives influence levels of β-catenin and Wnt target genes at protein and transcriptional level. -Successful introduction and selection of the miniturbo plasmid into U2OS cells. Western blots and immunofluorescence verification. -Novel Proteomic networks of Beta-catenin protein interactions in U2OS cells. The results illustrate the dynamic PPI network of β-catenin in a 2D cancer model and how those interactions are modulated in the presence of small molecule inhibitors for therapeutic indications.ConclusionsTargeting β-catenin directly for Oncotherapy has been difficult with very little success. Further characterization and understanding of the dynamic β-catenin interactome may pave an avenue for addressing this challenge
- …
