87 research outputs found
Are patients and physicians willing to accept less-radical procedures for cervical cancer?
No full textOzdemir, Aykut/0000-0001-5457-3312; Basaran, Derman/0000-0002-2689-1417WOS: 000433285800006PubMed ID: 29770621Objective: To evaluate the opinions of women who underwent surgery for cervical cancer (CC) and physicians who treat CC about the acceptability of increased oncological risk after less-radical surgery. Methods: One hundred eighty-two women who underwent surgery for CC and 101 physicians participated in a structured survey in 3 tertiary cancer centers in Czech Republic and Turkey. Patients and physicians were asked whether they would accept any additional oncological risks, which would be attributable to the omission of parametrectomy (radical hysterectomy/trachelectomy vs. simple hysterectomy/trachelectomy) or pelvic lymph node dissection (systematic resection vs. sentinel lymph node sampling). Results: Although 52.2% of patients reported morbidity related to their previous treatment, the majority of patients would not accept less-radical surgical treatment if it was associated with any increased risk of recurrence (50%-55%, no risk; 17%-24%, risk < 0.1%). Physicians tended to accept a significantly higher risk than patients in the Czech Republic, but not in Turkey. Patients with higher education levels, more advanced-stage of disease, or adverse events related to previous cancer treatment, and patients who received adjuvant therapy were significantly more likely to accept an increased oncological risk. Conclusion: Patients, even if they suffered from morbidity related to previous CC treatment, do not want to choose between oncological safety and a better quality of life. Physicians tend to accept the higher oncological risk associated with less-radical surgical procedures, but attitudes differ regionally. Professionals should be aware of this tendency when counselling the patients before less-radical surgery.Charles University in Prague [UNCE 204065, PROGRES-Q28/LF1]; Czech Ministry of HealthMinistry of Health, Czech Republic [MZ CR-RVO VFN64165]This work was supported by Charles University in Prague (UNCE 204065 and PROGRES-Q28/LF1) and by a project from the Czech Ministry of Health (MZ CR-RVO VFN64165)
From the History of Soviet Chekhovian Studies of the 1920s-1940s: on Two Editions of "The Portrait of Chekhov's Creativeness" by A. B. Derman
No full textIn the history of Russian chekhovian studies the works by A. B. Derman appear in two points of view that are not equally relevant today. Though Derman repeats the official interpretations of Chekhov'slegacy (for example in his critical biographical essay “A. P. Chekhov” (1939) and “Moscow in the life and work of A. P. Chekhov” (1948) and other newspaper and magazine articles, he is also the author of a curious hypothesis, with the help of which he tried to explain the dominants of Chekhov's poetics, as well as to give an exhaustive psychologicalportrait of the writer. Curious hypothesis was formulated in his monograph “The portrait of Chekhov's creativeness” and partly in its subsequently added alterations. The hypothesis lies in the idea of “disharmony”of Chekhov's character: the primacy of the rational part over the emotional one. In Derman's opinion.В статье рассматриваются две редакции монографии А. Б. Дермана "Творческий портрет Чехова"
From the History of Soviet Chekhovian Studies of the 1920s – 1940s: on Two Editions of “The Portrait of Chekhov’s Creativeness” by A. B. Derman
No full textIn the history of Russian chekhovian studies the works by A. B. Derman appear in two points of view that are not equally relevant today. Though Derman repeats the official interpretations of Chekhov’s legacy (for example in his critical biographical essay “A. P. Chekhov” (1939) and “Moscow in the life and work of A. P. Chekhov” (1948) and other newspaper and magazine articles, he is also the author of a curious hypothesis, with the help of which he tried to explain the dominants of Chekhov’s poetics, as well as to give an exhaustive psychological portrait of the writer. Curious hypothesis was formulated in his monograph “The portrait of Chekhov’s creativeness” and partly in its subsequently added alterations. The hypothesis lies in the idea of “disharmony” of Chekhov’s character: the primacy of the rational part over the emotional one. In Derman’s opinion, Chekhov’s mentally evolution was built on the conscious overcoming of the defect, including through creativity, which had reflective and compensatory functions in this process. A comparison of the latter version of “The portrait of Chekhov’s creativeness” with the first edition gives us an interesting facts for characterizing the ideological processes which were typical for soviet criticism and literary studies from 1929s to the 1940s. This article focuses on the following problems: what did literary critics write about the first edition of “The portrait of Chekhov’s creativeness”, and how Derman corrected his work, resulting in the second version of “The portrait of Chekhov’s creativeness” (1944), which he did not publish
The Limits of Empire: Imperial History in the Wake of the Transnational Turn
No full textThe participants in this panel engage with recent historiography—and with each other—to debate the limits of imperial frameworks for understanding the past. Does the current emphasis on transnational approaches to the past add to, or detract from, imperial perspectives? Does the analytical validity of imperial containers fade during the modern era? Do stark divisions between the early modern Age of Empires and the modern Age of Nations obscure more than they clarify? The three papers presented will address these questions by drawing on case studies from Nazi Germany, twentieth-century China, and the eighteenth-century Atlantic world. In doing so, they aim to initiate a discussion of imperial history that will be of interest to scholars working on diverse temporal and geographic topics. Joshua Derman (Hong Kong University of Science and Technology) examines how the opposition between land and sea empires was thematized by Carl Schmitt, a controversial German theorist whose work is often uncritically cited by historians of empire today. Schmitt’s theories of land and sea cannot provide a coherent heuristic for historians, Derman argues; rather, they represent the product of a shifting field of dubious ideological positions. Shellen Wu (University of Tennessee) proposes revising twentieth-century Chinese history by stepping back from the discourse of the nation, and refocusing attention on the geographical expanse of the modern Chinese state. The rise of geopolitics, she argues, proves an invaluable framework for understanding how the discourses of science, race, and empire combined in the twentieth century to formulate a new ideology of empire. Turning our attention to the eighteenth-century Atlantic world, Christopher Magra (University of Tennessee) argues that capitalist behavior complicates the utility of imperial analytical frameworks. Merchants living in colonial Massachusetts—like their Dutch, French, and Spanish counterparts—flouted imperial commercial regulations, traded directly with foreign entrepreneurs, and defied the efforts of imperial customs agents in their pursuit of profits. Self-interested profit maximizers certainly made use of imperial legal and political institutions, but they did so to suit their own ends. The session will be chaired and commented by Jeremy Adelman, Walter Samuel Carpenter III Professor in Spanish Civilization and Culture and Director of the Council for International Teaching and Research at Princeton University. Prof. Adelman studies the history of Latin America in comparative and world contexts. He is the author or editor of ten books, including most recently Worldly Philosopher: The Odyssey of Albert O. Hirschman, which will be published in March 2013
THE COMPARISON OF VITAMIN D LEVELS OF HEALTHY AND GESTATIONAL DIABETIC PREGNANT WOMEN
No full textAim: To evaluate and compare 25-hydroxyvitamin D [25(OH)D3] levels of women with gestational diabetes mellitus (GDM) and those with normal glucose tolerance (NGT). Material and Method: A total of 40 women (20 with GDM and 20 with NGT) admitted to the clinic of obstetrics and gynecology due to follow-ups between the 24th and 28th gestational weeks and exposed to 50 and/or 100 gr oral glucose tolerance testing (OGTT) were enrolled into this prospective case-controlled study. Patients with GDM and controls with NGT were defined according to the 2013 criteria of the American College of Obstetricians and Gynecologists (ACOG). Age, height, weight, body mass index (BMI), history of previous diseases and surgeries, vitamin D replacement, clothing style (in this region 95% of participants dress in a style that prevents the sun from reaching skin) exercising status, and familial history were recorded. Serum samples were collected between the 24th and 28th gestational weeks to measure 25(OH)D3 levels via the chemiluminescence method. Results: Mean 25(OH)D3 levels were found as 8.71 +/- 3.36 ng/mL (ranging from 4.20 to 18.84). Vitamin D deficiency (< 10 ng/mL) and insufficiency( 10-30 ng/ml) were observed at the rate of 70% and 30%, respectively. 25(OH)D3 levels were 9.40 +/- 3.53ng/mL in patients with GDM and 8.0 +/- 3.11 ng/mL in controls with NGT. In terms of vitamin D deficiency, no statistically significant difference was found between the GDM and NGT groups. Discussion: 25(OH)D3 levels were found to be similar or lower in patients with GDM and those with NGT. We consider that prospective, randomized-controlled and comprehensive studies with larger populations are needed to illuminate the role of 25(OH)D3 levels in the development of GDM
Hedging with Stochastic and Local Volatility
No full textWe derive the local volatility hedge ratios that are consistent with a stochastic instantaneous volatility and show that this ‘stochastic local volatility’ model is equivalent to the market model for implied volatilities. We also show that a common feature of all Markovian single factor stochastic volatility models, (log)normal mixture option pricing models and ‘sticky delta’ models is that they predict incorrect dynamics for implied volatility. As a result they over-hedge the Black-Scholes model in the presence of a market skew and this explains the poor delta hedging performance of these models reported in the literature. Whilst the traditional ‘sticky tree’ local volatility models do not possess this unfortunate property, they cannot be used for pricing without exogenous and ad hoc smoothing of results. However the stochastic local volatility framework allows one to extend a good pricing model into a good hedging model. The theoretical results are supported by an empirical analysis of the hedging performance of seven models, each with different volatility characteristics, on the SP500 index skew.Local volatility, stochastic volatility, implied volatility, hedging, dynamic delta hedging, volatility dymamics
Radical Hysterectomy and Total Abdominal Vaginectomy for Primary Vaginal Cancer
No full textThe aim of this surgical video is to demonstrate en bloc radical removal of uterus and vagina in a patient with clinical early-stage vaginal cancer. Surgical treatment was offered to our patient for clinical early-stage primary vaginal cancer. An en bloc radical hysterectomy, systematic pelvic lymphadenectomy, and total abdominal vaginectomy were performed. Postoperative adjuvant radiation or chemotherapy was not recommended for completely resected pathologic stage I disease with no lymph node involvement and negative surgical margins. Radical surgery can be a treatment option for selected patients with primary vaginal cancer
A.NAVOY'S GHAZALS TRANSLATION AND ANALYSE
No full textThe article is devoted to the French translation of A. Navoi's gazelle, which begins “Meni men istagan uz sukhbatiga arjumand etmas” and “Jonga chun derman not erdi ulmakim kayfiyati” by Hamid Ismoilov and JeanPierre Balpa. The author studied the work of translators in this area and conducted a deep analysis of the translation of a ghazal, that is, an Eastern work translated into Western European languages
General Rules and the Normativity of Causal Inferences in the First Book of Hume\u27s Treatise
No full textIn the paper, the author has undertaken the task of illuminating the meanings and connections that constitute Hume’s account of causality. The author’s method is critical, questioning the logical consistency and explanatory power of Hume’s skeptical causality and inference, only to eventually reveal the validity of Hume’s argument. Much of the analysis is spent making sense of the seemingly contradictory or confusing statements Hume makes in his Treatise; lots of examples help this process. The paper includes addressing the paradoxical connection between our internal/subjective general rules and our customs. It also examines the interesting question of how to judge the good or bad character of a potential new custom
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