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EFEKTIVITAS EKSTRAK ETANOL DAUN EFEKTIVITAS EKSTRAK ETANOL DAUN SIDAGURI (Sida rhombifolia L.) TERHADAP PENURUNAN KADAR ASAM URAT PADA TIKUS JANTAN GALUR WISTAR HIPERURISEMIA
No full textSidaguri leaves (Sida rhombifolia L.) Have been shown to contain flavonoid compounds, where they are efficacious as hyperuricemia. This study aims to determine effectiveness ethanol extract of sidaguri leaves as antihyperuricemia in white rats. The study was conducted using the method of potassium oxanate induction and measured using glucometers. 15 animals were divided into 5 groups, namely negative control, positive control, group I combination of ethanol extract of sidaguri leaves 50 mg / kg body weight, group II ethanol extract of sidaguri leaves 100 mg / kg body weight, group III ethanol extract of sidaguri leaves 200 mg / kg body weight for 5 hours. Examination of antihyperuricemia effects is done by comparing the uric acid levels value of the rats before and after treatment. The results of this study indicate that the three dose ethanol extract of sidaguri leaves provide an antihyperuricemia effect and based on one-way Anova, Tuckey and LSD data analysis, shows that the dose of 50 mg / kg body weight is effective as antihyperuricemia and does not have a significant difference (p> 0.05). The conclusion of this study is that the dose is the most effective in decreases uric acid levels in white rats, which is a dose of 200 mg / kg body weight because it mostly decreased uric acid levels
Formulasi Dan Uji Sifat Fisik Gel Hand Sanitizer Ekstrak Etanol Daun Lidah Mertua(Sansevieria Trifasciata Prain)
Full text linkGel hand sanitizer telah banyak digunakan sebagai salah satu cara untuk menjaga kesehatan dan kebersihan tangan yang praktis dan mudah dibawa. Umumnya gel handsanitizer mengandung senyawa alkohol sebagai antiseptik untuk membunuh bakteri, tetapi penggunaan gel antiseptik yang mengandung alkohol dalam jangka panjang dapat menimbulkan iritasi. Oleh karena itu, diperlukan bahan alternatif alami yang ramah di kulit. dan tidak mengiritasi kulit,.salah satu tanaman yang memiliki daya antibakteri adalah daun lidah mertua (sansevieria trifasciata prain). Tujuan penelitian ini untuk mengetahui formulasi dan uji sifat fisik gel handsanitizer dari ekstrak daun lidah mertua (sansevieria trifasciata prain). Penelitian ini merupakan penelitian eksperimen dengan data hasil penelitian disajikan secara deskriptif. Gel dibuat dalam tiga formula dengan kosentrasi yang berbeda yaitu 10%, 20%, 30%. Evaluasi fisik gel yang dilakukan meliputi uji organoleptik, homogenitas, daya lekat, pH, viskositas, dan hedonik. Hasil evaluasi menunjukan formula 1 (10%) dan formula 2 (20%) dan formula 3 (30%). memenuhi semua syarat pada evaluasi sifat fisik gel yang meliputi uji organoleptik, homogenitas, daya lekat, pH, viskositas, dan hedonik
PENYULUHAN TENTANG PENGARUH PEMBERIAN HANDSAPLAS EKSTRAK RHIZOM JAHE MERAH DAN DAUN SALAM SEBAGAI RHEMATOID ARTHERITIS PADA PASIEN DI PUSKESMAS TALUN KENAS
Full text linkRheumatoid arthritis is the most common arthritis in the elderly, caused by autoimmune processes and often recurring. The purpose of the study was to analyze the risk factors for recurrence of rheumatoid arthritis in elderly people aged 40 to 65 years. This survey design uses quantitative descriptions. The respondents of this study were selected from 150 respondents using purposive sampling technique based on elderly patients with RA. The variables were examined using questionnaires developed by the researchers themselves and tested for validity and reliability. From the results of the study it is known that there are three factors associated with rheumatoid arthritis patients are age factors, lifestyle factors and dietary factors. This is also due to the fact that there are more women than men. The conclusion of this study is that the risk factors for recurrence of rheumatoid arthritis in the elderly are activity, lifestyle and eating habits. Therefore, the activity factor is the most powerful factor of influence and many respondents stated that heavy work or activity is often done repeatedly. Suggestions for further research can explore additional factors that can aggravate RA recurrence, and respondents should be able to reduce excessive activity to avoid recurrence
A FORMULATION OF HAND BODY LOTIO FORMULATION OF HAND BODY LOTION EXTRACT ethanol from lily leaves (Crinum asiaticum L.) AS A SKIN MOISTURIZER
No full textLily leaves (Crinum asiaticum L.) have bioactivity as antioxidants and contain chemical compounds such as glycosides, flavonoids, saponins, tannins and triterpenoids. This study aims to formulate daffodil leaf extract into a hand body lotion dosage form and observe the effectiveness on volunteer skin for 4 weeks. This research was conducted experimentally. Samples were taken from daffodil leaves (Crinum asiaticum L.), then extracted by maceration with 96% ethanol and concentrated using a rotary evaporator. The ethanol extract of daffodil leaves was formulated with concentrations of 5%, 8% and 11%. The preparation evaluation test includes homogeneity, organoleptic, pH, emulsion type, irritation test, and effectiveness test of the preparation to moisturize the skin. The results showed that the ethanol extract of daffodil leaves could be used to make homogeneous grated emulsion preparations which were stable during 4 weeks of storage, pH 7.52-7.25, oil-in-water emulsion type and did not disappear. Any hand cream product that contains narcissus leaf ethanol can increase skin moisture. The composition of the most effective hand and body cream in the treatment of dry skin is a preparation with a concentration of 11% ethanol extract of lily leaves, which increases skin healing by 40.35% and is applied to the skin within 1 month
Perbandingan Konsentrasi Ekstrak Etanol Daun Bau-Bau (Chromolaena odorata (L.) King & H.E. Robins) Dan Ekstrak Etanol Temu Putih (Curcuma zedoria (Berog) Rosc) terhadap Penyembuhan Luka Bakar pada Kelinci
Full text linkDaun Bau-Bau (Chromolanea odorata (L) King & H Robins) mengandung senyawa minyak atsiri, flavonoid, alkaloid, fenol, saponin, dan tannin. Temu putih (Curcuma zedoria (Berog.)Rosc) mengandung kurkumin, tritepenoid, flavonoida, saponin dan minyak astiri. Tujuan penelitian ini untuk membandingkan efektivitas Ekstrak Etanol Daun Bau-Bau dan Ekstrak Etanol Rimpang Temuputih. Ekstraksi sampel menggunakan etanol 96%. Hasil ekstraksi dibagi 7 kelompok konsentrasi yaitu 25%,15%, 10% dan Aquadest sebagai kontrol negatif.Menurut Hasil Analisis Data Anova One Way (Uji Tuckeys B) Diameter luka bakar dari hari pertama sampai ke 14 hari pengamatan mengalami penurunan, kelompok kelinci yang diberi perlakuan dengan ekstrak daun bau-bau konsentrasi 25% pada hari ke- 14 diameter luka bakar mengalami perubahan dengan efektifitas 2 cm (p=0,0). Pada kelompok ekstrak etanol temuputih konsentrasi 25% pada hari ke-14 diameter luka bakar mengalami perubahan dengan efektifitas 1,08 cm (p=0,64). Ekstrak Etanol Daun Bau-Bau Lebih Efektif untuk menyembuhkan luka bakar dibandingkan dengan Ekstrak Etanol Temu Putih.
 
ANALISA KUALITAS LIMBAH CAIR RUMAH SAKIT SEMBIRING, DELI TUA
Full text linkAnalysis of Liquid Waste Quality in Public Hospitals It is very important to prevent the danger of disease. This research was conducted to find out the waste of Sembiring Deli Tua Hospital in the District of Deli Tua before being processed (Inlet) in terms of wastewater quality standards. Analyzing the quality of liquid waste is done by examining samples in the Health Laboratory for chemical parameters including pH, BOD (Biochemical Oxygen Demand), COD (Chemical Oxygen Demand), TSS, free NH, and phosphate and Total E.Coli. Measurements are carried out by laboratory testing to analyze the quality or quality of wastewater disposal that is seen whether it is in accordance with the quality standards of liquid waste for hospital activities according to the decision of the state minister of environment of the Republic of Indonesia. With the discovery of wastewater parameters that do not meet the requirements, it is expected that the Sembiring Deli Tua General Hospital must continue testing all parameters at the monitoring point
Aktivitas Antibakteri Ekstrak Etanol dan Fraksi Daun Morbesi-Besi (Tarenna polycarpa (Miq.) Koord. ex Valenton) terhadap Beberapa Bakteri
No full textMorbesi-besi leave from the tribe is a kind of tea plant Rubiaceae. Mulberry-leave steel is widely used as antidiabetic drugs, cholesterol, anti-inflammatory and antibacterial. Morbesi-besi leaves contain chemical compounds such as flavonoids, glycosides, steroids / triterpenoids, anthraquinone, saponins and tannins. This study aims to determine the antibacterial activity of ethanol extract and fractions morbesi-iron leaves against some bacterial. Phytochemical screening test done on the powder botanicals, extracts ethanol, n-hexane fraction, the fraction of ethyl acetate and the remaining fraction. Antibacterial activity test was performed using the agar diffusion method to measure the diameter of the clear zone around the paper discs. Testing fraction of n-hexane and ethylacetate performed by TLC using silica gel GF254. He test results of phytochemical screening on botanicals and ethanol extracts are generating the steroid / triterpenoid, glycosides, flavonoids, saponins, antarquinon and tannins, the results of a screening test on a fraction of n-hexane produce triterpenoids / steroids, the results of a screening test on a fraction of ethyl acetate resulted in flavonoids, glycosides, saponins, tannins and screening results in the remaining fraction produces saponins and tannins. Antibacterial activity test results showed inhibition of the Gram-positive and Gram-negative. Ethanol and ethyl acetate extract fractions have the highest antibaketri activity inhibitory concentration of 500 mg / ml inhibitory diameter of 26.8 mm for the ethanol extract of the bacterium Salmonella. typhi, and 27.4 mm in the ethyl acetate fraction for Sthaphylococcus aureus bacteria, while at the :fraction of the n hexane and the remaining fraction showed inhibition were not high as the ethanol extract fraction dab ethylacetate. Diameter resistor in n-hexane fraction of 22. 7 mm in bacterial. Antibacterial activity test results showed inhibition of the Gram positive and Gram-negative. Ethanol and ethyl acetate extract fractions have the highest antibaketri activity inhibitory concentration of 500 mg / ml inhibitory diameter of 26.8 mm for the ethanol extract of the bacterium Salmonella typhi, and 27.4 mm in the ethyl acetate fraction for Sthaphylococcus aureus bacteria, while at the fraction of the n hexane and the remaining fraction showed inhibition were not high as the ethanol extract fraction dab ethylacetate. Diameter resistor in n-hexane fraction of 22. 7 mm in bacteria. on Staphylococcus epidermidis and the remaining fraction has a diameter of 12.4 mm on the inhibition of bacterial acne Propianebacterium. Results 1LC of n-hexane fraction stain visually memunjukkan 5, 9 stain by spraying H2SO4 and 7 stain by spraying Liebermann - Burchard, a compound contained in the n-hexane fraction antibacterial activity is suspected steroids and triterpenoid.121 HalamanTesis Magiste
Antibacterial Activity Test of Red Ginger Leaves (Zingiber Officinale Rosc. Var. Rubrum) and Gel Preparations of Active Fractions as Anti-inflammatory Against Excision Wounds Infected by Bacteria
No full textBackground: Red ginger leaves are a natural material empirically used by communities to
treat wounds. The leaves contain flavonoid compounds such as quercetin, luteolin, and
resveratrol, which possess wound-healing properties.
Objective: This study aimed to determine the antibacterial activity of the ethanol extract
and active fractions of red ginger leaves, analyze their components, and formulate a gel
preparation from the ethyl acetate fraction of red ginger leaves. The gel was applied to
excision wounds in rats infected with Staphylococcus aureusto assess its anti-inflammatory
effect.
Method: The antibacterial activity of the ethanol extract and ethyl acetate fraction was
tested using the diffusion method in vitro. The ethyl acetate fraction of red ginger leaves
was isolated through column chromatography, and the active compounds were
characterized using UV- Vis spectrophotometry, FTIR, LC-MS/MS, and NMR. The active
fraction was formulated into a gel with concentrations of 1%, 3%, and 5%. The gel was
evaluated, and antibacterial and anti-inflammatory activity tests were performed. Voltaren
was used as a positive control and a gel base as a negative control. Wound healing was
assessed in rats infected with Staphylococcus aureus, with parameters including wound
area, percentage of wound healing, histopathology (epidermal thickness and angiogenesis
count), and TNF-α expression.
Results: The antibacterial activity test indicated that the ethyl acetate fraction at a
concentration of 300 mg/mL exhibited the best inhibition against Staphylococcus aureus,
with an inhibition zone diameter of 14.92±0.37 mm. Two isolates were obtained from the
ethyl acetate fraction through column chromatography: a yellow isolate and a purple
isolate. Characterization of the isolates revealed the compounds 1-hydroxy-3,3-
dimethylbutane-2-one and bis(2-ethylhexyl) benzene-1,2-dicarboxylate. The gel
formulation met the evaluation criteria. The 5% ethyl acetate fraction gel exhibited the best
activity against Staphylococcus aureus, with an inhibition zone diameter of 15.07 ± 0.15
mm, an epidermal thickness of 45423.84 ± 7235.03 µm, an angiogenesis count of 26.33 ±
0.31, and a TNF-α level of 81.3 ± 25.05 pg/mL. The positive control (Voltaren gel) and
negative control (gel base) showed inhibition zone diameters of 15.07 ± 0.15 mm;
epidermal thicknesses of 66493.89 ± 20345.10 µm and 25813.55 ± 5495.68 µm,
respectively; angiogenesis counts of 30.60 ± 4.95 and 14.67 ± 1.82, respectively; and TNFα levels of 98.49 ± 29.92 pg/mL and 82.48 ± 21.08 pg/mL, respectively.
Conclusion: The antibacterial activity test demonstrated that the ethyl acetate fraction had
significant inhibitory effects. The compounds identified from the isolates were 1-hydroxy3,3-dimethylbutane-2-one and bis 2-ethylhexyl) benzene-1,2-dicarboxylate. The ethyl
acetate fraction gel formulation passed the evaluation tests, and the 5% concentration was
most effective in inhibiting Staphylococcus aureus and promoting excision wound healing
in rats infected with the bacteria327 PagesDisertasi Dokto
Antibacterial Activity Test of Red Ginger Leaves (Zingiber Officinale Rosc. Var. Rubrum) and Gel Preparations of Active Fractions as Anti-inflammatory Against Excision Wounds Infected by Bacteria
No full textBackground: Red ginger leaves are a natural material empirically used by communities to
treat wounds. The leaves contain flavonoid compounds such as quercetin, luteolin, and
resveratrol, which possess wound-healing properties.
Objective: This study aimed to determine the antibacterial activity of the ethanol extract
and active fractions of red ginger leaves, analyze their components, and formulate a gel
preparation from the ethyl acetate fraction of red ginger leaves. The gel was applied to
excision wounds in rats infected with Staphylococcus aureusto assess its anti-inflammatory
effect.
Method: The antibacterial activity of the ethanol extract and ethyl acetate fraction was
tested using the diffusion method in vitro. The ethyl acetate fraction of red ginger leaves
was isolated through column chromatography, and the active compounds were
characterized using UV- Vis spectrophotometry, FTIR, LC-MS/MS, and NMR. The active
fraction was formulated into a gel with concentrations of 1%, 3%, and 5%. The gel was
evaluated, and antibacterial and anti-inflammatory activity tests were performed. Voltaren
was used as a positive control and a gel base as a negative control. Wound healing was
assessed in rats infected with Staphylococcus aureus, with parameters including wound
area, percentage of wound healing, histopathology (epidermal thickness and angiogenesis
count), and TNF-α expression.
Results: The antibacterial activity test indicated that the ethyl acetate fraction at a
concentration of 300 mg/mL exhibited the best inhibition against Staphylococcus aureus,
with an inhibition zone diameter of 14.92±0.37 mm. Two isolates were obtained from the
ethyl acetate fraction through column chromatography: a yellow isolate and a purple
isolate. Characterization of the isolates revealed the compounds 1-hydroxy-3,3-
dimethylbutane-2-one and bis(2-ethylhexyl) benzene-1,2-dicarboxylate. The gel
formulation met the evaluation criteria. The 5% ethyl acetate fraction gel exhibited the best
activity against Staphylococcus aureus, with an inhibition zone diameter of 15.07 ± 0.15
mm, an epidermal thickness of 45423.84 ± 7235.03 µm, an angiogenesis count of 26.33 ±
0.31, and a TNF-α level of 81.3 ± 25.05 pg/mL. The positive control (Voltaren gel) and
negative control (gel base) showed inhibition zone diameters of 15.07 ± 0.15 mm;
epidermal thicknesses of 66493.89 ± 20345.10 µm and 25813.55 ± 5495.68 µm,
respectively; angiogenesis counts of 30.60 ± 4.95 and 14.67 ± 1.82, respectively; and TNFα levels of 98.49 ± 29.92 pg/mL and 82.48 ± 21.08 pg/mL, respectively.
Conclusion: The antibacterial activity test demonstrated that the ethyl acetate fraction had
significant inhibitory effects. The compounds identified from the isolates were 1-hydroxy3,3-dimethylbutane-2-one and bis 2-ethylhexyl) benzene-1,2-dicarboxylate. The ethyl
acetate fraction gel formulation passed the evaluation tests, and the 5% concentration was
most effective in inhibiting Staphylococcus aureus and promoting excision wound healing
in rats infected with the bacteria327 PagesDisertasi Dokto
PENGARUH EKSTRAK UMBI BAWANG PUTIH DAN UMBI BAWANG MERAH TERHADAP LUKA BAKAR PADA KELINCI
Full text linkBurns are one of the most common types of injuries in the community. The content of alliin in garlic (Allium sativum L) and onion (Allium cepavarascalonicum) is believed to help heal burns, with its biological activity as anti-aggregation of platelet cells, boost fibrinolysis and as an anti-bacterial. Objective of this research is to know the effect of gaelic extract (Allium sativum L) and red onion (Allium cepa var ascalonicum) to burn on rabbit.The methodology of this research is an experimental method based on a complete randomized design.sample used in this research and onion bulbs taken in Berastagi Subdistrict, Karo Regency, North Sumatera Province.Result of this research show that subjects of Garlic extract with 15% concentration gave the fastest healing effect on 7th day, 10% and 5% dose gave healing effect on the 8th day. Giving onion bulbs extract at 15%, 10% and 5% concentration gave healing effect of burn on 8th day. The healing of burns in the comparison group was on the 8th day while the longest burn healing in the control group was on the 10th day. Conclusion is an effect that can be found in the extract of garlic and onion extract to the burn on the rabbit
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