101,952 research outputs found
Making use of available and emerging data to predict the hazards of engineered nanomaterials by means of in silico tools: A critical review
No full textThe heterogeneity of engineered nanomaterials (NMs), with respect to physicochemical properties and observed (eco)toxicological effects, makes their case-by-case testing for Risk Assessment unsustainable in terms of costs, time, and number of test animals. This has required the development of Integrated Approaches to Testing and Assessment (IATA) in compliance with the 3R (Replacement, Reduction, and Refinement) principles of reducing animal testing to assist industries and regulators in decision making related to the safety of NMs. The application of non-testing in silico methods such as (Quantitative) Structure-Activity Relationships ((Q)SARs) and Grouping for Read-Across is fundamental to IATA. Therefore, the goal of this manuscript is to critically review the available in silico methods to predict the hazards for human health posed by NMs by applying the OECD (Q)SAR model validation principles. Moreover, we provide an overview on the existing databases, highlighting the importance of data curation. We find that available approaches are applied mainly to predicting in vitro endpoints, and that most of the models do not build on such internationally recognized databases, but on in-house datasets or on data retrieved from the literature. Our analysis shows that more efforts are needed to properly develop and validate in silico models for hazard prediction as alternatives to in vivo tests. Moreover, the Applicability Domain (highlighting the chemical space where such models were trained and hence provide more reliable results) of such models is not always assessed, and the uncertainty and sensitivity of the current methods are not sufficiently evaluated. To address these challenges, we propose a roadmap for future research in this area, including the adoption of more advanced Machine Learning techniques
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
The Right to Strike under the United States Constitution: Theory, Practice, and Possible Implications for Canada
No full textAnswering critics of the Canadian Supreme Court's judgment in B.C. Health, the author argues that the Court laid the foundation for a principled and durable doctrine protecting constitutional labour rights, one that goes directly to the heart of the matter — the inequality of workers’ power in the employment relation. In the author’s view, two paths could lead from B.C. Health to the recognition of Charter protec- tion for a right to strike: one that treats the right as an accessory to col- lective bargaining, and one that upholds the right directly on the basis of the Charter values of equality and participation. The author supports the latter approach, contending that constitutional rights should be defined in relation to fundamental values, in a way that is not contingent on time-bound or fact-sensitive assessments about the role of strikes within a particular collective bargaining regime. Although a Charter right to strike may involve the courts in difficult choices about when to defer to legislative policy decisions, and courts may lack the institutional capac- ity to deal effectively with labour law issues, the author points out that judges can look to ILO standards for expert guidance. Noting that the U.S. experience in this area might be of considerable use to Canadians, the author concludes by providing an overview of American case law concerning a constitutional right to strike.Peer reviewe
Emplacement and temporal constraints of the Gondwanan intrusive complexes of northern Patagonia: La Esperanza plutono-volcanic case
No full textTwo main lines of evidence disagree whether or not the Patagonian blocks collided with Gondwana. All models invoke the voluminous magmatism of the La Esperanza Complex as evidence for active subduction magmatic arc or to a postcollisional setting. The evolution of this bimodal igneous suite is reassessed with field, geochronological (SHRIMP U-Pb zircon and K-Ar mica) and petrophysical data. Emplacement of high-K calk-alkaline granitic magmas occurred at shallow crustal levels (2–8 ± 2 km depth) related to the development and collapse of a caldera associated with a regional NW-SE structural trend. Magmatism involved intermediate hybrid pulses at 273 ± 2 Ma and 255 ± 2 Ma (Prieto Granodiorite) that shifted like a yo-yo to acidic magmas at 260 ± 2 Ma and 250 ± 2 Ma (Donosa and Calvo granites). Absence of solid-state deformation features and the low anisotropy degrees in the granites indicate that its fabric is magmatic in origin. Magnetic fabric in granodiorites displays a concentrical pattern with subhorizontal foliations and lineations. Parallel to the volcanic axis, magnetic foliations and moderately plunging lineations indicate a common feeder system for plutonics and volcanics. Donosa Granite shows a discordant pattern with WNW-ESE ENE-WSW trending low plunging lineations and foliations. The plutono-volcanic system construction (273–255 Ma) followed NW-SE and NE-SW diamond shape faults trends and supracrustal discontinuities. Magmatic Climax is bracketed at 260 Ma. The collapse of the edifice is evidenced by the intrusion of acid magma plugs and dike swarms between 250 and 246 Ma. A similar age range was identified in other areas of Patagonia related to syn and postcollisional tectonic events. No evidence of tectonic activity such as major uplift, metamorphism or thrusting was found excepting regional strike-slip faulting and extension. Therefore, La Esperanza Complex is a high crustal level episode, and as such may not have structurally recorded an active collision during its crystallization and cooling.Fil: Martínez Dopico, Carmen Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geocronología y Geología Isotopica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geocronología y Geología Isotópica; ArgentinaFil: Lopez, Monica Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geocronología y Geología Isotopica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geocronología y Geología Isotópica; ArgentinaFil: Rapalini, Augusto Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Geociencias Basicas, Aplicadas y Ambientales de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Geociencias Basicas, Aplicadas y Ambientales de Buenos Aires; ArgentinaFil: Wemmer, Klaus. Universität Göttingen; AlemaniaFil: Fanning, Mark. Australian National University; AustraliaFil: Basei, Miguel A. S.. Universidade de Sao Paulo; Brasi
G-Rank: Unsupervised Continuous Learn-to-Rank for Edge Devices in a P2P Network
No full textRanking algorithms in traditional search engines are powered by enormous training data sets that are meticulously engineered and curated by a centralized entity. Decentralized peer-to-peer (p2p) networks such as torrenting applications and Web3 protocols deliberately eschew centralized databases and computational architectures when designing services and features. As such, robust search-and-rank algorithms designed for such domains must be engineered specifically for decentralized networks, and must be lightweight enough to operate on consumer-grade personal devices such as a smartphone or laptop computer. We introduce G-Rank, an unsupervised ranking algorithm designed exclusively for decentralized networks. We demonstrate that accurate, relevant ranking results can be achieved in fully decentralized networks without any centralized data aggregation, feature engineering, or model training. Furthermore, we show that such results are obtainable with minimal data preprocessing and computational overhead, and can still return highly relevant results even when a user’s device is disconnected from the network. G-Rank is highly modular in design, is not limited to categorical data, and can be implemented in a variety of domains with minimal modification. The results herein show that unsupervised ranking models designed for decentralized p2p networks are not only viable, but worthy of further research.https://github.com/awrgold/G-RankComputer Scienc
Author inscription in The Chinese slave-girl: a story of woman's life in China
No full textThis edition includes a gift inscription by author Rev. J.A. Davis, "To Rev. A. G. Russell with the warmest regards of the author J.A. Davis."Davis, John Agnell, 1839-1897
Wissenschaftliche Bibliographie Hilarion G. Petzold 1958 – 2014 mit Anhang von 2007 als Einführung
No full textDieses Archiv enthält die Gesamtbiliograpie der Werke des Autors bis Dez. 2013 nebst einiger Texte „Über H. G. Petzold“ und einen Anhang mit einer Einführung in die Struktur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author up to Dec. 2013 and some texts about H. G. Petzold, moreover an appendix with an introduction to the structure of the work in its epistemological structure and composition as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2014-petzold-h-g-2014-wissenschaftliche-gesamtbibliographie-1958-2014/peerReviewedpublishedVersio
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