Institut Kesehatan Medistra Lubuk Pakam Open Journal System
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From Laboratory to Algorithm: The Role of Computational Methods in New Drug Design Discovery in the Digital Era
No full textIn the digital era, the integration of computational methods in drug discovery has revolutionized laboratory practices, enhancing efficiency and accuracy in drug development. This article provides a comprehensive review of the crucial role of computational technology in accelerating the discovery of new drug compounds, highlighting its impact on the effectiveness and success of pharmaceutical development. Traditional drug discovery methods often require extensive time and high costs, with relatively low success rates in clinical trials. To address these challenges, various computational approaches, such as Molecular Docking, Quantitative Structure-Activity Relationship (QSAR), and machine learning, have been widely adopted in the pharmaceutical industry. This study employs a systematic approach to explore different computational techniques and their applications in identifying potential drug candidates. Findings indicate that computational tools significantly expedite the drug development process, reduce costs, and improve the success rates of clinical trials. The conclusion emphasizes the importance of leveraging computational technology as an innovative strategy in pharmaceutical research and development, ultimately accelerating the discovery of safer and more effective therapies.
Keywords: Computation, Drug Discovery, Digital Era, QSAR, Molecular Docking
Formulation and Evaluation of Feminine Hygiene Preparation from Lemongrass (Cymbopogon nardus) and Its Inhibitory Activity Against Candida albicans
No full textBackground: Fungal infections are a common health problem in tropical countries, including Indonesia, where the hot and humid climate favors the growth of pathogenic microorganisms. One of the fungi that frequently causes infections in women is Candida albicans, the main agent responsible for vaginal discharge. Synthetic antibacterial and antifungal compounds often cause side effects, adverse events, relatively high costs, and the risk of fungal resistance due to excessive use. This situation has encouraged people to return to natural ingredients (“back to nature”) as safer, more effective, and more economical alternatives. One plant with strong potential as a natural antifungal agent is citronella (Cymbopogon nardus). This plant is widely known as a cooking spice, massage oil ingredient, and traditional herbal remedy, and it is abundantly available in the Hutaginjang area, North Tapanuli Regency. Objective: This study aimed to formulate and evaluate a feminine hygiene preparation containing citronella extract and to test its antifungal activity against Candida albicans. Method: The research was conducted experimentally. Results: The results showed that all formulations met the physical property standards set by SNI, with viscosity ranging from 2000–50,000 cps and pH between 4.0–5.0, which is suitable for the vaginal area. Antifungal testing revealed that inhibition zones increased with higher extract concentrations—10%, 15%, and 20% extracts produced inhibition zones of 10.5 mm, 13.3 mm, and 17.1 mm, respectively. The 60% extract yielded a 22.5 mm inhibition zone (categorized as very strong), approaching that of the positive control ketoconazole (29.1 mm). Statistical analysis (Shapiro-Wilk, ANOVA, Tukey HSD, Duncan) indicated that the data were normal, homogeneous, and showed significant differences between treatments. Conclusion: It can be concluded that higher concentrations of citronella extract are more effective in inhibiting the growth of Candida albicans
Antibacterial Activity Test of 96% Ethanol Extract of Red Ginger (Zingiber officinale var. rubrum) Against the Growth of StreptococcusPneumoniae Bacteria
No full textAbstract
Background: Pneumonia is an infectious disease with a high global prevalence that contributes significantly to mortality in children and adults. Red ginger (Zingiber officinale var. rubrum), a traditional Indonesian medicinal plant, has been identified as having antibacterial, antioxidant, and anti-inflammatory properties. Some of its natural constituents, such as flavonoids, have shown antimicrobial activity with a low toxicity profile. Therefore, the phytochemical content in red ginger is assumed to be able to combat Streptococcus pneumoniae bacteria, which is one of the main etiologies of Pneumonia. Objective: Evaluating the potential of 96% ethanol extract of red ginger (Zingiber officinale var. rubrum) as an antimicrobial agent in inhibiting the growth of Streptococcus pneumoniae bacteria. Method: This study applied a true experimental approach with a post-test design to evaluate the effectiveness of 96% ethanol extract of red ginger (Zingiber officinale var. rubrum) as an agent that inhibits the growth of Streptococcus pneumoniae bacteria. The method used was the disc diffusion method (Kirby-Bauer). Results: The study showed that the ethanol extract of red ginger (Zingiber officinale var. rubrum) exhibited antibacterial activity; however, its effectiveness in inhibiting the growth of Streptococcus pneumoniae was not significant.Conclusion: The 96% ethanol extract of red ginger (Zingiber officinale var. rubrum) demonstrated resistance, showing only minimal inhibitory activity against Streptococcus pneumoniae. This condition contrasts with the positive control, chloramphenicol, which produced a significant inhibition zone and was categorized as sensitive. Therefore, the effectiveness of red ginger extract in inhibiting the growth of this bacterium is considerably lower than that of chloramphenicol
The Relationship Between Nurse Response Time In Treating Open Fractur Patients And The Risk Of Hypovolemic Shock In The Emergency Room Of Grandmed Hospital Lubuk Pakam
No full textIntroduction:Open fractures are bone injuries involving skin disruption, leading to direct bone exposure and a high risk of contamination. Emergency care reports indicate that around 50% of trauma patients die en route to the hospital, 35% due to severe injuries. Timely nursing response is crucial in early emergency management, especially in open fractures. This study aimed to assess the association between nurses' response time and the risk of hypovolemic shock in patients with open fractures. Methods:A descriptive correlational study was conducted from September to October 2024 at the Emergency Department of Grandmed Hospital, Lubuk Pakam. Thirty-one nurses were selected using total sampling. Data were obtained through structured observations of eligible nurses. Results: Delayed response was observed in 32.3% of nurses, with hypovolemic shock occurring in 32.3% of patients. Fisher’s Exact Test revealed a significant association between nursing response time and hypovolemic shock risk (p = 0.040). Discussion: Delayed nursing interventions were significantly linked to increased hypovolemic shock risk. The findings underscore the need for effective leadership and prompt nursing action to prevent complications
The Relationship Between Use of the Transmedic Application with Efficiency of Patient Registration
No full textThe transmedic application is a hospital management information system designed to manage patient data and support operational activities at Grandmed Hospital Lubuk Pakam. Its utilization is expected to improve the efficiency of patient registration services. This study aims to analyze the relationship between the use of the Transmedic application and the efficiency of patient registration at Grandmed Hospital Lubuk Pakam in 2025. The research employed a quantitative method with a cross-sectional design. All 33 registration officers were included as the sample using a total sampling technique. Data were collected through questionnaires and analyzed using the chi-square test with a significance level of 0.05. The results indicated that the majority of respondents (54.5%) used the Transmedic application optimally, with the same percentage reporting high efficiency in patient registration. Statistical testing revealed a significant relationship between the use of the Transmedic application and the efficiency of patient registration services (p = 0.001 < 0.05). It is recommended that hospital management optimize the use of the Transmedic application by improving infrastructure, ensuring the availability of adequate devices, stable internet connections, and regular system maintenance to prevent technical obstacles
Factors Associated with Community Perception of Public Safety Center (PSC) in Silinda District, Serdang Bedagai Regency
No full textThe Public Safety Center (PSC) serves as a rapid, precise, and careful response facility for communities in emergency situations, providing 24/7 services. This study aims to identify factors related to community perception of PSC in Silinda District, Serdang Bedagai Regency. Using a quantitative method with a cross-sectional design. The population in this study consists of all residents in Silinda District, Serdang Bedagai Regency, totaling 5,055 people. The sampling technique used in this study is purposive sampling. the study found that Education has the most significant influence on community perception of PSC, With P value = 0,000 and EXp(B) = 192,893. This indicates that individuals with higher education tend to have a more positive perception of PSC. The analysis concludes that Education and Knowledge are factors related to community perception of PSC in Silinda District. The conclusion is that public perception of the Public Safety Center (PSC) is influenced by several factors. There is no significant relationship between the age variable and public perception of the PSC. However, there is a significant relationship between the level of education and public knowledge and their perception of the PSC, indicating that the higher a person's education and knowledge, the more positive their perception of PSC services. Meanwhile, variables related to needs such as information, facilities and infrastructure, and healthcare personnel do not show a significant relationship with public perception. It is recommended to increase awareness and knowledge about PSC and its role in enhancing safety and security
Relationship Between the Mid-Upper Arm Circumference of Pregnant Women and the Birth Length of Newborn Babies.
No full textBirth length has been used as an indicator of infants' nutritional status, reflecting the results of linear fetal growth during pregnancy. Meanwhile, the nutritional status of pregnant women can be assessed using the mid-upper arm circumference (MUAC). In Indonesia, MUAC is primarily utilized to classify chronic energy deficiency (CED) and has not been explored as a predictor of infants' nutritional status based on birth length. This study aims to analyze the relationship between MUAC and birth length. A retrospective cohort study was conducted involving 55 pregnant women aged 20-35 years who attended prenatal check-ups and gave birth between January and December 2018. Data were collected from patient records at the Maternal and Child Health Unit of Pulokulon I Community Health Center in Grobogan Regency in July 2019. Pregnant women with incomplete data, those diagnosed with anemia, and babies born prematurely were excluded from the analysis. Data were analyzed using the Rank-Spearman correlation test with SPSS version 16. The analysis of maternal demographic characteristics revealed that only maternal age had a significant impact on the baby's birth length, with a Pearson correlation test showing p = 0.04. The average maternal mid-upper arm circumference was 26.01 ± 3.45 cm, while the average birth length was 48.76 ± 1.49 cm. The study concluded that there was no significant relationship between maternal mid-upper arm circumference and birth length (p-value = 0.931). Further research is needed across various community health centers, involving a larger sample size and additional maternal variables, to determine the effectiveness of mid-upper arm circumference as an indicator for predicting infants' nutritional status.
The analysis of the factors influencing the awareness of post-operative neurosurgery patients in the ICU of a hospital
No full textBackground: Nurses' caring behavior significantly affects the quality of service and patient satisfaction. However, in Indonesia, the quality of nurses' caring behavior is still relatively low. High workloads and low work motivation can affect the quality of nurses' caring behavior. This study aims to analyze the relationship between work motivation and workload on nurses' caring behavior at Puskesmas Tigalingga in 2025.Objective: This study aims to determine the relationship between work motivation and workload on nurses' caring behavior at Puskesmas Tigalingga in 2025. Research Method: This study uses a quantitative design with a non-experimental descriptive correlation approach. The study was conducted at Puskesmas Tigalingga with a population of 57 nurses and midwives. The sampling technique used was Total Sampling. Data were collected using questionnaires and analyzed using Chi-Square tests and multiple logistic regression. Results: The results of the study indicate a significant relationship between work motivation and caring behavior (p-value = 0.003), as well as between workload and caring behavior (p-value = 0.003). Logistic regression analysis showed that workload has the greatest impact on caring behavior, with an Odds Ratio (OR) = 12.49. Conclusion: Managing workload effectively and increasing work motivation are crucial for improving nurses' caring behavior. Both factors play an important role in improving the quality of nursing services and patient satisfaction at Puskesmas Tigalingga
Factors Associated with Unsafe Actions by Brick Makers in Tanjung Mulia Village Pagar Merbau District Deli Serdang Regency
No full textBrick maker is one of the informal sector industries that are mostly occupied by the people of Indonesia. Personal factors are one of the dominant factors influencing unsafe action, namely knowledge, training, workload and fatigue. This research is a quantitative study with an analytic observational study using a cross sectional study design. The purpose of this study is to explain the factors associated with unsafe action on brick makers in Tanjung Mulia Village, Pagar Merbau District in 2025. The number of samples was determined using simple random sampling method and obtained a sample of 53 workers. Data collection was carried out by interview using a questionnaire and observation sheet. The independent variables in this study are factors such as the level of knowledge, education and workload, while the dependent variable is unsafe action. The results showed that most brick makers experienced unsafe action with the category of lack of knowledge of 45 people (84.9%) and heavy workload category of 39 people (73.6%). There is a relationship between knowledge and unsafe action (p value = 0.002) and there is a relationship between workload and unsafe action (p value = 0.016). The conclusion of this study is that there is a relationship between the level of knowledge and workload with unsafe action. The advice that can be given is that every brick maker prioritizes safety and health while working in order to minimize unsafe action (unsafe action)
Evaluation of the Implementation of the Generic Regional Health Information System (SIKDA) Using the HOT-Fit Model Approach at Waihoka Community Health Center, Ambon City.
No full textHumans, organizations, and technology are essential components in the implementation of the Generic Regional Health Information System (SIKDA). To improve the quality of healthcare services at Waihoka Community Health Center in Ambon, it is expected that fast, precise, and accurate access to information will be available to support policy-making and decision-making in service delivery. This study is a descriptive qualitative research approach using in-depth interviews, observations, and document analysis conducted with seven informants: one key informant from SP3 of the Ambon City Health Office, two main informants (the head of Waihoka Community Health Center and the administrative head responsible for SIKDA), and four supporting informants. The research findings indicate that the implementation of the Generic Regional Health Information System (SIKDA) at Waihoka Community Health Center has not been optimal. Several challenges were identified, including performance issues, a lack of human resources, and limited facilities and infrastructure (computers) in KIA-KAB, MTBS, laboratory, dental clinic, and cashier units. Additionally, there is no official decree appointing SIKDA officers, no guideline books or standard operating procedures (SOPs) for using SIKDA, non-real-time data entry, system errors, and a lack of integration between the P-Care application and the Generic SIKDA system