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Expression of proinflammatory and fibrotic cytokines in synovial tissue during hip osteoarthritis and carpal tunnel syndrome
No full textCiljevi istraživanja: Utvrditi serumsku koncentraciju i lokalni tkivni izražaj upalnih citokina
TNF-α, IL-1ß te fibrotičkih i antifibrotičnih činitelja TGF-ß1 i BMP-7 u sinovijalnoj
membrani zgloba kuka kod osteoartritisa (OA) i subsinovijalnom tkivu kod sindroma
karpalnog tunela (SKT) u bolesnika sa i bez komorbiditeta ove dvije bolesti.
Ispitanici i metode: U istraživanju je sudjelovalo 60 bolesnika zaprimljenih u bolnicu radi
kirurškog liječenja ugradnje totalne endoproteze zgloba kuka zbog OA te kirurške
dekompresije karpalnog tunela kod pacijenata sa SKT. U istraživanju je sudjelovalo 15
zdravih ispitanika kod kojih je mjerena serumska vrijednost istraživanih činitelja te je korišten
kadaverični tkivni materijal na kojem je analiziran tkivni izražaj i lokalizacija istih činitelja.
Imunohistokemijskom metodom utvrđivan je lokalni tkivni izražaj TNF-α, IL-1ß, TGF-ß1 i
BMP-7 u sinovijalnoj membrani kod OA zgloba kuka i subsinovijalnom tkivu kod SKT, a
njihova serumska koncentracija određivana je ELISA metodom.
Rezultati: Serumske razine BMP-7, IL-1β i TNF-α u bolesnika sa SKT, OA i skupini zdravih
ispitanika bila je unutar normalnog raspona i nije se značajno razlikovala među skupinama,
dok je serumska razina TGF-β1 bila značajno viša u skupini SKT bolesnika (16,36 pg/ml;
p<0,0001). Serumska razina BMP-7 bila je značajno viša u bolesnika kojima je
dijagnosticiran OA i SKT u komorbiditetu (2,6 pg/ml, 3,2 pg/ml, p<0,0001). Lokalnog
tkivnog izražaja IL-1ß i TGF-ß1 nije bilo niti u jednoj skupini ispitanika OA i SKT, dok je
umjereni izražaj TNF-α utvrđen u sinoviocitima i perivaskularnoj stromi sinovijalne
membrane OA ispitanika te izraziti izražaj BMP-7 u sinovijalnoj membrani OA ispitanika i u
subsinovijalnom tkivu ispitanika sa SKT.
Zaključak: Rezultati ukazuju na značaj razlika serumskih razina i lokalnog tkivnog izražaja
fibrotičkih i morfogenetskih citokina TGF-ß1 i BMP-7 u bolesnika sa i bez komorbiditeta OA
i SKT.Objectives: To determine the serum concentration and local tissue expression of
inflammatory cytokines TNF-α, IL-1ß and fibrotic and antifibrotic factors TGF-ß1 and BMP -
7 in the synovial membrane of the hip joint in OA and subsynovial tissue in CTS in patients
with and without comorbidity of these two diseases.
Patients and methods: In this study60 patients were participated which were undergoing
surgical treatment for total hip arthroplasty due to severe OA, and surgical decompression of
the carpal tunnel in patients with end stage of CTS. Also, 15 healthy subjects participated in
the research, in whom the serum value of the investigated factors were measured.
Furthermore, cadaveric tissue material was used for the control of tissue expression and
localization of the inflammatory and fibrotic factors. The local tissue expression of TNF-α,
IL-1ß, TGF-ß1 and BMP-7 in the synovial membrane in OA of the hip joint and in the
subsynovial tissue in CTS was determined by the immunohistochemical method, and their
serum concentration was determined by the ELISA method.
Results: The serum levels of BMP-7, IL-1β and TNF-α in patients with CTS, OA and the
group of healthy subjects were within the normal range and did not differ significantly
between these groups, while the serum level of TGF-β1 was significantly higher in the group
of CTS patients (16.36 pg/ml; p < 0.0001). The serum level of BMP-7 was significantly
higher in patients diagnosed with both OA and CTS (2.6 pg/ml, 3.2 pg/ml, p<0.0001). There
was no local tissue expression of IL-1ß and TGF-ß1 in any group of subjects with OA and
CTS, while moderate expression of TNF-α was found in synoviocytes and perivascular
stroma of the synovial membrane of OA subjects, and strong expression of BMP-7 both in the
synovial membrane of OA subjects and in the subsynovial tissue of subjects with CTS.
Conclusion: The results indicate the significance of differences in serum levels and local
tissue expression of fibrotic and morphogenic cytokines TGF-ß1 and BMP-7 in patients with
and without comorbidities of OA and SKT
Expression of proinflammatory and fibrotic cytokines in synovial tissue during hip osteoarthritis and carpal tunnel syndrome
No full textCiljevi istraživanja: Utvrditi serumsku koncentraciju i lokalni tkivni izražaj upalnih citokina
TNF-α, IL-1ß te fibrotičkih i antifibrotičnih činitelja TGF-ß1 i BMP-7 u sinovijalnoj
membrani zgloba kuka kod osteoartritisa (OA) i subsinovijalnom tkivu kod sindroma
karpalnog tunela (SKT) u bolesnika sa i bez komorbiditeta ove dvije bolesti.
Ispitanici i metode: U istraživanju je sudjelovalo 60 bolesnika zaprimljenih u bolnicu radi
kirurškog liječenja ugradnje totalne endoproteze zgloba kuka zbog OA te kirurške
dekompresije karpalnog tunela kod pacijenata sa SKT. U istraživanju je sudjelovalo 15
zdravih ispitanika kod kojih je mjerena serumska vrijednost istraživanih činitelja te je korišten
kadaverični tkivni materijal na kojem je analiziran tkivni izražaj i lokalizacija istih činitelja.
Imunohistokemijskom metodom utvrđivan je lokalni tkivni izražaj TNF-α, IL-1ß, TGF-ß1 i
BMP-7 u sinovijalnoj membrani kod OA zgloba kuka i subsinovijalnom tkivu kod SKT, a
njihova serumska koncentracija određivana je ELISA metodom.
Rezultati: Serumske razine BMP-7, IL-1β i TNF-α u bolesnika sa SKT, OA i skupini zdravih
ispitanika bila je unutar normalnog raspona i nije se značajno razlikovala među skupinama,
dok je serumska razina TGF-β1 bila značajno viša u skupini SKT bolesnika (16,36 pg/ml;
p<0,0001). Serumska razina BMP-7 bila je značajno viša u bolesnika kojima je
dijagnosticiran OA i SKT u komorbiditetu (2,6 pg/ml, 3,2 pg/ml, p<0,0001). Lokalnog
tkivnog izražaja IL-1ß i TGF-ß1 nije bilo niti u jednoj skupini ispitanika OA i SKT, dok je
umjereni izražaj TNF-α utvrđen u sinoviocitima i perivaskularnoj stromi sinovijalne
membrane OA ispitanika te izraziti izražaj BMP-7 u sinovijalnoj membrani OA ispitanika i u
subsinovijalnom tkivu ispitanika sa SKT.
Zaključak: Rezultati ukazuju na značaj razlika serumskih razina i lokalnog tkivnog izražaja
fibrotičkih i morfogenetskih citokina TGF-ß1 i BMP-7 u bolesnika sa i bez komorbiditeta OA
i SKT.Objectives: To determine the serum concentration and local tissue expression of
inflammatory cytokines TNF-α, IL-1ß and fibrotic and antifibrotic factors TGF-ß1 and BMP -
7 in the synovial membrane of the hip joint in OA and subsynovial tissue in CTS in patients
with and without comorbidity of these two diseases.
Patients and methods: In this study60 patients were participated which were undergoing
surgical treatment for total hip arthroplasty due to severe OA, and surgical decompression of
the carpal tunnel in patients with end stage of CTS. Also, 15 healthy subjects participated in
the research, in whom the serum value of the investigated factors were measured.
Furthermore, cadaveric tissue material was used for the control of tissue expression and
localization of the inflammatory and fibrotic factors. The local tissue expression of TNF-α,
IL-1ß, TGF-ß1 and BMP-7 in the synovial membrane in OA of the hip joint and in the
subsynovial tissue in CTS was determined by the immunohistochemical method, and their
serum concentration was determined by the ELISA method.
Results: The serum levels of BMP-7, IL-1β and TNF-α in patients with CTS, OA and the
group of healthy subjects were within the normal range and did not differ significantly
between these groups, while the serum level of TGF-β1 was significantly higher in the group
of CTS patients (16.36 pg/ml; p < 0.0001). The serum level of BMP-7 was significantly
higher in patients diagnosed with both OA and CTS (2.6 pg/ml, 3.2 pg/ml, p<0.0001). There
was no local tissue expression of IL-1ß and TGF-ß1 in any group of subjects with OA and
CTS, while moderate expression of TNF-α was found in synoviocytes and perivascular
stroma of the synovial membrane of OA subjects, and strong expression of BMP-7 both in the
synovial membrane of OA subjects and in the subsynovial tissue of subjects with CTS.
Conclusion: The results indicate the significance of differences in serum levels and local
tissue expression of fibrotic and morphogenic cytokines TGF-ß1 and BMP-7 in patients with
and without comorbidities of OA and SKT
Expression of proinflammatory and fibrotic cytokines in synovial tissue during hip osteoarthritis and carpal tunnel syndrome
No full textCiljevi istraživanja: Utvrditi serumsku koncentraciju i lokalni tkivni izražaj upalnih citokina
TNF-α, IL-1ß te fibrotičkih i antifibrotičnih činitelja TGF-ß1 i BMP-7 u sinovijalnoj
membrani zgloba kuka kod osteoartritisa (OA) i subsinovijalnom tkivu kod sindroma
karpalnog tunela (SKT) u bolesnika sa i bez komorbiditeta ove dvije bolesti.
Ispitanici i metode: U istraživanju je sudjelovalo 60 bolesnika zaprimljenih u bolnicu radi
kirurškog liječenja ugradnje totalne endoproteze zgloba kuka zbog OA te kirurške
dekompresije karpalnog tunela kod pacijenata sa SKT. U istraživanju je sudjelovalo 15
zdravih ispitanika kod kojih je mjerena serumska vrijednost istraživanih činitelja te je korišten
kadaverični tkivni materijal na kojem je analiziran tkivni izražaj i lokalizacija istih činitelja.
Imunohistokemijskom metodom utvrđivan je lokalni tkivni izražaj TNF-α, IL-1ß, TGF-ß1 i
BMP-7 u sinovijalnoj membrani kod OA zgloba kuka i subsinovijalnom tkivu kod SKT, a
njihova serumska koncentracija određivana je ELISA metodom.
Rezultati: Serumske razine BMP-7, IL-1β i TNF-α u bolesnika sa SKT, OA i skupini zdravih
ispitanika bila je unutar normalnog raspona i nije se značajno razlikovala među skupinama,
dok je serumska razina TGF-β1 bila značajno viša u skupini SKT bolesnika (16,36 pg/ml;
p<0,0001). Serumska razina BMP-7 bila je značajno viša u bolesnika kojima je
dijagnosticiran OA i SKT u komorbiditetu (2,6 pg/ml, 3,2 pg/ml, p<0,0001). Lokalnog
tkivnog izražaja IL-1ß i TGF-ß1 nije bilo niti u jednoj skupini ispitanika OA i SKT, dok je
umjereni izražaj TNF-α utvrđen u sinoviocitima i perivaskularnoj stromi sinovijalne
membrane OA ispitanika te izraziti izražaj BMP-7 u sinovijalnoj membrani OA ispitanika i u
subsinovijalnom tkivu ispitanika sa SKT.
Zaključak: Rezultati ukazuju na značaj razlika serumskih razina i lokalnog tkivnog izražaja
fibrotičkih i morfogenetskih citokina TGF-ß1 i BMP-7 u bolesnika sa i bez komorbiditeta OA
i SKT.Objectives: To determine the serum concentration and local tissue expression of
inflammatory cytokines TNF-α, IL-1ß and fibrotic and antifibrotic factors TGF-ß1 and BMP -
7 in the synovial membrane of the hip joint in OA and subsynovial tissue in CTS in patients
with and without comorbidity of these two diseases.
Patients and methods: In this study60 patients were participated which were undergoing
surgical treatment for total hip arthroplasty due to severe OA, and surgical decompression of
the carpal tunnel in patients with end stage of CTS. Also, 15 healthy subjects participated in
the research, in whom the serum value of the investigated factors were measured.
Furthermore, cadaveric tissue material was used for the control of tissue expression and
localization of the inflammatory and fibrotic factors. The local tissue expression of TNF-α,
IL-1ß, TGF-ß1 and BMP-7 in the synovial membrane in OA of the hip joint and in the
subsynovial tissue in CTS was determined by the immunohistochemical method, and their
serum concentration was determined by the ELISA method.
Results: The serum levels of BMP-7, IL-1β and TNF-α in patients with CTS, OA and the
group of healthy subjects were within the normal range and did not differ significantly
between these groups, while the serum level of TGF-β1 was significantly higher in the group
of CTS patients (16.36 pg/ml; p < 0.0001). The serum level of BMP-7 was significantly
higher in patients diagnosed with both OA and CTS (2.6 pg/ml, 3.2 pg/ml, p<0.0001). There
was no local tissue expression of IL-1ß and TGF-ß1 in any group of subjects with OA and
CTS, while moderate expression of TNF-α was found in synoviocytes and perivascular
stroma of the synovial membrane of OA subjects, and strong expression of BMP-7 both in the
synovial membrane of OA subjects and in the subsynovial tissue of subjects with CTS.
Conclusion: The results indicate the significance of differences in serum levels and local
tissue expression of fibrotic and morphogenic cytokines TGF-ß1 and BMP-7 in patients with
and without comorbidities of OA and SKT
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
"TRZAJNE OZLJEDE" VRATNE KRALJEŽNICE Veza između mehaničke ozljede i oštećenja živčanog tkiva
Full text linkDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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