187,305 research outputs found
sj-pdf-1-imr-10.1177_03000605221105356 - Supplemental material for Medical laboratory staff satisfaction and their perspective on the role of health institutions to combat COVID-19 pandemic
No full textSupplemental material, sj-pdf-1-imr-10.1177_03000605221105356 for Medical laboratory staff satisfaction and their perspective on the role of health institutions to combat COVID-19 pandemic by Buddha Bahadur Basnet, Deepa Satyal, Roshan Pandit, Anjila Maharjan, Rashmi Karki, Shyam Kumar Mishra, Srijana GC, Til Bahadur Basnet in Journal of International Medical Research</p
Liposomes-in-chitosan hydrogel boosts potential of chlorhexidine in biofilm eradication in vitro
No full textSuccessful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity of liposomally-associated membrane active antimicrobials (MAA) and could potentially improve bacterial and biofilm eradication. Therefore, liposomes (∼300 nm) bearing chlorhexidine (CHX; ∼50 μg/mg lipid) as a model MAA were incorporated into chitosan hydrogel. The novel CHX-liposomes-in-hydrogel formulation was optimized for skin therapy. It significantly inhibited the production of nitric oxide (NO) in lipopolysaccharide (LPS)-induced macrophage and almost completely reduced biofilm formation. Moreover, it reduced Staphylococcus aureus and Pseudomonas aeruginosa adherent bacterial cells in biofilm by 64.2–98.1 %. Chitosan hydrogel boosted the anti-inflammatory and antimicrobial properties of CHX
sj-pdf-1-inq-10.1177_00469580221082783 – Supplemental Material for Knowledge, practice and psychological symptoms among medical laboratory staff during COVID-19 pandemic in Nepal: An online based survey
No full textSupplemental Material, sj-pdf-1-inq-10.1177_00469580221082783 for Knowledge, practice and psychological symptoms among medical laboratory staff during COVID-19 pandemic in Nepal: An online based survey by Buddha Bahadur Basnet, Deepa Satyal, Roshan Pandit, Til Bahadur Basnet, Sandeep Khattri and Shyam Kumar Mishra in INQUIRY: The Journal of Health Care Organization, Provision, and Financing</p
Utilizing liposomal quercetin and gallic acid in localized treatment of vaginal Candida infections
No full textVulvovaginal candidiasis (VVC) is a widely spread fungal infection that causes itching, pain and inflammation at the vaginal site. Although common, currently available treatment suffers from limited efficacy and high recurrence. In addition, the growing problem of resistance to azole drugs used in current treatments emphasizes the need for superior treatment options. Antimicrobial polyphenols are an attractive approach offering multitargeting therapy. We aimed to develop novel liposomes for simultaneous delivery of two polyphenols (quercetin, Q, and gallic acid, GA) that, when released within the vaginal cavity, act in synergy to eradicate infection while alleviating the symptoms of VVC. Q was selected for its anti-itching and anti-inflammatory properties, while GA for its reported activity against Candida. Novel liposomes containing only Q (LP-Q), only GA (LP-GA) or both polyphenols (LP-Q+GA) were in the size range around 200 nm. Q was efficiently entrapped in both LP-Q and in LP-Q+GA (85%) while the entrapment of GA was higher in LP-Q+GA (30%) than in LP-GA (25%). Liposomes, especially LP-Q+GA, promoted sustained release of both polyphenols. Q and GA acted in synergy, increasing the antioxidant activities of a single polyphenol. Polyphenol-liposomes were not cytotoxic and displayed stronger anti-inflammatory effects than free polyphenols. Finally, LP-GA and LP-Q+GA considerably reduced C. albicans growth
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Advanced topical delivery systems for membrane-active antimicrobials. Exploring nature to improve antimicrobial wound therapy
No full textCurrently, approximately 2% of the general population will experience at least one chronic wound throughout their lifetime. The numbers are expected to rise due to an aging population with a heightened disease burden. These wounds are major burdens for the patients; therefore, we need to find innovative approaches for bacterial eradication and improved wound treatment. We aimed to utilize nature’s toolbox to improve the effect of novel antimicrobial compounds, such as synthetic mimics of antimicrobial peptides (SMAMPs) and other membrane-active antimicrobials (MMAs), using pharmaceutical technology. In this project, we developed delivery systems based on liposomes and chitosan to improve anti-inflammatory, antimicrobial, anti-biofilm, and wound healing properties of novel SMAMPs. From the initial studies with the model compound chlorhexidine (CHX), liposomes-in-chitosan hydrogel was deemed the most suitable systems, and therefore selected for further development of delivery systems for two novel SMAMPs, namely 7e-SMAMP and 7a-SMAMP. From these studies, we confirmed that the 7e-SMAMP-liposomes and 7a-SMAMP incorporated in liposomes-in-chitosan hydrogel exhibited anti-inflammatory properties and a high level of biocompatibility. Furthermore, the anti-biofilm activities against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa of 7e-SMAMP improved upon its incorporation in liposomes and cell migration could be improved by incorporation of 7a-SMAMP in liposomes. Overall, the MAA-comprising liposomes-in-hydrogel systems proved to be suitable formulations with good biocompatibility and enhanced anti-inflammatory, antimicrobial, anti-biofilm, and wound healing properties. The novel delivery system comprising SMAMPs bears great potential as a platform in the therapeutic management of infected chronic skin wounds
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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