303 research outputs found
Confusões de escala e espelhamentos em Instantâneo da desmedida, de Vilma Arêas
No full textThis article aims to analyze the mirroring present in “Instantâneo da desmedida,” the penultimate text in Um beijo por mês (2018), by Vilma Arêas. By locating her character in an art gallery with photographs of diferente scales, the author enables an endless game capable of generating reflections around literary art itself, since the arrangement of objects articulates occurrences that disturb the spectator, confusing her as to the real scale of scenes and spaces, like the “snapshots” of Arêas's volume. Based on these considerations, we highlight mise en abyme as one of the foundations of Vilma Arêas' writing. To this end, the proposal for a possible analysis of the mentioned text is launched here from the formulations of Lucien Dallenbach (1979; 1977; 1972), among other theorists. Furthermore, André Malraux's (2006; 1996) reflections on the imaginary museum will help in the discussion.Este artículo busca analizar el reflejo presente en Instantâneo da desmedida, penúltimo texto de Um beijo por mês (2018), de Vilma Arêas. Al crear un personaje que, en una visita a una galería de arte, se encuentra con fotografías de diferentes escalas, el autor permite un juego abismal capaz de generar reflexiones en torno al arte literario, ya que la disposición de los objetos articula acontecimientos que perturban a la espectadora, confundiéndola en cuanto a la escala real de escenas y espacios, como las "instantáneas" del volumen de Arêas. En base a estas consideraciones, destacamos mise en abyme como uno de los fundamentos de la escritura de Vilma Arêas. Con este fin, la propuesta para un posible análisis del texto mencionado se lanza aquí a partir de las formulaciones de Lucien Dallenbach (1979; 1977; 1972), entre otros teóricos. Además, las reflexiones de André Malraux (2006; 1996) sobre el museo imaginario ayudarán en la discusión.Este artigo busca analisar o espelhamento presente em Instantâneo da desmedida, penúltimo texto de Um beijo por mês (2018), de Vilma Arêas. Ao criar uma personagem que, em visita a uma galeria de arte, depara-se com fotografias de diferentes escalas, a autora possibilita um jogo abismal capaz de gerar reflexões em torno da própria arte literária, uma vez que o arranjo dos objetos articula ocorrências que perturbam a espectadora, confundindo-a quanto à real escala das cenas e espaços, tais como os “instantâneos” do volume de Arêas. Com base nessas considerações, salientamos a mise en abyme como uma das bases de produção da escrita de Vilma Arêas. Para tanto, lança-se aqui a proposta de uma análise possível ao texto mencionado a partir das formulações de Lucien Dallenbach (1979; 1977; 1972), entre outros teóricos. Ademais, as reflexões de André Malraux (2006; 1996) acerca do museu imaginário auxiliarão na discussão
Suspension of boundaries: transdifferentiation in Vilma Vukelić’s memoirs. A contribution to the retention of Austrian literature and culture in post-1918 Croatia
No full textThe memoirs of the Croatian-Austrian author Vilma Vukelić capture the identity of the city of Osijek at the turn of the 19th and the 20th centuries, as well as the personal identity of the author, who is first portrayed as a child and then as a young girl, Vilma. Earlier analyses of the text were based on multicultural perspectives which provide only a superficial insight into the complex processes of identity formation as it is described in Tragovi prošlosti (the original title: Spuren der Vergangenheit). The article thus presents the culturalist concept of transdifference developed by Breinig and Lösch. The core of the concept is a process of identity formation which flows through differences while suspending the imposed binary structure, without revoking them. The method has proved to be effective and brought a new perspective on belonging and alterity in the multicultural imperial setting
Stem cell renewal : germinal progenitor plasticity and role of the Fancg gene in the hematopoietic stem cell functions
No full textLa préservation d’un stock de cellules souches fonctionnelles est indispensable pour le maintien de nombreux tissus chez l’adulte. Les cellules souches se multiplient pour s’auto-renouveller et entrent en différenciation donnant naissance à des progéniteurs puis à des cellules matures. Récemment, la possibilité pour les progéniteurs de se reprogrammer en cellules souches et de réacquérir un potentiel de régénération à long terme a été suggérée notamment dans le tissu germinal. Ainsi, l’auto-renouvellement et la reprogrammation des progéniteurs pourraient jouer un rôle dans le maintien du pool de cellules souches. Mon travail de thèse portait sur l’étude de ces deux mécanismes de régénération des cellules souches chez la souris. J’ai tout d’abord étudié la reprogrammation des progéniteurs germinaux au cours de la spermatogenèse. Ce travail montre la capacité des progéniteurs germinaux mâles, les spermatogonies différenciées, à modifier leur programme de différenciation et à générer de nouvelles cellules souches germinales après transplantation testiculaire. Les progéniteurs germinaux pourraient ainsi constituer une réserve de « cellules souches potentielles ». Le tissu germinal possède donc une certaine plasticité. La seconde partie de mon travail porte sur l’implication du gène Fancg de l’anémie de Fanconi, voie de réponse aux dommages à l’ADN, dans l’auto-renouvellement et la fonctionnalité des cellules souches hématopoïétiques au cours de l’hématopoïèse. L’intégrité génétique des cellules souches doit en effet être préservée tout au long de la vie de l’individu. Cette étude montre que l’invalidation du gène Fancg perturbe le processus de migration, la quiescence, et la régulation de l’expression de certains gènes clés des fonctions des cellules souches. Ces altérations participent au déficit fonctionnel des cellules souches hématopoïétiques observées dans le modèle murin Fancg-/-.The long-term maintenance of the stem cell pool is necessary to preserve the functionality of an organ throughout life. Stems cells proliferate in order to selfrenew or to be committed to differentiate to produce progenitors and finally highly specialized cells. Recent reports have suggested that germinal progenitors could reprogram into stem cells and reacquire a potential to regenerate tissue at long-term. Thus, the stem cell selfrenewal process and the reprogramming of progenitors could play a role in the maintenance of the stem cell pool. The project of my thesis focused on those two mechanisms of stem cell regeneration in the mouse model. First, I investigated the reprogramming process of the germinal progenitors during spermatogenesis. Our results show that male germinal progenitors, the differentiating spermatogonia, can change their differentiation program and generate new functional germinal stem cells after testicular transplantation. The germinal progenitors could constitute a pool of potential stem cell, and underscores the plasticity of the germinal lineage. A second part of my project dealt with the involvement of fancg, a gene of the Fanconi anemia DNA damage response pathway, in the selfrenewal and in the functions of the hematopoietic stem cells. The maintenance of the genetic integrity throughout life is particulary important for stem cells in order to safeguard the stem cell pool. Our study show that fancg deficiency induces the impairment of the migration potential and of the quiescence of stem cells, and modifies the expression of several key genes regulating stem cell functions. Those alterations contribute to the functional impairment of the hematopoietic stem cells observed in Fancg-/- mice
Renouvellement des cellules souches : plasticité des progéniteurs germinaux et rôle du gène Fancg dans la fonction des cellules souches hématopoïétiques
No full textThe long-term maintenance of the stem cell pool is necessary to preserve the functionality of an organ throughout life. Stems cells proliferate in order to selfrenew or to be committed to differentiate to produce progenitors and finally highly specialized cells. Recent reports have suggested that germinal progenitors could reprogram into stem cells and reacquire a potential to regenerate tissue at long-term. Thus, the stem cell selfrenewal process and the reprogramming of progenitors could play a role in the maintenance of the stem cell pool. The project of my thesis focused on those two mechanisms of stem cell regeneration in the mouse model. First, I investigated the reprogramming process of the germinal progenitors during spermatogenesis. Our results show that male germinal progenitors, the differentiating spermatogonia, can change their differentiation program and generate new functional germinal stem cells after testicular transplantation. The germinal progenitors could constitute a pool of potential stem cell, and underscores the plasticity of the germinal lineage. A second part of my project dealt with the involvement of fancg, a gene of the Fanconi anemia DNA damage response pathway, in the selfrenewal and in the functions of the hematopoietic stem cells. The maintenance of the genetic integrity throughout life is particulary important for stem cells in order to safeguard the stem cell pool. Our study show that fancg deficiency induces the impairment of the migration potential and of the quiescence of stem cells, and modifies the expression of several key genes regulating stem cell functions. Those alterations contribute to the functional impairment of the hematopoietic stem cells observed in Fancg-/- mice.La préservation d’un stock de cellules souches fonctionnelles est indispensable pour le maintien de nombreux tissus chez l’adulte. Les cellules souches se multiplient pour s’auto-renouveller et entrent en différenciation donnant naissance à des progéniteurs puis à des cellules matures. Récemment, la possibilité pour les progéniteurs de se reprogrammer en cellules souches et de réacquérir un potentiel de régénération à long terme a été suggérée notamment dans le tissu germinal. Ainsi, l’auto-renouvellement et la reprogrammation des progéniteurs pourraient jouer un rôle dans le maintien du pool de cellules souches. Mon travail de thèse portait sur l’étude de ces deux mécanismes de régénération des cellules souches chez la souris. J’ai tout d’abord étudié la reprogrammation des progéniteurs germinaux au cours de la spermatogenèse. Ce travail montre la capacité des progéniteurs germinaux mâles, les spermatogonies différenciées, à modifier leur programme de différenciation et à générer de nouvelles cellules souches germinales après transplantation testiculaire. Les progéniteurs germinaux pourraient ainsi constituer une réserve de « cellules souches potentielles ». Le tissu germinal possède donc une certaine plasticité. La seconde partie de mon travail porte sur l’implication du gène Fancg de l’anémie de Fanconi, voie de réponse aux dommages à l’ADN, dans l’auto-renouvellement et la fonctionnalité des cellules souches hématopoïétiques au cours de l’hématopoïèse. L’intégrité génétique des cellules souches doit en effet être préservée tout au long de la vie de l’individu. Cette étude montre que l’invalidation du gène Fancg perturbe le processus de migration, la quiescence, et la régulation de l’expression de certains gènes clés des fonctions des cellules souches. Ces altérations participent au déficit fonctionnel des cellules souches hématopoïétiques observées dans le modèle murin Fancg-/-
Aplicación de las metáforas y la realidad virtual en bibliotecas: El proyecto VILMA
No full textThe evolution of user interfaces has been mainly guided by a single principle: the challenge of approximating the design model of the system to the user. During the last years a new trend has been arising in the user interface design field: the virtual reality, that it can be considered as a natural progress in the human computer interaction evolution.Digital libraries can take advantage of virtual reality as VILMA (VIrtual Library with a Multi-layer Architecture) does. This digital library uses the traditional library metaphor. (Author)La evolución de las interfaces de usuario se ha guiado básicamente por un principio: el reto de aproximar el modelo de diseño del sistema al usuario. En los últimos años se ha ido desarrollando una nueva tendencia en el diseño de las interfaces de usuario, la realidad virtual, que puede ser considerada como una progresión natural en la evolución de la interacción persona-ordenador. Las bibliotecas electrónicas pueden aprovecharse de las ventajas de la realidad virtual como lo hace VILMA (VIrtual Library with a Multi-layer Architecture). Se presenta esta biblioteca electrónica, que utiliza la metáfora de la biblioteca tradicional mediante el uso de la realidad virtual. (Autor
Diálogos intertextuais e traços memorialísticos em A solidão mais funda, de Ângela Vilma
No full textABSTRACT: This article analyzes the poetic production of the book A solidão mais funda, by the author from Bahia Ângela Vilma, from the perspective that there are two movements in the work. In the first, there are poems that try to dialogue with canonical authors, such as Fernando Pessoa, Cecília Meireles, Vinícius de Moraes, Carlos Drummond de Andrade, Manuel Bandeira, among others. In the second, there is a memorialistic trace, heir above all from Herberto Sales, an author whose work the poet had read since her adolescence. For this, we use the concepts of remembrance and reminiscence of Walter Benjamin (1892-1940), according to which the writer's act of remembering comes not only from his recollection, but also articulates memory and creative imagination, which is also treated by Gaston Bachelard (1884-1962). Thus, the poet starts from recollections, consciously or unconsciously: sometimes reconfiguring them according to the imagination of the lyrical self, sometimes fictionalizing them, making the reader live again their subjectivities.RESUMO: O presente artigo analisa a produção poética do livro A solidão mais funda, da autora baiana Ângela Vilma, sob a perspectiva de que existem, na obra, dois movimentos. No primeiro, poemas que ensaiam dialogar com autores canônicos, como Fernando Pessoa, Cecília Meireles, Vinícius de Moraes, Carlos Drummond de Andrade, Manuel Bandeira, entre outros. No segundo, está presente o traço memorialístico, herdeiro sobretudo de Herberto Sales, autor cuja obra a poeta lia desde a adolescência. Para isso, valemo-nos dos conceitos de recordação e reminiscência de Walter Benjamim (1892-1940), segundo o qual, o ato de lembrar do escritor provém não só de sua rememoração, como também articula memória e imaginação criativa, que também é tratado Gaston Bachelard (1884-1962). Assim, a poeta parte de rememorações, consciente ou inconscientemente: ora reconfigurando-as segundo a imaginação do eu-lírico, ora ficcionalizando-as, fazendo o leitor reviver suas subjetividades.
 
Germline Stem Cells: The First Guards of Heredity
No full textThe genes involved in the cellular response to DNA damage are crucial for ensuring DNA integrity during spermatogenesis. In this issue of Cell Stem Cell, Takubo et al. (2008) show that ATM, a key kinase of the DNA damage response, is also involved in maintaining the stem cell potential of undifferentiated spermatogonia
"Analysis of adaptation process. ab ""grigeo"" case.
No full textANALYSIS OF ADAPTATION PROCESS AB “GRIGEO” CASE VILMA ULINSKĖ Bachelor thesis Management and business administration programme Vilnius University, Faculty of Economics and Business administration Supervisor – assoc. prof. dr. Roma Adomaitienė Vilnius, 2021 Summary 74 pages, 27 pictures, 8 tables, 41 references. The main purpose of this paper is, based on detailed literature analysis of adaptation process and tools applied, to adapt and use the knowledge, gained by this method, for researching the adaptation process of the selected company and providing practical suggestions for process improvement. The work consists of two main parts: literature analysis, the research, its results and proposals for process improvement. Literature analysis reviews the concepts of adaptation and socialization, their differences and similarities, examines in detail, the stages of the process presented by different authors and the tools used in it, identifies the benefits of the adaptation process and its tools for companies. After the literature analysis, author continued researching the adaptation process and tools of the selected company, by using interview and questionnaire methods. Information, received by interviewing Recruitment and Talent Acquisition Group Manager, was used to create questionnaires. 2 questionnaires were created: for employees, who are working in a company a year and less, and to their direct managers. The main purpose of the interview was to examine all segments of the adaptation process from the perspective of the Human Resources Department. The purpose of the questionnaires was to find out whether the adaptation process creates a system, and whether the tools used are effective. The performed research revealed that not all the tools are effective and even not used for part of employees, the process does not create a system. The conclusions and recommendations summarize the main concepts of literature analysis and the results of the performed research. Suggestions include practical proposals, created or renewed by the author, how to improve the process. Few of it are included in to the company HR Management Procedure
Diagnostics of neuroinfection caused by human herpesviruses using nucleic acid amplification methods
No full textof thesis Diagnostics of neuroinfection caused by human herpesviruses using nucleic acid amplification methods author: MUDr. Klára Labská supervisor: doc. MUDr. Vilma Marešová, CSc. In recent years, the diagnosis of neuroinfections has undergone a shift towards molecular biology methods. Our research focused on the predictive value of the capture of herpesvirus (HV) DNA in cerebrospinal fluid. In the first study, we examined the presence of DNA neurotropic herpes viruses (HSV1, HSV2, VZV and HHV6) in cerebrospinal fluid in immunocompetent patients with laboratory-confirmed tick-borne meningoencephalitis and enterovirus meningitis and meningoencephalitis. The control group consisted of patients with proven absence of an inflammation in the cerebrospinal fluid. Patients were followed for 6 months. The course of the disease and its consequences, including laboratory tests, were compared between groups of patients with and without the presence of HV DNA. In the second study, we tried to demonstrate the presence of HSV1 DNA in cerebrospinal fluid during its symptomatic reactivation in patients with purulent meningitis. In our group of immunocompetent patients with non-purulent inflammation in the cerebrospinal fluid, the proportion of HV DNA positive patients reached 7.5% (13 out of 173), we also..
Diagnostics of neuroinfection caused by human herpesviruses using nucleic acid amplification methods
No full textof thesis Diagnostics of neuroinfection caused by human herpesviruses using nucleic acid amplification methods author: MUDr. Klára Labská supervisor: doc. MUDr. Vilma Marešová, CSc. In recent years, the diagnosis of neuroinfections has undergone a shift towards molecular biology methods. Our research focused on the predictive value of the capture of herpesvirus (HV) DNA in cerebrospinal fluid. In the first study, we examined the presence of DNA neurotropic herpes viruses (HSV1, HSV2, VZV and HHV6) in cerebrospinal fluid in immunocompetent patients with laboratory-confirmed tick-borne meningoencephalitis and enterovirus meningitis and meningoencephalitis. The control group consisted of patients with proven absence of an inflammation in the cerebrospinal fluid. Patients were followed for 6 months. The course of the disease and its consequences, including laboratory tests, were compared between groups of patients with and without the presence of HV DNA. In the second study, we tried to demonstrate the presence of HSV1 DNA in cerebrospinal fluid during its symptomatic reactivation in patients with purulent meningitis. In our group of immunocompetent patients with non-purulent inflammation in the cerebrospinal fluid, the proportion of HV DNA positive patients reached 7.5% (13 out of 173), we also..
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