1,590 research outputs found

    Ashburn Anstalt v WJ Arnold & Co. Ltd [1989] Ch 1, Court of Appeal

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    Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Ashburn Anstalt v WJ Arnold &amp; Co. Ltd [1989] Ch 1, Court of Appeal. The document also includes supporting commentary from author Aruna Nair.</p

    Treść i dynamika objawienia imienia Bożego w Księdze Wyjścia Część I: Analiza narracji Wj 3,16–24,18

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    The article addresses the significance of the formulas of the Divine Name: יְהוָה, אֶהְיֶה אֲשֶׁר אֶהְיֶה, and אֶהְיֶה (Exod 3:14–15). Referring to the narrative character of the Book of Exodus and assuming that the ambiguous formulas of the Divine Name in the initial part of the story are elements of a deliberate literary strategy, the author proposes interpreting these formulas using a narrative method. An analysis of two narrative sections of the Book of Exodus (3:16–18:27; 19:1–24:18) reveals that God, whose presence is initially depicted as concealed, is later portrayed, through the presentation of the Name formulas, as manifesting His presence through active intervention. The narrated events, in which YHWH acts on behalf of the Israelites against their enemies (Exod 3:16–18:27) and subsequently leads them to covenantal commitment (Exod 19:1–24:18), present God-YHWH as being. This notion clearly aligns with the declaration embedded in the Name formulas.Artykuł podejmuje zagadnienie znaczenia formuł imienia Bożego: יְהוָה, אֶהְיֶה אֲשֶׁר אֶהְיֶה oraz אֶהְיֶה (Wj 3,14-15). Odwołując się do narracyjnego charakteru Księgi Wyjścia oraz przyjmując założenie, że niejednoznaczne formuły imienia Bożego w początkowej części opowieści stanowią element przemyślanej strategii literackiej, autor proponuje tłumaczenie tych formuł za pomocą metody narratywnej. Przeprowadzona analiza dwóch fragmentów narracji Księgi Wyjścia (3,16–18,27; 19,1–24,18) pozwala zauważyć, iż Bóg, którego obecność na początkowym etapie opowieści zaprezentowana zostaje jako niejawna, wraz z przedstawieniem formuł imienia, ukazany zostaje jako manifestujący swoją obecność w aktywnym działaniu. Opowiedziane wydarzenia, w których JHWH jest podmiotem działającym na rzecz Izraelitów przeciw ich wrogom (Wj 3,16–18,27), a następnie doprowadzającym ich do zawarcia przymierza (Wj 19,1–24,18), ukazują Boga-JHWH jako będącego, co w czytelny sposób koresponduje z deklaracją zawartą w formułach imienia

    The role of exergaming in Parkinson’s disease rehabilitation: a systematic review of the evidence

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    Evidence for exercise based computer games (exergaming) as a rehabilitation tool for people with Parkinson’s disease (PD) is only now emerging and is yet to be synthesised. To this end, we conducted a systematic review of the exergaming literature to establish what is known about the safety, feasibility and effectiveness of exergaming for rehabilitation of motor symptoms experienced by people with PD. Seven electronic databases were searched for key terms surrounding exergaming and PD. Data were extracted by two reviewers independently. From an initial yield of 1217 articles, seven were included in the review. Six studies used commercial games with the Nintendo Wii fit platform. The scientific quality of reporting was generally good, however the overall methodological design of studies was weak, with only one randomised controlled trial being reported. Safety: Participant safety was not measured in any of the studies. Feasibility: People with PD were able to play exergames, improve their performance of gameplay and enjoyed playing. However, one study observed that people with PD had difficulty with fast and complex games. Effectiveness: Six studies showed that exergaming elicited improvements in a range of clinical balance measures or reduction in the severity of motor symptoms. Results from the only randomised controlled trial showed that exergaming was as effective as traditional balance training for people with PD to improve the UPDRS II, standing balance and cognition, with improvements in both groups retained 60 days after the training ended. In conclusion, exergaming is an emerging tool to help rehabilitate motor skills in people with PD. Although we were able to establish that exergaming is feasible in people with PD, more research is needed to establish its safety and clinical effectiveness, particularly in the home. The use of commercial games may be too difficult for some people with PD and exergames tailored specifically to the rehabilitation needs and capabilities of people with PD are required for optimal efficacy, adherence and safety

    Processing of acoustic cues for voicing in English: a MMN study

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    Speech perception normally utilizes multiple acoustic cues in perception of specific speech sound contrast. This study investigates which acoustic cues are responsible for syllable final stop consonant voicing in English using speech and non-speech stimuli. Specifically we study vocalic duration and F1 offset frequency cues using three experimental paradigms. Two paradigms used behavioural methods and explored identification (Exp1) and discrimination (Exp2) and one an electrophysiological method to investigate the neural correlates of processing in a mismatch negativity (MMN) experiment (Exp3). In Exp1 we presented the [bot]-[bod] continuum varying either in duration or F1 cues. Exps 2 and 3 employed a 2 (Frequency: high low) x 2 (Duration (long, short) design resulting in four different versions of English non-words [bot] and [bod] and their corresponding non-speech analogues. Nine subjects participated in Exp 1 and eight in Exps 2 & 3. The findings from Exp 1 revealed that the duration cue plays an important role in British English syllable final stop voicing. Further support for this finding was revealed in Exp 3 with larger MMN amplitude for the duration cue compared with the frequency cue

    Pre-pausal devoicing and glottalisation in varieties of the south-western Arabian peninsula

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    A wide range of modern Arabic dialects exhibit devoicing in pre-pausal (utterance-final) position. These include Cairene [20], Gulf Arabic, San’ani [8], [18], Manaxah [19], Central Highland Yemeni dialects [1], Rijal Alma‘ (Asiri p.c.), Central Sudanese (Dickins p.c.), Çukurova [15], Kinderib [9], E. Fayyum [2]. In some dialects, pausal devoicing is reported to be accompanied by aspiration (e.g. Cairene, [19]), in others by glottalisation (e.g. Fayyum, [2]; Manaxah, [18]; San’ani, [8], [18]). As preliminary work to a study of pausal phenomena in the south-western Arabian Peninsula, we examine data from two Arabic dialects – San’ani (SA), spoken in the Old City of San’a, Yemen, and the Asiri dialect of Rijal Alma‘ (RA) – and from Mehriyōt, an eastern dialect of the modern south Arabian language, Mehri, spoken in Yemen. We begin by presenting a summary of pausal phenomena in SA. We then consider the behaviour of final oral stops – velar, coronal and labial – final coronal fricatives, final nasals and liquids, and final vowels. Initial comparison with data from RA and Mehriyōt indicates that utterance-final devoicing is more advanced in SA than in the other varieties, and involves a greater range of segment types. The first set of pausal examples were extracted from Watson’s recordings of spontaneous SA monologues on the Semitic Spracharchiv. The main speaker is a young semi educated woman.1 Those forms which exist as lexemes in RA, plus lexemes involving similar pre-pausal segments in comparable syllable types, were recorded utterance-finally by Yahya Asiri, a native speaker of RA. Pausal forms for Mehriyōt were extracted from the late Alexander Sima’s recordings of spontaneous speech on the Semitic sound archive [16]. The Mehriyōt speaker is a low- to semi-educated early middle-aged man. Data were analysed using the phonetic analysis programme PRAAT (www.praat.org)

    Treść i dynamika objawienia imienia Bożego w księdze Wyjścia Część II: Analiza narracji Wj 25,1-40,38

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    The article constitutes a continuation of the study addressing the significance of the formulas of the Divine Name: יְהוָה, אֶהְיֶה אֲשֶׁר אֶהְיֶה, and אֶהְיֶה (Exod 3:14–15). The analysis focuses on the subsequent textual material of the Book of Exodus (Exod 25:1–40:38), where YHWH is primarily portrayed as manifesting His presence in the Tabernacle, which He commands to be built as His dwelling place. Applying the method of narrative analysis to the entirety of the narrative material, the author concludes that the primary communicative aim of the book is to present God as being. This concept is signaled in the formulas of the Divine Name and confirmed throughout the narrative representation of the events. The depiction of YHWH’s presence intensifies progressively as the narrative unfolds, with God transitioning from an unknown name and imperceptible presence to being known by the name YHWH and permanently present among the Israelites.Artykuł stanowi kontynuację studium podejmującego temat znaczenia formuł imienia Bożego: יְהוָה, אֶהְיֶה אֲשֶׁר אֶהְיֶה oraz אֶהְיֶה (Wj 3,14-15). Analizie poddana zostaje dalsza partia materiału tekstualnego Księgi Wyjścia (Wj 25,1–40,38), gdzie JHWH zaprezentowany jest przede wszystkim jako manifestujący swoją obecność w przybytku, który nakazuje zbudować na mieszkanie dla siebie. Stosując metodę analizy narratywnej do całości materiału narracyjnego, autor dochodzi do wniosku, że głównym celem komunikacyjnym księgi jest ukazanie Boga jako będącego, co jest sygnalizowane w formułach imienia Bożego i potwierdzone w całej narracyjnej reprezentacji wydarzeń. Prezentacja obecności JHWH staje się coraz bardziej intensywna wraz z postępem narracji, a Bóg przechodzi od nieznanego imienia i niedostrzegalnej obecności do bycia znanym w imieniu JHWH i trwale obecnym pośród Izraelitów

    Depth Control for Blind Water Jet Drilling in Bone

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    Abstract - When surgically drilling blind holes in bone using a Water Jet (WJ), control over the resulting depth is a challenging issue of paramount concern. This thesis was part of a project aimed at replacing the awl and mallet technique used in traditional microfracture procedures with an arthroscopic high-pressure WJ instrument is capable of accurately drilling 2–4 mm deep holes in subchondral bone. The focus of this paper was to develop, analyze and evaluate concepts for ensuring the depthwise accuracy of a microfracturing WJ. Research was performed on both WJ systems and the microfracture procedure, and a thorough problem analysis detailing all concerning requirements and parameters was set up. It was determined that due to the strong non-uniformity of human bone, both spatially and between subjects, a WJ capable of monitoring the depth and implementing a closed-loop control system was needed to ensure safe and accurate drilling. To measure the depth of the hole and allow for feedback control, a flexible Nickel Titanium probe concept was devised and tested. The concept featured a 3D printed nozzle with built-in WJ orifice and depth probe, which could be extended down the hole made by the WJ by an ex-vivo actuator featurimg load and displacement sensors. When the load sensor detected a sudden rise in extension resistance, bottom contact was assumed and the hole depth was calculated based on the displacement of the probe. A proof-of-concept experiment showed the viability of using a flexible probe to measure the depth. Additionally, the algorithm produced for calculating the depth was shown to be robust against the hysteresis and backlash exhibited by the setup. When probing holes with depths of 0, 1, 2, 3, 4 and 5 mm and bore diameters of 1, 1.5, and 2 mm drilled in solid PMMA, the prototype managed an error mean of 0.00 mm with a SD of 0.19 mm. To test the probe in holes shaped as expected during microfracture surgery, a virtual interference experiment was carried out using mCT scans of WJ-drilled bones and simulated probes of varying diameters. Seven scans were probed from 4 different angles each; the results suggested that a probe with a 0.2–0.3 mm diameter was optimal in terms of traversing the hole without blockages and without risking over-penetration. Moreover, this thesis produced recommendations on carrying the project further, towards a fully integrated system capable of drilling accurate blind holes in human bone, in a closed-loop depth-controlled manner.BMEBioMechanical EngineeringMechanical, Maritime and Materials Engineerin

    Mojżesz wysłannik Jahwe (Wj 1,1–14,31)

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    The Exodus of&nbsp;the Israelites from Egypt was the most important event in the history of&nbsp;the Chosen People. The historical and theological context of&nbsp;the biblical events contained in Exodus 1:1–14:31 was described.The aim of&nbsp;the research became the analysis and interpretation of&nbsp;the theological message contained in the first part of&nbsp;the Exodus recounting the liberation of&nbsp;the Israelites from Egyptian slavery (Exodus 1:1–14:31).In the analysis and exegesis of&nbsp;biblical texts, the intertextual method was used, as well as the historical-critical method over the issue of&nbsp;Moses’ mission.As a&nbsp;result of&nbsp;the study, it can be concluded that: 1) the knowledge of&nbsp;the God of&nbsp;Israel and His intentions is the key theme of&nbsp;the first fifteen chapters of&nbsp;the Exodus. Yahweh is the main protagonist of&nbsp;the events described in the Book of&nbsp;Exodus. He is their author and perpetrator; 2) the theme of&nbsp;the first part of&nbsp;the Exodus is the conflict over whom Israel is to serve; 3) the historical sources do not reflect in their entirety the facts known from the biblical account, for the reason that the Bible is not a&nbsp;historical chronicle, but a&nbsp;record of&nbsp;God’s revelation. Its main task is to convey theological content.The conclusions to be drawn are: 1) the revelation that was to Moses also applies to the Israelites, as well as to the Egyptians. However, the times and the manner of&nbsp;revelation change. God’s words are addressed to everyone, including modern people.The study conducted does not exhaust the subject of&nbsp;Moses’ mission to Israel. It is not a&nbsp;complete characterization of&nbsp;Moses. At the same time, it is necessary to keep in mind the further impact of&nbsp;the message of&nbsp;the Exodus on subsequent generations of&nbsp;Israel, as well as on modern times. The study can become a&nbsp;contribution to further theological reflection on the message of&nbsp;the Exodus.Wyjście Izraelitów z&nbsp;Egiptu było najważniejszym wydarzeniem w&nbsp;historii narodu wybranego. Został opisany kontekst historyczno-teologiczny wydarzeń biblijnych zawartych w&nbsp;Wj&nbsp;1,1–14,31.Celem badań stała się analiza i&nbsp;interpretacja przesłania teologicznego zawartego w&nbsp;pierwszej części Księgi Wyjścia opowiadającej o&nbsp;wyzwoleniu Izraelitów z&nbsp;niewoli egipskiej (Wj&nbsp;1,1–14,31).Przy analizie i&nbsp;egzegezie tekstów biblijnych wykorzystano metodę intertekstualną, a&nbsp;także historyczno-krytyczną nad zagadnieniem misji Mojżesza.W&nbsp;wyniku przeprowadzonych badań można stwierdzić, że: 1) poznanie Boga Izraela i&nbsp;Jego zamiarów jest kluczowym tematem pierwszych piętnastu rozdziałów Księgi Wyjścia. Jahwe jest głównym bohaterem wydarzeń opisanych w&nbsp;Księdze Wyjścia. On jest ich sprawcą i&nbsp;autorem; 2) tematem pierwszej części Księgi Wyjścia jest konflikt o&nbsp;to, komu służyć ma Izrael; 3) źródła historyczne nie odzwierciedlają w&nbsp;całości faktów znanych z&nbsp;relacji biblijnej, dlatego że Biblia nie jest kroniką historyczną, lecz zapisem objawienia Bożego. Jej głównym zadaniem jest przekaz treści teologicznej.Wnioski, jakie należy wyciągnąć to: 1) objawienie, które było do Mojżesza, dotyczą także Izraelitów, jak i&nbsp;do Egipcjan. Zmieniają się jednak czasy i&nbsp;sposób objawienia. Słowa Boga skierowane są do wszystkich, również do ludzi współczesnych.Przeprowadzone badania nie wyczerpują tematu misji Mojżesza względem Izraela. Nie jest pełną charakterystyką Mojżesza. Należy przy tym pamiętać o&nbsp;dalszym oddziaływaniu przesłania Księgi Wyjścia na kolejne pokolenia Izraela, a&nbsp;także na czasy współczesne. Badanie mogą stać się przyczynkiem do dalszej refleksji teologicznej nad przesłaniem Księgi Wyjścia

    Mitochondrial metabolism reveals a functional architecture in intact islets of Langerhans from normal and diabetic Psammomys obesus

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    The cells within the intact islet of Langerhans function as a metabolic syncytium, secreting insulin in a coordinated and oscillatory manner in response to external fuel. With increased glucose, the oscillatory amplitude is enhanced, leading to the hypothesis that cells within the islet are secreting with greater synchronization. Consequently, non-insulin-dependent diabetes mellitus (NIDDM; type 2 diabetes)-induced irregularities in insulin secretion oscillations may be attributed to decreased intercellular coordination. The purpose of the present study was to determine whether the degree of metabolic coordination within the intact islet was enhanced by increased glucose and compromised by NIDDM. Experiments were performed with isolated islets from normal and diabetic Psammomys obesus. Using confocal microscopy and the mitochondrial potentiometric dye rhodamine 123, we measured mitochondrial membrane potential oscillations in individual cells within intact islets. When mitochondrial membrane potential was averaged from all the cells in a single islet, the resultant waveform demonstrated clear sinusoidal oscillations. Cells within islets were heterogeneous in terms of cellular synchronicity (similarity in phase and period), sinusoidal regularity, and frequency of oscillation. Cells within normal islets oscillated with greater synchronicity compared with cells within diabetic islets. The range of oscillatory frequencies was unchanged by glucose or diabetes. Cells within diabetic (but not normal) islets increased oscillatory regularity in response to glucose. These data support the hypothesis that glucose enhances metabolic coupling in normal islets and that the dampening of oscillatory insulin secretion in NIDDM may result from disrupted metabolic coupling. <br/
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